Expert’s Corner

Global Cancer Care

How ASCO’s Regional Councils Are Having an International Impact on Patients With Cancer

Jo Cavallo  /  February 25, 2024

In September 2023, ASCO announced the establishment of its fourth regional council, the Central and Eastern European Regional Council, which includes representatives from 17 countries, with the goal of expanding ASCO’s mission globally to “conquer cancer through research, education, and promotion of...

Issues in Oncology

How Being a Member of the President’s National Cancer Advisory Board Is Contributing to High-Quality Oncology Care

Jo Cavallo  /  January 25, 2024

This past year, President Joe Biden announced the appointment of six members to the National Cancer Advisory Board (NCAB; see related article). This board plays a crucial role in advising and assisting the director of the National Cancer Institute (NCI) in setting the activities of the national canc...

Issues in Oncology
Global Cancer Care

Improving Cancer Control in a Changing World

Jo Cavallo  /  December 25, 2023

On October 16 and 17, 2023, the Union for International Cancer Control (UICC) welcomed more than 350 attendees from over 75 countries to its World Cancer Leaders’ Summit in Long Beach, California, to discuss some of the most challenging issues facing patients with cancer worldwide. The theme of this...

Issues in Oncology

How ASCO Is Tackling the Need to Improve Workforce Diversity and the Looming Oncology Workforce Shortage

Jo Cavallo  /  November 10, 2023

On June 29, 2023, the U.S. Supreme Court, in a 6-to-3 decision, essentially overturned affirmative action in college admissions, which had allowed, since 1978, for colleges and universities to consider race as a factor in student admissions.1 The ruling will impact enrollment decisions at public and...

Breast Cancer

Tracking the Progress Being Made in the Treatment of Breast Cancer and the Challenges Ahead

Jo Cavallo  /  October 10, 2023

Jame Abraham, MD, FACP, has been in the field of oncology for more than 2 decades, he and says this is both one of the most exhilarating and challenging times in cancer care. “What excites me the most are the innovations in treatment that are literally transforming the lives of our patients and allo...

Issues in Oncology

Accelerating Progress Against Cancer and Other Life-Threatening Diseases

Jo Cavallo  /  September 25, 2023

Cancer—and the quest to accelerate more effective treatments and potential cures for all life-threatening diseases—has perhaps shaped the life of financier Michael Milken more than his legendary career on Wall Street. In the early 1970s, Mr. Milken’s mother-in-law was diagnosed with metastatic brea...

Lung Cancer

Data Analysis of Young-Onset Lung Cancer Reveals Key Differences Compared With the Disease in Older Adults

Jo Cavallo  /  September 10, 2023

Lung cancer, both small cell and non–small cell, is the second most common cancer in both men and women in the United States, with about 238,340 new cases diagnosed each year, and the leading cause of cancer-related mortality, accounting for more than 127,000 deaths annually.1 Lung cancer in younge...

Issues in Oncology

The Emerging Role of Exercise in Cancer Prevention and Treatment

Ronald Piana  /  March 10, 2021

The holistic benefits derived from exercise in preventing and ameliorating chronic health conditions such as cardiovascular disease and diabetes are well documented. However, less is known about the salutary effects exercise may have across the cancer setting, especially during treatment. Originall...

Issues in Oncology

Newer Cancer Therapies Offer Hope but Also May Confer Cardiac Risk

Ronald Piana  /  December 10, 2021

Since many different chemotherapeutic agents have been linked with cardiac adverse events, there is a growing need for strategies for the assessment and mitigation of treatment-induced cardiotoxicity. Moreover, the rapid rise of immunotherapies has added a new dimension to this clinical setting. ...


How the Cancer Moonshot Aims to Improve the Quality of Life for Adolescent and Young Adult Cancer Survivors

Jo Cavallo  /  August 25, 2023

Several recent studies have shown an increasingly disturbing trend: the incidence of early-onset cancers—those diagnosed in individuals younger than age 50—is on the rise, and not just in the United States but globally as well. Worldwide, in 2019, there were a reported 1.19 million new cases of canc...

Issues in Oncology

Keeping Staff and Patients Safe From Workplace Violence

Jo Cavallo  /  July 25, 2023

The statistics are chilling. According to estimates from the U.S. Bureau of Labor Statistics, workers in the fields of health care and social services are five times more likely to suffer from a workplace violence injury than workers overall.1 The Bureau statistics show that the rate of injuries fro...

Geriatric Oncology
Global Cancer Care

Assessing Geriatric Oncology Practice in Portugal

Jo Cavallo  /  July 10, 2023

The global population is aging rapidly. Currently, there are more than 703 million people worldwide aged 65 and older, representing 9.1% of the global population. It is estimated that this percentage will grow to 15.9%—1.5 billion people—by 2050.1 And with that growing aging population will come inc...

Issues in Oncology

Involving All of Society to End Cancer as We Know It

Jo Cavallo  /  June 10, 2023

This has been a year of firsts and seconds for Monica M. Bertagnolli, MD, FACS, FASCO. This past October, Dr. Bertagnolli became the 16th Director of the National Cancer Institute (NCI), the first woman and the first clinical trials cooperative group chair to hold that position. Then, 2 months later...

Making the Art of Oncology and Cancer Care Central to Her Presidential Term

Jo Cavallo  /  May 25, 2023

Lynn M. Schuchter, MD, FASCO, has said that volunteering and working with ASCO over many years has been the highlight of her career. She served on the ASCO Board of Directors from 2009 to 2012 and on several ASCO committees, including terms as Chair of the Annual Meeting Scientific Program Committee...

Issues in Oncology

How Patient Navigation Programs Are Helping Drive Equitable Care for Patients With Cancer and Improve Outcomes

Jo Cavallo  /  March 10, 2023

Although patient navigation is increasingly recognized as an important component in the delivery of patient-centered cancer care, the service is not universally available across all cancer programs in the United States, often because of the concerns of extra cost without tangible financial benefits....

Issues in Oncology

Understanding the Health Disparities That Sexual and Gender Minorities Face in Oncology Care

Jo Cavallo  /  February 25, 2023

In its programming for the 2022 ASCO Annual Meeting, ASCO included a special Education Session on “Gender-Based and Sexual Orientation Inequities: Promoting Inclusion, Visibility, and Data Accuracy in Oncology.” The session offered a comprehensive discussion on the challenges that sexual and gender ...

Issues in Oncology

Ensuring a More Diverse, Equitable, and Inclusive Workforce Within the SWOG Cancer Research Network

Jo Cavallo  /  January 25, 2023

For more than 2 decades, Don S. Dizon, MD, FACP, FASCO, has devoted his medical career to the care of women’s cancers and the sexual health of cancer survivors of all genders and sexual identities. Early in his career, Dr. Dizon founded the Center for Sexuality, Intimacy, and Fertility at Women &...

Breast Cancer
Gynecologic Cancers
Issues in Oncology

How the American Cancer Society Aims to Improve Outcomes in Breast and Cervical Cancers and Reduce Health Disparities

Jo Cavallo  /  December 25, 2022

Just days before the publication of the 2022 Annual Report to the Nation on the Status of Cancer on October 27, 2022,1 which showed a continued downward trend in cancer deaths, Karen Knudsen, MBA, PhD, Chief Executive Officer of the American Cancer Society (ACS), joined the First Lady Dr. Jill Biden...

Issues in Oncology

New Approaches Still Needed to Treat Patients With Cancer Who Have Serious Mental Illness

Ronald Piana  /  December 25, 2022

Although mandates by ASCO and the American Cancer Society to meet the needs of underserved populations have drawn much-needed awareness to the issue, patients with cancer who experience bipolar disorder, schizophrenia, and other debilitating mental illnesses continue to experience significantly wors...

Pancreatic Cancer

How the Pancreatic Cancer Early Detection Consortium Aims to Advance Survival Rates in This Deadly Disease

Jo Cavallo  /  December 10, 2022

The statistics are grim: Worldwide, pancreatic cancer is the 12th most common cancer and the seventh leading cause of cancer mortality.1 In the United States, the malignancy has the highest mortality rate of all major cancers. It is currently the third leading cause of cancer-related death after lun...

Breast Cancer

Study Finds Nearly Half of Black Women With Metastatic Breast Cancer Never Receive Information About Clinical Trial Participation

Jo Cavallo  /  November 10, 2022

When Stephanie L. Walker, RN, was diagnosed with metastatic breast cancer in 2015, she was not given information about an appropriate clinical trial or help navigating her way through the financial difficulties she was having after a stroke from complications of the cancer forced her to leave her jo...


The Evolving Role of PI3K Inhibitors in Double-Refractory CLL

Chase Doyle  /  November 10, 2022

The treatment paradigm for chronic lymphocytic leukemia (CLL) continues to evolve in the first-line setting and beyond, with the availability of Bruton’s tyrosine kinase (BTK) inhibitors, the BCL2 inhibitor venetoclax, and novel combinations of these agents with anti-CD20 monoclonal antibodies. ...

Prostate Cancer

A Urologic Surgeon Shares His Insights on Robotic Radical Prostatectomy

Ronald Piana  /  October 25, 2022

In 2000, the da Vinci Surgical System broke new ground by becoming the first robotic surgery system approved by the U.S. Food and Drug Administration for general laparoscopic surgery. In its early years, robot-assisted radical prostatectomy was characterized by some in the surgical community as an e...

Global Cancer Care

Update on the Impact of the Russian Invasion of Ukraine on Patients With Cancer

Jo Cavallo  /  October 10, 2022

In the more than 7 months since Russia invaded Ukraine on February 24, 2022, cancer care for Ukrainian citizens has changed dramatically. Ukraine was once a country able to provide its approximately 160,000 newly diagnosed patients with cancer each year with modern diagnostic methods, including tiss...

Multiple Myeloma

Is Science Getting Closer to Preventing Multiple Myeloma?

Jo Cavallo  /  August 25, 2022

About 3 years ago, researchers from Dana-Farber Cancer Institute launched PROMISE (Predicting Progression of Developing Myeloma in a High-Risk Screen Population; identifier NCT03689595), a large, ambitious screening study to identify individuals at high risk of developing multiple...

Multiple Myeloma

Patients With Multiple Myeloma May Face CAR T-Cell Shortages

Alice Goodman  /  September 25, 2022

From microchips to automobiles, people in the United States are experiencing shortages of all kinds of products, and oncology treatments are no exception. In particular, shortages related to chimeric antigen receptor (CAR) T-cell therapy have been reported, most acutely, for B-cell maturation antige...

Issues in Oncology

How EQRx Aims to Reengineer the Health-Care System to Produce More Effective, Less Costly Cancer Drugs

Jo Cavallo  /  September 10, 2022

The numbers are dizzying. The costs of cancer care in the United States are rising so fast that by 2030, it is projected the national cancer-attributable costs will total more than $246 billion, up from $183 billion in 2015—a 34% increase.1 And although the total global economic burden of cancer is ...

CNS Cancers

Deciphering the Elusive Origin and Pathways of Brain Metastases

Ronald Piana  /  July 25, 2022

The effective treatment of patients with brain metastases is an unmet need because, until fairly recently, patients with brain metastases were excluded from clinical trials of systemic therapies. However, the emergence of molecular targeted therapies has allowed a new treatment approach in patients ...

Former NCI Director Takes Stock of His Accomplishments and Looks Ahead to the Next Challenge

Jo Cavallo  /  July 10, 2022

After nearly 5 years as Director of the National Cancer Institute (NCI), interrupted by 7 months as Acting Commissioner for the U.S. Food and Drug Administration (FDA), Norman E. “Ned” Sharpless, MD, left his position on April 29 to concentrate on his family and contemplate his next career choice. D...

Issues in Oncology

Raising the Bar: Rethinking the Accelerated Drug Approval Process

Ronald Piana  /  July 10, 2022

Our growing knowledge of the molecular and genomic drivers of cancer has translated into a robust pipeline of promising anticancer agents. However, bringing new drugs from the lab to the patient with cancer can be frustratingly slow. To that end, the accelerated approval system was created by the U....

Issues in Oncology

How Social Media Is Fueling an Epidemic of Misinformation and Disinformation—and Distrust in Science

Jo Cavallo  /  June 10, 2022

The COVID-19 pandemic and the confluence of events that followed—including the rapid development of vaccines, the mixed messaging on mitigation efforts to prevent coronavirus infection, and the growing political polarization—helped spark public mistrust and skepticism toward science. This mistrust h...

ASCO’s President-Elect Makes Partnering With Patients the Cornerstone of His Presidential Term

Jo Cavallo  /  June 3, 2022 - Narratives Special Issue

This year, Eric P. Winer, MD, FASCO, takes on two new leadership roles in his illustrious medical career. In February, Dr. Winer left his positions as Chief Clinical Development Officer and Senior Vice President for Medical Affairs at Dana-Farber Cancer Institute, and Leader of the Dana-Farber/Harva...

Global Cancer Care

How St. Jude and the WHO Are Sparking an International Movement to Increase Treatment Access for Children With Cancer

Jo Cavallo  /  May 25, 2022

The toll of cancer on children, especially those living in low-resource countries, is staggering. Each year, an estimated 400,000 children and adolescents worldwide develop cancer,1 and despite improved survival rates, the global 5-year net childhood cancer survival rate is only 37.4%,2 making cance...

Global Cancer Care

How ASCO, ECO, and WHO Are Marshalling Resources to Provide Care for Ukrainian Civilians and Refugees With Cancer

Jo Cavallo  /  April 25, 2022

Since Russia invaded Ukraine on February 24, the number of attacks on health-care facilities continues to mount. According to the World Health Organization (WHO), as of March 16, there have been 43 attacks on health facilities, including 34 attacks that have directly impacted health facilities and 7...


Protecting the Immunocompromised From COVID-19: Practical Information for Physicians

Chase Doyle  /  April 10, 2022

COVID-19 may have caught the world off guard in 2020, but in the 2 years since the pandemic began, several effective monoclonal antibodies and antiviral drugs have emerged to protect the most vulnerable patients. The ASCO Post spoke with Gunjan L. Shah, MD, a hematologic oncologist at Memorial Sloa...

Issues in Oncology

Emerging Issues Regarding Artificial Intelligence in Cancer Research and Clinical Practice

Ronald Piana  /  March 10, 2022

Artificial intelligence (AI) has captured society’s imagination and generated enthusiasm for its potential to improve our quality of life, especially in the health-care arena. The availability of high-dimensionality data sets along with innovations in high-performance computing and deep-learning arc...

Pain Management

Studies Show That Laws to Limit Opioid Prescribing Have Hampered Pain Control for Patients With Cancer

Ronald Piana  /  February 25, 2022

In 2015, an unprecedented phenomenon occurred in the United States: according to the World Bank Group, the nation’s average life expectancy fell from 78.8 years in 2014 to 78.7 years in 2015, then to 78.5 years in 2017. The last time our life expectancy registered a similar decline was in the years ...

Issues in Oncology

Challenges for Oncologists as They Reach Retirement Age

Ronald Piana  /  February 10, 2022

In 2014, The ASCO Post spoke with Mark J. Clemons, MB BS, BMedSci, MSc, MD, FRCP, FRCPC, of Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada, about the retirement challenges faced by many oncologists. With market demand expected to exceed supply of oncologists soon, it is clear retirement is n...

Gastrointestinal Cancer
Cost of Care
Issues in Oncology

Assessing Value in Gastrointestinal Cancer Treatments

Ronald Piana  /  February 10, 2022

The era of precision oncology, in which molecular biomarkers are used to help guide drug delivery, has dovetailed with the emerging issues of value-based care and cost containment. To shed light on these issues and more, The ASCO Post spoke with Hanna K. Sanoff, MD, MPH, Clinical Medical Director of...

Issues in Oncology

Recent Study Aims to Improve the Quality of Cancer Care in Rural Areas

Ronald Piana  /  January 25, 2022

Despite growing national awareness of health-care inequities, cancer care for many rural Americans remains inadequate. To shed some light on the challenges faced by patients with cancer in rural areas, The ASCO Post spoke with Mary Charlton, PhD, Associate Professor of Epidemiology in the University...

Issues in Oncology

Developing a Comprehensive System for Personalized Survivorship-Centered Care Plans

Jo Cavallo  /  January 25, 2022

By 2040, the number of cancer survivors in the United States is expected to climb from 17 million today to 26.1 million, with most living 5 years or more after their diagnosis. However, many of these survivors will need ongoing monitoring for treatment-related side effects and cancer recurrence afte...

Colorectal Cancer

Does Geography Play a Role in Early-Onset Colorectal Cancer in Young Black Men?

Jo Cavallo  /  January 25, 2022

Although the incidence and mortality rates in colorectal cancer have dropped by 3.6% each year from 2007 to 2016 for people aged 55 and older—mainly because of increased colorectal cancer screening, advances in therapy, and reductions in smoking—these rates have increased by 2% each year during the ...

Colorectal Cancer

Solving the Conundrum of Young-Onset Colorectal Cancer

Jo Cavallo  /  December 25, 2021

Although research so far has failed to uncover the root causes of the development of young-onset colorectal cancer, what is certain is that although colorectal cancer rates are declining in older adults, they are on a steady rise in people younger than age 50, especially those between the ages of 18...

Issues in Oncology

Establishing a Health Equity Report Card to Eradicate Disparities in Cancer Care

Jo Cavallo  /  December 10, 2021

Although enormous progress over the past 50 years in every aspect of cancer care, including prevention, screening, chemotherapy, targeted therapy, surgery, radiation therapy, and supportive care, has resulted in increases in lives saved—from 3 million in 1971 to 16.9 million in 2019—the burden of ca...

Prostate Cancer

Adding Value to Clinical Decision-Making in Nonmetastatic Castration-Resistant Prostate Cancer

Ronald Piana  /  October 10, 2021

Several recent investigations have led to the U.S. Food and Drug Administration (FDA) approval of novel antiandrogens to treat nonmetastatic castration-resistant prostate cancer. Yet, this work has not addressed the treatment of nonmetastatic hormone-sensitive biochemically recurrent prostate cancer...

Global Cancer Care

Building a ‘Better Normal’ of Oncology Care to Strengthen Global Health Security After the COVID-19 Pandemic

Jo Cavallo  /  September 25, 2021

During the opening session of the 2021 ASCO Annual Meeting, Julio Frenk, MD, PhD, MPH, President of the University of Miami, gave a riveting presentation in which he described the devastating effects of the global COVID-19 pandemic on patients with cancer as well as on fragile and fragmented health-...

Issues in Oncology
Palliative Care

Improving End-of-Life Discussions With Patients Who Have Advanced Cancer

Jo Cavallo  /  September 10, 2021

Although studies have shown that patients with advanced cancer want their oncologists to discuss their advance care plans with them, fewer than half of those patients have that conversation. The reasons are many, including the difficulty many oncologists have in initiating conversations about noncur...

Issues in Oncology
Palliative Care

Balancing a Reverence for Life With a Belief That Patients Have a Right to a Dignified Death

Jo Cavallo  /  May 25, 2021

The U.S. right-to-die movement took root in the mid-1970s, when Derek Humphry helped his wife, who was dying of breast cancer, take her own life. Five years later, Mr. Humphry founded the Hemlock Society, the first right-to-die organization in the United States,1 and set off a firestorm of controver...

Issues in Oncology
Global Cancer Care

How Climate Change Is Impacting Cancer Care and What Can Be Done to Reduce Oncology’s Footprint on the Environment

Jo Cavallo  /  August 10, 2021

Worldwide, the global average surface temperature has risen at a similar rate of 0.17°F per decade since 1901, with the warmest year on record occurring in 2016 and the second warmest occurring in 2020. However, according to NOAA, since the late 1970s, the United States has warmed faster than the gl...

Multiple Myeloma

Defining Cure in Multiple Myeloma

Jo Cavallo  /  July 10, 2021

The past 2 decades have seen so many advances in the treatment of multiple myeloma; in addition, median patient survival has grown from just 3 years in the late 1990s to between 8 and 10 years today,1 with some patients exceeding that prognosis by many years. Although still considered a stubbornly i...