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Showing 13101 - 13150Study Finds Chemotherapy Accelerates Molecular Aging in Patients With Breast Cancer
Physicians have long suspected that chemotherapy can accelerate the aging process in patients treated for cancer. Using a test developed at UNC Lineberger Comprehensive Cancer Center to determine molecular aging, oncologists have directly measured the impact of anticancer chemotherapy drugs on...
Phase II Trial Shows Feasibility of Customized Adjuvant Treatment in NSCLC, but Phase III Trial Canceled Due to Unreliability of ERCC1 Readouts
In the phase II Tailored Postsurgical Therapy in Early-Stage NSCLC (TASTE) trial (IFCT-0801), reported in the Journal of Clinical Oncology, Wislez et al examined the feasibility of customized adjuvant treatment based on EGFR mutation status and expression of ERCC1 (excision repair...
DNA Test Can Help Predict Bladder Cancer Recurrence
A DNA methylation marker test performed on patients with noninvasive urothelial carcinoma can predict tumor recurrence with high sensitivity and specificity, according to a study by Su et al. The findings may help eliminate costly and unnecessary invasive exams and reveals the importance of DNA...
Experts Call for More Awareness of Sexual Dysfunction in Lung Cancer Patients
Many lung cancer patients suffer difficulties with sexual expression and intimacy, yet for too long the topic has been ignored by doctors and researchers, experts said at the 4th European Lung Cancer Conference (ELCC) in Geneva, Switzerland. Researchers have estimated that sexual dysfunction...
Long-Term Benefit With Dasatinib After Imatinib Failure in Chronic-Phase CML
Patients with chronic myeloid leukemia (CML) in the chronic phase who are resistant or intolerant to imatinib (Gleevec) can experience long-term benefit with dasatinib (Sprycel), according to results of a randomized phase III study. The CA180-034 study also found that early molecular and...
Gene Implicated in Progression and Relapse of Triple-Negative Breast Cancer
Scientists from Weill Cornell Medical College, New York, and Houston Methodist, Houston, have found that a gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of the triple-negative form of the disease. The research by Chen et al, published in Nature,...
Immunotherapy Data Herald New Era of Lung Cancer Treatment
A new era of lung cancer therapy is dawning, using drugs that can prevent tumor cells from evading the immune system, experts reported at the 4th European Lung Cancer Congress. For decades, scientists and doctors thought immunotherapy was of marginal benefit in lung cancer, said ESMO spokesperson...
Erlotinib and Gefitinib Offer Similar Benefit in EGFR-Mutated Non–Small Cell Lung Cancer
A retrospective study has shown that two targeted therapy drugs—erlotinib (Tarceva) and gefitinib (Iressa)—achieved similar outcomes among people with metastatic or recurrent non–small cell lung cancer (NSCLC) harboring an EGFR mutation. These EGFR tyrosine kinase inhibitors have...
PARP Inhibitor Veliparib Might Benefit Women With Resistant Gynecologic Cancers and BRCA Mutation
Preliminary research suggests that a targeted oral agent may improve outcomes while minimizing side effects in women with gynecologic cancers who carry a BRCA mutation and whose disease is not responding to other therapies. According to a phase II study presented at the Society of Gynecologic...
Bariatric Surgery May Lower Risk of Uterine Cancer
Women who had bariatric surgery to lose weight had a 70% lower risk of uterine cancer and an even lower risk if they kept the weight off, according to findings presented at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer, held in Tampa, Florida, from March 22 to 25. ...
Audit of NHS Breast Cancer Screening Programme Reveals Significant Variations Between Hospitals in Treatment Outcomes for DCIS
Analysis of data from the UK NHS Breast Screening Programme has shown significant variations in the outcomes of treatment for women with ductal carcinoma in situ (DCIS) between UK hospitals. Dr. Jeremy Thomas, a consultant pathologist at the Western General Hospital, Edinburgh, told the 9th...
ASCO Issues Updated Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer
A review by ASCO’s Update Committee of new data from randomized clinical trials has led to a change in recommendations for the use of sentinel lymph node biopsy in patients with early-stage breast cancer. The updated guideline will enable more women with early-stage breast cancer to avoid the ...
Investigational Cancer Vaccine Shows Renewed Potential in Non–Small Cell Lung Cancer
Researchers at UC Davis have found that the investigational cancer vaccine tecemotide, when administered with the chemotherapeutic agent cisplatin, boosted immune response and reduced the number of tumors in mice with lung cancer. The study also found that radiation treatments did not...
Obesity and Diabetes Have Adverse Effects on Outcomes Across Breast Tumor Types, Should Be Taken Into Account When Planning Treatment
Both obesity and diabetes have adverse effects on outcomes in breast cancer patients who receive neoadjuvant chemotherapy, according to research presented at the 9th European Breast Cancer Conference. Although a high body mass index (BMI) is known to have a negative impact on cancer development and ...
Analysis of SWOG Trials Indicates No Survival Difference After 1 Year in Cancer Patients Treated In vs Out of Clinical Trials
In a study reported in the Journal of the National Cancer Institute, Unger et al evaluated whether cancer patients from SWOG clinical trials were similar to nontrial patients in baseline characteristics and survival. They found that, overall, trial participation in standard treatment arms did not...
Regular Physical Activity Reduces Breast Cancer Risk Irrespective of Age or Weight
Participating in athletic activities for more than an hour a day reduces the risk of breast cancer, and this applies to women of any age and any weight, regardless of geographic location, according to research presented at the 9th European Breast Cancer Conference in Glasgow. Compared with the...
Genetic Testing May Improve Selection of Women With Estrogen Receptor–Positive Breast Cancer for 10 vs 5 Years of Hormonal Therapy
Genetic analyses of results from 1,125 postmenopausal women being treated for estrogen-responsive breast cancer have shown that some of them are more likely than others to have a late recurrence of their cancer and might benefit from 10 years of hormone therapy rather than 5 years. Women who had...
Health Gap Between Adult Survivors of Childhood Cancer and Siblings Widens With Age
Adult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers, heart disease, and other serious health conditions beyond the age of 35, according to the latest findings from the Childhood Cancer Survivor...
No Difference in Bone Mineral Density Changes With Adjuvant Exemestane vs Anastrozole in Women With Early Breast Cancer
In a companion study (MA.27B) to the open-label phase III National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) MA.27 trial in women with early breast cancer reported in The Lancet Oncology, Goss et al found that adjuvant aromatase inhibitor treatment with exemestane, a mildly...
ASCO Urges Raising the Bar for Cancer Clinical Trials
The American Society of Clinical Oncology is calling on cancer researchers, clinical trial sponsors, and drug developers to employ clinical trial designs that aim to significantly extend the lives of people with cancer. In a Special Article published in the Journal of Clinical Oncology, Ellis...
NCCN Cancer Survivorship Guidelines Expanded to Address Two Common Conditions
The National Comprehensive Cancer Network (NCCN) has expanded its Survivorship Guidelines to include a section on cancer-associated cognitive impairment, and to include chemotherapy-induced peripheral neuropathy as a component of the Adult Cancer Pain section. The inaugural guidelines for...
Report Shows More Screening Has Led to a 30% Drop in Colon Cancer Rates
Findings from a report by Siegel et al of the American Cancer Society (ACS) show that the rate at which people are diagnosed with colorectal cancer in the United States has dropped by 30% in the last 10 years among people aged 50 years and older. The researchers say the decline in incidence is due...
NCCN Advocates for Universal Lynch Syndrome Screening in Newly Diagnosed Colorectal Cancer
The National Comprehensive Cancer Network (NCCN) is recommending that newly diagnosed colorectal cancer patients be screened for Lynch syndrome, previously called hereditary nonpolyposis colorectal cancer. The NCCN’s proactive position should greatly help identify individuals and their...
Patient With Bladder Cancer Shows Exceptional Response to Everolimus/Pazopanib Combination
A phase I study by Wagle et al of a combination of everolimus and pazopanib in patients with advanced solid tumors has identified a patient with bladder cancer who had a 14-month complete response. The patient had two concurrent mutations in mTOR, the target of everolimus (Afinitor), which may have ...
Antibody Could Be Used to Target Tumor-Enhancing Protein, Study Shows
In a phase I study published in PLOS ONE, treating patients with advanced melanoma and kidney cancer with an antibody that targets a tumor-enhancing protein was found to have an acceptable safety profile and showed preliminary evidence of antitumor activity. The findings by Morris et al shed light...
First Comprehensive Report on U.S. Cancer Care Finds Patient Access Threatened by Growing Demand, Physician Shortages
The first-ever comprehensive assessment of challenges facing the U.S. cancer care system suggests that patient access to cancer care will be threatened as growing demand for care outstrips the supply of oncologists, and as cost pressures force the closure of small physician practices that form the...
Study Finds CT Scans Predict Chemotherapy Response in Pancreatic Cancer
Computed tomography (CT) scans routinely taken to guide the treatment of pancreatic cancer may provide an important secondary benefit. According to new research published in the Journal of Clinical Investigation by Koay et al, the scans also reflect how well chemotherapy will penetrate the tumor,...
Study Examines Gene Expression of Adjacent Airway Field Cancerization in NSCLC
Seemingly healthy cells may in fact hide clues that lung cancer will later develop, according to a study led by researchers at The University of Texas MD Anderson Cancer Center. The research is published online in the Journal of the National Cancer Institute. Examination of gene expression in...
Lung Complications Measured by Simple Questionnaire Predict Survival in Chronic Graft-vs-Host Disease
A simple questionnaire that rates breathing difficulties on a scale of 0 to 3 may be able to predict survival in patients with chronic graft-vs-host disease, according to a study by Palmer et al published in Biology of Blood and Marrow Transplantation. Although a poor National Institutes of Health ...
Epigenetic Imprint of Chemotherapy Linked to Inflammation in Breast Cancer Survivors
Many breast cancer survivors experience fatigue and other debilitating symptoms that persist months to years after their course of treatment has ended. Now researchers at the Winship Cancer Institute of Emory University have found clues that may explain how these symptoms can linger. Chemotherapy...
Novel Cancer Vaccine Shows Promise in Ovarian Cancer and Mesothelioma
A novel approach to cancer immunotherapy may provide a new and cost-effective strategy against ovarian cancer and mesothelioma. In a study published in the Journal of Hematology & Oncology, Yuan et al reported that a fusion protein engineered to combine a molecule targeting a tumor-cell-surface ...
Common Cancers Evade Detection by Silencing Parts of Immune System Cells, Study Finds
Immunotherapy for ovarian, breast, and colorectal cancer has so far had limited success, primarily because the immune system often can’t destroy the cancer cells. According to a report published in Oncotarget, researchers at Johns Hopkins have identified genes that have been repressed through ...
BPA Exposure May Be Linked to Prostate Cancer, Study Shows
A new study suggests that levels of bisphenola A (BPA) in men’s urine may be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both nonmalignant and malignant prostate cells. The research, published in PLOS ONE, provides the first evidence that...
Yoga Regulates Stress Hormones and Improves Quality of Life for Women With Breast Cancer Undergoing Radiation Therapy
For women with breast cancer undergoing radiation therapy, yoga offers unique benefits beyond fighting fatigue, according to a study by Chandwani et al published in the Journal of Clinical Oncology. While simple stretching activities counteracted fatigue, patients who participated in yoga exercises ...
Study Finds Possible New Gene Target for Lung Cancer
Researchers have identified a potential new gene mutation that may drive lung cancer development and growth. In a study in the Journal of Clinical Investigation by Imielinski et al, a patient with advanced lung cancer who was found to have the ARAF S214Csomatic gene mutation achieved nearly a...
African Americans Have Higher Prevalence of Multiple Myeloma Precursor Than Whites and Hispanics
A large population-based study by Landgren et al has found that African Americans are more likely to have a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS), a precursor to the development of multiple myeloma, compared with whites or Hispanics. The study is published...
Event-Free Survival at 24 Months Can Serve as Endpoint for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
In a study reported in the Journal of Clinical Oncology, Maurer et al found that patients with diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy who achieve event-free survival at 24 months have overall survival that does not differ significantly from that in the general...
CAR T-Cell Therapy Yields Promising Complete Response Rates in Patients With Relapsed/Refractory B-Cell ALL
In a recent study published in Science Translational Medicine, Davila et al found that 88% of patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) who were treated with genetically modified versions of their own immune cells achieved overall complete response. Most...
Large Study Shows Preventive Ovarian Surgery in BRCA1 Mutation Carriers Should Be Performed Early for Greatest Benefit
The findings of a large international prospective study published in the Journal of Clinical Oncology by Finch et al suggest for the first time that women with BRCA1 mutations should have prophylactic oophorectomy by age 35, as waiting until a later age appears to increase the risk of ovarian...
Methotrexate-Induced Neurotoxicity Does Not Preclude Rechallenge in Children With ALL
In a study reported in the Journal of Clinical Oncology, Bhojwani et al from St. Jude Children’s Research Hospital assessed clinical, pharmacokinetic, and genetic risk factors for methotrexate-related clinical neurotoxicity and asymptomatic leukoencephalopathy in children with acute...
Natural Compound Attacks HER2-Positive Breast Cancer Cells
A common compound known to fight lymphoma and skin conditions actually has a second method of action that makes it particularly deadly against certain aggressive breast tumors, according to a study reported by Xia et al in PLOS ONE. The compound, psoralen, is a natural component found in foods such ...
Unilateral Radiotherapy for Advanced Tonsil Cancer Yields Favorable Outcome
New research suggests that it is safe to limit radiation therapy to lymph nodes on only one side of the neck for lateralized tonsil cancer. In addition, the study findings show that primary tumor location, rather than the amount of lymph node involvement on the tumor side of the neck, drives the...
Avoiding Radiation to Major Salivary Glands in Head and Neck Cancer Is Safe and Improves Quality of Life
New research is showing that sparing the contralateral submandibular gland during radiation therapy in the treatment of locally advanced head and neck cancer is technically feasible and safe even in advanced-stage, node-positive disease and base-of-tongue lesions. Limiting radiation to these major...
Study Finds Combining a Novel Biomarker With HPV Status Predicts Patient Outcome in Head and Neck Cancer
Using next-generation sequencing and the clinical data of patients with head and neck squamous cell carcinoma, researchers found that combining mutant-allele tumor heterogeneity as a biomarker with patients’ human papillomavirus (HPV) status provides a reliable predictor of patient survival....
Distant Metastases Occur Later and in More Subsites in Patients With HPV-Positive Squamous Cell Carcinoma of the Oropharynx
Patients with human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx had a longer time to development of distant metastasis after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented...
New Finding Points to Potential Options for Targeting Stem Cells in Triple-Negative Breast Cancer
New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University has found that a protein that regulates an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells. This finding may provide a potential target for...
Researchers Discover Preleukemic Stem Cell at Root of AML Relapse
Researchers have discovered a preleukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML). The research, published online in Nature, is a significant step forward in...
Normal Enzyme Pairs With Mutated FLT3 to Fuel AML Progression
Findings from a study by Puissant et al suggest that the wild-type form of enzyme SYK pairs with FLT3, the most commonly mutated enzyme found in acute myeloid leukemia (AML), to promote progression of the cancer. The molecular partnership also promotes AML cells’ resistance to treatment with...
Study Identifies Possible Genetic Markers in Breast Cancer Brain Metastases
Scientists from the Translational Genomics Research Institute (TGen) have uncovered the possible genetic origins of breast cancers that metastasize to the brain. The compendium of new genetic targets may be be used to identify potential methods of diagnosis and novel therapeutics for patients with...
SSO-ASTRO Consensus Guideline: Margins Wider Than 'No Ink on Tumor' Do Not Further Reduce Risk of Ipsilateral Breast Tumor Recurrence
The Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) formed a multidisciplinary expert panel in 2013 to examine the relationship between surgical margin width and ipsilateral breast tumor recurrence and develop guidelines on margins for breast-conserving...
