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Showing 3901 - 3950Breast Cancer Rates Are Rising Among African American Women
Although, historically, white women aged 40 years and older have had the highest incidence rates of breast cancer, the rising rate of breast cancer among African American women—especially among women aged 50 to 59—is narrowing the gap, according to a study by American Cancer Society...
ECC 2013: PI3KCA-Mutant Tumors Not Likely to Respond to Neoadjuvant HER2 Blockade
In patients with early breast cancer receiving anti-HER2 therapy in the NeoALTTO trial, mutations in PIK3CA were associated with lower rates of pathologic complete response, Jose Baselga, MD, reported at the European Cancer Congress 2013 (Abstract 1859) in Amsterdam. In patients treated with the...
Increases in Melanoma Incidence and Mortality Unremitting Over 6 Decades, Study Finds
In a study reported in Journal of Clinical Oncology, Alan C. Geller, MPH, RN, of the Harvard School of Public Health, and colleagues assessed long-term trends in the incidence and mortality of melanoma in Connecticut, a state with complete and consistent tumor registration. They found...
Meta-Analysis Suggests Fluorouracil or Gemcitabine Is Optimum Adjuvant Treatment for Pancreatic Cancer
A meta-analysis reported in The Lancet Oncologyby Wei-Chih Liao, MD, of National Taiwan University Hospital and colleagues indicates that fluorouracil (5-FU) or gemcitabine is optimal adjuvant therapy for pancreatic adenocarcinoma. Chemoradiation was associated with poorer survival and...
Tremelimumab Shows Some Activity in Chemotherapy-Resistant Advanced Malignant Mesothelioma, Phase II Study Finds
Tremelimumab is an anticytotoxic T-lymphocyte antigen 4 (CTLA4) monoclonal antibody, a class of inhibitor that has shown activity in multiple tumor types. Ipilimumab (Yervoy), another agent in this class, was found to significantly prolong overall survival in metastatic melanoma despite a...
Phase II Study Shows Durable Effect of Lenalidomide in Relapsed/Refractory Mantle Cell Lymphoma
In a phase II study (MCL-001, EMERGE) reported in Journal of Clinical Oncology, Andre Goy, MD, of Hackensack University Medical Center, and colleagues evaluated the use of single-agent lenalidomide (Revlimid) in bortezomib (Velcade)-treated patients who had relapsed/refractory mantle cell lymphoma. ...
Low-Dose CT Screening Identifies More Early Lung Cancer But Has Lower Positive Predictive Value vs Radiography
Results of the two rounds of annual incidence screening with low-dose computed tomography (CT) vs radiography in the National Lung Screening Trial (NLST) were recently reported by Denise R. Aberle, MD, of University of California at Los Angeles, and colleagues in The New England Journal of...
Cabozantinib Improves Disease-Free Survival in Progressive Medullary Thyroid Cancer
Cabozantinib (Cometriq) is an inhibitor of hepatocyte growth factor receptor (MET), VEGFR2, and rearranged during transfection (RET) tyrosine kinases. In a phase III trial reported in Journal of Clinical Oncology, Rosella Elisei, MD, of the University of Pisa, and colleagues found that cabozantinib ...
Could MRI Be a Better Breast Cancer Screening Tool Than Mammography?
German investigators reported at the 2013 Breast Cancer Symposium in San Francisco that an abridged magnetic resonance imaging (MRI) protocol can accurately detect cancers among women whose mammographic screenings were negative (Abstract 1). MRI, therefore, may reveal the type of tumor that...
First-Line Brivanib Not Noninferior to Sorafenib in Advanced Hepatocellular Carcinoma
The investigational drug brivanib is a dual inhibitor of VEGF and fibroblast growth factor signaling, both implicated in hepatocellular carcinoma. In a noninferiority trial (BRISK-FL) reported in Journal of Clinical Oncology, Philip J. Johnson, MD, of the Institute of Translational Medicine,...
School-Age Drinking Increases Breast Cancer Risk
The more alcohol young women drink before motherhood, the greater their risk of future breast cancer, according to new research from Washington University School of Medicine in St. Louis. Previous studies have looked at breast cancer risk and alcohol consumption later in life or at the effect of...
Study Compares Rituximab Maintenance to Observation After First-Line Treatment in Older Patients With Advanced Follicular Lymphoma
In an Italian study reported in the Journal of Clinical Oncology by Umberto Vitolo, MD, and colleagues in the Fondazione Italiana Linfomi, treatment-naive patients aged > 60 years with advanced follicular lymphoma were randomized to rituximab [Rituxan] maintenance or observation after brief ...
High-Tech Imaging Contributes to Overdiagnosis, Overtreatment of Low-Risk Thyroid Cancers
A study from the Mayo Clinic Center for the Science of Health Care Delivery finds that advances in imaging technologies, including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), are fueling an epidemic in the diagnosis and treatment of thyroid cancers that are unlikely...
More Prudent Interpretation of Thyroid Ultrasound Could Reduce Unnecessary Biopsies
Thyroid ultrasound imaging could be used to identify patients who have a low risk of thyroid cancer for whom biopsy could be deferred, according to a retrospective case-control study by Rebecca Smith-Bindman, MD, of the University of California, San Francisco, School of Medicine, and colleagues in...
Chinese Study Shows Icotinib Noninferior to Gefitinib in Advanced NSCLC
In the noninferiority ICOGEN trial reported in Lancet Oncology, Yuankai Shi, MD, of the Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs. Beijing, and colleagues compared the oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor icotinib with gefitinib...
Panobinostat Combined With Bortezomib and Dexamethasone Can Recapture Responses in Heavily Pretreated Patients With Multiple Myeloma
The combination of the investigational histone deacetylase inhibitor panobinostat (Faridak) with bortezomib (Velcade) and dexamethasone was able to recapture responses in 34.5% of heavily pretreated, bortezomib-refractory patients with multiple myeloma in the phase II PANORAMA 2 trial. The 55...
Cost-Effectiveness of MRI Screening for Women With Familial Risk of Breast Cancer in the Netherlands
Annual screening for breast cancer with magnetic resonance imaging (MRI) has been found to be cost-effective in women aged 30 to 60 years who are BRCA1 or BRCA2 carriers or who have a 50% chance of being a carrier, and such screening is recommended in these women by many authorities. It is unclear...
Yoga Improves Sleep Quality in Cancer Patients With Sleep Disruption
It is estimated that 30% to 90% of cancer patients experience impairment of sleep quality post-treatment and such impairment can be severe enough to increase morbidity and mortality. Preliminary evidence indicates that yoga may improve sleep in cancer patients. In a study reported in the Journal of ...
Risk of Pancreatic Cancer May Be Reduced by Better Diet
In a study reported in the Journal of the National Cancer Institute, Hannah Arem, MHS, PhD, of the National Institutes of Health, and colleagues analyzed the association between quality of diet according to the 2005 Dietary Guidelines for Americans—Healthy Eating Index 2005...
Indoor Tanning Common Among Young White Females Despite Skin Cancer Risk
Indoor tanning, defined as using a tanning booth, sun bed, or sunlamp, is common among non-Hispanic white female high school students and young adults, despite risks of melanoma and nonmelanoma skin cancer, according to Gery P. Guy, Jr, PhD, MPH, and colleagues of the Centers for Disease...
Night or Rotating Shift Work Associated With Increased Risk for High PSA
Some data support an association between circadian disruption and prostate cancer. In a study reported in Journal of the National Cancer Institute, Erin E. Flynn-Evans, PhD, of the Division of Sleep Medicine at Brigham and Women’s Hospital, and colleagues assessed the association between...
Best of ASCO 2013: VeriStrat Assay May Help Select NSCLC Patients for Second-Line Therapy
VeriStrat, a serum-based protein assay, can help select which patients with non–small cell lung cancer (NSCLC) who are not known to have epidermal growth factor receptor (EGFR) mutations might benefit from an EGFR-targeted agent, according to a study described at the 2013 Best of ASCO Los...
Circulating Estrogens and Androgens Are Associated With Breast Cancer Risk in Premenopausal Women
In a study reported in Lancet Oncology, Timothy Key, PhD, of Oxford University, and colleagues in the Endogenous Hormones and Breast Cancer Collaborative Group analyzed data from seven prospective studies to determine associations between sex hormones and risk of breast cancer in premenopausal...
Risk for Lymphoma Increases in Celiac Patients With Persistent Villous Atrophy
Although celiac disease is associated with an increased risk of lymphoma, including enteropathy-associated T-cell lymphoma, it was not known whether persistent atrophy of the villi, the fingerlike projections that normally absorb nutrients, contributed to that risk. In a large population-based...
Study Reveals Genes That Drive Glioblastoma
A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published online...
Experts Discuss Challenges in Counseling Patients About Contralateral Prophylactic Mastectomy
Many factors play into why women diagnosed with breast cancer often choose overly aggressive treatment even when there is little evidence to show clinical benefit: the shock and fear of suddenly being confronted with a major health threat, the impression of having to make treatment decisions...
Lenalidomide plus Dexamethasone Delays Progression and Improves Survival in High-risk Smoldering Multiple Myeloma
In a study reported in The New England Journal of Medicine, María-Victoria Mateos, MD, PhD, of the Universidad de Salamanca, and colleagues compared induction lenalidomide (Revlimid) plus dexamethasone followed by maintenance lenalidomide with observation in patients with high-risk...
Digital Breast Tomosynthesis Reduces Breast Cancer Screening Recall Rate Compared to Mammography Alone
The addition of tomosynthesis to standard digital mammography resulted in a 30% reduction in overall recall rates among women being screened for breast cancer, according to a new study published online in Radiology. The results demonstrate that digital tomosynthesis is an effective tool in reducing ...
U.S. Preventive Services Task Force Recommends Screening for Lung Cancer in High-risk Individuals
The U.S. Preventive Services Task Force posted its final evidence report and draft recommendation statement on screening for lung cancer. The Task Force is providing an opportunity for public comment on this draft recommendation statement; comments can be submitted from July 30 to August ...
Particulate Matter Air Pollution Contributes to Increased Risk of Lung Cancer in Europe
Ambient air pollution has been associated with lung cancer risk. In a study reported in Lancet Oncology by Ole Raaschou-Nielsen, PhD, of the Danish Cancer Society Research Center, and colleagues, lung cancer incidence in European countries was prospectively assessed according to several measures of ...
CDC Report Shows Stagnated HPV Vaccination Rate for Girls
For the first time since the human papillomavirus (HPV) vaccine became available for adolescent girls in 2006, the vaccination rate for the teenagers has stalled, according to data published in the Centers for Disease Control and Prevention’s (CDC’s) Morbidity and Mortality Weekly...
National Lung Screening Trial Analysis Supports Risk-based Targeting of Smokers for Low-dose CT Screening
The National Lung Screening Trial (NLST) showed that screening with low-dose computed tomography (CT) resulted in a 20% reduction in lung cancer mortality compared with chest radiography in participants aged 55 to 74 years with a minimum of 30 pack-years of smoking and no more than 15 years since...
HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study
A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...
ASCO Releases Updated Guideline on Interventions for Women at Increased Risk for Breast Cancer
The American Society of Clinical Oncology (ASCO) issued a newly updated clinical practice guideline today on pharmacologic prevention interventions for premenopausal and postmenopausal women who are at increased risk for breast cancer. Compared to the previous version of the guideline, this third...
Aspirin May Help Prevent Cancer in Patients with Barrett’s Esophagus
Although aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce cancer mortality by 20%, exactly why these drugs reduce the number of cancer incidences and deaths is not known. Now, a small longitudinal study of 13 patients with Barrett’s esophagus is...
Volumetric Growth Rate of Small Colorectal Polyps on CT Colonography May Be Useful Risk Marker
The growth rates and clinical importance of small colorectal polyps have not been well established. In a study reported in Lancet Oncology, Perry J. Pickhardt, MD, of the University of Wisconsin School of Medicine and Public Health, and colleagues found that volumetric growth rate on computed...
WHO Tobacco Control Policies Estimated to Prevent 7.4 Million Premature Deaths by 2050
Tobacco control measures put in place in 41 countries between 2007 and 2010 are predicted to prevent an estimated 7.4 million premature deaths by 2050, according to a study published in the July issue of the Bulletin of the World Health Organization. The study is one of the first to ...
Survival Rates for Patients with Burkitt’s Lymphoma Improve, Especially among Young Adults
Although Burkitt’s lymphoma remains one of the most highly aggressive forms of B-cell non-Hodgkin lymphoma and is associated with human immunodeficiency virus (HIV) infection, a recent study published in Blood has found a marked improvement in patient survival over the past decade, especially ...
BRAF Mutation Status May Have Effect on Benefit of Aspirin Use for Patients with Colorectal Cancer
In two large studies, the association between aspirin use and risk of colorectal cancer was affected by BRAF mutation status, with regular aspirin use associated with a lower risk of BRAF wild-type colorectal cancer but not with risk of BRAF-mutated cancer. The findings, published today in JAMA,...
Use of Advanced Treatment Technologies Increases among Men at Low Risk of Dying from Prostate Cancer
Use of advanced treatment technologies for prostate cancer, such as intensity-modulated radiotherapy (IMRT) and robotic prostatectomy, has increased among men with low-risk disease, high risk of noncancer mortality, or both, a population of patients who are unlikely to benefit from these...
New Study Finds AICR Recommendations Cut Breast Cancer Risk
Postmenopausal women who follow at least five Recommendations for Cancer Prevention from the American Institute for Cancer Research (AICR) cut their risk of developing breast cancer by more than half, compared to those who meet none, suggests a new study that adds to previous research showing...
ASCO 2013: Top Five Things Oncologists Need to Know about Cancer in Older Adults
A workforce shortage of geriatricians and other health professionals trained and certified in caring for older patients with cancer is colliding with the aging of the population and the increasing number of older Americans with cancer. After describing factors contributing to these dual challenges, ...
Some Stage II/III HER2-positive Tumors May Be Treated with Targeted Therapy without Chemotherapy
Results from a multicenter phase II study of patients with locally advanced HER2-positive breast cancer who receive targeted therapy with trastuzumab (Herceptin) and lapatinib (Tykerb) “support the hypothesis that selected patients with HER2-positive tumors may not need...
ASCO 2013: Weekly Paclitaxel Is Less Toxic but as Effective for Women with Higher-risk Early-stage Breast Cancer
Low-dose weekly administration of paclitaxel resulted in equal progression-free survival but reduced overall toxicity compared to every-2-week dose-dense administration for women with higher-risk early-stage breast cancer who have undergone surgery, according to a phase III randomized trial....
ASCO 2013: Cervical Cancer Screening Using Visual Inspection with Vinegar Reduces Mortality by 31% in Large Study in India
Cervical cancer mortality was reduced by 31% over a period of 15 years among women screened with biennial visual inspection with acetic acid (VIA), or vinegar, delivered by primary health workers in a large randomized study conducted among 150,000 women in India. The researchers estimate this...
ASCO 2013: Most U.S. Oncologists Report High Career Satisfaction, but Many Suffer Symptoms of Burnout
Although a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, according to a Mayo Clinic–led study released during the ASCO 2013 Annual Meeting (Abstract 6533). “Oncology can be a tremendously rewarding...
ASCO 2013: Everolimus Significantly Delays Tumor Growth in Women with HER2-positive Advanced Breast Cancer
The addition of everolimus (Afinitor), an mTOR inhibitor, to trastuzumab (Herceptin) and vinorelbine significantly extended progression-free survival in women with HER2-positive advanced breast cancer, compared to treatment with placebo plus trastuzumab and vinorelbine, in the phase III BOLERO-3...
New Method to Test Breast Lesions Could Better Detect Cancer and Reduce Repeat Biopsies
A newly developed, single-step Raman spectroscopy algorithm has the potential to simultaneously detect microcalcifications and enable diagnosis of the associated breast lesions with high precision, according to data published in Cancer Research, a journal of the American Association for Cancer...
Women Smokers May Have Greater Risk for Colon Cancer Than Men
Smoking increased the risk for developing colon cancer, and female smokers may have a greater risk than male smokers, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. “Globally, during the last 50...
Few Breast Cancer Survivors Maintain Adequate Physical Activity Despite Benefits
Breast cancer survivors are among the women who could most benefit from regular physical activity, yet few meet national exercise recommendations during the 10 years after being diagnosed, according to a study by researchers at Fred Hutchinson Cancer Research Center. Prior studies and available...
