Advertisement

Search Results

Advertisement



Your search for The ASCO Post matches 17639 pages

Showing 17001 - 17050


St. Jude Children’s Research Hospital Appoints James R. Downing, MD, as CEO

St. Jude Children’s Research Hospital announced the appointment of James R. Downing, MD, as its new CEO, effective July 15, 2014. Dr. Downing most recently has served as the Deputy Director, Executive Vice President and Scientific Director of the hospital. He succeeds William E. Evans,...

colorectal cancer

Synthetic Triterpenoids Show Promise in Preventing Colitis-Associated Colon Cancer in Preclinical Study

Researchers from Case Western Reserve and Dartmouth have shown that a class of small antioxidant molecules carries promise for suppressing colon cancer associated with colitis. These preclinical findings, published in the Journal of Clinical Investigation, offer hope that physicians ultimately will ...

breast cancer

BPA Stimulates Growth of Breast Cancer Cells, Diminishes Effect of Treatment

Bisphenol A (BPA), a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at ICE/ENDO 2014, the annual joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago. The ...

hematologic malignancies
lymphoma

Early Evidence Suggests Proton Therapy May Offer Safe, Long-Term Treatment for Hodgkin Lymphoma

Despite some success in treating patients with Hodgkin lymphoma, many patients may experience late effects of radiation therapy and chemotherapy treatment, including the possible onset of breast cancer or heart disease. A study by Hoppe et al from the University of Florida Proton Therapy Institute...

issues in oncology

New Tool Predicts Financial Pain for Cancer Patients

In an online report in the journal Cancer, a team of University of Chicago cancer specialists have described the first tool—11 questions, assembled and refined from conversations with more than 150 patients with advanced cancer—to measure a patient’s risk for, and ability to...

prostate cancer

Development of Orteronel for Prostate Cancer Voluntarily Discontinued by Takeda

Takeda Pharmaceutical Company Limited announced today that it has voluntarily decided to end the development program for orteronel (TAK-700), an investigational oral, nonsteroidal, selective inhibitor of 17,20-lyase, for prostate cancer. The decision follows the results of two phase III...

breast cancer
issues in oncology

Racial Disparities in Sentinel Lymph Node Biopsy in Women With Breast Cancer

A study by Black et al from The University of Texas MD Anderson Cancer Center, Houston, found that the use of sentinel lymph node biopsy to stage early breast cancer increased in both black and white women from 2002 to 2007, but the rates remained lower in black than white patients, a disparity...

Diversity of Intestinal Tract Bacteria Associated With Mortality Outcomes After Stem Cell Transplant, Study Shows

New research published online in Blood suggests that the diversity of bacteria in the gastrointestinal tract of patients receiving stem cell transplants may be an important predictor of their post-transplant survival. Potential Connections Previous studies have shown that the intensive treatment...

issues in oncology

‪Survey Finds Booming E-Cigarette Online Market

Researchers at the University of California, San Diego, School of Medicine have completed the first comprehensive survey of e-cigarettes for sale online, and the results, they believe, underscore the complexity in regulating the rapidly growing market for the electronic nicotine delivery devices....

lung cancer

Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network

A unique public-private collaboration among the National Cancer Institute (NCI), SWOG Cancer Research, Friends of Cancer Research, the Foundation for the National Institutes of Health (FNIH), five pharmaceutical companies (Amgen, Genentech, Pfizer, AstraZeneca, and AstraZeneca’s global...

cns cancers

Brain Tumor Risk Greater in Women Who Begin Menstruation at Older Age, Study Reports

Women who begin menstruation at an older age have a significantly increased risk of developing a brain tumor, a Moffitt Cancer Center study shows. The results are part of a large multicenter study to determine potential risk factors associated with the development of glioma and meningioma. The...

head and neck cancer

FDA Approves Radioactive Diagnostic Imaging Agent to Help Determine the Extent of Head and Neck Cancer in the Body

The U.S. Food and Drug Administration today approved a new use for technetium 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent used to help doctors determine the extent to which squamous cell carcinoma has spread in the body’s head and neck region. In 2013,...

breast cancer

FDA Approves Magnetic Resonance Contrast Agent for Evaluation of Breast Cancer

The U.S. Food and Drug Administration has approved a new indication for gadobutrol (Gadavist) injection for intravenous use with magnetic resonance imaging (MRI) of the breast to assess the presence and extent of malignant breast disease. The approval is based on priority review of two multicenter...

Barbara L. McAneny, MD, To Serve as Chair of the AMA Board of Trustees

Barbara L. McAneny, MD, a practicing oncologist from Albuquerque, New Mexico, has been re-elected to the Board of Trustees of the American Medical Association (AMA) and will assume the position of Board Chair when the trustees gather for their first postelection meeting. Dr. McAneny, who has...

breast cancer
issues in oncology

Mammography Has Led to Fewer Late-Stage Breast Cancers, Study Finds

In the past 30 years, since mammography was introduced, late-stage breast cancer incidence has decreased by 37%, a new study published in Cancer has found. The analysis by Helvie et al took into account an observed underlying trend of increased breast cancer incidence present since the 1940s....

lung cancer
issues in oncology

Smokers With BRCA2 Mutation Have Increased Risk of Developing Lung Cancer

Around a quarter of smokers who carry a mutation in the BRCA2 gene will develop lung cancer at some point in their lifetime, a large-scale, international study reveals. Scientists described a previously unknown link between lung cancer and a particular BRCA2 mutation, which occurs in around 2% of...

gynecologic cancers

ASCO 2014: Cediranib Plus Olaparib Significantly Increases Progression-Free Survival in Women With Recurrent Ovarian Cancer

The combination of two investigational oral drugs, the PARP inhibitor olaparib and the antiangiogenic drug cediranib, significantly extended progression-free survival and increased the overall response rate compared to olaparib alone in a phase II study among women with recurrent,...

lung cancer

ASCO 2014: Ceritinib Shows Rapid, Durable Response in ALK-Positive NSCLC

In a phase I study, ceritinib (Zykadia) was found to shrink tumors in patients with anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer (NSCLC), regardless of whether patients had received previous treatment with an ALK inhibitor. The study was presented at the 2014 ASCO...

cns cancers

ASCO 2014: Addition of Chemotherapy to Radiotherapy Improves Survival in Low-Grade Glioma

In a long-term follow-up analysis of RTOG 9802, the addition of PCV (procarbazine [Matulane], lomustine [CeeNu], and vincristine) to radiotherapy prolonged both progression-free survival and overall survival in adult patients with low-grade glioma. The findings were reported at the 2014 ASCO Annual ...

bladder cancer

ASCO 2014: Investigational Anti–PD-L1 Antibody Demonstrates Promising Activity in Certain Patients With Metastatic Bladder Cancer

In a phase I study, the investigational anti–programmed death-ligand 1 (PD-L1) monoclonal antibody MPDL3280A demonstrated promising overall response rates in patients with previously treated metastatic urothelial bladder cancer whose tumors were characterized as PD-L1–positive. The ...

lymphoma

ASCO 2014: Bortezomib Combination Significantly Improves Progression-Free Survival in Newly Diagnosed Mantle Cell Lymphoma

An international, randomized phase III study found that replacing vincristine with bortezomib (Velcade) in R-CHOP (rituximab [Rituxan] plus cyclophosphamide, doxorubicin, vincristine, and prednisone) significantly improved outcomes in newly diagnosed patients with mantle cell lymphoma who were...

colorectal cancer

ASCO 2014: Patients With Metastatic Colon Cancer Respond to New Combination Therapy, Phase IB Study Shows

In a new study presented at the 2014 ASCO Annual Meeting in Chicago (Abstract 3516), researchers from The University of Texas MD Anderson Cancer Center found patients with advanced colorectal cancer responded well to a combination therapy of the drugs vemurafenib (Zelboraf), cetuximab (Erbitux),...

breast cancer
gynecologic cancers
issues in oncology
issues in oncology
issues in oncology

ASCO 2014: Women With BRCA Mutations Report Significant Side Effects Following Risk-Reducing Salpingo-Oophorectomy

The majority of women with BRCA1 and BRCA2 mutations experience sexual dysfunction, menopausal symptoms, cognitive and stress issues, and poor sleep following risk-reducing salpingo-oophorectomy, according to results of a new study from the Abramson Cancer Center and the Perelman School of Medicine ...

prostate cancer

ASCO 2014: Men Who Receive Radiation Therapy for Prostate Cancer Have Increased Long-Term Risk of Bladder or Rectal Cancer

Men with prostate cancer generally have an excellent prognosis, but questions remain about the risk of second primary malignancies after initial therapy for localized disease. According to a new study presented at the 2014 ASCO Annual Meeting in Chicago (Abstract 5034), although the overall risk of ...

breast cancer

Study Identifies Risk of Chemotherapy-Related Hospitalization for Early-Stage Breast Cancer Patients

Oncologists now have a new understanding of the toxicity levels of specific chemotherapy regimens used for women with early-stage breast cancer, according to research from The University of Texas MD Anderson Cancer Center. The retrospective study, reported in the Journal of Clinical Oncology by...

supportive care

FDA Approves Palonosetron Hydrochloride to Prevent Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients

The U.S. Food and Drug Administration (FDA) has approved palonosetron hydrochloride (Aloxi) injection for the prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy, in children aged 1...

breast cancer

ASCO Guideline Update Recommends Tamoxifen for Up to 10 Years for Women With Nonmetastatic Hormone Receptor–Positive Breast Cancer

The American Society of Clinical Oncology (ASCO) has issued an update to its clinical practice guideline on the use of adjuvant endocrine therapy for women with stage I to III hormone receptor–positive breast cancer. The guideline was published in the Journal of Clinical Oncology. Duration...

pancreatic cancer
issues in oncology

Gene Mutation Found for Aggressive Form of Pancreatic Cancer

Researchers have identified a mutated gene common to adenosquamous carcinoma tumors, the first known unique molecular signature for this rare, but particularly virulent, form of pancreatic cancer. The findings by Liu et al are published in Nature Medicine. Pancreatic cancer is the fourth leading...

colorectal cancer

FDA Approves Panitumumab Plus FOLFOX for Wild-Type KRAS Metastatic Colorectal Cancer

The U.S. Food and Drug Administration (FDA) has approved panitumumab (Vectibix) for use in combination with FOLFOX (fluorouracil, leucovorin, oxaliplatin) as first-line treatment in patients with wild-type KRAS (exon 2) metastatic colorectal cancer. This approval converts the accelerated...

breast cancer
issues in oncology

Majority of Women Undergoing Contralateral Prophylactic Mastectomy Have No Major Risk Factors for Developing Cancer in Both Breasts

Patients deciding to undergo contralateral prophylactic mastectomy as part of initial treatment for breast cancer is a growing challenge in the management of the disease. Removing the unaffected breast has not been shown to increase survival, and the more aggressive procedure is associated with...

pancreatic cancer

Supportive Tumor Tissue Surrounding Cancer Cells Hinders Pancreatic Cancer Progression, Preclinical Study Reports

Fibrous tissue long suspected of making pancreatic cancer worse actually supports an immune attack that slows tumor progression but cannot overcome it, scientists at The University of Texas MD Anderson Cancer Center reported in the journal Cancer Cell. “This supportive tissue that’s...

The Cancer Community Mourns the Passing of Selma Schimmel

The cancer community is mourning the death of Selma Schimmel who passed away on May 21, 2014, from malignant psoas syndrome, a complication of ovarian cancer. Ms. Schimmel died at Providence Tarzana Medical Center near her home in Los Angeles, California. She was 59. A tireless and fierce advocate ...

lung cancer
issues in oncology

Study Uses Comprehensive Genomic Tumor Testing to Match Lung Cancer Patients With Targeted Therapies

In a recent study by the Lung Cancer Mutation Consortium (LCMC), investigators incorporated tumor genotyping into therapeutic decision-making for patients with lung adenocarcinomas. An oncogenic driver was detected in 64% of tumors from patients in this study. According to data from this study...

prostate cancer
issues in oncology

Study Reveals More Than One-Third of Patients With ‘Low-Risk’ Prostate Cancer on Conventional Biopsy Have More Aggressive Tumors on Targeted Biopsy

According to a new study by researchers at the University of California, Los Angeles, selection of men for active surveillance for prostate cancer should be based not on conventional biopsy, but on a new, imaging-guided targeted prostate biopsy. The new biopsy method is now a routine part of the...

survivorship

Study Suggests Less Frequent Cardiac Screening May Be Preferable for Survivors of Childhood Cancer

One of the first studies to analyze the effectiveness of screening survivors of childhood cancer for early signs of impending congestive heart failure found improved health outcomes but suggested that less frequent screening than currently recommended may yield similar clinical benefit. Researchers ...

solid tumors
solid tumors

Studies Evaluate Racial Variations, Cost, and Influence of Access to Care in the Management and Treatment of Testicular Cancer

A series of studies evaluating the cost-effectiveness, risks, and outcomes associated with detecting, diagnosing, and treating testicular cancer were presented at a press conference during the 2014 Annual Scientific Meeting of the American Urological Association in Orlando, Florida. Although...

prostate cancer

Results of Three Studies Indicate 17-Gene Assay Is a Significant Predictor of Prostate Cancer Aggressiveness at the Time of Diagnosis

According to the results from three studies published in European Urology, the 17-gene Oncotype DX Genomic Prostate Score is a significant predictor of disease aggressiveness at the time of diagnosis before intervention with radiation or surgery. The test provides more precise and individualized...

gynecologic cancers
issues in oncology

U.S. Cervical Cancer Rates Higher Than Previously Reported, Particularly Among Older Women and African American Women

Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African American women, according to a study by Rositch et al published in Cancer. Current U.S. cervical cancer screening guidelines do not recommend routine Pap smears...

lung cancer
issues in oncology

Analysis Finds Wide Variation in Lung Cancer Rates Globally

The only recent comprehensive analysis of lung cancer rates for women around the world found that lung cancer rates are dropping in young women in many regions of the globe, pointing to the success of tobacco control efforts. However, rates continue to increase among older women in many countries,...

breast cancer

Obesity Substantially Increases Breast Cancer Mortality Only in Women With Premenopausal Estrogen Receptor–Positive Disease

A new study of 80,000 women with early breast cancer in 70 clinical trials finds that obesity is associated with a 34% higher risk of breast cancer–related death only among the 20,000 premenopausal women who had estrogen receptor–positive disease. Obesity had little effect in...

lung cancer
issues in oncology

Study Projects Nationwide Low-Dose CT Screening Will Identify More—and Earlier-Stage—Lung Cancers, but Comes With Substantial Medicare Costs

A new model projects 5-year outcomes of implementing the recent U.S. Preventive Services Task Force (USPSTF) recommendations for annual low-dose computed tomography (CT) lung cancer screening in a high-risk Medicare population. The model estimates that gradual implementation of the screening...

Novel Targeted Drug May Provide a New Treatment Option for Patients With Recurrent Pigmented Villonodular Synovitis

According to early results from a phase I study, a new targeted drug, PLX3397, appears remarkably active against a rare neoplastic joint disorder known as pigmented villonodular synovitis. The study evaluated patients whose disease had progressed despite all other available therapies. More than...

lung cancer

New EGFR Inhibitor AZD9291 Shows Promising Activity in Treatment-Resistant Non–Small Cell Lung Cancer

Findings from a phase I study of a new mutant-selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AZD9291, point to a promising new treatment option for patients with advanced, EGFR-mutant, non–small cell lung cancer (NSCLC) that is resistant to standard EGFR...

prostate cancer

Delaying Androgen Deprivation Therapy May Be Safe for Men With Prostate Cancer Relapse Detected by PSA Testing

According to a large, population-based observational study of men who had a prostate-specific antigen (PSA)-only based relapse after prostate surgery or radiation therapy, delaying androgen deprivation therapy until the onset of symptoms or appearance of cancer on a scan does not substantially...

leukemia
issues in oncology

Novel Target Found for Chemotherapy-Resistant Leukemia Cells

Researchers at Children’s Hospital Los Angeles have discovered that by targeting a particular receptor, chemotherapy-resistant cancer cells can be killed in an acute form of childhood leukemia, offering the potential for a future treatment for patients who would otherwise experience relapse...

multiple myeloma

Immunotherapy May Be Effective in the Treatment of Multiple Myeloma

A new study by researchers at The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) provides evidence that genetically modifying immune cells might effectively treat multiple myeloma. The findings by ...

NIH Study Demonstrates That a New Cancer Immunotherapy Method Could Be Effective Against Epithelial Cell Cancers

A new method for using immunotherapy to specifically attack tumor cells that have mutations unique to a patient’s cancer has been developed by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health. The researchers demonstrated that the human immune...

gynecologic cancers

Glutamine Ratio Is Key Indicator of Tumor Aggression in Ovarian Cancer, Study Finds

An analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new test to determine whether ovarian cancer cells have the potential to metastasize. The study, which was published in Molecular Systems Biology, also suggests how ovarian cancer treatments can be tailored based on...

prostate cancer

Statin Use Associated With Reduced Risk of Prostate Cancer Recurrence

Men who begin taking statins after prostate cancer surgery are less likely to have a recurrence of their cancer, according to a retrospective analysis led by researchers at Duke Medicine. The study by Allott et al was published in BJU International. “Our findings suggest that beginning...

colorectal cancer

Dual Method to Remove Precancerous Colon Polyps May Substantially Reduce Health-Care Costs

A surgical method combining two techniques for removing precancerous polyps during colonoscopies can substantially reduce the recovery time and the length of hospital stays, which may translate into significant cost savings, according to research presented this week at Digestive Disease Week in...

Advertisement

Advertisement




Advertisement