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Showing 22001 - 22050HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study
A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...
American Ginseng Improves Cancer-related Fatigue
In a collaborative phase III trial of the North Central Cancer Treatment Group and Mayo Clinic reported in Journal of the National Cancer Institute by Debra L. Barton, RN, PhD, of the Mayo Clinic, and colleagues, patients with cancer-related fatigue were treated with Wisconsin ginseng (a common...
Accelerated Partial-breast Irradiation Using 3D Conformal Radiation Therapy Causes More Adverse Events Compared with Whole-breast Irradiation
The RAPID trial compared accelerated partial-breast irradiation using three-dimensional (3D) conformal external-beam radiation therapy vs whole-breast irradiation in women with invasive or in situ breast cancer ≤ 3 cm. As reported by Ivo A. Olivotto, MD, FRCPC, of the British Columbia Cancer...
Alternate-day, Low-dose Aspirin May Reduce Colon Cancer Risk
Low-dose aspirin (100 mg) taken every other day may reduce a woman’s risk of developing colon cancer, according to an observational study published in the Annals of Internal Medicine. The findings are based on a large long-term study of 38,876 healthy women enrolled in the Women’s...
Molecular Relative of p53 Tumor-suppressor Protein also Helps Cancer Cells Thrive
The protein TAp73 shares extensive common gene sequences with the tumor-suppressor protein p53, and previous studies have suggested that it may function similarly to p53 to prevent tumor formation. However, unlike p53, the most commonly mutated gene in human tumors, TAp73 is rarely mutated and is...
Cancer Survivors Might Have a Decreased Risk for Alzheimer's Disease
The results from a large cohort study of 3.5 million veterans in the Veterans Affairs (VA) Boston Healthcare System show that most types of cancer were associated with a reduced risk of developing Alzheimer’s disease of between 9% and 51%. The cancers associated with the greatest reduction in ...
Cancer Patients with Cardiovascular Risk Factors Who Receive Chest Radiation Should Have Cardiovascular Screening Every 5 to 10 Years
Cancer patients who receive chest radiation should be screened for heart disease every 5 to 10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology and the American Society of Echocardiography. Their recommendations are outlined in the ...
Bevacizumab/Pemetrexed Maintenance Increases Progression-free Survival vs Bevacizumab Alone in Advanced Nonsquamous NSCLC
Maintenance therapy is associated with improved survival in non–small cell lung cancer (NSCLC), but few studies have compared active agents in this setting. In a phase III trial (AVAPERL trial) reported in Journal of Clinical Oncology by Fabrice Barlesi, MD, PhD, of Aix Marseille...
Cancer Organizations Provide Support for Required Cancer Center Distress Screening Programs
The American Psychosocial Oncology Society (APOS) has announced recommendations to support a new criterion for cancer center accreditation. In 2015, the American College of Surgeons (ACoS) Commission on Cancer (CoC) will require cancer centers to implement screening programs for...
Most Commonly Used Ovarian Cancer Cell Lines Do Not Resemble Ovarian Cancer
Researchers from Memorial Sloan-Kettering Cancer Center recently discovered that the most frequently used cancer cell lines in ovarian cancer research are not suitable models of ovarian cancer. Their findings are the result of a detailed review of genomic data that recently became publicly...
Significant Improvement in Overall Survival Seen with Pemetrexed Maintenance after Pemetrexed/Cisplatin Induction in Patients with Advanced NSCLC
In the phase III PARAMOUNT trial, pemetrexed (Alimta) continuation maintenance therapy significantly reduced the risk of disease progression by 38% compared with placebo after pemetrexed/cisplatin induction in patients with advanced nonsquamous non–small cell lung cancer (NSCLC). Final...
Whole-exome Sequencing of the NCI-60 Cell Line Panel Provides a Genomic Resource for Cancer Biology and Systems Pharmacology
The NCI-60 cell lines, which represent cancers of lung, colon, brain, ovary, breast, prostate, and kidney as well as leukemia and melanoma, are the most frequently studied human tumor cell lines in cancer research and have generated the most extensive cancer pharmacology database worldwide. As...
Anxiety Is a Long-term Problem for Cancer Survivors and Spouses
An analysis assessing whether depression and anxiety are more common in long-term survivors of cancer compared with their spouses and with healthy control subjects has found that anxiety, rather than depression, is most likely to be a lingering problem for both cancer survivors and their spouses....
Nerves Play Key Role in Triggering Prostate Cancer and Promoting Metastases
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of...
Jamie H. Von Roenn, MD, Joins ASCO as Head of Education, Science, and Professional Development
Jamie H. Von Roenn, MD, Professor of Medicine at the Northwestern University Feinberg School of Medicine, has been named as the Senior Director of the Education, Science and Professional Development Department of the American Society of Clinical Oncology (ASCO). A long-time ASCO member and...
Protein Targeted for Cancer Drug Development Is Essential for Normal Heart Function
Scientists at St. Jude Children’s Research Hospital have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health. This dual role complicates efforts to develop cancer drugs that target the protein, but may lead to new therapies for heart muscle...
Study Confirms Link Between High Blood Levels of Omega-3 Fatty Acids and Increased Risk of Aggressive Prostate Cancer
A second large, prospective study by scientists at Fred Hutchinson Cancer Research Center has confirmed the link between high blood concentrations of omega-3 fatty acids and an increased risk of prostate cancer. Study Details Published online in the Journal of the National Cancer Institute, the...
Critical Pathway in Cell Cycle May Lead to Cancer Development
A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, published today in Molecular Cell, suggest a potential target for preventive measures...
Targeted Genetic Dependency Screen Identifies New Treatment Targets for Lung Cancer
According to research published in PNAS, scientists have used an efficient new screening strategy to identify gene mutations in tumor cells that are possible drug targets for the most common form of lung cancer. Researchers from the Cancer Research UK’s Paterson Institute for Cancer Research ...
New Drug Application Submitted for Ibrutinib in the Treatment of Two B-cell Malignancies
Pharmacyclics, Inc, today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the investigational oral Bruton's tyrosine kinase inhibitor ibrutinib, for two relapsed/refractory B-cell malignancy indications: mantle cell lymphoma (MCL) and...
Infertility in Men Raises Their Risk for Cancer
A cohort study of 2,238 men who were evaluated for infertility at a clinic in Texas from 1989 to 2009 found that those men who had azoospermia, a condition in which no measurable sperm is present, had a 2.2-fold higher cancer risk compared with those who were nonazoospermic. The study was published ...
Soy Protein Supplementation Does Not Reduce Risk of Prostate Cancer Recurrence after Radical Prostatectomy
Among men who had undergone radical prostatectomy, daily consumption of a beverage powder supplement containing soy protein isolate for 2 years did not reduce or delay development of biochemical recurrence of prostate cancer compared to men who received placebo, according to a study in the July 10...
Technologies for Monitoring Minimal Residual Disease May Help Predict Outcomes for Patients with Leukemia
New evidence suggests that using advanced genetics technologies to monitor for remaining cancer cells after treatment may soon become an effective tool to inform treatment decisions and ultimately predict patient outcomes for patients with a particularly aggressive form of acute lymphocytic...
Nearly Half of Sarcoma Surgeries Performed by Nononcologists
Nearly half the surgical procedures for sarcoma done at 85 academic medical centers were performed by surgeons untrained in oncology, according to national data analyzed by researchers from the University of California Davis Medical Center, Sacramento. Orthopedic oncologists and surgical...
New Guidelines Issued in the Treatment of Multiple Myeloma–related Bone Disease
The International Myeloma Working Group (IMWG) has developed clinical practice recommendations for the management of multiple myeloma–related bone disease based on published study data through August 2012. Consensus of the interdisciplinary panel of clinical experts on the plasma-cell...
Afatinib Prolongs Progression-free Survival Compared with Cisplatin plus Pemetrexed in EGFR-mutant Advanced Lung Adenocarcinoma
Afatinib is an oral selective ErbB family inhibitor that irreversibly blocks signaling from EGFR/ErbB1, HER2/ErbB2, and ErbB4 and has exhibited broad-spectrum activity against EGFR mutations in preclinical studies. A phase II study of afatinib in EGFR-mutation positive lung adenocarcinoma showed...
High Prediagnosis Red Meat Consumption Associated with Increased All-cause Mortality in Patients with Colorectal Cancer
There is evidence that diets high in red and processed meat are associated with increased risk of colorectal cancer. In a study reported in Journal of Clinical Oncology, Marjorie L. McCullough, ScD, and colleagues from the Epidemiology Research Program of the American Cancer Society examined the...
ASCO Releases Updated Guideline on Interventions for Women at Increased Risk for Breast Cancer
The American Society of Clinical Oncology (ASCO) issued a newly updated clinical practice guideline today on pharmacologic prevention interventions for premenopausal and postmenopausal women who are at increased risk for breast cancer. Compared to the previous version of the guideline, this third...
Five-year Survival Data from the Phase III CLASSIC Trial Show a 34% Reduction in Gastric Cancer Mortality
For patients with advanced gastric cancer, treatment with chemotherapy after surgery can reduce the risk of cancer-related death by 34% over 5 years compared to surgery alone, researchers reported at the 15th ESMO World Congress in Gastrointestinal Cancer (Abstract 007), held July 3 to 6 in...
African Americans with Chronic Lymphocytic Leukemia Do Not Live as Long as Caucasians, Despite Equal Care
A new analysis has found that among patients with chronic lymphocytic leukemia (CLL), African Americans more commonly present with advanced disease and tend to have shorter survival times than Caucasians despite receiving the same care. The results, published early online in Cancer, suggest that...
Two HIV Patients Show No Signs of Disease Following Bone Marrow Transplants for Hodgkin Lymphoma
Timothy Henrich, MD, Associate Physician in the Division of Infectious Disease at Brigham and Women’s Hospital in Boston, reported that two patients with long-standing HIV infections have no detectable levels of the disease in their blood cells, even though they stopped taking their...
Proton Radiation Is Not Associated with Increased Risk of Secondary Cancers When Compared with Photon Radiation
A retrospective cohort study of 558 patients treated with proton radiation from 1973 to 2001 at the Harvard Cyclotron Laboratory in Cambridge, Massachusetts, and data from 558 matched patients treated with photon therapy in the Surveillance, Epidemiology, and End Results (SEER) Program cancer...
Single Men, Smokers at Higher Risk for Oral HPV Infection
Smokers and single men are more likely to acquire oncogenic oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico, and Brazil also reported that newly acquired oral HPV...
ASCO and Other Cancer Groups Ask for Guidance on Protecting Patient Access to Clinical Trials
A jointly signed letter by ASCO and more than 50 other cancer and health-care organizations to the Secretary of Health and Human Services (HHS) Kathleen Sebelius and Acting Secretary of the Department of Labor (DOL) Seth D. Harris asks that they provide clear federal regulations and guidance on...
Increasing Incidence of Papillary Thyroid Cancer Linked to Overdiagnosis
The rapid increase in papillary thyroid cancer in the United States may not be linked to increase in occurrence, but instead may be linked to an increase in the diagnosis of precancerous conditions and to a person's insurance status, according to a study published online in Thyroid. "This [study]...
Stereotactic Body Radiation Therapy Safe and Effective for Patients with Stage I Non–Small Cell Lung Cancer
According to a recently published analysis in the Journal of Thoracic Oncology, stereotactic body radiotherapy (SBRT) is safe and effective for patients with stage I non–small cell lung cancer (NSCLC) in a multicenter environment. In addition, radiotherapy dosage was identified as a major...
Intercalated Chemotherapy plus Erlotinib Improves Survival in Asian Patients with Advanced NSCLC and Known or Unknown EGFR Mutation Status
In a phase III trial (FASTACT-2) conducted in 28 centers in seven Asian countries, Yi-Long Wu, MD, of the Guangdong Academy of Medical Sciences and colleagues found that the intercalated combination of erlotinib (Tarceva) and chemotherapy improved progression-free survival vs chemotherapy alone as...
WHO Tobacco Control Policies Estimated to Prevent 7.4 Million Premature Deaths by 2050
Tobacco control measures put in place in 41 countries between 2007 and 2010 are predicted to prevent an estimated 7.4 million premature deaths by 2050, according to a study published in the July issue of the Bulletin of the World Health Organization. The study is one of the first to ...
Biomarker Predicts Risk of Breast Cancer Recurrence after Tamoxifen Treatment
A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment. In a report published online in the Journal...
Acupuncture May Reduce Arm Lymphedema in Patients with Breast Cancer
Arm lymphedema affects approximately 30% of breast cancer survivors, with rates increasing with longer follow-up and cases presenting well beyond the active treatment period. Lymphedema is observed even with use of less-invasive surgical techniques for staging, and risk is further increased by such ...
Progression of Renal Cell Carcinoma Linked to Shifts in Tumor Metabolism
Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma. Their findings demonstrate that normal...
Scientists Develop Mathematical Model to Predict Cancer Cells’ Resistance to Therapy
New research using mathematical models of different types of cancer—including melanoma, pancreatic, and colorectal—to determine the evolutionary dynamics of lesions in response to treatment is revealing why and how cancer cells resist targeted therapies. The study by Ivana Bozic, PhD,...
Surgeons Report Melanoma Recurs after 10 Years in More than 6% of Patients
Recurrence of melanoma skin cancer 10 or more years after initial treatment is more common than previously thought, occurring in more than 1 in 20 patients. However, according to a new study, these patients tend to live longer after their cancer returns than patients whose melanoma recurs in the...
Active Surveillance May Miss Aggressive Prostate Cancers in African American Men
A study of more than 1,800 men aged 52 to 62 suggests that African Americans diagnosed with very low-risk prostate cancers are much more likely than white men to actually have aggressive disease that goes unrecognized with current diagnostic approaches. Although prior studies have found it safe to...
Survival Rates for Patients with Burkitt’s Lymphoma Improve, Especially among Young Adults
Although Burkitt’s lymphoma remains one of the most highly aggressive forms of B-cell non-Hodgkin lymphoma and is associated with human immunodeficiency virus (HIV) infection, a recent study published in Blood has found a marked improvement in patient survival over the past decade, especially ...
Study Sets Guidelines for Stem Cell Transplants in Older Patients with Myelodysplastic Syndromes
A new study by an international team of scientists provides the first statistically based guidelines for determining whether a stem cell transplant is appropriate for older patients with myelodysplastic syndromes (MDS), the most common blood disorders in people over 60 years of age, and frequently...
Among White Adolescents and Young Adults with Melanoma, Males Have Higher Mortality Than Females
Melanoma is the third most common cancer among adolescents and young adults, but few studies have explored the survival differences by sex in this population. A new study published in JAMA Dermatology sought to determine whether long-term survival varied between white male and female...
Study Shows Isoflavone Exposure Has Little Effect on Breast Cancer Risk or Recurrence
According to a review of studies examining the impact of isoflavones in soyfoods on breast cancer risk, clinical evidence indicates that exposure to isoflavones, which are classified as both phytoestrogens and selective estrogen receptor modulators, has little effect on the markers of breast cancer ...
BRAF Mutation Status May Have Effect on Benefit of Aspirin Use for Patients with Colorectal Cancer
In two large studies, the association between aspirin use and risk of colorectal cancer was affected by BRAF mutation status, with regular aspirin use associated with a lower risk of BRAF wild-type colorectal cancer but not with risk of BRAF-mutated cancer. The findings, published today in JAMA,...
Use of Advanced Treatment Technologies Increases among Men at Low Risk of Dying from Prostate Cancer
Use of advanced treatment technologies for prostate cancer, such as intensity-modulated radiotherapy (IMRT) and robotic prostatectomy, has increased among men with low-risk disease, high risk of noncancer mortality, or both, a population of patients who are unlikely to benefit from these...
