Advertisement

Search Results

Advertisement



Your search for The A,The A matches 32802 pages

Showing 31351 - 31400


issues in oncology

Study Identifies Irinotecan Dosing Levels Based on UGT1A1 Genotype

Risk of severe irinotecan-associated neutropenia is related in part to presence of the UGT1A1*28 variant, which is linked to reduced elimination of the irinotecan active metabolite SN-38. In a study reported in the Journal of Clinical Oncology, Innocenti et al identified appropriate irinotecan...

supportive care

Long-Term Central Venous Catheter Use Associated With Three- to Sixfold Increased Risk of Infection in Older Patients With Cancer

In a retrospective SEER (Surveillance, Epidemiology, and End Results)/Medicare data analysis reported in the Journal of Clinical Oncology, Lipitz-Snyderman et al found that long-term central venous catheter use was associated with a three- to sixfold increase in risk of infection in older...

multiple myeloma

High-Dose Melphalan Plus Autologous Stem Cell Transplantation as Consolidation Shows Benefit in Relapsed Multiple Myeloma After Previous Transplant

In a UK phase III trial (NCRI Myeloma X Relapse [Intensive] Trial) reported in The Lancet Oncology, Cook et al found that high-dose melphalan plus salvage autologous stem cell transplantation significantly prolonged time to progression vs cyclophosphamide in patients with relapsed multiple myeloma...

cns cancers

Brain Tumor Invasion Along Blood Vessels May Lead to New Cancer Treatments, Preclinical Study Suggests

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain’s protective barrier, preclinical study published in Nature Communications indicated. The finding by Watkins et al could ultimately lead to new ways to bring about the ...

breast cancer

Fox Chase Cancer Center Researchers Recommend Updating the Staging Criteria for Breast Cancers With Skin Involvement

Invasive breast cancers with skin involvement, regardless of size or lymph node involvement, are automatically classified as stage III locally advanced tumors, which suggests that they are a relatively serious form of cancer with poor survival. In a study published in the Journal of the American...

sarcoma

Cyclophosphamide Noninferior to Ifosfamide as Part of Consolidation Treatment in Standard-Risk Ewing Sarcoma

In a European phase III noninferiority trial (Euro-EWING99-R1) reported in the Journal of Clinical Oncology, Le Deley et al found that cyclophosphamide was noninferior in event-free survival vs ifosfamide in combination with vincristine/dactinomycin as consolidation therapy in patients with...

issues in oncology

Patient Navigation Improves Time to Diagnosis Resolution and Treatment Initiation

In the Patient Navigation Research Program study reported in the Journal of the National Cancer Institute, Freund et al found that a patient navigation intervention improved diagnostic resolution and timely treatment initiation in a clinical population comprising predominantly racial/ethnic...

head and neck cancer
gastroesophageal cancer

French Phase III Trial Shows No Benefit of Neoadjuvant Chemoradiation in Stage I and II Esophageal Cancer

The effect of neoadjuvant chemoradiation therapy in early-stage esophageal cancer is not clear. In the phase III FFCD 9901 trial reported in the Journal of Clinical Oncology, Mariette et al found that neoadjuvant chemoradiation including fluorouracil (5-FU) and cisplatin did not improve R0...

colorectal cancer
issues in oncology

Study Identifies Patient and Tumor Characteristics Associated With BRAF and KRAS Mutations in Colon Cancer

In a study in the population of the North Central Cancer Treatment Group (NCCTG)/Alliance N0147 adjuvant trial reported in the Journal of the National Cancer Institute, Gonsalves et al identified patient and tumor characteristics that are associated with KRAS and BRAF V600E mutations in colon...

cns cancers

Preclinical Study Reveals Heparan Sulfate Suppresses Growth of Neuroblastoma

A heparin derivative differentiated cancer cells and caused neuroblastomas to regress without causing severe bleeding, according to the findings of a preclinical study presented in The Journal of Clinical Investigation. Knelson et al identified novel roles for heparan sulfate proteoglycans in...

breast cancer

Frailty Predicts Noninitiation but Not Discontinuation of Adjuvant Hormonal Therapy in Older Women With Breast Cancer

In a study reported in the Journal of Clinical Oncology, Sheppard et al found that frailty was a significant predictor of not starting adjuvant hormonal therapy in breast cancer patients aged ≥ 65 years, but was not predictive of discontinuation of treatment. Study Details The study was...

hepatobiliary cancer

No Survival Benefit With Everolimus After Failure of Sorafenib in Advanced Hepatocellular Carcinoma

The multikinase inhibitor sorafenib (Nexavar) is the only effective systemic treatment available in advanced hepatocellular carcinoma. In the phase III EVOLVE-1 trial reported in JAMA, Zhu et al found no survival benefit from treatment with the mTOR inhibitor everolimus (Afinitor) after sorafenib...

breast cancer

Adjuvant Paclitaxel Not Equivalent to Doxorubicin/Cyclophosphamide in Breast Cancer With 0 to 3 Positive Axillary Nodes

In the phase III Cancer and Leukemia Group B (CALGB) 40101/Alliance trial reported in the Journal of Clinical Oncology, Shulman et al found that noninferiority of adjuvant single-agent paclitaxel was not established vs doxorubicin/cyclophosphamide for relapse-free survival in women with operable...

hematologic malignancies
leukemia

Researchers Identify Events Causing Bone Marrow Inflammation Leading to Blood Disorders

According to a new study, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia. The discovery, published by the journal Cell Stem Cell, points the way to potential...

leukemia

FDA Grants Breakthrough Therapy Designation to Investigational Chimeric Antigen Receptor Therapy for Relapsed/Refractory ALL

The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy status to CTL019, an investigational chimeric antigen receptor (CAR) therapy for the treatment of pediatric and adult patients with relapsed/refractory acute lymphoblastic leukemia (ALL). The Breakthrough Therapy filing...

hepatobiliary cancer

FDA Grants Orphan Drug Designation to ENMD-2076 for Hepatocellular Carcinoma

CASI Pharmaceuticals, Inc, announced that its investigational agent ENMD-2076 has received orphan drug designation from the U.S. Food & Drug Administration (FDA) for the treatment of hepatocellular carcinoma. ENMD-2076 is an orally active Aurora A/angiogenic kinase inhibitor with a unique...

gynecologic cancers
issues in oncology

ABCA Transporter Gene Expression Is Associated With Poor Outcome in Epithelial Ovarian Cancer

In a study reported in the Journal of the National Cancer Institute, Hedditch et al found that expression of ATP-binding cassette (ABC) transporter genes of the A subfamily (ABCA) had a significant impact on outcome in epithelial ovarian cancer. High ABCA1, Low ABCA5 Expression Analysis of gene...

pancreatic cancer

Adding Oxaliplatin to Leucovorin/Fluorouracil Increases Survival in Second-Line Treatment of Gemcitabine-Refractory Pancreatic Cancer

In the German phase III CONKO-003 trial reported in the Journal of Clinical Oncology, Oettle et al found that second-line oxaliplatin, leucovorin, and fluorouracil (5-FU) significantly increased overall survival and time to progression vs leucovorin/5-FU in patients with advanced pancreatic cancer...

solid tumors

No Survival Benefit of Video-Assisted Thoracoscopic Partial Pleurectomy vs Talc Pleurodesis in Malignant Pleural Mesothelioma

In light of nonrandomized studies suggesting benefit of video-assisted thoracoscopic partial pleurectomy (VAT-PP) in symptom control and survival, Rintoul et al performed a randomized trial (MesoVATS) of VAT-PP vs talc pleurodesis in malignant pleural mesothelioma. As reported in The Lancet, this...

No Increased Risk for Cancer in Patients Receiving Tumor Necrosis Factor–Alpha Antagonists for Inflammatory Bowel Disease

Some data indicate an increased risk for cancer in patients receiving tumor necrosis factor (TNF)-alpha antagonists (eg, infliximab [Remicade], adalimumab [Humira], certolizumab pegol [Cimzia]) for rheumatoid arthritis. Studies with follow-up of ≤ 1 year have not found increased risk in patients ...

lymphoma
lymphoma

FDA Approves Belinostat for Relapsed or Refractory Peripheral T-Cell Lymphoma

The U.S. Food and Drug Administration (FDA) has granted accelerated approval to belinostat (Beleodaq), a histone deacetylase inhibitor, for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma, a rare and fast-growing type of non-Hodgkin lymphoma (NHL). “This is...

lung cancer

Propensity-Matched Analysis Shows Similar Outcomes for Segmentectomy vs Lobectomy in Stage I NSCLC

Recent retrospective, single-institution analyses have suggested that anatomic segmentectomy results in freedom from recurrence and survival rates similar to those achieved by lobectomy in lung cancer. In a large propensity-matched analysis reported in the Journal of Clinical Oncology, Landreneau...

breast cancer
gynecologic cancers
issues in oncology

Study Identifies Modifiers of Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

In a systematic review and meta-analysis reported in the Journal of the National Cancer Institute, Friebel et al attempted to identify factors that appear to modulate risk of breast and ovarian cancer in women who have inherited BRCA1 or BRCA2 mutations. Although the ability to perform...

multiple myeloma
sarcoma

Scientists Engineer Nanoparticles to Prevent Bone Cancer, Strengthen Bones

A research collaboration between Dana-Farber Cancer Institute and Brigham and Women’s Hospital has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent...

breast cancer
issues in oncology

Abbreviated Screening MRI Protocol Is Highly Accurate in Breast Cancer Detection in Women at Increased Risk

As reported in the Journal of Clinical Oncology, Kuhl et al assessed whether an abbreviated breast magnetic resonance imaging (MRI) protocol, consisting of one pre- and one postcontrast acquisition and derived images—first postcontrast–subtracted (FAST) and maximum-intensity...

breast cancer
issues in oncology

Study Shows Annual MRI Plus Mammography May Be Effective Screening Program for Women at High Risk for Breast Cancer

The Ontario Breast Screening Program expanded in July 2011 to include screening of high-risk women aged 30 to 69 years with annual magnetic resonance imaging (MRI) and digital mammography. As reported by Chiarelli et al in Journal of Clinical Oncology, a study of the initial screen in the program...

colorectal cancer
issues in oncology
issues in oncology

Multifaceted Intervention Improves Adherence to Annual Colorectal Cancer Screening in Primarily Latino Community Health Centers

Colorectal cancer screening rates are low among Latinos and people living in poverty. In a study reported in JAMA Internal Medicine, Baker et al found that a multifaceted intervention more than doubled adherence to screening with fecal occult blood testing in a largely Latino and uninsured...

colorectal cancer

5-Year Results of the European EXPERT-C Trial Show Benefit of Cetuximab in TP53 Wild-Type Rectal Cancer Subgroup

In an updated analysis of the European phase II EXPERT-C trial reported in the Journal of the National Cancer Institute, Sclafani et al found that adding cetuximab (Erbitux) to neoadjuvant capecitabine plus oxaliplatin (CAPOX) followed by chemoradiotherapy, surgery, and adjuvant CAPOX produced no...

issues in oncology

HIV-Infected People With Early-Stage Cancers Are Up to Four Times More Likely to Go Untreated for Cancer

HIV-infected people diagnosed with cancer are two to four times more likely to go untreated for their cancer compared to uninfected cancer patients, according to a large retrospective study from researchers in Penn Medicine’s Abramson Cancer Center and the National Cancer Institute (NCI). The ...

solid tumors
gastroesophageal cancer

Adding Rilotumumab to First-Line Chemotherapy May Benefit Patients With Advanced Gastric or Esophagogastric Junction Adenocarcinoma

Hepatocyte growth factor (HGF) and its receptor MET have been found to promote the proliferation, migration, and survival of tumor cells and to play a role in gastric cancer. In a phase II study reported in The Lancet Oncology, Iveson et al found evidence of benefit from adding the anti-HGF...

leukemia

FDA Grants Breakthrough Therapy Designation to Blinatumomab for Acute Lymphoblastic Leukemia

The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to blinatumomab for adults with Philadelphia chromosome–negative relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL), a rapidly progressing cancer of the blood and bone marrow....

colorectal cancer

Postdiagnosis Calcium and Milk Intake May Be Associated With Improved Overall Survival in Colorectal Cancer Patients

Higher intakes of calcium, vitamin D, and dairy product are associated with lower risk of colorectal cancer, but the effect of such intake on survival in colorectal cancer is unclear. In a study reported in the Journal of Clinical Oncology, Yang et al found that higher postdiagnosis intake of...

leukemia
survivorship

Excess Risk of Chronic Late Effects of Treatment in Children With Standard-Risk ALL

Given the changes in treatment of children with acute lymphoblastic leukemia (ALL), the risk of late effects in those treated with current protocols may be different from that in children treated decades ago. In a study of survivors of childhood standard-risk ALL reported in The Lancet Oncology,...

skin cancer

Surgical Treatment for Metastatic Melanoma of the Liver Increases Overall Survival in Select Group of Patients

Surgical resection markedly improved survival among metastatic melanoma patients whose disease is isolated to a few areas in the liver, according to new study findings published in the Journal of the American College of Surgeons. These results mark a departure for melanoma, which is most often...

skin cancer
issues in oncology

New Screening Approach Identifies Cancer Mutations in Melanoma That May Lead to More Effective Immunotherapies

Although cancer immunotherapy with adoptive transfer of tumor-infiltrating lymphocytes represents an effective treatment for patients with metastatic melanoma, the antigen targets recognized by these effective tumor-infiltrating lymphocytes remain unclear. According to a new study, a novel...

colorectal cancer

Phase III Trial Shows Improved Survival With TAS-102 in Metastatic Colorectal Cancer Refractory to Standard Therapies

The new combination agent TAS-102 can improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers reported at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona (Abstract O-0022). “Around 50%...

breast cancer

Telephone-Based Intervention Produces Weight Loss in Postmenopausal Women With Breast Cancer Receiving Letrozole

Obesity is associated with poorer outcome in women with operable breast cancer. In the LISA study reported in the Journal of Clinical Oncology, Goodwin et al found that a 24-month telephone-based intervention was effective in reducing body weight in postmenopausal breast cancer patients receiving...

gynecologic cancers
issues in oncology

American College of Physicians Issues Guideline Recommending Against Routine Pelvic Exams for Asymptomatic Women

A new evidence-based clinical practice guideline from the American College of Physicians (ACP) is recommending that physicians should not offer routine pelvic examinations to asymptomatic, average-risk, nonpregnant women. The recommendation stems from a review of 52 published articles from 1946...

skin cancer

Phase II Trial Shows Improved Progression-Free Survival but Greater Toxicity With Selumetinib vs Chemotherapy in Metastatic Uveal Melanoma

Oncogenic mutations in GNAQ and GNA11, resulting in MAPK pathway activation, are observed in > 80% of uveal melanomas. In a phase II trial reported in JAMA, Carvajal et al found that treatment with the MEK1/MEK2 inhibitor selumetinib significantly prolonged progression-free survival vs...

breast cancer
issues in oncology

Study of Over 450,000 Women Finds 3D Mammography Detects More Invasive Cancers and Reduces Recall Rates

Researchers found that three-dimensional (3D) mammography (also known as digital breast tomosynthesis) detected significantly more invasive cancers than a traditional mammogram alone and reduced call-backs for additional imaging. Published in JAMA, this is the largest study reported to...

breast cancer
health-care policy

Immediate Breast Reconstruction After Mastectomy More Likely Among Canadian Women With Higher Income Who Are Treated at Teaching Hospitals

In a study reported in the Journal of Clinical Oncology, Zhong et al assessed factors associated with use of immediate breast reconstruction after treatment or prophylaxis for breast cancer among women in the Canadian universal health-care system. Immediate breast reconstruction was more likely in...

pancreatic cancer

No Benefit of Adding Telomerase Peptide Vaccine to Chemotherapy in Patients With Advanced Pancreatic Cancer

In a UK phase III TeloVac trial reported in The Lancet Oncology, Middleton et al found that the sequential or concurrent addition of the telomerase peptide vaccine GV1001 to gemcitabine/capecitabine did not improve survival in patients with locally advanced or metastatic pancreatic cancer. GV1001...

health-care policy

Uninsured Young Adults Have Poorer Cancer-Specific Outcomes

The Patient Protection and Affordable Care Act is likely to improve insurance coverage for young adults. In a study reported in the Journal of Clinical Oncology, Aizer et al examined the association between insurance status and cancer outcomes among young adults, finding that the uninsured...

head and neck cancer

HPV-Positive Disease Predicts Longer Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma

Patients with human papillomavirus (HPV)-positive oropharyngeal cancer have reduced risk of progression compared with those with HPV-negative disease, but the effect of HPV status on overall survival after progression has not been clear. In a study reported in the Journal of Clinical Oncology,...

pancreatic cancer

Adding Novel Agent to Standard Therapy Improves Survival in Patients With Pancreatic Cancer After Prior Gemcitabine-Based Therapy

The addition of the novel agent MM-398 to standard treatment improved overall survival in patients with metastatic pancreatic cancer who have already received gemcitabine, according to a phase III trial reported at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona (Abstract...

gynecologic cancers

FDA Advisory Committee Votes Against Accelerated Approval for Olaparib in Ovarian Cancer

The U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) voted 11 to 2 that current evidence from clinical studies does not support an accelerated approval for use of olaparib as a maintenance treatment for women with platinum-sensitive relapsed ovarian cancer who have...

colorectal cancer

No Disease-Free Survival Benefit of Adding Cetuximab to FOLFOX4 in KRAS Exon 2 Wild-Type Resected Stage III Colon Cancer

In an interim analysis of the European phase III PETACC-8 trial reported in The Lancet Oncology, Taieb et al found no disease-free survival or overall survival benefit with the addition of cetuximab (Erbitux) to standard adjuvant FOLFOX4 (oxaliplatin, fluorouracil, leucovorin) therapy in patients...

St. Jude Children’s Research Hospital Appoints James R. Downing, MD, as CEO

St. Jude Children’s Research Hospital announced the appointment of James R. Downing, MD, as its new CEO, effective July 15, 2014. Dr. Downing most recently has served as the Deputy Director, Executive Vice President and Scientific Director of the hospital. He succeeds William E. Evans,...

issues in oncology

High Neutrophil-to-Lymphocyte Ratio Is Associated With Poorer Survival in Solid Tumors Overall and in Individual Cancer Types

In a systematic review and meta-analysis reported in Journal of the National Cancer Institute, Templeton et al found that high neutrophil-to-lymphocyte ratio, a marker of inflammation, is associated with significantly poorer overall survival in solid tumors overall and by individual category. High...

colorectal cancer

Synthetic Triterpenoids Show Promise in Preventing Colitis-Associated Colon Cancer in Preclinical Study

Researchers from Case Western Reserve and Dartmouth have shown that a class of small antioxidant molecules carries promise for suppressing colon cancer associated with colitis. These preclinical findings, published in the Journal of Clinical Investigation, offer hope that physicians ultimately will ...

Advertisement

Advertisement




Advertisement