Search Results
Your search for ,are matches 22257 pages
Showing 21601 - 21650Rituximab Active in Nodular Lymphocyte–Predominant Hodgkin Lymphoma
Mature results of a phase II study reported in the Journal of Clinical Oncology by Advani et al indicate that rituximab (Rituxan) is active in nodular lymphocyte–predominant Hodgkin lymphoma, which is characterized by expression of CD20 by malignant cells. Most patients relapsed, but durable...
Leukemia & Lymphoma Society Applauds FDA's Approval of Ibrutinib for CLL
In response to FDA's approval earlier this week of ibrutinib (Imbruvica) to treat patients with chronic lymphocytic leukemia (CLL) who had received at least one prior therapy, The Leukemia & Lymphoma Society (LLS) issued the following statement: "After the FDA designated ibrutinib as a...
Blacks, Hispanics, Older Americans Not Benefiting Equally From Improvements in Colon Cancer Treatment
While new and better treatments have improved the odds of survival for patients diagnosed with late-stage colorectal cancer, that progress has been largely confined to non-Hispanic whites and Asians and those under age 65, according to a new study published in Cancer Causes and Control. Sineshaw et ...
Researchers Discover Preleukemic Stem Cell at Root of AML Relapse
Researchers have discovered a preleukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML). The research, published online in Nature, is a significant step forward in...
Compound Screening Identifies Novel Treatment Options for Gastrointestinal Stromal Tumors
Using high-throughput screening of already FDA-approved chemotherapeutic agents in gastrointestinal stromal tumors (GIST) cell lines, researchers have discovered that GIST cells display a high sensitivity to transcriptional and topoisomerase II inhibitors. The finding could bring new treatments to...
No Difference in Recurrence After 5 Years With or Without Radiotherapy Following Sector Resection in Stage I Breast Cancer
The 20-year follow-up of the Swedish Uppsala/Örebro trial, reported by Wickberg et al in the Journal of Clinical Oncology, shows that improved control of recurrence over 5 years with radiotherapy after sector resection in patients with stage I breast cancer is followed by similar...
No Mortality Benefit of Mammography Screening in 25-Year Follow-up of Canadian National Breast Screening Study
As reported in BMJ by Miller et al, the 25-year follow-up of the Canadian National Breast Screening Study has shown no mortality benefit of annual mammography screening for breast cancer compared with physical examination or usual care. Mammography screening was associated with...
Normal Enzyme Pairs With Mutated FLT3 to Fuel AML Progression
Findings from a study by Puissant et al suggest that the wild-type form of enzyme SYK pairs with FLT3, the most commonly mutated enzyme found in acute myeloid leukemia (AML), to promote progression of the cancer. The molecular partnership also promotes AML cells’ resistance to treatment with...
FDA Approves Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia
The U.S. Food and Drug Administration (FDA) today expanded the approved use of ibrutinib (Imbruvica) for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one previous therapy. Ibrutinib, an oral Bruton’s tyrosine kinase inhibitor, was previously...
Small Panel of FISH Cytogenetic Markers Distinguishes Risk in Medulloblastoma Subgroups
Among the four major molecular subgroups of medulloblastoma, WNT tumors are associated with excellent prognosis, whereas SHH and Group 4 tumors are associated with intermediate and Group 3 tumors with poor prognosis. In a study reported in the Journal of Clinical Oncology, Shih et al identified a...
Study Identifies Possible Genetic Markers in Breast Cancer Brain Metastases
Scientists from the Translational Genomics Research Institute (TGen) have uncovered the possible genetic origins of breast cancers that metastasize to the brain. The compendium of new genetic targets may be be used to identify potential methods of diagnosis and novel therapeutics for patients with...
SSO-ASTRO Consensus Guideline: Margins Wider Than 'No Ink on Tumor' Do Not Further Reduce Risk of Ipsilateral Breast Tumor Recurrence
The Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) formed a multidisciplinary expert panel in 2013 to examine the relationship between surgical margin width and ipsilateral breast tumor recurrence and develop guidelines on margins for breast-conserving...
Researchers Identify Biomarker for Noncancerous Pancreatic Cysts
Researchers at the Indiana University School of Medicine have discovered a highly accurate, noninvasive test to identify benign pancreatic cysts, which could spare patients the cost and risk of surveillance or potentially dangerous surgical intervention. The findings are reported in the Journal of...
Novel Photon-Counting Technique Increases Detection Rate in Screening Mammography
As mammography screening has shifted to digital technology, a range of computed radiography and direct radiography systems have emerged. Digital mammography screening with a new photon-counting technique offers high diagnostic performance, according to a study reported by Weigel et al in Radiology. ...
MicroRNA-181a Shows Promise as a Biomarker for Late-Stage Ovarian Cancer
In patients with late-stage epithelial ovarian cancer, high levels of microRNA-181a may be predictive of chemotherapy resistance and disease progression, according to the results of a study reported by Parikh et al in Nature Communications. Thus, microRNA-181a may serve as a biomarker for prognosis ...
Study Identifies Functional Cooperative Mutations of SETD2 in the Development of Acute Leukemia
Using data from the whole-genome sequencing of a pair of 3-year-old female monozygotic twins, one healthy and one with the multilineage form of acute myeloid leukemia (AML), a team of scientists from China and the United States have identified a novel molecular target that could offer a new...
Coordination of Care Improves Patient-Reported Quality of Supportive Care Among Patients With Colorectal Cancer
In a study reported in the Journal of Clinical Oncology, van Ryn et al assessed patient-reported quality of care among patients with colorectal cancer in the Veterans Affairs health-care system. The investigators found significant gaps in patient-centered quality of supportive care, but also found...
Promising Effects of High-Dose Parenteral Ascorbate in Ovarian Cancer
Oral ascorbate, or vitamin C, has been shown to be ineffective in cancer clinical trials. However, recent studies have indicated that millimolar concentrations of ascorbate achieved in blood and tissue with intravenous dosing is associated with cancer cell killing without harm to normal tissue. In...
Brachytherapy Offers Lower Rate of Breast Preservation vs Standard Radiation for Older Women With Breast Cancer
When comparing treatments designed to enable long-term breast preservation for older women with invasive breast cancer, researchers found those treated with brachytherapy were at higher risk for a later mastectomy, compared to women treated with standard radiation therapy. The findings, published...
Obesity Linked to Poor Survival in Patients With Tongue Cancer
Cancer experts from Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College are collaborating to understand the link between obesity and cancer. Most recently, their research has yielded an interesting association: Obesity prior to diagnosis is associated with a fivefold increase...
Newly Created Risk Stratification Database Aids in Predicting Outcomes in Prostate Cancer
The pan-Canadian Prostate Cancer Risk Stratification database was created to report on the patient, tumor, and treatment factors that were predictive of biochemical and clinical outcomes in patients who underwent radiotherapy for prostate cancer. Risk stratification in the management of those with...
High Incidence of Complications Other Than Urinary Incontinence or Erectile Dysfunction After Prostatectomy or Radiotherapy for Prostate Cancer
Studies of complications of surgery or radiotherapy for prostate cancer generally focus on incontinence and erectile dysfunction. In a population-based cohort study reported in The Lancet Oncology, Nam et al assessed the frequency of other complications associated with such treatment and found high ...
Progression-Free Survival Can Be Used as Surrogate for Overall Survival in Metastatic Melanoma Trials With Dacarbazine Control Group
In a meta-analysis reported in The Lancet Oncology, Flaherty et al found that progression-free survival is a reliable surrogate for overall survival in clinical trials in metastatic melanoma that include dacarbazine as control treatment. Study Details In the analysis, 1,649 reports and meeting...
Optimized Radiation Treatment Schedule for Glioblastoma May Extend Survival
An altered radiation treatment schedule for glioblastoma, the most common and lethal form of brain cancer, extended the survival period of mice with the disease, according to a new study published in Cell. Because the research involved mice, the study does not recommend a specific new schedule for...
Biomarker May Predict Response to Ipilimumab in Advanced Melanoma
Among patients with advanced melanoma, presence of higher levels of the protein vascular endothelial growth factor (VEGF) in blood was associated with poor response to treatment with the immunotherapy ipilimumab (Yervoy), according to a study by Yuan et al published in Cancer Immunology Research....
Potential Therapeutic Role for Aspirin in the Management of Sporadic Vestibular Schwannoma
In patients with sporadic vestibular schwannoma, aspirin may be of benefit in minimizing tumor growth, according to the results of a retrospective study presented by Kandathil et al in Otology and Neurotology. This finding may eliminate the need for invasive therapy and may complement existing...
ASCO Issues New Recommendations for Family History-Taking in Oncology Setting
When oncologists see a new patient, they should emphasize careful documentation of first- and second-degree cancer family history, according to new recommendations published by the American Society of Clinical Oncology. The recommendations are the first to focus on family history-taking...
Cytoreductive Nephrectomy Improves Survival in Metastatic Renal Cell Carcinoma Patients With Longer Life Expectancy
Prior to the advent of targeted therapy, cytoreductive nephrectomy was associated with a 6-month improvement in overall survival in metastatic renal cell carcinoma. With the development of new and better targeted therapies for metastatic renal cell carcinoma, the appropriate use of cytoreductive...
Patients With Near-Complete Response After Induction Therapy May Be Candidates for Bladder-Sparing Therapy
Bladder-sparing approaches are typically reserved for patients with bladder cancer who have a complete response to combined modality induction therapy (radiation plus chemotherapy). A new phase II study suggests that patients with near-complete response should also be considered for bladder-sparing ...
Studies Evaluate Trends in the Surgical Management of Penile Cancer
A large retrospective population-based study shows that potentially fatal penile cancers are surgically undertreated in the United States and more benign penile cancers are surgically overtreated. Even though penile cancer is rare in the United States, accounting for about 1,570 new cases in 2013...
Prostate Health Index May Provide New Tool to Identify Patients Assigned to Watchful Waiting Who Require Immediate Treatment
A simple tool called “phi” appears to be able to identify which patients assigned to active surveillance for prostate cancer are more likely to require treatment. Phi, or the prostate health index, is calculated from three serum measurements: PSA, free/total PSA, and a new measurement,...
Prolonged Hormone Therapy Exposure Increases Risk of Diabetes and Cardiovascular Disease in Older Patients With Prostate Cancer
Although androgen deprivation therapy extends survival in men with prostate cancer, its use is associated with unwanted side effects. In addition to the well-known side effects of impaired sexual function and hot flashes, prolonged exposure to androgen deprivation therapy can also lead to diabetes...
Study Examines Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
In the randomized, phase III CA184-043 trial, ipilimumab (Yervoy) improved progression-free survival and prostate-specific antigen (PSA) response compared with placebo, but failed to improve overall survival significantly in postdocetaxel metastatic castration-resistant prostate cancer....
Bladder Cancer Study Uncovers Potential Drug Targets and Molecular Similarities to Other Cancers
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for urothelial carcinoma of the bladder, a common cancer that causes about 150,000 deaths worldwide each year. The researchers also found molecular similarities to some subtypes of breast,...
New Society Launched for Advanced Practitioners in Hematology and Oncology
The Advanced Practitioner Society for Hematology and Oncology (APSHO) announced its launch as a new organization focused on meeting the unique educational and professional needs of the advanced practitioner in hematology and oncology. The formation of the Society was made public January 26, 2014,...
Following USPSTF Mammography Screening Guidelines Could Save Billions of Dollars and Result in More Women Screened
Although controversial, reducing mammography screening frequency from annually to biennially for women aged 50 to 74 could save the health-care system billions of dollars annually and screen 15% more women compared with the current practice, according to a cost analysis by O’Donoghue et al....
Study Reports Success in Targeted Therapy for Lung Adenocarcinoma
The most common genetic subtype of lung cancer, which has long defied treatment with targeted therapies, has had its growth halted by a combination of two already-in-use drugs in laboratory and animal studies, setting the stage for clinical trials of the drugs in patients. The study, published in...
Early Termination Not Unique to Genitourinary Cancer Clinical Trials
An analysis of 7,776 adult cancer clinical trials registered on Clinicaltrials.gov showed that approximately 20% of trials failed to be completed for reasons unrelated to the efficacy or side effects of the intervention. In 2010, a report from the Institute of Medicine entitled “A National...
Angiotensin System Inhibitors Improve Survival in Hypertensive Patients With Metastatic Renal Cell Carcinoma
According to a retrospective study, the use of angiotensin system inhibitors, such as lisinopril, captopril, and losartan, improved the survival of patients with metastatic renal cell carcinoma by 9 months, compared with patients who were not receiving these types of agents. Survival was even...
New Clues May Link Hereditary Cancer Genes to Increased Risk of Cancer From Alcohol
In laboratory experiments conducted on human cell lines at the Johns Hopkins Sidney Kimmel Cancer Center, scientists have shown that people carrying certain mutations in two hereditary cancer genes, BRCA2 and PALB2, may have a higher than usual susceptibility to DNA damage caused by acetaldehyde, a ...
Melatonin May Potentially Slow Tumor Growth in Estrogen Receptor–Negative Breast Cancers
An early-stage study shows melatonin may have the potential to help slow the growth of certain breast cancer tumors, according to researchers from Henry Ford Hospital in Detroit and Foundation for Research Support of the State of São Paulo. The study, published online in the journal PLoS...
New Mathematical Model Helps Predict Tumor Evolution and Treatment Effectiveness
A study by Almendro et al analyzed breast cancer tumors before and after treatment for important characteristics, including chromosome copy number, the presence or absence of certain protein markers, and their proliferative capacity. The scientists then used the data to develop computational models ...
ASCO Survey of Oncologists Finds High Overall Career Satisfaction, but Nearly Half Report Burnout
A survey of oncologists by Shanafelt et al has found that approximately 45% had at least one symptom of burnout, with risk being greatest among younger oncologists and those spending more hours per week devoted to direct patient care. However, overall career satisfaction remains high, especially...
No Survival Benefit of Adjuvant 5-FU–Based Chemotherapy After Neoadjuvant Radiotherapy or Chemoradiation for Resectable Rectal Cancer
As reported in The Lancet Oncology by Bosset et al, long-term results of the European Organisaton for Research and Treatment of Cancer (EORTC) trial 22921 indicate that adjuvant fluorouracil (5-FU)-based chemotherapy after preoperative radiotherapy with or without chemotherapy does not affect...
Study Shows 20% of Women With Ovarian Cancer Have Inherited Genetic Mutations That Increase Risk of Disease
A large-scale genetic analysis of women with ovarian cancer with no known family histories of breast or ovarian cancer has found that one-fifth of them had inherited alterations in genes known to be associated with these cancers. The findings could lead to the development of better screening...
Advanced Rai Stage Predicts Poor Outcome of Skin Cancer in CLL
Chronic lymphocytic leukemia (CLL) is associated with increased risk of skin cancer. In a study reported in JAMA Dermatology, Velez et al attempted to determine whether progression of CLL indicated by advanced Rai stage is associated with worse skin cancer outcomes. They found that risk of death...
Model of Individualized Estimates Shows Risk of Overdiagnosis in Screening-Detected Prostate Cancers Varies Widely by Age, PSA, and Gleason Score
It is estimated that overdiagnosis occurs in approximately 20% to 40% of prostate cancers detected at screening in U.S. men aged 50 to 84 years, with the likelihood of overdiagnosis varying widely according to patient age and tumor characteristics. In a study reported in the Journal of the...
11-Protein Signature Distinguishes Good and Poor Outcome in Node-Negative, Adjuvant Therapy–Naive, Triple-Negative Breast Cancer
In a study reported in the Journal of the National Cancer Institute, Liu et al performed global proteomic profiling in samples from patients with triple-negative breast cancer in an attempt to identify a risk signature. They identified a novel 11-protein signature that independently predicts...
One-Fifth of Hospitalizations for Patients With Gastrointestinal Cancer Considered Avoidable
In a study reported in the Journal of Clinical Oncology, Brooks et al found that oncology clinicians considered 19% of hospitalizations for patients with gastrointestinal cancers to be avoidable. Study Details In the study, 201 sequential hospital admissions in 154 patients with gastrointestinal...
High Prevalence of Platinum-Related Hearing Loss in Children With High-Risk Neuroblastoma, With Differences According to Audiometry Scales
The reported prevalence of platinum-associated ototoxicity in children with high-risk neuroblastoma varies widely due to small patient samples and use of disparate grading scales. In a study reported in the Journal of Clinical Oncology, Landier et al in the Children’s Oncology Group assessed...
