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Showing 21201 - 21250Study Suggests Proteins Involved in Immunity May Be Responsible for Cancer-causing Mutations
A set of proteins involved in the body’s natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings, published in Nature Genetics, suggest that these naturally produced mutations are just as...
HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study
A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...
Molecular Relative of p53 Tumor-suppressor Protein also Helps Cancer Cells Thrive
The protein TAp73 shares extensive common gene sequences with the tumor-suppressor protein p53, and previous studies have suggested that it may function similarly to p53 to prevent tumor formation. However, unlike p53, the most commonly mutated gene in human tumors, TAp73 is rarely mutated and is...
Cancer Patients with Cardiovascular Risk Factors Who Receive Chest Radiation Should Have Cardiovascular Screening Every 5 to 10 Years
Cancer patients who receive chest radiation should be screened for heart disease every 5 to 10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology and the American Society of Echocardiography. Their recommendations are outlined in the ...
Cancer Organizations Provide Support for Required Cancer Center Distress Screening Programs
The American Psychosocial Oncology Society (APOS) has announced recommendations to support a new criterion for cancer center accreditation. In 2015, the American College of Surgeons (ACoS) Commission on Cancer (CoC) will require cancer centers to implement screening programs for...
Use of Androgen Deprivation Therapy for Treatment of Prostate Cancer Associated with Increased Risk of Acute Kidney Injury
In a study that included more than 10,000 men with nonmetastatic prostate cancer, use of androgen deprivation therapy was associated with a significantly increased risk of acute kidney injury, with variations observed with certain types of androgen deprivation therapies, according to a study in the ...
Most Commonly Used Ovarian Cancer Cell Lines Do Not Resemble Ovarian Cancer
Researchers from Memorial Sloan-Kettering Cancer Center recently discovered that the most frequently used cancer cell lines in ovarian cancer research are not suitable models of ovarian cancer. Their findings are the result of a detailed review of genomic data that recently became publicly...
Colorectal Cancer Survivors Face Increased Risk of Developing Subsequent Cancers of Different Types
According to a new study, colorectal cancer survivors face an increased risk of developing subsequent primary cancers, particularly second colorectal cancers and small intestinal cancers. These findings, published online in Cancer, may help in the development of screening guidelines for patients...
Nerves Play Key Role in Triggering Prostate Cancer and Promoting Metastases
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of...
FDA Approves Afatinib for EGFR-mutant Late-stage Non–Small Cell Lung Cancer
The U.S. Food and Drug Administration (FDA) today approved the tyrosine kinase inhibitor afatinib (Gilotrif) for the first-line treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors express epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21...
Jamie H. Von Roenn, MD, Joins ASCO as Head of Education, Science, and Professional Development
Jamie H. Von Roenn, MD, Professor of Medicine at the Northwestern University Feinberg School of Medicine, has been named as the Senior Director of the Education, Science and Professional Development Department of the American Society of Clinical Oncology (ASCO). A long-time ASCO member and...
Protein Targeted for Cancer Drug Development Is Essential for Normal Heart Function
Scientists at St. Jude Children’s Research Hospital have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health. This dual role complicates efforts to develop cancer drugs that target the protein, but may lead to new therapies for heart muscle...
Study Confirms Link Between High Blood Levels of Omega-3 Fatty Acids and Increased Risk of Aggressive Prostate Cancer
A second large, prospective study by scientists at Fred Hutchinson Cancer Research Center has confirmed the link between high blood concentrations of omega-3 fatty acids and an increased risk of prostate cancer. Study Details Published online in the Journal of the National Cancer Institute, the...
Critical Pathway in Cell Cycle May Lead to Cancer Development
A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, published today in Molecular Cell, suggest a potential target for preventive measures...
Targeting Errant Immune System Enzyme Kills Myelodysplastic Cells
Scientists have successfully targeted a malfunctioning immune system enzyme to kill diseased cells from patients with myelodysplastic syndrome (MDS), a precursor to acute myeloid leukemia (AML). Reporting their results in Cancer Cell, researchers say their successful laboratory tests in human MDS...
Factors Influencing Delay in Breast Cancer Treatment Differ for African American and White Women
Different factors influence delay between diagnosis and first course of treatment for breast cancer for African American and white women, according to a recently published study in Cancer Epidemiology, Biomarkers & Prevention. The study used data from the Carolina Breast Cancer Study (CBCS)...
Targeted Genetic Dependency Screen Identifies New Treatment Targets for Lung Cancer
According to research published in PNAS, scientists have used an efficient new screening strategy to identify gene mutations in tumor cells that are possible drug targets for the most common form of lung cancer. Researchers from the Cancer Research UK’s Paterson Institute for Cancer Research ...
New Drug Application Submitted for Ibrutinib in the Treatment of Two B-cell Malignancies
Pharmacyclics, Inc, today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the investigational oral Bruton's tyrosine kinase inhibitor ibrutinib, for two relapsed/refractory B-cell malignancy indications: mantle cell lymphoma (MCL) and...
Soy Protein Supplementation Does Not Reduce Risk of Prostate Cancer Recurrence after Radical Prostatectomy
Among men who had undergone radical prostatectomy, daily consumption of a beverage powder supplement containing soy protein isolate for 2 years did not reduce or delay development of biochemical recurrence of prostate cancer compared to men who received placebo, according to a study in the July 10...
Technologies for Monitoring Minimal Residual Disease May Help Predict Outcomes for Patients with Leukemia
New evidence suggests that using advanced genetics technologies to monitor for remaining cancer cells after treatment may soon become an effective tool to inform treatment decisions and ultimately predict patient outcomes for patients with a particularly aggressive form of acute lymphocytic...
ASCO Releases Updated Guideline on Interventions for Women at Increased Risk for Breast Cancer
The American Society of Clinical Oncology (ASCO) issued a newly updated clinical practice guideline today on pharmacologic prevention interventions for premenopausal and postmenopausal women who are at increased risk for breast cancer. Compared to the previous version of the guideline, this third...
Five-year Survival Data from the Phase III CLASSIC Trial Show a 34% Reduction in Gastric Cancer Mortality
For patients with advanced gastric cancer, treatment with chemotherapy after surgery can reduce the risk of cancer-related death by 34% over 5 years compared to surgery alone, researchers reported at the 15th ESMO World Congress in Gastrointestinal Cancer (Abstract 007), held July 3 to 6 in...
African Americans with Chronic Lymphocytic Leukemia Do Not Live as Long as Caucasians, Despite Equal Care
A new analysis has found that among patients with chronic lymphocytic leukemia (CLL), African Americans more commonly present with advanced disease and tend to have shorter survival times than Caucasians despite receiving the same care. The results, published early online in Cancer, suggest that...
Single Men, Smokers at Higher Risk for Oral HPV Infection
Smokers and single men are more likely to acquire oncogenic oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico, and Brazil also reported that newly acquired oral HPV...
ASCO and Other Cancer Groups Ask for Guidance on Protecting Patient Access to Clinical Trials
A jointly signed letter by ASCO and more than 50 other cancer and health-care organizations to the Secretary of Health and Human Services (HHS) Kathleen Sebelius and Acting Secretary of the Department of Labor (DOL) Seth D. Harris asks that they provide clear federal regulations and guidance on...
FDA Grants Priority Review to Obinutuzumab in CLL and Pertuzumab in Neoadjuvant Therapy for HER2-positive Early-stage Breast Cancer
Two drugs were given Priority Review designation by FDA earlier this week. Obinutuzumab (GA101) was granted Priority Review for the treatment of chronic lymphocytic leukemia (CLL), based on final stage 1 data from the pivotal CLL11 trial. FDA also granted Priority Review to a pertuzumab (Perjeta)...
Novel Drug Combination Shows Activity in Recurrent Ovarian Cancer
A novel pairing of two investigational cancer drugs in patients with recurrent ovarian cancer showed promising activity and had manageable toxicities, according to a phase I trial published online in the European Journal of Cancer. The combination of the poly(ADP-ribose) polymerase (PARP)...
Increasing Incidence of Papillary Thyroid Cancer Linked to Overdiagnosis
The rapid increase in papillary thyroid cancer in the United States may not be linked to increase in occurrence, but instead may be linked to an increase in the diagnosis of precancerous conditions and to a person's insurance status, according to a study published online in Thyroid. "This [study]...
Stereotactic Body Radiation Therapy Safe and Effective for Patients with Stage I Non–Small Cell Lung Cancer
According to a recently published analysis in the Journal of Thoracic Oncology, stereotactic body radiotherapy (SBRT) is safe and effective for patients with stage I non–small cell lung cancer (NSCLC) in a multicenter environment. In addition, radiotherapy dosage was identified as a major...
WHO Tobacco Control Policies Estimated to Prevent 7.4 Million Premature Deaths by 2050
Tobacco control measures put in place in 41 countries between 2007 and 2010 are predicted to prevent an estimated 7.4 million premature deaths by 2050, according to a study published in the July issue of the Bulletin of the World Health Organization. The study is one of the first to ...
Biomarker Predicts Risk of Breast Cancer Recurrence after Tamoxifen Treatment
A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment. In a report published online in the Journal...
Oral Apixaban Lowers Rates of Major Bleeding in Patients with Acute Venous Thromboembolism
Single-agent apixaban (Eliquis) may simplify the treatment of patients with acute venous thromboembolism, according to a new study published online in The New England Journal of Medicine. In the phase III AMPLIFY trial, the oral factor Xa inhibitor anticoagulant was found to be as effective as ...
Progression of Renal Cell Carcinoma Linked to Shifts in Tumor Metabolism
Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma. Their findings demonstrate that normal...
Surgeons Report Melanoma Recurs after 10 Years in More than 6% of Patients
Recurrence of melanoma skin cancer 10 or more years after initial treatment is more common than previously thought, occurring in more than 1 in 20 patients. However, according to a new study, these patients tend to live longer after their cancer returns than patients whose melanoma recurs in the...
Active Surveillance May Miss Aggressive Prostate Cancers in African American Men
A study of more than 1,800 men aged 52 to 62 suggests that African Americans diagnosed with very low-risk prostate cancers are much more likely than white men to actually have aggressive disease that goes unrecognized with current diagnostic approaches. Although prior studies have found it safe to...
Study Sets Guidelines for Stem Cell Transplants in Older Patients with Myelodysplastic Syndromes
A new study by an international team of scientists provides the first statistically based guidelines for determining whether a stem cell transplant is appropriate for older patients with myelodysplastic syndromes (MDS), the most common blood disorders in people over 60 years of age, and frequently...
Among White Adolescents and Young Adults with Melanoma, Males Have Higher Mortality Than Females
Melanoma is the third most common cancer among adolescents and young adults, but few studies have explored the survival differences by sex in this population. A new study published in JAMA Dermatology sought to determine whether long-term survival varied between white male and female...
Study Reveals Abstracts with Financial Conflicts of Interest Have Higher Meeting Prominence, Better Peer Review Score
Beverly Moy, MD, Clinical Director of the Breast Oncology Program at Massachusetts General Hospital, and colleagues recently analyzed the relationship between declaration of financial conflicts of interest and "research prominence" for abstracts presented at American Society of Clinical Oncology...
Lugano 2013: Vitamin D Deficiency Associated with Worse Outcome in Elderly Patients with Aggressive B-cell Lymphoma Receiving R-CHOP or CHOP
Vitamin D deficiency recently was shown to be associated with worse outcome in patients with non-Hodgkin lymphoma. To determine whether such an association exists in patients with aggressive B-cell lymphoma, Jörg T. Bittenbring, of Saarland University Medical School, Germany, and colleagues in ...
BRAF Mutation Status May Have Effect on Benefit of Aspirin Use for Patients with Colorectal Cancer
In two large studies, the association between aspirin use and risk of colorectal cancer was affected by BRAF mutation status, with regular aspirin use associated with a lower risk of BRAF wild-type colorectal cancer but not with risk of BRAF-mutated cancer. The findings, published today in JAMA,...
Use of Advanced Treatment Technologies Increases among Men at Low Risk of Dying from Prostate Cancer
Use of advanced treatment technologies for prostate cancer, such as intensity-modulated radiotherapy (IMRT) and robotic prostatectomy, has increased among men with low-risk disease, high risk of noncancer mortality, or both, a population of patients who are unlikely to benefit from these...
New Study Finds AICR Recommendations Cut Breast Cancer Risk
Postmenopausal women who follow at least five Recommendations for Cancer Prevention from the American Institute for Cancer Research (AICR) cut their risk of developing breast cancer by more than half, compared to those who meet none, suggests a new study that adds to previous research showing...
Researchers Identify and Map Signaling Pathway from EGFR to MCM7 Protein
Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point. A team led by scientists at The University of Texas MD Anderson Cancer Center reported the tie between...
Investigators Identify Promising Biomarker for Predicting HPV-related Oropharyngeal Cancer
Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, In their study, at least one in three individuals with oropharyngeal cancer had antibodies to HPV, compared to...
Deep Sequencing Accurately Predicts Prolonged Survival in Multiple Myeloma Patients
A study by the Spanish Myeloma Group comparing the prognostic value of traditional response criteria and minimal residual disease measurement in patients with multiple myeloma found that a sequencing-based method called LymphoSIGHT and multiparameter flow cytometry analysis both accurately...
Virus Combination Effective Against Temozolomide-resistant Glioblastoma Multiforme
A combination of the myxoma virus and the immune suppressant rapamycin can kill glioblastoma multiforme, the most common and deadliest malignant brain tumor, according to new research published in Neuro-Oncology. Study lead author Peter A. Forsyth, MD, Chair of the Neuro-oncology Program at Moffitt ...
Screening Colonoscopy Associated with Increased Survival Duration and Rates for Patients with Colon Cancer
Patients with colon cancer identified on screening colonoscopy appear to have lower-stage disease on presentation and better outcomes independent of their staging, according to a report published online today in JAMA Surgery. Since their introduction in 2000, National Institutes of Health...
Mortality Appears to be Higher for Patients with Thicker Single Primary Melanomas than for Thicker Multiple Primary Melanomas
Although overall mortality rates due to single primary melanomas and multiple primary melanomas appear to be similar, relative mortality for thicker single primary melanomas appears to be greater than that for thicker multiple primary melanomas, according to a study by Anne Kricker, PhD, of the...
Observation Is Safe, Cost-saving Option for Patients with Low-risk Prostate Cancer
Many men with low-risk, localized prostate cancers can safely choose active surveillance or watchful waiting instead of undergoing immediate treatment and have better quality of life while reducing health-care costs, according to a study by researchers at Dana-Farber Cancer Institute and...
Investigational New Drug Application Filed for CFI-400945
Investigators from Princess Margaret Cancer Centre in Toronto and the University of California, Los Angeles, have submitted an Investigational New Drug (IND) application for CFI-400945, a novel drug candidate targeting the enzyme PLK4, which plays a crucial role in cell division. The news was...
