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Showing 2001 - 2050AI Model Using Daily Step Counts May Help Predict Unplanned Hospitalizations During Cancer Therapy
An artificial intelligence (AI) model developed by researchers may assist in predicting the likelihood that a patient may have an unplanned hospitalization during radiation treatments for cancer. The machine-learning model uses daily step counts as a proxy to monitor patients’ health as they go...
Xuesong Han, PhD, on Medicaid Expansion and Receipt of Palliative Care Among Individuals Newly Diagnosed With Advanced-Stage Cancers
Xuesong Han, PhD, of the American Cancer Society, discusses findings showing that among newly diagnosed patients with stage IV cancers, Medicaid expansion was associated with increases in receipt of palliative care, although overall usage was low. The increase varied by cancer type. Improving...
NCI Honors Augusto Ochoa, MD, for His Contributions to Community-Based Cancer Clinical Trials
The National Cancer Institute (NCI) chose Augusto Ochoa, MD, of Louisiana State University (LSU) Health, as the 2022 recipient of the Harry Hynes Award for Outstanding Contributions to Clinical Trials and Community Research. The award was presented during the NCI Community Oncology Research Program ...
Can Patients With Cancer Treated With Immunotherapy Safely Receive mRNA COVID-19 Vaccines?
New research confirmed the safety of mRNA COVID-19 vaccines in individuals with cancer who are undergoing immunotherapy, according to a novel study published by Widman et al in JNCCN–Journal of the National Comprehensive Cancer Network. The researchers analyzed the frequency of immune-related...
Multicenter Study Sheds Light on Features of Invasive Lobular Carcinoma
A multicenter analysis of patients with invasive lobular carcinoma—the second most common histologic subtype of invasive breast cancer in the United States—showed that, despite its prevalence, invasive lobular carcinoma was detected later with worse outcomes vs invasive ductal carcinoma and had...
Exercise May Improve Cardiorespiratory Fitness During and After Chemotherapy
During chemotherapy, physical exercise intervention may be safe, improve long-term cardiorespiratory fitness, and alleviate some of the adverse effects of cancer treatment, according to a novel study published by van der Schoot et al in JACC: CardioOncology. The findings suggested that if exercise...
Hair-Straightening Chemicals May Be Associated With Higher Uterine Cancer Risk
Individuals who reported using chemical hair-straightening products may be at greater risk for uterine cancer compared to those who did not report using these products, according to a new study published by Chang et al in the Journal of the National Cancer Institute (JNCI). The researchers found no ...
ACS CAN Survey: Female Patients With Cancer Report Less Satisfaction, More Challenges With Cancer Care
Female patients with cancer were less satisfied with the quality of their cancer care than male patients with cancer, according to the results of a survey conducted by the Survivor Views program of the American Cancer Society Cancer Action Network (ACS CAN). In addition, female patients were more...
Samyukta Mullangi, MD, MBA, on Predictors of Compliance With Payer-Led Oncology Clinical Pathways
Samyukta Mullangi, MD, MBA, of Memorial Sloan Kettering Cancer Center, discusses her findings showing that physicians’ prescribing behavior may be influenced by payer-led pathways. Pathway compliance was associated with higher medical costs during a 6-month baseline period but lower health-care...
Regina Barragán-Carrillo, MD, on Breast Cancer Screening in the Transgender Population
Regina Barragán-Carrillo, MD, of Mexico’s National Institute of Medical Sciences and Nutrition Salvador Zubirán, discusses her findings showing that currently, physicians have limited knowledge about breast cancer screening in transgender patients. Were this topic addressed with widespread...
Study Examines Efficacy, Cost of FIT vs Multitarget Stool DNA Testing for Colorectal Cancer Screening
Commercially available noninvasive screening tests for colorectal cancer—the fecal immunochemical test (FIT) and the Cologuard multitarget stool DNA test—are equally effective for screening patients with early-stage colorectal cancer. However, FIT costs about one-fifth of the multitarget stool DNA...
Timely Surveillance With Chest Imaging May Benefit Patients With Metastatic Colorectal Cancer
Patients with colorectal cancer who have certain clinical characteristics may benefit from more frequent chest imaging to help identify and target cancer that has metastasized to the lungs, according to a new study presented at the 2022 Scientific Forum of the American College of Surgeons Clinical...
Jensa C. Morris, MD: Oncology Hospitalist Co-Management May Be Linked to Efficient, High-Quality Care and Education
Jensa C. Morris, MD, of the Yale School of Medicine, Smilow Hospitalist Service, discusses her findings on the benefits of hospitalist co-management of patients with cancer: It reduced the length of hospital stay by 1 day, increased early discharge (before 11:00 AM) by threefold; raised the...
Study Identifies How Cancer-Causing Gene Might Regulate Genetic Variation in Prostate Cancer
Researchers at the Barts Cancer Institute at the Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan may have identified a novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in...
Researchers Find Possible Link Between Immune Cells’ Closest Neighbors and Survival Time in Patients With Pancreatic Cancer
Researchers have discovered that the organization of different types of immune cells within pancreatic tumors may be associated with how well patients with pancreatic cancer respond to treatment, as well as how long they survive. This information could eventually lead to new ways of treating...
Researchers Discover Predictive Biomarker of Response to Therapy in Patients With Microsatellite-Stable Metastatic Colorectal Cancer
Researchers have unmasked mutations in the RNF43 gene as predictive biomarkers of a response to treatment with anti-BRAF/EGFR combination therapy in patients with microsatellite-stable BRAF V600E–mutated metastatic colorectal cancer. Data showed that patients with tumors harboring loss-of-function...
Computer Platform May Help Match Patients With Cancer to Targeted Therapy Trials
As more patients with cancer have their tumors genomically profiled and more therapies targeting genomic alterations enter clinical trials, the task of connecting patients with trials for which they are eligible can be especially challenging. The novel computer platform MatchMiner, developed by the ...
Recent FDA Approvals in Breast Cancer
In the past year, the U.S. Food and Drug Administration (FDA) approved four treatment options for patients with breast cancer, which are summarized herein. T-DXd for HER2-Low Breast Cancer On August 5, 2022, the FDA approved fam-trastuzumab deruxtecan-nxki (Enhertu; T-DXd) for adult patients with...
S.M. Qasim Hussaini, MD, on Colon Cancer Treatment Outcomes and Historical Housing Discrimination
S. M. Qasim Hussaini, MD, of the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, discusses findings from a nationwide study of the association between living in areas with discriminatory mortgage practices from the 1930s with present-day access to quality colon cancer care. The...
Effect of Social Factors on Cancer Screening Rates Across U.S. Counties
Populations in U.S. counties defined as more vulnerable based on social factors—including socioeconomic status and racial and ethnic minority status—may be significantly less likely to receive timely breast, cervical, and colorectal cancer screenings, according to a recent study published by Bauer...
Mediterranean Diet May Improve Immunotherapy Response Rates and Progression-Free Survival in Advanced Melanoma, New Study Suggests
Following a Mediterranean diet rich in fiber, monounsaturated fatty acids, and polyphenols may be associated with improved immunotherapy response rates and progression-free survival in patients with advanced melanoma, according to a recent study presented at the United European Gastroenterology...
Study Analyzes Postimaging Diagnoses of Pancreatic Cancer
Computed tomography (CT) and magnetic resonance imaging (MRI) scans may miss the detection of some pancreatic cancer tumors, narrowing the window for life-saving curative surgery, according to new research presented at the United European Gastroenterology (UEG) Week 2022 (Abstract OP192). The...
Sandra L. Wong, MD, on Severe Symptom Reporting in Patients With Cancer Who Have Undergone Surgery
Sandra L. Wong, MD, of the Dartmouth-Hitchcock Medical Center, discusses her study findings showing that when patients with cancer who have had surgery reported severe symptoms via an electronic patient-reported outcomes questionnaire at six cancer centers, it appeared to be beneficial without...
Qinjin Fan, PhD, on Equitable Lung Cancer Care and Mortgage Discrimination
Qinjin Fan, PhD, of the American Cancer Society, explores the question of how mortgage discrimination is linked to lower rates of guideline-concordant care for patients with non–small cell lung cancer. This study highlights the critical need to understand the pathways through which mortgage denials ...
Study Finds Cost of Cancer Care May Impact Health of Low-Income Survivors
The cost of cancer treatment may negatively impact the physical and mental health of survivors who are living in poverty, according to a recent study published by Coughlin et al in the Journal of Oncology Practice. The findings provide important information about the impact social determinants may...
Decrease in Breast Cancer Mortality Rate Continues, but Gap Persists for Black Women: From American Cancer Society Report
Although breast cancer death rates dropped by 43% from 1989 to 2020, Black women continue to be 40% more likely to die of the disease, despite a lower incidence, according to findings outlined in the American Cancer Society’s report Breast Cancer Statistics, 2022, and a companion study published by ...
Vanderbilt University Medical Center Selects New Director of the Division of Infectious Diseases
Kelly Dooley, MD, PhD, MPH, has been appointed Addison B. Scoville Jr. Professor of Medicine and Director of the Division of Infectious Diseases in the Department of Medicine at Vanderbilt University Medical Center (VUMC). Dr. Dooley comes to Vanderbilt from The Johns Hopkins School of Medicine in...
Update on the Impact of the Russian Invasion of Ukraine on Patients With Cancer
In the more than 7 months since Russia invaded Ukraine on February 24, 2022, cancer care for Ukrainian citizens has changed dramatically. Ukraine was once a country able to provide its approximately 160,000 newly diagnosed patients with cancer each year with modern diagnostic methods, including...
Stephen A. Strickland, Jr, MD, MSCI, Joins the Sarah Cannon Transplant & Cellular Therapy Network
Sarah Cannon, the Cancer Institute of HCA Healthcare, announced recently that Stephen A. Strickland, Jr, MD, MSCI, has been named the Director of Leukemia Research for the Transplant & Cellular Therapy Network. In this role, Dr. Strickland provides scientific leadership and oversees Sarah...
Massey Cancer Center and VCU Health Appoint Paula M. Fracasso, MD, PhD, FACP, to Leadership Roles
Paula M. Fracasso, MD, PhD, FACP, has joined Virginia Commonwealth University (VCU) Massey Cancer Center and VCU Health as Deputy Director of the cancer center and Senior Vice President of the cancer service line at VCU Health. The cancer service line is a collaborative model designed to fulfill...
Scott M. Welford, PhD, Named Sylvester’s Tumor Biology Research Program Co-Leader
Scott M. Welford, PhD, Professor and Biology Division Chief in Radiation Oncology at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, will lead the center’s Tumor Biology Research Program with Wael El-Rifai, MD, PhD, Associate Director of Basic Science at ...
Shaji K. Kumar, MD, Named Editor-in-Chief of The Hematologist
Shaji K. Kumar, MD, an expert in multiple myeloma and monoclonal gammopathies, has been appointed to the position of Editor-in-Chief of The Hematologist: ASH News and Reports, the official member news magazine of the American Society of Hematology (ASH). As the seventh Editor-in-Chief of the...
Reshma Jagsi, MD, DPhil, FASCO, Named New Chair of Emory Radiation Oncology
Reshma Jagsi, MD, DPhil, FASCO, recently joined Emory School of Medicine as Chair of the Department of Radiation Oncology. Dr. Jagsi was formerly the Newman Family Professor, Deputy Chair, and Residency Program Director in the Department of Radiation Oncology and Director of the Center for...
Cristina R. Ferrone, MD, Named Chair of Cedars-Sinai Department of Surgery
Following an extensive national search, Cedars-Sinai Medical Center, Los Angeles, has appointed Cristina R. Ferrone, MD, as Chair of the Department of Surgery. Currently Professor of Surgery at Harvard Medical School and Director of the Office of Clinical Careers for Massachusetts General...
Health-Related Quality of Life for Survivors of Metastatic Prostate Cancer
Survivors of prostate cancer originally diagnosed with metastatic disease may experience significantly worse health-related quality of life than those diagnosed with early-stage disease and individuals without a cancer history across all domains, according to a new study by Zheng et al published in ...
Medicaid Expansion and Palliative Care Use Among Patients Newly Diagnosed With Advanced Cancer
Recent data showed that Medicaid expansion may be associated with increased use of palliative care among newly diagnosed individuals with stage IV cancer, although overall usage of palliative care was low. In addition, the increase after Medicaid expansion varied by cancer type, according to a...
Historical Housing Discrimination May Adversely Affect Contemporary Colon Cancer Care and Outcomes
Recent findings showed that historical housing discrimination may negatively affect contemporary care and outcomes for patients diagnosed with colon cancer, according to a study by Hussaini et al in the Journal of Clinical Oncology. The findings were also presented at the 2022 ASCO Quality Care...
Joannie M. Ivory, MD, MSPH, on Increasing Participation of Black Patients With Cancer in Clinical Trials
Joannie M. Ivory, MD, MSPH, of The University of North Carolina at Chapel Hill, discusses ways to raise the number of Black patients with cancer who take part in clinical trials. More successful accrual may be linked to conducting trials where Black patients live and designing studies to recruit a...
Changchuan Jiang, MD, MPH, on Transportation Barriers, Delays in Cancer Care, and Increased Mortality for Patients With Cancer
Changchuan Jiang, MD, MPH, of Roswell Park Comprehensive Cancer Center, discusses the lack of transportation as a potentially modifiable barrier to care for patients with cancer. Timely intervention may reduce visits to hospital emergency departments, lower costs, and improve outcomes (Abstract 70).
New Study Highlights Sexual Problems Among Young Women Who Have Had Cancer
Young women who are cancer survivors may be at a much higher risk of sexual problems, including loss of libido and discomfort, according to research published by Wettergren et al in the journal Acta Oncologica. The study also suggests that cancer type and intensity of treatment may influence the...
Transportation Barriers Among Cancer Survivors: Effect on ER Use and Mortality
New research showed that cancer survivors who delayed care due to a lack of transportation were more likely to use the emergency room (ER), according to the study published by Jiang et al in the Journal of Clinical Oncology. They also had the highest risks of all-cause and cancer-specific...
Is Mortgage Discrimination Adversely Associated With Receipt of Guideline-Concordant NSCLC Care?
Findings reported by researchers from the American Cancer Society (ACS) and Johns Hopkins University showed that area-level mortgage discrimination may be adversely associated with receipt of guideline-concordant care among patients with non–small cell lung cancer (NSCLC) in the United States,...
Christopher E. Jensen, MD, on Older Adults With AML: A Price Paid for High-Intensity Chemotherapy?
Christopher E. Jensen, MD, of the University of North Carolina School of Medicine, talks about older adults with acute myeloid leukemia who receive high-intensity chemotherapy. Although they may live longer, much of their survival gains may be spent engaged in oncology care (Abstract 376).
Study Investigates Potential Embryonic Origin of Medulloblastomas
Medulloblastomas may exist in a premalignant form at birth after initially developing during the first or second trimester of pregnancy, according to a new international study published by Hendrikse et al in Nature. As medulloblastomas typically present around age 7, the team’s discovery is the...
Research Examines a New Tool for Discovering Cancer-Driving Structural Variations
An advanced software tool for analyzing DNA sequences from tumor samples has uncovered new, likely cancer-driving genes. In a study, Weill Cornell Medicine researchers designed the software, known as CSVDriver, to map and analyze the locations of large mutations, known as structural variants, in...
IASLC Names Co-Chairs of the 2023 World Conference on Lung Cancer
Three thoracic oncologists were named co-chairs of the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer (WCLC), which will take place September 9–12 in Singapore. Co-chairs work with IASLC to plan the annual research meeting, select program track...
Real-World Experience With Durvalumab at the Mayo Clinic Mirrors PACIFIC Trial Findings
Concurrent chemoradiation therapy followed by durvalumab has become the standard of care in patients with unresectable, locally advanced non–small cell lung cancer (NSCLC), based on the PACIFIC trial.1 However, clinical trials have predetermined inclusion and exclusion criteria, and they evaluate...
Real-World Evidence Confirms Survival Benefit of Durvalumab in Locally Advanced Non–Small Cell Lung Cancer
In locally advanced non–small cell lung cancer (NSCLC), immunotherapy consolidation with the PD-L1 inhibitor durvalumab improved overall survival in the PACIFIC trial,1 thus leading to its use after chemoradiotherapy as a standard of care. Real-world evidence of durvalumab’s effect on overall and...
Expert Point of View: Jacek Jassem, MD
Abstract discussant Jacek Jassem, MD, of the Medical University of Gdansk, Poland, underscored smoking as the most important cause of lung cancer, noting that between 85% and 90% of patients with lung cancer are current or former smokers. “Lung cancer screening, which has recently become standard...
Study Finds High-Intensity Intervention Helped One-Third of Participants in Lung Cancer Screening Program to Quit Smoking
Despite significant advancements in cancer therapy, the number-one stopper of lung cancer remains the most basic intervention: quitting smoking. Unfortunately, for long-term smokers, that intervention can sometimes be the most challenging. According to data presented during the International...
