Search Results
Your search for it matches 15886 pages
Showing 14901 - 14950ASCO 2015: Pembrolizumab Produces Clinically Meaningful Response in Patients With Recurrent or Metastatic Head and Neck Cancer
Immunotherapy with pembrolizumab (Keytruda) produced a clinically meaningful overall response rate in a study among 132 patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The overall objective response rate was 24.8%, and 57% of patients experienced some tumor...
ASCO 2015: Nivolumab Extends Survival for Patients With Nonsquamous Non–Small Cell Lung Cancer
Superior overall survival was experienced by patients receiving the anti–PD-1 antibody nivolumab (Opdivo) in a randomized phase III study of patients with nonsquamous non–small cell lung cancer (NSCLC) whose disease progressed after a platinum-based doublet chemotherapy. Study...
ASCO 2015: Mismatch Repair Deficiency Predicts Response to Pembrolizumab Among Patients With Colorectal and Other Cancers
A phase II study identified the first genomic marker—mismatch repair deficiency—to predict clinical benefit of immune checkpoint blockade with the anti–PD-1 antibody pembrolizumab (Keytruda). Among 50 patients with colorectal cancer, 62% of the 25 patients with mismatch...
Blood Thinners Safe for Cancer Patients With Brain Metastases
Cancer patients with brain metastases who develop blood clots may safely receive blood thinners without increased risk of dangerous bleeding, according to a study published by Donato et al in Blood. Cancer increases a patient’s risk of developing blood clots, and an anticoagulant is often...
Two Studies Highlight Benefit of Stereotactic Body Radiotherapy in Locally Advanced Pancreatic Cancer
Two studies from researchers at Johns Hopkins Kimmel Cancer Center add to preliminary evidence that high-dose radiation treatment, or stereotactic body radiotherapy, appears to be safe and as effective as standard radiation treatment for certain patients with locally advanced pancreatic cancer....
Minority of Medicare Patients Have Adequate Cardiac Monitoring During Adjuvant Trastuzumab-Based Chemotherapy for Breast Cancer
In a study reported in the Journal of Clinical Oncology, Chavez-MacGregor et al found that the majority of older breast cancer patients receiving trastuzumab (Herceptin)-based chemotherapy do not receive adequate cardiac monitoring. Study Details The study involved 2,203 patients aged ≥...
ASCO 2015: African Americans Prone to Display Negative Perceptions of Cancer-Related Clinical Trials
African American patients have a disproportionately high rate of cancer and yet are less likely than Caucasian patients to participate in oncologic clinical trials that can significantly improve quality of life. Researchers from Fox Chase Cancer Center and Temple University explored the differences ...
Second-Line Dovitinib Shows Some Activity in FGFR2-Mutant and FGFR2-Nonmutant Advanced Endometrial Cancer
In a phase II study reported in The Lancet Oncology, Konecny et al found that the multi–tyrosine kinase inhibitor dovitinib appeared to delay progression in some patients as second-line treatment in fibroblast growth factor receptor 2 (FGFR2)-mutant and -nonmutant advanced or metastatic...
Study Links Paternal Age to Child’s Risk of Developing Blood and Immune System Cancer in Adulthood
A new study links a father's age at birth to the risk that his child will develop blood and immune system cancers as an adult, particularly for only children. The study, published by Teras et al in the American Journal of Epidemiology, found no association between having an older mother and these...
ASCO Releases Proposal for Payment Reform to Support Higher-Quality, More Affordable Cancer Care
Expanding on the Consolidated Payments for Oncology Care (CPOC) payment model circulated last year to improve the quality and affordability of care for patients with cancer, ASCO’s new Patient-Centered Oncology Payment: Payment Reform to Support Higher Quality, More Affordable Cancer Care...
Histologic Subtype Classification of Lung Adenocarcinoma Predicts Disease-Free but Not Overall Survival Benefit From Adjuvant Chemotherapy
In an analysis reported in the Journal of Clinical Oncology, Tsao et al found that classification by histologic subtype for invasive lung adenocarcinoma was not predictive of overall survival benefit of adjuvant therapy in patients undergoing complete resection but did appear to predict benefit of...
AUA 2015: New Studies Call for Smarter Approach to Prostate Cancer Screening
Prostate cancer is one of the most common cancers in American men, yet controversy over the utilization and frequency of prostate-specific antigen (PSA) screening methods remains, due to the overdiagnosis and overtreatment of men with low-grade, less-aggressive forms of the disease. At the 110th...
AUA 2015: Sperm Banking Rates Increase With Fertility Counseling for Cancer Patients
Fertility counseling for men with cancer, prior to initiating treatment, can increase the rate of sperm preservation, according to a new survey by Rotker et al presented during the 110th Annual Scientific Meeting of the American Urological Association (AUA; Abstract PD52-11). Chemotherapy can...
Urine-Based Test Improves on PSA for Detecting Prostate Cancer
A new urine-based test improved prostate cancer detection—including detecting more aggressive forms of prostate cancer—compared to traditional models based on prostate-specific antigen (PSA) levels. The results were published by Tomlins et al in European Urology. The test, developed at ...
American College of Physicians Offers Advice on High-Value Screening in Five Cancers
To provide guidance on high-value cancer care screening strategies, the American College of Physicians (ACP) recently reviewed clinical guidelines issued by various medical organizations for screening strategies in five common cancers for asymptomatic, average-risk adults. The five cancers focused...
Poorer Melanoma-Specific Survival With Stage ≥ T2b Tumors With NRAS or BRAF Mutation
In a population-based study reported in JAMA Oncology, Thomas and colleagues found significantly poorer disease-specific survival among melanoma patients with stage ≥ T2b tumors with NRAS or BRAF mutation. Study Details The study included data from 912 U.S. or Australian patients in the...
Study Finds Noninvasive Colon Cancer Screening May Be Promising for African Americans
In a first-of-its-kind clinical trial, physician-scientists at University Hospitals (UH) Case Medical Center, Seidman Cancer Center, and Case Western Reserve University School of Medicine found that a new, noninvasive technology for colon cancer screening is a promising alternative to colonoscopy...
Androgen-Deprivation Therapy May Lead to Cognitive Impairment in Prostate Cancer Patients
Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. This side effect, when occurring with chemotherapy, is commonly referred to as “chemobrain.” Signs of cognitive impairment...
Study Shows Tomosynthesis Detects More Breast Cancers Than Traditional Mammography
One-view digital breast tomosynthesis detects 40% more breast cancers than two-view digital mammography does, according to a major screening study from Lund University in Sweden. The study’s results were published by Lång et al in European Radiology. This is the first large-scale study ...
ASCO 2015: Adding Chemotherapy to Initial Therapy Improves Survival in Patients With Advanced, Hormone-Naive Prostate Cancer
The UK-led STAMPEDE trial found that adding docetaxel chemotherapy to standard hormone therapy markedly improved survival for men with newly diagnosed advanced prostate cancer not previously treated with hormone therapy (hormone-naive). Men who received docetaxel plus standard therapy lived on...
ASCO 2015: Adding Elotuzumab Significantly Reduces Risk of Progression for Relapsed Multiple Myeloma
Interim results of a phase III trial suggest an innovative immune-based therapy may offer a new option for patients with relapsed multiple myeloma. The new monoclonal antibody elotuzumab, added to standard lenalidomide (Revlimid) and dexamethasone therapy, extended the duration of remissions by...
No Significant Difference in Outcome for ABVD Plus Radiotherapy vs Stanford V in Stage I or II Bulky Mediastinal Hodgkin Lymphoma
As reported in the Journal of Clinical Oncology by Advani et al, a subset analysis of the phase III North American Intergroup E2496 trial showed no significant difference in failure-free or overall survival between ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) plus radiotherapy vs the...
FDA Grants Fast Track Designation to Evofosfamide for Advanced Pancreatic Cancer
The U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the development of evofosfamide (TH-302), administered in combination with gemcitabine, for previously untreated patients with metastatic or locally advanced unresectable pancreatic cancer. Evofosfamide is an...
At-Risk Patients Often Opt Out of Comprehensive Multiplex Cancer Screening
Some at-risk patients opted out of comprehensive cancer gene screening when presented with the opportunity to be tested for the presence of genes linked to various cancers, according to a recent study led by researchers at the Perelman School of Medicine at the University of Pennsylvania and the...
Donepezil Provides Modest Improvement in Cognitive Function Domains in Irradiated Brain Tumor Survivors
In a phase III trial reported in the Journal of Clinical Oncology, Rapp et al found that the neurotransmitter modulator donepezil may modestly improve some cognitive function domains in patients undergoing cranial irradiation for brain tumors. Improvements were greater in patients with greater...
Weak Sunlight Exposure May Be a Risk Factor in Pancreatic Cancer
Researchers at University of California San Diego School of Medicine recently found that pancreatic cancer rates are highest in countries with the least amount of sunlight. These findings were published by Garland et al in The Journal of Steroid Biochemistry and Molecular Biology. “If...
Two-Week International Diet Swap Shows Potential Effects of Food on Colon Cancer Risk
African Americans and Africans who swapped their typical diets for just 2 weeks similarly exchanged their respective risks of colon cancer, as reflected by alterations of their gut bacteria, according to an international study led by researchers at the University of Pittsburgh School of...
ASCO Endorses ASTRO Guideline on External-Beam Radiotherapy for Patients With Locally Advanced NSCLC
ASCO issued an endorsement of the American Society for Radiation Oncology (ASTRO) evidence-based guideline on external-beam radiotherapy for patients with locally advanced non–small cell lung cancer (NSCLC). The ASCO endorsement was published by Bezjak et al in the Journal of Clinical...
Surgical Interventions for Terminal Cancer Patients Remain Prevalent
The number of surgeries performed on terminally ill cancer patients has not dropped in recent years, despite more attention to the importance of less invasive care for these patients to relieve symptoms and improve quality of life. But new research from the University of California, Davis, also...
Increased Lifetime Risk of Cardiovascular Disease for Patients Treated for Hodgkin Lymphoma as Adolescents or Adults
Survivors of Hodgkin lymphoma treated as adolescents or adults are at increased risk of cardiovascular disease throughout their lives, according to results of a retrospective cohort study of 2,524 Dutch patients followed for a median of 20 years. “Treating physicians and patients should be...
Bilateral Prophylactic Mastectomy Rarely More Cost-Effective Than Screening Mammography for High-Risk Women
Annual screening mammography is significantly more cost-effective than bilateral prophylactic mastectomy in managing the care of most women at high risk for breast cancer. Women with a known BRCA gene mutation, which carries an exceptionally high risk, are a notable exception. These were the...
Overnight Fasting May Reduce Breast Cancer Risk in Women
A decrease in the amount of time spent eating and an increase in overnight fasting reduces glucose levels and may reduce the risk of breast cancer among women. Researchers at the University of California, San Diego School of Medicine reported these findings in Cancer Epidemiology, Biomarkers &...
American College of Physicians Releases Best Practice Advice for Cervical Cancer Screening in Average-Risk Women
The American College of Physicians (ACP) released its clinical advice for cervical cancer screening in asymptomatic, average-risk women 21 years or older. Women at average risk are defined as those with no history of a precancerous lesion (cervical intraepithelial neoplasia grade 2 or a more severe ...
Childhood Cancer Survivors More Likely to Claim Social Security Support as Adults
Today, more than 80% of childhood cancer patients survive because of advances in treatment and care. However, recent studies have shown that some of these more than 420,000 United States childhood cancer survivors face future health-related challenges as they become adults such as a second cancer...
Two Studies Examine the Significant Postoperative Risk of Life-Threatening Blood Clots in Patients With Lung Cancer
New evidence suggests that patients with lung cancer who undergo surgery are at higher risk of developing venous thromboembolism, including deep-vein thrombosis and pulmonary embolism, than previously thought, with elevated risks of complications or death. When thromboemboli occur, they may be...
Genomic Analyses Point to the Potential of Personalized Care for Liver Cancer Patients
A new study presented at The International Liver Congress 2015 in Vienna showed that using genomic analyses to understand how and when carcinogenic mutations occur in patients with hepatocellular carcinoma may make it possible to identify specific molecular profiles linked to tumor aggressiveness...
Fallopian Tube Removal May Protect Premenopausal Women at High Risk for Ovarian Cancer From Some Surgical Side Effects
A new surgical approach that removes the fallopian tubes—while sparing the ovaries—may provide premenopausal women at high risk for ovarian cancer, particularly those with BRCA1/2 mutations, with a surgical option that minimizes cancer risk while also reducing some of the negative...
FDA Announces Clinical Trial Endpoints for Approval of Non–Small Cell Lung Cancer Drugs
This week, the U.S. Food and Drug Administration (FDA) released its guidance for industry document Clinical Trial Endpoints for the Approval of Non–Small Cell Lung Cancer Drugs and Biologics, which allows companies to use several types of clinical trial endpoints, including overall survival...
One-Third of Breast Cancer Patients Concerned About Genetic Risk
A new study from the University of Michigan Comprehensive Cancer Center found that many women diagnosed with breast cancer are concerned about the genetic risk of developing other cancers themselves, or of a loved one developing cancer. These findings were published by Jagsi et al in the Journal of ...
Crizotinib Receives Breakthrough Therapy Designation for the Treatment of ROS1-Positive Non–Small Cell Lung Cancer
The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to crizotinib (Xalkori) for the potential treatment of patients with ROS1-positive non–small cell lung cancer (NSCLC). Crizotinib currently is approved in the United States for the treatment of patients...
AACR 2015: Study Identifies a Frequent Genomic Alteration in Pleomorphic Invasive Lobular Carcinoma
Research from Rutgers Cancer Institute of New Jersey shows genomic profiling identifies mutations in a gene associated with a rare subset of breast cancer—mutations that cannot otherwise be identified with standard clinical analysis of cells and tissue. The findings, presented at the AACR...
AACR 2015: New PARP Inhibitor Combination Shows Early Promise for a Wide Range of Cancer Patients
A combination of two molecularly targeted drugs, olaparib (Lynparza) and the investigational agent AZD5363, was safe and yielded responses in patients with a variety of cancer types, including breast, ovarian, and prostate cancers, regardless of BRCA1/2-mutation status, according to data from the...
U.S. Preventive Services Task Force Clarifies Mammography Recommendations for Women in Their 40s
The U.S. Preventive Services Task Force (USPSTF) has issued its updated draft recommendation statement on mammography screening guidelines. The revised guidelines still recommend that women aged 50 to 74 get mammography screening for breast cancer every 2 years and now states that the decision to...
AACR 2015: Long-Term, Regular Aspirin Use Modestly Decreased Cancer Risk
Long-term, regular aspirin use was associated with a modestly reduced overall risk for cancer, driven primarily by a reduction in the risk for colorectal cancers, according to research presented at the AACR Annual Meeting 2015, held April 18 to 22 in Philadelphia (Abstract 876). “Previous...
AACR 2015: Olaparib and Investigational PI3K Inhibitor BKM120 Combination Active Against Ovarian and Breast Cancer Subtypes
Combination treatment with the poly ADP-ribose polymerase (PARP) inhibitor olaparib (Lynparza) and the investigational phosphatidylinositol-3-kinase (PI3K) inhibitor BKM120 was safe and yielded evidence of clinical benefit for women with triple-negative breast cancer and for those with high-grade...
AACR 2015: Dual mTOR Inhibitor-Fulvestrant Combination Feasible, With Clinical Benefit for Advanced Breast Cancer Patients
The dual mTOR inhibitor AZD2014, when combined with the hormonal therapy fulvestrant (Faslodex), was found to be safe in patients with advanced estrogen receptor–positive breast cancer, and some of them experienced clinical benefit from the drug combination, according to phase I clinical...
AACR 2015: Metformin Use May Not Improve Pancreatic Cancer Survival
Metformin use did not improve survival of patients with pancreatic ductal adenocarcinoma in a retrospective cohort study presented at the AACR Annual Meeting 2015, held April 18 to 22 in Philadelphia (Abstract LB-183). “The diabetes drug metformin is being used in some cancer treatment...
Study Examines Impact of Hospital Volume on Complication Rates in Patients Undergoing Robotic Prostate Surgery
A disincentive for hospitals that have invested in expensive technology for robotic surgery may be jeopardizing prostate cancer patients who seek out the procedure, concluded a study published by Sammon et al in BJU International. The study compared complication rates in hospitals with low...
AACR 2015: Black Women Found to Have Denser Breast Tissue Than White Women
Breast density, which is associated with breast cancer risk, was found to be higher in black women than white women when measured using novel quantitative methods, according to research presented at the AACR Annual Meeting 2015, held April 18 to 22 in Philadelphia (Abstract 2770). “Since...
AACR 2015: HPV Vaccine Provides Protection at Multiple Sites, Even Among Some Previously Exposed Patients
Vaccination of women aged 18 to 25 with the human papillomavirus (HPV) vaccine resulted in strong protection against future infection at three anatomic sites among women without prior HPV exposure and may still offer some protection in those with evidence of prior exposure. These findings were...
