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Showing 15001 - 15050Past Exposure to Thiopurines Associated With Increased Risk of Myeloid Disorders in Patients With Inflammatory Bowel Disease
Past exposure to immunosuppressive drugs called thiopurines has been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, among patients with inflammatory bowel disease (IBD). The findings were reported by Lopez et al in Clinical...
Improved Prognosis Seen in Older Women With Mammography-Detected Breast Cancer
Mammography-detected breast cancer is associated with a shift to earlier stage diagnosis in older women, subsequently reducing the rate of more advanced, difficult-to-treat cases, according to a new study by Malmgren et al published in the journal Radiology. The findings lend support to regular...
Blood and Saliva Tests Help Predict Recurrence of HPV-Related Oral Cancer
Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus (HPV) shed from cancer cells lingering in the mouth or other...
Musculoskeletal Pain May Be Sign of Potential Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML
In a letter to the Journal of Clinical Oncology, Richter et al describe a potential tyrosine kinase inhibitor withdrawal syndrome characterized by musculoskeletal pain after stopping tyrosine kinase inhibitor treatment for chronic myeloid leukemia (CML). Onset After Tyrosine Kinase Inhibitor...
Growth-Driving Cancer Cells May Be Better Targets for Therapy Than Cells That Proliferate the Fastest, Study Suggests
Of the many subgroups of cells vying for control within a cancerous tumor, the most dangerous may not be those that can proliferate the fastest, researchers at Dana-Farber Cancer Institute reported in a study published in Nature. The findings have important implications for the treatment of cancer...
Results of Genomic Analysis Suggest Strategy for Overcoming Ibrutinib Resistance in Mantle Cell Lymphoma
Although the Bruton tyrosine kinase (BTK) inhibitor ibrutinib (Imbruvica) has shown unprecedented clinical activity in mantle cell lymphoma, about 32% of patients do not respond to the drug and majority of responders eventually relapse. Genomic sequencing of tumor and healthy tissue from patients...
Adults With Exclusively Pulmonary Metastases From Ewing Sarcoma May Benefit From Whole-Lung Irradiation
Nearly half of adult patients with lung-only metastases from Ewing sarcoma who received whole-lung irradiation were free of pulmonary relapse at 3 years, according to the results of a retrospective study in the International Journal of Radiation Oncology • Biology • Physics. With few...
Researchers Identify Genetic Mutations Linked to Salivary Gland Tumors
Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that...
Improved Overall Survival With Primary Over Consolidation Intraperitoneal Chemotherapy After Optimal Cytoreduction for Advanced Ovarian Cancer
Compared with intravenous (IV) followed by consolidation intraperitoneal (IP) chemotherapy, primary IV/IP chemotherapy was associated with a statistically significant improvement in overall survival—but not progression-free survival—in patients with advanced epithelial ovarian cancer...
Study Helps Compare Risks of Endoscopic vs Surgical Resection for Early Esophageal Cancer
A new study published in the Journal of the National Cancer Institute by researchers at Northwestern Medicine shed new light on the risks associated with the growing popularity of endoscopic resection in the treatment of localized, early-stage esophageal cancer. Merkow et al found that the...
Combination Afatinib and Cetuximab Yields Benefit in Lung Cancer Patients Resistant to EGFR Inhibitors
A phase Ib study has found that a combination of the EGFR-targeted agents afatinib (Gilotrif) and cetuximab (Erbitux) yielded clinical responses in patients with EGFR-mutant lung cancer that had stopped responding to the EGFR inhibitors erlotinib (Tarceva) and gefitinib (Iressa). The combination...
Adding Induction Chemotherapy to Chemoradiotherapy Does Not Improve Survival in Patients With N2 or N3 Locally Advanced Head and Neck Cancer
In a phase III trial reported in the Journal of Clinical Oncology, Cohen et al found that induction chemotherapy before chemoradiotherapy did not improve overall survival vs chemoradiotherapy alone in patients with N2 or N3 locally advanced squamous cell carcinoma of the head and neck. The study...
New Molecular Test Increases Odds of Correct Surgery for Thyroid Cancer Patients
The routine use of a molecular testing panel developed at the University of Pittsburgh Medical Center greatly increases the likelihood of performing the correct initial surgery for patients with thyroid nodules and cancer, reported researchers from the University of Pittsburgh Cancer Institute. The ...
Adaptive Intensity-Modulated Radiation Therapy Strategy May Ensure Adequate Target Coverage in Patients With Cervical Cancer
A novel, dosimetry-triggered, adaptive intensity-modulated radiation therapy strategy for patients with cervical cancer may minimize the risk of target underdosing in the setting of very small margins and substantial interfractional motion, according to a study by Lim et al in the International...
Dutch Phase II Study Supports Phase III Evaluation of Bevacizumab Plus Lomustine, but Not Bevacizumab Alone, in Recurrent Glioblastoma
Bevacizumab (Avastin) is frequently used in patients with recurrent glioblastoma, although it is unclear whether responses observed with such treatment result in improved overall survival. In the phase II Dutch BELOB study reported in The Lancet Oncology, Taal et al found that overall survival...
Antipain Agent Shrinks Oral Cancers, Sparing Healthy Tissue
Mouse models of human oral cancer treated with an agent called capsazepine showed dramatic tumor shrinkage without damage to surrounding tissues, researchers from the School of Dentistry and School of Medicine at The University of Texas Health Science Center at San Antonio found. The findings by...
FDA Approves Idelalisib for Three Types of Blood Cancers
The U.S. Food and Drug Administration (FDA) has approved idelalisib (Zydelig) for the treatment of patients with three types of blood cancers. Idelalisib is being granted traditional approval to treat patients with relapsed chronic lymphocytic leukemia (CLL). Used in combination with rituximab...
Metabolic Enzyme Stops Growth of Most Common Type of Kidney Cancer
In an analysis of metabolites in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. The new study, published in Nature by Simon et al, demonstrated that an enzyme called FBP1,...
Corticosteroids Improve Fatigue, Appetite Loss, and Patient Satisfaction but Not Pain in Opioid-Treated Advanced Cancer Patients, Small Study Shows
In a small Norwegian study reported in the Journal of Clinical Oncology, Paulsen et al found that methylprednisolone treatment improved fatigue, appetite loss, and patient satisfaction but not pain in patients with advanced cancer receiving opioid treatment for pain. Study Details In the study,...
Two Common Gene Variants Associated With Longer Telomere Length May Increase the Risk of Glioma
Two common gene variants that lead to longer telomere length may increase the risk of glioma, according to the results of a study presented by Walsh et al in Nature Genetics. This finding suggests that telomere length may prove to be a promising epidemiologic risk factor for cancer. It is well...
Cutaneous Embolization of Doxorubicin Drug-Eluting Beads in Patient With Liver Metastases From Breast Cancer
In a case report in JAMA Dermatology, Grieshaber et al describe finding cutaneous embolization of doxorubicin-eluting microspheres following transarterial chemoembolization in a woman with unresectable liver metastasis from breast cancer. Presentation The patient presented with painful pruritic...
Blocking Tumor-Derived Protein Halts Cachexia in Preclinical Study
New research raises the prospect of more effective treatments for cachexia, a profound wasting of fat and muscle occurring in about half of all cancer patients, raising their risk of death, according to scientists from Dana-Farber Cancer Institute. In a study reported in Nature, Spiegelman et al...
Study Compares Tamoxifen Gel Applied to the Breast With Oral Tamoxifen in Women With DCIS
A randomized, double-blind, placebo-controlled phase II trial comparing the antiproliferative effect of transdermal 4-hydroxytamoxifen gel (4-OHT), a potent antiestrogenic metabolite of tamoxifen, applied to the breast and oral tamoxifen in women with ductal carcinoma in situ (DCIS), has found the...
Testicular Cancer Rates Are on the Rise in Young Hispanic Americans
A new analysis has found that rates of testicular cancer have been rising dramatically in recent years among young Hispanic American men, but not among their non-Hispanic counterparts. Published early online in Cancer, the findings indicate that greater awareness is needed concerning the increasing ...
Variations in Key Gene Predict Prostate Cancer Patients’ Risk for Radiation-Induced Toxicity
Key genetic variants may affect how cancer patients respond to radiation treatments, according to a study recently published in Nature Genetics. The research team, which included researchers at the Icahn School of Medicine at Mount Sinai, found that variations in the TANC1 gene are associated with...
Study Identifies Novel Genomic Changes in Lung Adenocarcinoma
Researchers from Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and other centers have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. Knowledge of these mutations could potentially identify a...
Brain Tumor Invasion Along Blood Vessels May Lead to New Cancer Treatments, Preclinical Study Suggests
Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain’s protective barrier, preclinical study published in Nature Communications indicated. The finding by Watkins et al could ultimately lead to new ways to bring about the ...
Fox Chase Cancer Center Researchers Recommend Updating the Staging Criteria for Breast Cancers With Skin Involvement
Invasive breast cancers with skin involvement, regardless of size or lymph node involvement, are automatically classified as stage III locally advanced tumors, which suggests that they are a relatively serious form of cancer with poor survival. In a study published in the Journal of the American...
Frailty Predicts Noninitiation but Not Discontinuation of Adjuvant Hormonal Therapy in Older Women With Breast Cancer
In a study reported in the Journal of Clinical Oncology, Sheppard et al found that frailty was a significant predictor of not starting adjuvant hormonal therapy in breast cancer patients aged ≥ 65 years, but was not predictive of discontinuation of treatment. Study Details The study was...
Researchers Identify Events Causing Bone Marrow Inflammation Leading to Blood Disorders
According to a new study, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia. The discovery, published by the journal Cell Stem Cell, points the way to potential...
Multifaceted Intervention Improves Adherence to Annual Colorectal Cancer Screening in Primarily Latino Community Health Centers
Colorectal cancer screening rates are low among Latinos and people living in poverty. In a study reported in JAMA Internal Medicine, Baker et al found that a multifaceted intervention more than doubled adherence to screening with fecal occult blood testing in a largely Latino and uninsured...
Excess Risk of Chronic Late Effects of Treatment in Children With Standard-Risk ALL
Given the changes in treatment of children with acute lymphoblastic leukemia (ALL), the risk of late effects in those treated with current protocols may be different from that in children treated decades ago. In a study of survivors of childhood standard-risk ALL reported in The Lancet Oncology,...
Surgical Treatment for Metastatic Melanoma of the Liver Increases Overall Survival in Select Group of Patients
Surgical resection markedly improved survival among metastatic melanoma patients whose disease is isolated to a few areas in the liver, according to new study findings published in the Journal of the American College of Surgeons. These results mark a departure for melanoma, which is most often...
Phase III Trial Shows Improved Survival With TAS-102 in Metastatic Colorectal Cancer Refractory to Standard Therapies
The new combination agent TAS-102 can improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers reported at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona (Abstract O-0022). “Around 50%...
American College of Physicians Issues Guideline Recommending Against Routine Pelvic Exams for Asymptomatic Women
A new evidence-based clinical practice guideline from the American College of Physicians (ACP) is recommending that physicians should not offer routine pelvic examinations to asymptomatic, average-risk, nonpregnant women. The recommendation stems from a review of 52 published articles from 1946...
Study of Over 450,000 Women Finds 3D Mammography Detects More Invasive Cancers and Reduces Recall Rates
Researchers found that three-dimensional (3D) mammography (also known as digital breast tomosynthesis) detected significantly more invasive cancers than a traditional mammogram alone and reduced call-backs for additional imaging. Published in JAMA, this is the largest study reported to...
St. Jude Children’s Research Hospital Appoints James R. Downing, MD, as CEO
St. Jude Children’s Research Hospital announced the appointment of James R. Downing, MD, as its new CEO, effective July 15, 2014. Dr. Downing most recently has served as the Deputy Director, Executive Vice President and Scientific Director of the hospital. He succeeds William E. Evans,...
Synthetic Triterpenoids Show Promise in Preventing Colitis-Associated Colon Cancer in Preclinical Study
Researchers from Case Western Reserve and Dartmouth have shown that a class of small antioxidant molecules carries promise for suppressing colon cancer associated with colitis. These preclinical findings, published in the Journal of Clinical Investigation, offer hope that physicians ultimately will ...
BPA Stimulates Growth of Breast Cancer Cells, Diminishes Effect of Treatment
Bisphenol A (BPA), a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at ICE/ENDO 2014, the annual joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago. The ...
New Tool Predicts Financial Pain for Cancer Patients
In an online report in the journal Cancer, a team of University of Chicago cancer specialists have described the first tool—11 questions, assembled and refined from conversations with more than 150 patients with advanced cancer—to measure a patient’s risk for, and ability to...
No Improvement in Long-Term Outcomes With Extended Colectomy for Sporadic Colorectal Cancer in Patients Younger Than Age 50
Extended colectomy in patients with sporadic colorectal cancer who were younger than age 50, in comparison with segmental resection, did not improve the risk of tumor recurrence or disease-free survival, according to the results of a retrospective study presented by Klos et al in the Journal of...
Development of Orteronel for Prostate Cancer Voluntarily Discontinued by Takeda
Takeda Pharmaceutical Company Limited announced today that it has voluntarily decided to end the development program for orteronel (TAK-700), an investigational oral, nonsteroidal, selective inhibitor of 17,20-lyase, for prostate cancer. The decision follows the results of two phase III...
Racial Disparities in Sentinel Lymph Node Biopsy in Women With Breast Cancer
A study by Black et al from The University of Texas MD Anderson Cancer Center, Houston, found that the use of sentinel lymph node biopsy to stage early breast cancer increased in both black and white women from 2002 to 2007, but the rates remained lower in black than white patients, a disparity...
Diversity of Intestinal Tract Bacteria Associated With Mortality Outcomes After Stem Cell Transplant, Study Shows
New research published online in Blood suggests that the diversity of bacteria in the gastrointestinal tract of patients receiving stem cell transplants may be an important predictor of their post-transplant survival. Potential Connections Previous studies have shown that the intensive treatment...
Surgical Treatment Delay May Not Result in Worse Outcomes in Patients With Colon Cancer
A “reasonable” delay prior to surgery for colon cancer may not result in worse outcomes, according to the results of a retrospective study presented by Amri et al in the Annals of Surgical Oncology. Flexibility in scheduling surgery may lead to an improvement in the quality and safety...
Survey Finds Booming E-Cigarette Online Market
Researchers at the University of California, San Diego, School of Medicine have completed the first comprehensive survey of e-cigarettes for sale online, and the results, they believe, underscore the complexity in regulating the rapidly growing market for the electronic nicotine delivery devices....
Priming Pancreatic Cancer Cells With a Vaccine May Allow Them to Respond to Immunotherapy
Pancreatic ductal adenocarcinoma is considered a “nonimmunogenic” neoplasm and does not typically respond to immunotherapy, in part due to a complex tumor microenvironment that provides a formidable barrier to immune infiltration and function. A new study by Lutz et al has found that by ...
Study Identifies Two Proteins as Markers of Response to Neoadjuvant Chemotherapy for Ovarian Cancer
A study by researchers from Danbury Hospital Biomedical Research Institute in Connecticut has found that patients with ovarian cancer who relapse shortly after neoadjuvant chemotherapy to shrink their tumor prior to surgery have high levels of expression of HGF and c-Met proteins. The...
Stage Migration and Dilution of Higher Stages With PET in Head and Neck Cancer in a Managed Care Setting
A study reported in JAMA Otolaryngology-Head & Neck Surgery by VanderWalde and colleagues suggests that increasing use of positron emission tomography (PET) for diagnosis and staging of head and neck cancer has resulted in considerable stage migration characterized by dilution of higher stages...
Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network
A unique public-private collaboration among the National Cancer Institute (NCI), SWOG Cancer Research, Friends of Cancer Research, the Foundation for the National Institutes of Health (FNIH), five pharmaceutical companies (Amgen, Genentech, Pfizer, AstraZeneca, and AstraZeneca’s global...
