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Showing 21001 - 21050Mayo Clinic: New DNA Sequences Hone in on Breast, Ovarian Cancer Risk
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences associated with breast cancer and ovarian cancer. The findings, which appear in three studies in the journals PLoS Genetics and Nature Genetics, will help reveal the underlying causes of these diseases and help researchers...
Many Doctors Do Not Provide Tobacco Cessation Assistance to Lung Cancer Patients
Physicians who care for lung cancer patients recognize the importance of tobacco cessation but often do not provide cessation assistance to their patients, according to a recent study published in the Journal of Thoracic Oncology. Survey Details An online survey was conducted in 2012 by the...
Moffitt Cancer Center Researchers Analyze HPV Vaccination Disparities among Girls from Low-income Families
Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health-care providers to determine the factors associated with disparities in human papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination...
ASCO Completes Prototype for CancerLinQ™, Marking First Demonstration of a “Learning Health System” to Transform Cancer Care
The American Society of Clinical Oncology announced yesterday that it has completed a prototype of CancerLinQ™, the Society’s groundbreaking health information technology (HIT) initiative to achieve higher quality, higher value cancer care with better outcomes for patients. The...
Higher Soy Intake Prior to Lung Cancer Diagnosis Linked to Longer Survival in Chinese Women
New results from a large observational follow-up study conducted in Shanghai, China, indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy. The study, published March 25 in the Journal of Clinical Oncology,...
Ganetespib Demonstrates Potency against ALK-positive Lung Cancer and Overcomes Crizotinib Resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK-positive non–small cell lung cancer (NSCLC). The drug, ganetespib, may also be effective for treating patients...
Cancer in Young Adults Is Focus of New Nationwide Study to Be Led by Fred Hutchinson Cancer Research Center Survivorship Program
The Fred Hutchinson Cancer Research Center Survivorship Program and its directors, K. Scott Baker, MD, and Karen Syrjala, PhD, have been selected to lead a nationwide study that aims to improve long-term health outcomes for cancer survivors between the ages of 18 and 39. Underway this spring, the...
Pathologists Identify Patterns of Mutations to Help Inform Design of Future Trials
Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non–small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the...
UC Davis Research Advances Efforts to Prevent Venous Thromboembolism
New research from the UC Davis Comprehensive Cancer Center, published in the Journal of Surgical Research, may help clinicians determine which patients are at highest risk for postsurgical blood clots in the legs or lungs. A team led by Robert J. Canter, MD, Associate Professor of Surgery at UC...
New Imaging Agent Enables Better Cancer Detection, More Accurate Staging
Researchers at the University of California, San Diego School of Medicine have shown that a new imaging dye, designed and developed at UC San Diego Moores Cancer Center, is an effective agent in detecting and mapping cancers that have reached the lymph nodes. The radioactive dye technetium Tc-99m...
Cancer Drug Shortages Mean Higher Costs and Greater Risk for Patients
A national survey of health professionals showed that drug shortages are taking a heavy toll on cancer patients, forcing treatment changes and delays that for some patients meant worse outcomes, more therapy-related complications, and higher costs. St. Jude Children’s Research Hospital...
Genetic Risk Strategies Needed for Young, Black, Female Breast Cancer Patients, Moffitt Cancer Center Study Shows
Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in The...
Moffitt Cancer Center Researchers Study Use of Dasatinib for Patients with High-risk MDS
Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib (Sprycel) for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed ...
Gene Profile May Help Identify Risk for Hormone-sensitive, Hormone-insensitive Breast Cancer
The overexpression or underexpression of a newly identified set of genes related to lipid metabolism may help physicians identify whether or not a woman is at risk for hormone receptor–positive or hormone receptor–negative breast cancer and to subsequently tailor prevention strategies...
Inherited Genetic Variations Have a Major Impact on Childhood Leukemia Risk
Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children’s Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute...
Study: Surgery Superior to Radiotherapy in Men with Localized Prostate Cancer
Surgery offers better survival benefit for men with localized prostate cancer, according to a large observational study, conducted by a group of researchers in Sweden and the Netherlands. The study, “Comparative oncologic effectiveness of radical prostatectomy and radiotherapy in prostate...
Radiation Raises Risk of Heart Disease in Women Treated for Breast Cancer
A population-based case control study of major coronary events in 2,168 women who underwent radiotherapy for breast cancer between 1958 and 2001 in Sweden and Denmark found a direct link between radiation dose and the occurrence of ischemic heart disease years later. Study Details The study,...
High-fat Dairy Products Linked to Poorer Breast Cancer Survival
Patients who consume high-fat dairy products following breast cancer diagnosis increase their chances of dying from the disease years later, according to a study by Kaiser Permanente researchers. The study, published in the Journal of the National Cancer Institute, is the first to examine the...
Survey of Oncology Providers Shows Sequestration Cuts Will Threaten Seniors' Cancer Care and Increase Medicare Costs
The Community Oncology Alliance (COA) has announced the results of a national survey of oncology providers about the impact of the sequestration cuts to Medicare payments for cancer drugs and services effective April 1, 2013. The survey revealed that the planned sequestration cuts to cancer...
More Than 60% of Ovarian Cancer Patients Do Not Receive Recommended Treatment, Study Shows
Women are 30% less likely to die of ovarian cancer if they have guideline-recommended treatment, yet nearly two-thirds of those with the disease do not receive it, often because they are cared for at hospitals that treat a small number of ovarian cancer patients. These are the findings of a study...
Intraperitoneal Chemotherapy Gives Ovarian Cancer Patients Better Chance of Survival
Patients with advanced ovarian cancer who undergo intensive treatment with chemotherapy that bathes the abdomen are significantly more likely to live longer than those who receive standard intravenous (IV) chemotherapy, according to a study that analyzed long-term follow-up from two landmark...
FDA Approves New Radioactive Diagnostic Imaging Agent to Help Locate Lymph Nodes in Patients with Certain Cancers
The FDA has approved technetium Tc 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent that helps doctors locate lymph nodes in patients with breast cancer or melanoma who are undergoing surgery to remove tumor-draining lymph nodes. Technetium Tc 99m tilmanocept is an...
Cancer Researchers Discover New Type of Retinoblastoma in Very Young Children
A team of Canadian and international cancer researchers led by Brenda Gallie, MD,at the Princess Margaret Cancer Centre, University Health Network (UHN), has discovered a new type of retinoblastoma, a rapidly developing eye cancer that affects very young children—a finding that may...
IOM Gauges Progress in Goals for Improving the Cancer Clinical Trials System
The National Cancer Policy Forum of the Institute of Medicine (IOM), in conjunction with ASCO, held a workshop in February to discuss a collaborative approach to making the National Cancer Institute (NCI)-funded clinical trials system more viable and productive. This was a follow-up meeting to...
Colon Cancer Patient Advocates and Physicians Urge Congress to Pass Bill Requiring Medicare Coverage of Virtual Colonoscopy
As Americans celebrate National Colorectal Cancer Awareness Month, the Colon Cancer Alliance, COLONTOWN—a survivor/patient support group for colorectal disease, including cancer—and the American College of Radiology call on Congress to pass the CT Colonography Screening...
Study Investigates Older Adults' Views on Cancer Screenings
A study from the Regenstrief Institute and the Indiana University Center for Aging Research has found that many older adults are hesitant to halt cancer screenings even when the screenings may no longer be beneficial or may even be potentially harmful. The study is among the first to explore older...
Study Finds Partial Kidney Removal Leads to Greater Survival and Cost Savings for Patients with Kidney Tumors
For patients with kidney tumors, a new study shows the health and economic advantages to removing just the tumor as opposed to the entire kidney. Robotic surgery, including the daVinci Surgical System and Firefly fluorescence imaging that lights up kidney tumors, are among the latest techniques to...
Tougher Criteria May Be Needed for African Americans Considering Prostate Cancer Surveillance
New research from The Cancer Institute of New Jersey suggests that more stringent criteria may be needed for African American men with prostate cancer when considering active surveillance of the disease. The findings, published in the latest online version of Urology found that the prevalence ...
Focal Therapy Offers Middle Ground for Some Prostate Cancer Patients
Men with low-risk prostate cancer who previously had to choose between aggressive treatment, with the potential for significant side effects, and active surveillance, with the risk of disease progression, may have a new option. Focal laser ablation uses precisely targeted heat, delivered through a...
Involving Other Providers in Palliative Care May Help Meet Growing Demand
As baby boomers age and the number of people with serious chronic illnesses continues to rise, the demand for experts in palliative medicine is sure to outstrip the supply, according Timothy E. Quill, MD, Professor of Medicine, Psychiatry and Medical Humanities in the Center for Ethics, Humanities...
Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer, Study Shows
A new study led by a researcher at the Perelman School of Medicine at the University of Pennsylvania adds support to current medical recommendations stating that colonoscopy screening substantially reduces an average-risk adult’s likelihood of being diagnosed with advanced colorectal...
Zora Brown, Prominent Cancer Research Advocate, Dies at 63
The American Association for Cancer Research (AACR) reported with sadness the loss of Zora Brown, a trustee for the AACR Foundation for the Prevention and Cure of Cancer, a breast and ovarian cancer survivor, and a pioneering advocate for cancer research and breast cancer awareness among...
Nearly One in Four Women Newly Diagnosed with Breast Cancer Report PTSD Symptoms
A study by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Medical Center, has found that nearly one in four women (23%) newly diagnosed with breast cancer reported symptoms consistent with post-traumatic stress disorder (PTSD)...
Cancer Doesn’t Change Adolescent Girls’ Desire to Have Children, Study Shows
Researchers at Moffitt Cancer Center and colleagues have found that healthy adolescent females have predetermined expectations for becoming parents in the future, but have concerns about fertility and childbearing should they develop a life-threatening illness, such as cancer. The...
'Where You’re Treated Matters' in Terms of Cancer Survival
A study of older patients with advanced head and neck cancers has found that where they were treated significantly influenced their survival. The study, led by researchers at Fred Hutchinson Cancer Research Center and published in the March 1 online edition of Cancer, found that patients who...
ASCO President: Sequestration Will Have Shattering Impact on Entire U.S. Cancer Enterprise
Statement by ASCO President Sandra M. Swain, MD, FACP, American Society of Clinical Oncology: Today marks the beginning of sequestration, the unprecedented automatic budget cuts that immediately take effect across the federal government—after months of futile negotiations by the President...
Infusion of Stem Cells and Specially Generated T-cells from Same Donor Improves Leukemia Survival
In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center have successfully infused large numbers of donor-derived T cells specific for a key antileukemic antigen in order to prolong survival in high-risk and relapsed...
Obesity, Physical Inactivity Linked with Risk for Certain Molecular Subtype of Colorectal Cancer
An increasing body mass index (BMI) was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according to data published in Cancer Research, a journal of the American...
Study Shows New Approach Connecting Smokers to Quit Lines Increases Smoking Cessation Treatment Enrollment
Self-identified smokers directly connected to a tobacco cessation quit line are 13 times more likely to enroll in a treatment program as compared to smokers who are handed a quit line referral card and encouraged to call on their own, according to a new study published online in JAMA Internal...
Breast Cancer Patients’ Fear of Developing Lymphedema Far Exceeds Risk
Women who have had the lymph nodes under their arm surgically removed during breast cancer treatment are warned to avoid certain practices that can cause lymphedema. Now, a new study published in the March issue of the Journal of the American College of Surgeons suggests that the vast majority of...
FDA Approves Regorafenib for Advanced Gastrointestinal Stromal Tumors
The FDA has expanded the approved use of regorafenib (Stivarga) to treat patients with metastatic or unresectable gastrointestinal stromal tumors (GIST) that no longer respond to treatment with imatinib (Gleevec) or sunitinib (Sutent). Regorafenib, a multikinase inhibitor, blocks several enzymes...
FDA Approves New Treatment for HER2-positive, Metastatic Breast Cancer
The FDA approved ado-trastuzumab emtansine (Kadcyla), referred to as T-DM1 during clinical research, for patients with HER2-positive, metastatic breast cancer who were previously treated with trastuzumab (Herceptin) and taxane chemotherapy. “[Ado-trastuzumab emtansine] is trastuzumab...
Researchers Identify Variations in Four Genes That Are Associated with an Increased Risk of Colorectal Cancer
An international research team co-led by cancer prevention researcher Ulrike Peters, PhD, MPH, and biostatistician Hsu Li, PhD, at Fred Hutchinson Cancer Research Center has identified variations in four genes that are linked to an increased risk of colorectal cancer. Dr. Peters and...
New Drug Combination Could Prevent Head and Neck Cancer in High-risk Patients
A new drug combination shows promise in reducing the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included preclinical and clinical analyses, were published in Clinical Cancer Research, a journal...
Selumetinib Shown to Reverse Radioiodine Resistance in Some Advanced Thyroid Cancers
The experimental drug selumetinib may allow some patients with advanced thyroid cancer to overcome resistance to radioiodine, the most effective therapy for the disease, according to new research from Memorial Sloan-Kettering Cancer Center. Published in the February 14 issue of the New England...
Risk of Leukemia After Cancer Chemotherapy Persists
While advancements in cancer treatment over the last several decades have improved patient survival rates for certain cancers, some patients remain at risk of developing treatment-related leukemia, according to results of a study published online in Blood, the Journal of the American Society of...
Selumetinib Reported to Benefit Patients with Recurrent Low-grade Ovarian Cancer
Low-grade serous ovarian cancer is less common and aggressive than the high-grade variety, but the disease is exceptionally difficult to treat when front-line therapy fails. "After surgery, with or without presurgical chemotherapy, when low-grade serous ovarian cancer persists or returns,...
AACR Hosts Congressional Briefing on Cancer Progress, NIH Funding
The American Association for Cancer Research (AACR) hosted a briefing on February 12 for members of Congress and their legislative staffs that highlighted progress in cancer research and treatment as well as challenges created by decreased levels of funding. The briefing was held in the Rayburn...
FDA Approves Pomalidomide for Advanced Multiple Myeloma
The FDA approved pomalidomide (Pomalyst) to treat patients with multiple myeloma whose disease progressed after being treated with other cancer drugs. Pomalidomide, an oral immunomodulatory agent, is intended for patients who have received at least two prior therapies, including lenalidomide...
Researchers Discover Mutations Linked to Relapse Of Childhood Leukemia
After an intensive 3-year hunt through the genome, researchers have pinpointed mutations that lead to drug resistance and relapse in acute lymphoblastic leukemia (ALL) ,the most common type of childhood cancer—the first time anyone has linked the disease’s reemergence to specific...
