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Showing 15701 - 15750Yoga Improves Sleep Quality in Cancer Patients With Sleep Disruption
It is estimated that 30% to 90% of cancer patients experience impairment of sleep quality post-treatment and such impairment can be severe enough to increase morbidity and mortality. Preliminary evidence indicates that yoga may improve sleep in cancer patients. In a study reported in the Journal of ...
Smoking Cessation and Prevention App Free on iTunes
An app to prevent teens from smoking and encourage them to quit if they have started is now available at no cost on the Apple iTunes Store. “Our app combines education and entertainment with comics and interactive games,” said Designer Alexander Prokhorov, MD, PhD, a Professor in the...
Risk of Pancreatic Cancer May Be Reduced by Better Diet
In a study reported in the Journal of the National Cancer Institute, Hannah Arem, MHS, PhD, of the National Institutes of Health, and colleagues analyzed the association between quality of diet according to the 2005 Dietary Guidelines for Americans—Healthy Eating Index 2005...
Preclinical Tests May Lead to New Approach to Treat CNS Lymphoma
A drug recently approved for use in multiple myeloma is now being tested for its ability to fight central nervous system (CNS) lymphoma, a deadly cancer of the immune system that can affect the brain, spinal cord and fluid, and eyes. The clinical trial, now open at the three campuses of Mayo Clinic ...
Researchers Identify Key Protein in Treatment-Resistant Prostate Cancer
Prostate cancer is one of the most common forms of cancer in men and the leading cause of cancer deaths in white, African American, and Hispanic men, according to the Centers for Disease Control. However, it remains unclear why, despite treatment, some prostate cancers progress and may become...
Multicenter Trial Finds BI-RADS 3 Breast Lesions Have Low Cancer Rate
Based on data from a multisite imaging trial involving more than 2,600 women, researchers say breast lesions categorized as “probably benign” on supplemental screening ultrasound could be reevaluated with imaging in 12 months, reducing patient anxiety, follow-up exams, and unnecessary...
New MRI Technique Reveals Brain Tumor Response to Antiangiogenesis Therapy
A new way of analyzing data acquired in magnetic resonance imaging (MRI) appears to be able to identify whether or not tumors are responding to antiangiogenesis therapy, which may help physicians determine the most appropriate treatments for patients. In a report published online in Nature...
Gene That Helps Control Aging Is Linked to Multiple Myeloma
A telomerase RNA component gene called TERC, which is responsible for regulating the length of caps on the ends of DNA molecules and believed to be involved in the aging process, has been linked to the development of multiple myeloma, according to a study published in Nature Genetics. Researchers...
Intrachromosomal Amplification of Chromosome 21 Associated With Poor Outcome in Children With ALL
Intrachromosomal amplification of a region of chromosome 21 (iAMP21; three or more extra copies of RUNX1 on an abnormal chromosome 21) is a recently identified recurrent genomic abnormality associated with poorer outcome in acute lymphoblastic leukemia (ALL). In a study reported in Journal of...
Neoadjuvant Carboplatin Before Radiotherapy May Reduce Risk of Relapse and Long-Term Side Effects in Men With Testicular Cancer
A new study published in the Annals of Oncology reports that giving men with testicular cancer a single dose of chemotherapy before radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side effects. As many as 96% of men with testicular cancer are predicted to ...
Tumor Measurements Predict Survival in Advanced Non–Small Cell Lung Cancer
For the two-thirds of lung cancer patients with locally advanced or metastatic disease, tumor size is not used currently to predict overall survival times. However, a new study led by researchers at UT Southwestern Medical Center has shown that even in advanced stages total tumor size can have ...
Study Finds 1 in 5 Women Don’t Believe Their Breast Cancer Risk
Despite taking a tailored risk assessment tool that factors in family history and personal habits, nearly 20% of women did not believe their breast cancer risk, according to a new study from the University of Michigan Comprehensive Cancer Center. The findings, published in Patient Education and...
Breastfeeding for More Than 6 Months May Protect Against Breast Cancer in Nonsmoking Women
A new analysis has found that breastfeeding for more than 6 months may safeguard nonsmoking mothers against breast cancer. However, the same does not seem to hold true for mothers who smoke. Published early online in the Journal of Clinical Nursing, the findings add to the list of benefits of...
‘Reprogrammed’ Treatment-Resistant Lymphomas Respond to Azacitidine
A phase I clinical trial showed diffuse large B-cell lymphomas resistant to chemotherapy can be reprogrammed to respond to treatment after being pretreated with drug azacitidine (Vidaza), according to a study published in Cancer Discovery. Patients whose lymphomas recur after initial chemotherapy...
Researchers Identify Key Mechanism Behind Castration-Resistant Prostate Cancer
A team of researchers from UC Davis, UC San Diego, and other institutions has identified a key mechanism behind aggressive prostate cancer. Published online today in Nature, the study shows that two long noncoding RNAs, PRNCR1 and PCGEM1, activate androgen receptors, circumventing...
Study Suggests Neural Stem Cells May Regenerate After Radiation Therapy
Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new research in mice suggests that neural stem cells, the body's source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like...
Best of ASCO 2013: Off-Label Prescribing of Chemotherapy Drugs Is Common but Most Meets NCCN Compendium Criteria
Off-label prescribing of drugs remains common in oncology, but about two-thirds of off-label prescribing is consistent with the National Comprehensive Cancer Network (NCCN) Drugs & Biologics Compendium, according to a study reviewed at Best of ASCO Chicago by Monika K. Krzyzanowska, MD, MPH, of ...
FDA Approves Dolutegravir to Treat HIV-1 Infection
The U.S. Food and Drug Administration (FDA) today approved dolutegravir (Tivicay), a new drug to treat HIV-1 infection. Dolutegravir is an oral integrase strand transfer inhibitor that interferes with one of the enzymes necessary for HIV to multiply. The drug is taken in combination with other...
Study Identifies Interleukin-11 as a Potential New Anticancer Target
According to a study published online today in Cancer Cell, the molecule interleukin-11 may be a potential new target for anticancer therapies. Until now, interleukin-11’s role in cancer development has been underestimated, but researchers have recently identified this molecule as a "dark...
Certain Major Birth Defects Associated With Moderately Increased Cancer Risk in Children
A multistate study led by researchers at the University of Utah has revealed that the risk for childhood cancer is moderately increased among children and young adolescents with certain types of major birth defects. Children born with nonchromosomal birth defects have a two-fold higher risk of...
Burkitt Lymphoma Survival Outcomes Improve for Younger Patients
According to a new study published in the journal Cancer, the survival outcome of patients with Burkitt lymphoma has improved substantially over the past decade, with notable exceptions. To help doctors and researchers better understand who responds well to treatment and who does not, the study...
NIH Scientists Visualize How Cancer Chromosome Abnormalities Form in Living Cells
For the first time, scientists have directly observed events that lead to the formation of a chromosome abnormality that is often found in cancer cells. The abnormality, called a translocation, occurs when part of a chromosome breaks off and becomes attached to another chromosome. The results of...
Whole-Genome Sequencing Reveals Mutation Signature in Aristolochic Acid–Associated Upper Urinary Tract Cancer
Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of...
Study Suggests Pattern in Lung Cancer Pathology May Predict Cancer Recurrence After Surgery
A new study by thoracic surgeons and pathologists at Memorial Sloan-Kettering Cancer Center shows that a specific pattern found in the tumor pathology of some lung cancer patients is a strong predictor of recurrence. Knowing that this feature exists in a tumor's pathology could be an important...
Biomarker May Predict Risk of Graft-vs-Host Disease After Stem Cell Transplant
Researchers from Indiana University, the University of Michigan, the Fred Hutchinson Cancer Research Center, and the Dana-Farber Cancer Institute have identified and validated a biomarker accessible in blood tests that could be used to predict which stem cell transplant patients are at highest risk ...
Study Analyzes Oncologists’ Attitudes Regarding Patient-Reported Outcomes
A recent study published in the Journal of Oncology Practice assessed the feasibility and value of incorporating patient reported outcomes into oncology practice. Although previous research has shown that using patient-reported outcomes in oncology can improve physician-patient communication and...
FDA Grants Orphan Drug Status to Eisai’s Investigational Compound E7777 for Cutaneous T-Cell Lymphoma
The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Eisai’s investigational compound E7777 for cutaneous T-cell lymphoma. E7777 is designed to have an improved purity profile and manufacturing process. It is currently in a pivotal trial intended to support ...
Tositumomab/Iodine-131 Tositumomab Regimen for Non-Hodgkin Lymphoma to Be Discontinued
GlaxoSmithKline announced today that it will discontinue the manufacture and sale of the tositumomab/iodine-131 tositumomab (Bexxar) therapeutic regimen on February 20, 2014. Tositumomab/iodine-131 tositumomab is currently approved in the United States and Canada for the treatment of patients with ...
Loss of MicroRNA Decoy Might Contribute to Development of Soft-Tissue Sarcoma
Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have discovered a novel mechanism responsible for the loss of a critical tumor-suppressor gene in rhabdomyosarcoma and other...
Metformin Use Reduces All-Cause and Prostate Cancer–Specific Mortality in Men With Diabetes
In a study reported in Journal of Clinical Oncology, David Margel, MD, PhD, of University of Toronto, and colleagues examined the effect of duration of antidiabetic medication exposure after prostate cancer diagnosis on all-cause and prostate cancer–specific mortality in men with diabetes....
Researchers Identify Origin of Inflammation-Driven Pancreatic Cancer
Researchers at Mayo Clinic in Florida have revealed the process by which pancreatitis—chronic inflammation of the pancreas—morphs into pancreatic cancer. They say their findings point to ways to identify pancreatitis patients at risk of pancreatic cancer and to potential drug therapies...
Risk for Lymphoma Increases in Celiac Patients With Persistent Villous Atrophy
Although celiac disease is associated with an increased risk of lymphoma, including enteropathy-associated T-cell lymphoma, it was not known whether persistent atrophy of the villi, the fingerlike projections that normally absorb nutrients, contributed to that risk. In a large population-based...
Percentage of Cancers Linked to Viruses Potentially Overestimated
The results of a large-scale analysis of the association between DNA viruses and human malignancies suggest that many of the most common cancers are not associated with DNA viruses. The findings, published in the August issue of the Journal of Virology, challenge earlier studies suggesting that as...
Study Reveals Genes That Drive Glioblastoma
A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published online...
Sanford-Burnham Researchers Map a New Metabolic Pathway Involved in Cell Growth
Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In a study published in...
Mechanism Offers Promising New Approach for Harnessing the Immune System to Fight Cancer
Scientists at St. Jude Children’s Research Hospital have discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. Researchers also found evidence that the same mechanism may operate in humans. The study was published online today...
Researchers Target ‘Cell Sleep’ to Lower Chances of Cancer Recurrence
An international research team led by scientists at the University of Pittsburgh Cancer Institute (UPCI) discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. The findings, published...
Omega-3 Fatty Acids May Aid in Treatment and Prevention of Skin and Oral Cancers
Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early- and late-stage oral and skin squamous cell carcinomas, according to new research from scientists at Queen Mary, University of London. The findings were published online...
FDA Warns of Rare but Serious Skin Reactions with Acetaminophen
The U.S. Food and Drug Administration (FDA) is informing the public that acetaminophen has been associated with a risk of rare but serious skin reactions. These skin reactions, known as Stevens-Johnson Syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis, can...
Targeted Therapy Identified for Protein that Protects and Nourishes Cancer
Scientists at The University of Texas MD Anderson Cancer Center who identified a protein’s dual role in cancer promotion have discovered a way to shut it down, opening a potential new avenue for cancer treatment. Reporting their findings in the journal Cell, the researchers describe the first ...
Researchers Uncover How a Potent Compound Kills Prostate Cancer Cells
A new study led by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress. The study, recently published in Oncotarget, uncovered...
Acute Myeloid Leukemia Induces Bone Marrow Failure by Inhibiting Production of Hematopoietic Stem Cells
Scientists studying acute myeloid leukemia (AML) have discovered that rather than displacing hematopoietic stem cells in the bone marrow as previously believed, the cancer is in fact inhibiting production of downstream hematopoietic cells, effectively putting them to sleep. The findings were...
Digital Breast Tomosynthesis Reduces Breast Cancer Screening Recall Rate Compared to Mammography Alone
The addition of tomosynthesis to standard digital mammography resulted in a 30% reduction in overall recall rates among women being screened for breast cancer, according to a new study published online in Radiology. The results demonstrate that digital tomosynthesis is an effective tool in reducing ...
Some Women with Abnormal Breast Lesions May Avoid Surgery
Surgery is not always necessary for women with a type of breast tissue abnormality associated with a higher risk of cancer, according to a new study published online in Radiology. Researchers said that periodic imaging and clinical exam are effective in these patients when radiology and pathology...
Decision Aids Reduce Men's Conflict about PSA Screening, but Don't Change Their Decisions
Men who decide to be screened for prostate cancer and those who forgo PSA screening stick with their decisions after receiving materials explaining the risks and benefits of the test, according to a study published in JAMA Internal Medicine. The study examined both Web-based and printed tools aimed ...
James L. Mulshine, MD, Comments on U.S. Preventive Services Task Force Recommendations for CT Screening for Lung Cancer in High-risk Individuals
The recommendation by the U.S. Preventive Services Task Force (USPSTF) for the use of low-dose, computed tomography (CT) to detect early lung cancer in high-risk individuals is a major milestone in the war on cancer. Lung cancer is the leading cause of cancer death across the world. Despite...
U.S. Preventive Services Task Force Recommends Screening for Lung Cancer in High-risk Individuals
The U.S. Preventive Services Task Force posted its final evidence report and draft recommendation statement on screening for lung cancer. The Task Force is providing an opportunity for public comment on this draft recommendation statement; comments can be submitted from July 30 to August ...
Higher Incidence of Non-Hodgkin Lymphoma Found in Regions with Close Proximity to Benzene Release Sites
The incidence of a non-Hodgkin lymphoma (NHL) is significantly higher in regions near facilities that release the chemical benzene into the environment, according to a new study published early online in Cancer. This and other studies like it will be critical to identifying and enacting public...
Gene Test Highly Accurate in Predicting Metastasis in Patients with Thymoma
Patients diagnosed with thymoma, a rare cancer of the thymus gland, may be able to avoid certain cancer treatments associated with severe adverse events if the results of a new test reveal they are at low risk of metastasis, according to a study published in PLOS ONE. The study, by researchers at...
Intratumoral IL-12 Injections Shrink Melanoma and Merkel Cell Tumors
Intratumoral injections of plasmid DNA encoding interleukin-12 (IL-12), facilitated in its delivery by electroporation, results in tumor regression in patients with both metastatic melanoma and Merkel cell carcinoma, according to findings reported at the 2013 World Cutaneous Malignancies Congress...
