Advertisement

Search Results

Advertisement



Your search for The ASCO Post matches 17639 pages

Showing 17051 - 17100


kidney cancer
kidney cancer

Study Confirms Clinical Benefit for Interleukin-2 Immunotherapy in Patients With Advanced Kidney Cancer

A retrospective study published online ahead of print in Urology by researchers at Roswell Park Cancer Institute found that patients with metastatic kidney cancer—even those with chronic renal insufficiency—can tolerate and benefit from high-dose interleukin-2 (HDIL-2) immunotherapy....

breast cancer

ASCO Releases Clinical Practice Guideline on Systemic Therapy for Patients With Advanced HER2-Positive Breast Cancer

Approximately 15% of patients with breast cancer have tumors that overexpress the HER2 protein, and these patients can benefit from HER2-targeted therapies. The American Society of Clinical Oncology recently released a clinical practice guideline on systemic therapy for patients with advanced...

leukemia

FDA Approves Omacetaxine Mepesuccinate for Injection for Home Administration

The U.S. Food and Drug Administration (FDA) has approved omacetaxine mepesuccinate (Synribo) for injection, for subcutaneous use, to include home administration, and also approved a related Medication Guide and Instructions for Use. With this approval, physicians who treat adults with chronic- or...

head and neck cancer

Hyperfractionated Radiation Therapy Improves Local-Regional Control Without Increasing Late Toxicity in Locally Advanced Head and Neck Cancer

Patients with locally advanced squamous cell carcinoma of the head and neck treated with hyperfractionated radiation therapy experienced improved local-regional control and, with patients censored at 5 years, improved overall survival with no increase in late toxicity, according to a study...

lung cancer
issues in oncology

Breath Analysis Offers Noninvasive Method to Detect Early Lung Cancer

Researchers at the University of Louisville School of Medicine are using breath analysis to detect the presence of lung cancer. Preliminary data indicate that this noninvasive tool offers the sensitivity of PET scanning and has almost twice the specificity of PET for distinguishing patients with...

lung cancer

FDA Approves Ceritinib for Late-Stage Lung Cancer

The U.S. Food and Drug Administration (FDA) has granted accelerated approval to ceritinib (Zykadia) for patients with a metastatic anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer (NSCLC) who were previously treated with crizotinib (Xalkori). Ceritinib is an ALK tyrosine...

lung cancer
issues in oncology

Poor Quality of Life Does Not Predict Low Survival Rates in High-Risk Lung Cancer Patients Undergoing Surgery

Quality of life is rarely reported in surgical publications, yet it can be an important metric that can be of use to physicians and patients when making treatment decisions. Prior studies of average-risk patients undergoing lobectomy suggested that low baseline quality-of-life scores predict worse...

leukemia

FDA Approves Mercaptopurine Oral Suspension for Acute Lymphoblastic Leukemia

On April 28, 2014, the U.S. Food and Drug Administration approved a 20 mg/mL oral suspension of mercaptopurine (Purixan) indicated for the treatment of patients with acute lymphoblastic leukemia (ALL) as part of a combination regimen. Successive clinical trials have demonstrated that mercaptopurine ...

issues in oncology

Novel DNA Vaccine Generates Immunity Against Tumor Vasculature Protein in Preclinical Study

Researchers from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania have employed a novel DNA vaccine that indirectly kills cancer cells by targeting a protein found in the tumor vasculature. The vaccine also indirectly creates an immune response to the ...

breast cancer
survivorship

Receiving Chemotherapy After a Breast Cancer Diagnosis May Affect a Patient’s Long-Term Employment

A new study has found that loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received. Published early online in Cancer, the findings by Jagsi et al support efforts to reduce the side effects and burden of...

gynecologic cancers

ASTRO Issues Guideline on the Role of Postoperative Radiation Therapy for Endometrial Cancer

The American Society for Radiation Oncology (ASTRO) has issued a new guideline, “The Role of Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based Guideline,” that details the use of adjuvant radiation therapy in the treatment of endometrial cancer. The...

gynecologic cancers
issues in oncology

FDA Approves First HPV Test for Primary Cervical Cancer Screening

The U.S. Food and Drug Administration (FDA) today approved the first human papillomavirus (HPV) DNA test that can be used as a primary cervical cancer screening test for women aged 25 years and older. The test also can provide information about the patient’s risk for developing cervical...

issues in oncology
issues in oncology

FDA Proposes to Extend Its Tobacco Authority to Additional Tobacco Products, Including E-Cigarettes

As part of its implementation of the Family Smoking Prevention and Tobacco Control Act signed by the President in 2009, the U.S. Food and Drug Administration (FDA) today proposed a new rule that would extend the agency’s tobacco authority to cover additional tobacco products. ...

FDA Approves Siltuximab for Rare Castleman’s Disease

The U.S. Food and Drug Administration (FDA) today approved siltuximab (Sylvant injection) for the treatment of patients with multicentric Castleman’s disease who are human immunodeficiency virus (HIV)-negative and human herpes virus-8 (HHV-8)-negative. Multicentric Castleman’s...

leukemia

FDA Grants Orphan Drug Designation to Alvocidib for the Treatment of Acute Myeloid Leukemia

The U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation to alvocidib, a potent cyclin-dependent kinase small-molecule inhibitor, for the treatment of patients with acute myeloid leukemia (AML). The agent is being tested in patients with intermediate- or high-risk AML, who...

prostate cancer

Experimental Drug Receives Fast Track Designation as Second-Line Chemotherapy for Metastatic Castration-Resistant Prostate Cancer

OncoGenex Pharmaceuticals, Inc, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to the investigation of custirsen (OGX-011) when administered in combination with cabazitaxel (Jevtana Kit)/prednisone for the treatment of men with metastatic...

issues in oncology

Researchers Identify Pathway That Drives Development of Cancer 'Stemness' and Drug Resistance

Most drugs used to treat lung, breast, and pancreatic cancers also promote drug resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego, School of Medicine have discovered a biomarker called CD61 on the surface of drug-resistant tumors that may be...

solid tumors

FDA Approves Ramucirumab for Stomach Cancer

The U.S. Food and Drug Administration (FDA) has approved ramucirumab (Cyramza) to treat patients with advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma with disease progression on or after prior treatment with fluoropyrimidine- or platinum-containing chemotherapy....

colorectal cancer

New Gene Variant Found That Increases the Risk of Colorectal Cancer From Eating Processed Meat

A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to a study published today in PLOS Genetics by Figueiredo et al. The study of over 18,000 people from the United States,...

leukemia
issues in oncology

Researchers Uncover Link Between Down Syndrome and Leukemia

Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven’t been able to explain why. In a new study published online in Nature Genetics, Lane et al tracked the genetic chain of events...

gynecologic cancers

FDA Discourages Use of Laparoscopic Power Morcellation for Removal of Uterus or Uterine Fibroids

In a safety communication notice issued yesterday, the U.S. Food and Drug Administration (FDA) discouraged the use of laparoscopic power morcellation for the removal of the uterus (hysterectomy) or uterine fibroids (myomectomy) in women because, based on an analysis of currently available data, it...

leukemia

FDA Approves Ofatumumab for Previously Untreated Chronic Lymphocytic Leukemia

The U.S. Food and Drug Administration (FDA) today approved ofatumumab (Arzerra) injection in combination with chlorambucil (Leukeran) for the treatment of previously untreated patients with chronic lymphocytic leukemia (CLL), for whom fludarabine-based therapy is considered inappropriate. Trial...

leukemia

Volasertib Granted Orphan Drug Designation for Acute Myeloid Leukemia

The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to volasertib for acute myeloid leukemia (AML). Volasertib is currently being evaluated in a phase III clinical trial for the treatment of patients aged 65 or older, with previously untreated AML, who are ineligible for ...

Unexpected Protein Partnership Has Implications for Cancer Treatment

Scientists have identified two unlikely partners found in macrophages that work together in response to cancer drugs to increase inflammation in a way that may alter tumor growth. The study by Lowe et al was published in Cancer Research. These partners are the p53 protein that suppresses tumors...

prostate cancer

Study Finds a Quarter of Men Drop Out of Prostate Cancer Monitoring, Casting Doubt on Safety of Active Surveillance

Noncompliance appears to be a major challenge for active surveillance, according to the results of long-term follow-up of patients with prostate cancer presented at the European Association of Urology 29th Annual Congress in Stockholm. Over a quarter of men dropped out of the active surveillance...

bladder cancer

Perioperative Chemotherapy for High-Risk Bladder Cancer Improves Survival but Is Not Routinely Administered

A recent study published in Cancer found that, contrary to treatment guidelines for high-risk bladder cancer, neoadjuvant chemotherapy is not commonly used in routine clinical practice. Utilization of adjuvant chemotherapy was found to be increasing over time and was associated with a substantial...

supportive care

ASCO Releases Adapted Guideline on Screening, Assessment, and Management of Fatigue in Adult Survivors of Cancer

A majority of cancer patients experience some level of fatigue during their course of treatment, and approximately 30% contend with persistent fatigue for years after treatment. Fatigue is among the most common and distressing long-term effects of cancer treatment and significantly affects patient...

cns cancers
issues in oncology

Gene Sequencing Project Discovers Mutations Tied to High-Grade Gliomas in Young Children

The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric high-grade gliomas. The findings by Wu et al were published in Nature Genetics and may lead to improved outcomes for children with these brain...

head and neck cancer

Study Examines Protein Expression Biomarkers in HPV-Negative Squamous Cell Carcinomas of the Head and Neck

A quartet of proteins that play critical roles in cell replication, cell death, and DNA repair could lead to better targets for therapy against treatment-resistant head and neck squamous cell cancers. In a study presented this week at the American Association for Cancer Research (AACR) Annual...

cns cancers
issues in oncology

Researchers Identify Transcription Factors Distinguishing Glioblastoma Stem Cells

The activity of four transcription factors appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by Suvà et al, published online in Cell, support the importance of epigenetics in...

issues in oncology

Older People With Faster Decline in Memory and Thinking Skills May Have Lower Risk of Cancer Death

Older people who are starting to have memory and thinking problems, but do not yet have dementia, may have a lower risk of dying from cancer than people who have no memory and thinking problems, according to a study by Benito-León et al published online in Neurology. “Studies have...

hepatobiliary cancer

FDA Approves Ethiodized Oil Injection for Imaging of Tumors in Adults With Known Hepatocellular Carcinoma

The U.S. Food and Drug Administration has approved ethiodized oil injection (Lipiodol) for selective hepatic intra-arterial use for imaging tumors in adults with known hepatocellular carcinoma. The agent received orphan drug designation for management of patients with known hepatocellular carcinoma ...

breast cancer

ASCO Endorses SSO/ASTRO Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stage I and II Invasive Breast Cancer

As reported in the Journal of Clinical Oncology by Buchholz et al, ASCO has endorsed the recently published Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stage I...

cns cancers
issues in oncology

Deep, Integrated Genomic Analysis Reclassifies Lower-Grade Brain Tumors

Using comprehensive genomic analysis, researchers have sorted low-grade brain tumors into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme, the most lethal of brain tumors. The findings were reported at the American Association for Cancer...

issues in oncology

Targeted Investigational Therapy Shows Anticancer Activity in Multiple Cancer Types

The investigational, oral drug BGJ398, which blocks the activity of fibroblast growth factor receptors (FGFRs), showed promising anticancer activity in patients with various types of cancer driven by FGFR genetic alterations, according to the results of a phase I clinical trial presented at the...

breast cancer
issues in oncology

Study Identifies Frequent Cause of Breast Cancer Resistance to Investigational PI3K-Alpha Inhibitor

Loss of the tumor suppressor PTEN was a frequent cause of resistance to the investigational drug BYL719, which blocks the activity of the PI3K-alpha protein, in a small sample of women with breast cancer that progressed after initially responding to BYL719 treatment, according to results presented...

prostate cancer

Six Months Hormonal Treatment in Addition to Radiotherapy Improves Survival for Men With Localized Prostate Cancer

Men with localized prostate cancer that is at risk of growing and spreading have a lower risk of disease progression and recurrence if they are treated with radiotherapy combined with androgen-deprivation therapy, according to new research. The findings, which were presented at the 33rd Conference...

leukemia

Experimental Drug Shows Promise for Treatment-Resistant Leukemia

Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia. The study by Ma et al, published in Blood, found that ...

breast cancer

Preclinical Study Identifies Potential New Approach to Overcome Breast Cancer Resistance to HER2-Targeted Therapies

Resistance to a combination of HER2-targeted therapies, trastuzumab (Herceptin) and lapatinib (Tykerb), was associated with elevated activation of a group of proteins called fibroblast growth factor receptors (FGFRs), which are the target of a number of drugs currently being developed, according to ...

lung cancer

Study Identifies Potential Predictor of Clinical Outcome in Patients With Lung Cancer Treated With MK-3475

Among patients with non–small cell lung cancer (NSCLC) treated with the investigational immune checkpoint inhibitor MK-3475, those whose tumors had high levels of the protein PD-L1 had significantly better outcomes, according to results of a phase I clinical trial presented at the American...

head and neck cancer

Prognosis of HPV-Positive Head and Neck Cancer Varies According to Tumor Site

Patients with cancer of the throat and who are positive for the human papillomavirus (HPV) have a good prognosis, but until now the effect of being HPV-positive on the prognosis of tumors located elsewhere in the head and neck was unknown. A new study presented at the 33rd Conference of the...

prostate cancer
issues in oncology

New Test Developed to Detect Men at High Risk of Prostate Cancer Recurrence

A new genetic signature to identify prostate cancer patients who are at high risk of their cancer recurring after surgery or radiotherapy has been developed by researchers in Canada, according to a study presented at the 33rd Conference of the European Society for Radiotherapy and Oncology in...

breast cancer

Investigational Drug Demonstrates Early Promise in Metastatic Breast Cancer

The novel oral drug LY2835219, an inhibitor of cyclin-dependent kinases (CDK) 4 and 6, showed early promise as monotherapy for patients with metastatic breast cancer, particularly for those with hormone receptor–positive disease, according to results of a phase I study presented at the...

issues in oncology
skin cancer

Biomarker Identifies Melanoma Patients Who May Respond to Immunotherapy MK-3475

Among melanoma patients treated with the PD-1 inhibitor MK-3475, those whose tumors had the protein PD-L1 had better immune responses and higher survival rates, according to results presented at the American Association for Cancer Research (AACR) Annual Meeting 2014 in San Diego. When the protein...

sarcoma
issues in oncology

Tumor-Suppressor Gene TP53 Mutated in 90% of Osteosarcomas

The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project found mutations in the tumor-suppressor gene TP53 in 90% of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer. The study by Chen et al was...

issues in oncology
bladder cancer
issues in oncology

Certain Genetic Variants May Help Identify Patients at Increased Risk of Bladder Cancer Recurrence

A new study by Andrew et al published in BJU International suggests that certain inherited DNA sequences may affect the prognosis of patients with bladder cancer. The findings may help physicians identify subgroups of patients with high-risk bladder cancer who should receive more frequent...

prostate cancer

Dose-Escalated Hypofractionated IMRT for Localized Prostate Cancer Has Similar Side Effects Compared to Conventional IMRT

Dose-escalated intensity-modulated radiotherapy with use of a moderate hypofractionation regimen (72 Gy in 2.4-Gy fractions) can safely treat patients with localized prostate cancer with limited grade 2 or 3 late toxicity, according to a study by Hoffman et al published in the International Journal ...

breast cancer
issues in oncology

Study Finds Routine Mammograms Offer Limited Benefit to Oldest Female Patients

Doctors should focus on life expectancy when deciding whether to order mammograms for their oldest female patients, since the harms of screening likely outweigh the benefits unless women are expected to live at least another decade, according to a review published online in JAMA by Walter and...

lung cancer
issues in oncology

Lack of Insurance Coverage a Barrier to Lung Cancer Screening

The majority of current and former smokers would welcome screenings for lung cancer if their insurance covered the spiral computed tomography (CT) scans, according to research from Roswell Park Cancer Institute and the Medical University of South Carolina. The study by Delmerico et al was published ...

breast cancer
issues in oncology

Digital Mammography Reduces Recall and Biopsy Rates

Population-based screening with full-field digital mammography is associated with lower recall and biopsy rates than screen-film mammography, suggesting that full-field digital mammography may reduce the number of diagnostic workups and biopsies that do not lead to diagnosis of breast cancer,...

Advertisement

Advertisement




Advertisement