Search Results
Your search for ,had matches 18492 pages
Showing 16701 - 16750Black Women Have Higher Frequency of BRCA Mutations Than Previously Reported
Women who have inherited mutations in the BRCA1 or BRCA2 gene are more likely to develop breast cancer or ovarian cancer, especially at a younger age. Approximately 5% of women with breast cancer in the United States have mutations in BRCA1 or BRCA2, based on estimates in non-Hispanic white women. ...
Preclinical and Clinical Evidence of Lack of Sprouting Angiogenesis in Development of Lymph Node Metastases
In preclinical and clinical studies reported in the Journal of the National Cancer Institute, Jeong et al found a lack of sprouting angiogenesis in the formation of lymph node metastases, suggesting a potential mechanism for resistance to antiangiogenic treatments in adjuvant settings. The study...
Longer Colonoscopies Linked to Lower Rate of Colorectal Cancer
Research by a Veterans Affairs team has confirmed that longer-lasting colonoscopies are associated with lower cancer rates. Their findings were published by Shaukat et al in Gastroenterology, and were based on nearly 77,000 screening colonoscopies. Experts already know about the link between...
Beta-Blockers May Prolong Survival in Women With Ovarian Cancer
In a first-of-its-kind study, researchers demonstrated a benefit in overall survival among patients with epithelial ovarian cancer receiving generic beta-blocker heart medications. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to...
Patients With Fewer Than 50 Moles May Be at Risk for More Aggressive Melanoma
People with more than 50 moles have an increased risk of developing melanoma, but those with fewer than 50 moles should still be alert for this disease. In fact, according to new research presented at the American Academy of Dermatology’s 2015 Summer Academy Meeting in New York, those with...
Imaging Probe May Be More Accurate Than the Best External Detector for Early Cervical Cancer Diagnosis
An endovaginal magnetic resonance imaging technique is more accurate at detecting early-stage cervical cancer than the best available external detection technique, a new study reported. Researchers at The Institute of Cancer Research and The Royal Marsden Hospital found that using an...
Study Finds Many Women Experience Long-Term Psychosocial Consequences of False-Positive Screening Mammography
Although mammographic screening leads to reductions in breast cancer mortality, some women experience psychosocial side effects and do not benefit from screening, according to a study by Bolejko et al investigating the prevalence and predictors of the psychosocial consequences of false-positive...
Long-Term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs May Be Associated With Reduced Colorectal Cancer Risk
A large population-based control study of the use of low-dose aspirin or other nonsteroidal anti-inflammatory drugs and colorectal cancer risk has found that taking 75 mg to 150 mg of aspirin for 5 years or longer was associated with a 27% reduced risk of colorectal cancer. In addition, 5 or more...
Digital Gene Expression Cell of Origin Assay Shows High Prognostic Ability in Diffuse Large B-Cell Lymphoma
In a study reported in the Journal of Clinical Oncology, Scott et al found that the digital gene expression–based Lymph2Cx assay produced concordant cell of origin assignments in formalin-fixed paraffin-embedded tissue biopsies from patients with diffuse large B-cell lymphoma and showed high...
FDA Approves Eltrombopag for Pediatric Patients With Chronic Immune Thrombocytopenia
The U.S. Food and Drug Administration approved eltrombopag (Promacta) for the treatment of thrombocytopenia in pediatric patients aged 1 year and older with chronic immune thrombocytopenia who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. The approval was...
Study Evaluates Breast Cancer Mortality in Women With DCIS
In a study reported in JAMA Oncology, Narod et al found that the risk of breast cancer mortality was elevated in some patients with ductal carcinoma in situ compared with the general population, with the risk being higher in younger vs older women and black vs white women. Approximately half of...
Study Identifies Genes Associated With Improved Survival for Patients With Pancreatic Cancer
A multi-institutional study has found a new set of genes that may indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the...
Danish Analysis Indicates Increased Risk of Late Adverse Outcomes in Patients Treated for Relapsed Disseminated Testicular Germ Cell Cancer
In a Danish analysis reported in the Journal of Clinical Oncology, Lauritsen et al found that patients with testicular germ cell cancer who survived after more than one line of treatment for disseminated disease had an increased risk of late toxicity and death resulting from causes other than germ...
Black Women Less Likely Than Women of Other Races and Ethnicities to Survive Endometrial Cancer
Non-Hispanic black women with endometrial cancer had worse outcomes than women of other racial/ethnic groups diagnosed with the same subtype of endometrial cancer and at the same stage of disease, according to a study published by Cote et al in Cancer Epidemiology, Biomarkers & Prevention....
Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment
Multigene testing of women who tested negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations—most commonly, moderate-risk breast and ovarian cancer genes, as well as Lynch syndrome genes (which increase the risk of ovarian cancer)—according to an...
Pembrolizumab Cutaneous Adverse Events May Predict Better Response
In a single-center retrospective review reported in JAMA Dermatology, Sanlorenzo et al found that cutaneous adverse events in patients receiving the anti–PD-1 agent pembrolizumab (Keytruda), currently approved for treatment of melanoma, may indicate better treatment response. Study Details...
Adjuvant Taxane-Based Chemotherapy Is Not Associated With Increased Risk of Lymphedema, Study Finds
In women with breast cancer, taxane-based chemotherapy—docetaxel and paclitaxel—did not appear to increase the incidence of lymphedema, according to a study by Swaroop et al in Breast Cancer Research and Treatment. However, the investigators did note that adjuvant chemotherapy with...
Analysis Indicates That Tubal Ligation Is Associated With Lower Endometrial Cancer Stage at Diagnosis and Improved Survival
In an analysis from the NRG Oncology/Gynecologic Oncology Group 210 trial reported in the Journal of the National Cancer Institute, Felix et al found that tubal ligation, which should impede transtubal passage of cells, was associated with lower stage of endometrial cancer at presentation and...
Complete Resection of High-Grade Gliomas Yields Better Survival in Children, Especially Girls
For children with aggressive brain cancers called high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer, according to a report published by McCrea et al in Neurosurgery. In addition to showing better survival with gross total...
Persistent HPV16 DNA in Post-Treatment Oral Rinse Associated With Poor Prognosis in HPV-Related Oropharyngeal Carcinoma
In a prospective cohort study reported in JAMA Oncology, Rettig et al found that persistent human papillomavirus (HPV) type 16 DNA in post-treatment oral rinses was associated with a poorer prognosis in patients with HPV-related oropharyngeal cancer. The study included 124 patients treated with...
Organ Transplant Recipients May Be More Likely to Develop Aggressive Melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant and three times more likely to die of the skin cancer, suggested new research by a multi-institutional team. The findings, reported by Robbins et al in the Journal of Investigative...
Study Finds Music Therapy Lowers Anxiety During Surgical Breast Biopsies
A first-of-its-kind study published by Bradley Palmer et al in the Journal of Clinical Oncology found that music therapy lessened anxiety for women undergoing surgical breast biopsies for cancer diagnosis and treatment. The 2-year study, conducted at University Hospitals (UH) Seidman Cancer Center, ...
Hypofractionation of Breast Radiotherapy Associated With Reduced Acute Toxicity
In an analysis reported in JAMA Oncology, Jagsi et al found that hypofractionation of whole-breast radiotherapy was associated with reduced acute toxicity compared with conventional fractionation. Study Details The study involved data on physician-assessed toxic effects and patient-reported...
Preclinical Study Shows MRI and Chemical Contrast Solution Combination Can Detect Breast Cancer Micrometastases
Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors through detecting micrometastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body....
Higher Coffee Intake Associated With Significantly Reduced Cancer Recurrence and Increased Survival in Patients With Late-Stage Colon Cancer
A large observational study investigating the effect of coffee consumption on advanced-stage colon cancer and survival has found that patients who drank four or more cups of coffee a day were 42% less likely to experience a recurrence than non-coffee drinkers and were 33% less likely to die from...
POLE-Mutant and Microsatellite-Unstable Endometrial Tumors May Be Candidates for Anti–PD-1 Treatment
In a study reported in JAMA Oncology, Howitt et al found that polymerase e (POLE)-mutant and microsatellite-unstable endometrial tumors may be candidates for anti–PD-1 (programmed cell death protein 1) immunotherapy. Study Details In the study, neoantigen load was predicted on the basis of...
Combining Interleukin-2 With Imiquimod and Topical Retinoid Therapy May Be Effective Against Cutaneous Metastatic Melanoma
A novel combination therapy appears to be effective in treating patients with melanoma skin metastases, according to new research from the University of California (UC) Davis. Led by Emanual Maverakis, MD, of the UC Davis Department of Dermatology, the research found that interleukin-2...
Researchers Identify Nerve-Guiding Protein That May Be Associated With Pancreatic Cancer Metastasis
Scientists at the Johns Hopkins Kimmel Cancer Center have identified a molecular partnership in pancreatic cancer cells that might help to explain how the disease metastasizes in some cases. Their findings reveal urgently needed new targets to treat pancreatic cancer and were published by Foley et...
Patients With Breast Cancer Over Age 80 Less Likely to Benefit From Chemotherapy Alone Than Younger Patients
Chemotherapy prolongs life for older adults with most types of cancer, but for women with breast cancer over age 80, the chances of survival with chemotherapy alone are significantly lower than in younger patients, according to a study led by researchers from the University of Texas...
French Phase II Trial Suggests No Benefit of Adding Bevacizumab to Paclitaxel in Advanced Angiosarcoma
In a French phase II trial reported in the Journal of Clinical Oncology, Ray-Coquard et al found no apparent benefit of paclitaxel plus bevacizumab (Avastin) compared with weekly paclitaxel in patients with inoperable locally advanced or metastatic angiosarcoma. Study Details In this...
Susceptibility Gene Identified for Familial Nonmedullary Thyroid Cancer
As reported in The New England Journal of Medicine, Gara et al identified a germline HABP2 mutation as a susceptibility gene for familial nonmedullary thyroid cancer. Identification of HABP2 Variant In a kindred study, whole-exome sequencing was performed using peripheral blood DNA from affected...
Limited Resection Not Equivalent to Lobectomy for Survival in Older Patients With Early-Stage Lung Cancer
In an analysis reported in the Journal of Clinical Oncology, Veluswamy et al found that limited resection was not equivalent to lobectomy in overall survival among older patients with stage IA invasive adenocarcinoma or squamous cell carcinoma of the lung. Among patients with adenocarcinoma,...
Medullablastomas Can Be Classified Noninvasively at Diagnosis
Medulloblastoma, the most commonly occurring malignant brain tumor in children, can be classified into four subgroups, each with a different risk profile requiring subgroup-specific therapy. Currently, subgroup determination is done after surgical removal of the tumor. Investigators at...
Investigational Topical Gel Is Safe and Effective in Patients With Cutaneous T-Cell Lymphoma, Phase I Trial Shows
Results of a phase I trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early-stage cutaneous T-cell lymphoma. Currently, there is no cure for...
Oral Contraceptives May Offer Long-Term Protection From Endometrial Cancer
In an individual-patient meta-analysis reported in The Lancet Oncology, the Collaborative Group on Epidemiological Studies on Endometrial Cancer found that oral contraceptive use was associated with long-term protection from endometrial cancer. Reduction in risk was greater for carcinomas than...
Long-Term Survival in Ovarian Cancer May Be Better Than Expected in Some Patients
Combing data collected on thousands of California patients with ovarian cancer, University of California Davis researchers have determined that almost one-third of patients survived at least 10 years after diagnosis. The findings upend the notion that women diagnosed with cancer of the ovaries...
Key Genetic Factor in Cell Proliferation in Moles Identified
Scientists have known for years that a mutation in the BRAF gene makes moles start to grow but until now have not understood why they sometimes do not become cancerous. Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that...
Study Finds Increased Short-Term Risk for Cardiovascular Disease Mortality After Chemotherapy for Testicular Nonseminoma
In a population-based study reported in the Journal of Clinical Oncology, Fung et al found a significantly increased risk of cardiovascular disease mortality during the first year after chemotherapy for testicular nonseminoma. No increased risk of cardiovascular disease mortality after surgery was...
Addition of Docetaxel to Androgen-Deprivation Therapy Improves Survival in Metastatic Prostate Cancer
In the phase III E3805 trial reported in The New England Journal of Medicine, Sweeney et al found that chemohormonal therapy with docetaxel plus androgen-deprivation therapy produced a significant 13.6-month increase in median overall survival vs androgen-deprivation therapy alone in men with...
Packaging Paclitaxel in Nanoparticles May Increase Drug Efficacy in Preclinical Models
Duke University researchers found that packaging the widely used cancer drug paclitaxel into nanoparticles more than doubled the drug’s effectiveness in destroying tumors in preclinical models. Their findings were published by Bhattacharyya et al in Nature Communications. Paclitaxel has been ...
Delay in Treatment, Missed Diagnostic Testing Found Among Patients With Lung Cancer
Patients undergoing surgery for lung cancer may wait too long to receive treatment, and too many patients skip vital diagnostic steps that are needed to help determine the best possible treatment, according to findings published by Faris et al in The Annals of Thoracic Surgery. The 5-year relative ...
Clinical Scoring System May Help Identify Appropriate Colorectal Cancer Screening Methods
Researchers investigating a risk index for colorectal cancer and advanced precancerous polyps among average-risk people have found that patients classified as low risk had fewer advanced adenomas than patients classified as high risk. Their findings suggest that those at low risk for colorectal...
Study Identifies Genetic Mutations That Predict Response to Chemotherapy in Bladder Cancer
Although cisplatin-based neoadjuvant chemotherapy before cystectomy is the standard of care for muscle-invasive bladder cancer, only between 25% and 50% of patients achieve a pathologic response. A study investigating biomarkers that can predict response to chemotherapy in patients with...
17-Year Follow-up Indicates Early but Not Overall Reduction in Breast Cancer Mortality With Annual Mammography Screening at Age 40-49 Years
The 17-year follow-up in the UK Age trial, reported in The Lancet Oncology by Moss et al, indicated a reduction in breast cancer mortality during the first 10 years after diagnosis but not thereafter among women invited for annual mammography screening from age 40 to 49 years compared with...
Birinapant in Combination With Carboplatin May Be Effective Against Serous Ovarian Cancer
High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but it frequently recurs after the first line of treatment. A team of University of California, Los Angeles, researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, ...
Proteins Found in Urine May Serve as Biomarker for Early-Stage Pancreatic Cancer
A team of researchers at Barts Cancer Institute–Queen Mary University of London has discovered a combination of three proteins found at high levels in urine that can accurately detect early-stage pancreatic cancer. The discovery could lead to a noninvasive, inexpensive test to...
Biomarker Signature May Predict Aggressive Disease in African American Men With Prostate Cancer
In a study reported in Journal of Clinical Oncology, Yamoah et al identified a biomarker signature that may predict aggressive disease in African American men with prostate cancer. Study Details In the study, distribution of mRNA expression levels of 20 biomarkers associated with prostate cancer...
Involved-Field Radiotherapy May Be Best Option for Stage IA Nodular Lymphocyte-Predominant Hodgkin Lymphoma
As reported by Eichenauer and colleagues in the Journal of Clinical Oncology, an analysis of long-term outcomes suggests that involved-field radiotherapy may be the best treatment option in patients with stage IA nodular lymphocyte-predominant Hodgkin lymphoma. Study Details The study involved...
Researchers Identify Marker for Basal-Like Breast Cancer
A new way to detect—and perhaps treat—one of the deadliest types of breast cancer may have been found. Led by researchers at Boston University School of Medicine (BUSM), the study was published by Papageorgis et al in Breast Cancer Research. A subset of the triple-negative breast...
Benefit of Adjuvant Letrozole vs Tamoxifen Is Greater in Lobular Than in Ductal Breast Cancer
In a BIG 1-98 trial analysis reported in the Journal of Clinical Oncology, Metzger Filho et al found that the benefit of adjuvant letrozole vs tamoxifen was greater in patients with lobular than ductal breast carcinoma. Study Details In the BIG 1-98 trial, postmenopausal women with hormone...
