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Showing 13051 - 13100AACR 2015: Combining Two Investigational Immunotherapy Drugs Safe, With Early Signs of Effectiveness
Combining the immunostimulatory anti-CD40 monoclonal antibody CP-870,893 with the immune checkpoint inhibitor tremelimumab was found to be safe, with clinical evidence of response in patients with advanced melanoma, according to phase I clinical trial data presented at the AACR Annual Meeting 2015, ...
AACR 2015: New Immunotherapy Yields Long-Lasting Responses in Some Patients With Advanced Melanoma
A first-in-class immunotherapy called IMCgp100 yielded durable responses in patients with advanced cutaneous melanoma and those with advanced ocular melanoma, according to data from a phase I/IIa clinical trial presented at the AACR Annual Meeting 2015, held April 18 to 22 in Philadelphia (Abstract ...
AACR 2015: Investigational CART-meso Immunotherapy Feasible for Patients With Advanced Cancers
Patients with advanced cancers who received mesothelin-directed chimeric antigen receptor–modified T cells (CART-meso), a type of investigational adoptive immunotherapy, tolerated the treatment well, and there was evidence that the infused immune cells persisted in the patients’ blood...
Evidence Grows That Melanoma Drugs May Benefit Some Lung Cancer Patients
A subset of lung cancer patients can derive important clinical benefits from drugs that are more commonly used to treat melanoma, the authors of a new academic clinical trial in Europe have reported at the European Lung Cancer Conference (ELCC) in Geneva (Abstract 21PD_PR). Oliver Gautschi, MD, a...
One-Quarter of Advanced Lung Cancer Patients Tested for EGFR Mutations Started on First-Line Therapy Before Test Results Available
Almost one in four patients (24%) with advanced lung cancer in Europe, Asia, and the United States are not receiving EGFR test results before being started on treatment, researchers reported at the European Lung Cancer Conference (ELCC) in Geneva (Abstract LBA2_PR). This lack of test results may...
Circulating Tumor DNA May Be Used to Detect EGFR Mutations in Lung Cancer
Cancer DNA circulating in the bloodstream of lung cancer patients can provide doctors with vital mutation information that can help optimize treatment when tumor tissue is not available, an international group of researchers has reported at the European Lung Cancer Conference (ELCC) in Geneva...
Physical Activity Helps Cancer Survivors Fend Off Side Effects
Three or more hours of walking per week can boost the vitality and health of prostate cancer survivors. Men and women who have survived colorectal cancer and are regular walkers also reported lower sensations of burning, numbness, tingling, or loss of reflexes that many often experience after...
ASCO Issues Statement Praising the Senate Repeal of SGR
In a statement, the American Society of Clinical Oncology praised the U.S. Senate’s 92-to-8 approval of legislation to repeal the Sustainable Growth Rate formula. ASCO President Peter Paul Yu, MD, FACP, FASCO, said, “Today's courageous vote by the U.S. Senate to finally end the...
More Extensive Lymph Node Clearance During Surgery for Esophageal Cancer May Not Improve Survival
A population-based cohort study indicates that “more extensive lymph node clearance during surgery for esophageal cancer may not improve survival,” van der Schaaf et al reported in the Journal of the National Cancer Institute. “These results challenge current clinical guidelines,...
Patients With Relapsed or Refractory CLL Who Discontinue Ibrutinib Early Have Poor Outcomes
Most patients with relapsed or refractory chronic lymphocytic leukemia (CLL) who discontinued ibrutinib (Imbruvica) early “were difficult to treat and had poor outcomes,” according to a study of patients enrolled in four different clinical trials of ibrutinib, with or without rituximab...
Study Finds Price of Cancer Drugs Varies Widely Based on Who’s Paying
Uninsured cancer patients are paying anywhere from 2 to 43 times what Medicare would pay for chemotherapy drugs, according to a new study from the University of North Carolina at Chapel Hill. These findings were published by Dusetzina et al in Health Affairs. Major Discrepancies Researchers led...
Study Finds Link Between Muscle-Building Supplements and Testicular Cancer
Men who reported taking muscle-building supplements, such as pills and powders with creatine or androstenedione, reported a significantly higher likelihood of having developed testicular cancer than men who did not use such supplements, according to a study by Li et al in the British Journal of...
Long-Term Study Shows Stress Management Techniques Improve Mood and Quality of Life for Breast Cancer Patients
A new study showed that providing women with skills to manage stress early in their breast cancer treatment can improve their mood and quality of life many years later. Published by Stagl et al in Cancer, the findings suggest that women given the opportunity to learn stress management techniques...
Increasing Number of Boys Vaccinated Against HPV Could Protect More People at the Same Price
Public health programs that devote a portion of their funding to encourage more boys to be vaccinated against human papillomavirus (HPV)—rather than merely attempting to raise coverage among girls—may ultimately protect more people for the same price, a study from Duke University...
Complete Regression of Metastatic Cervical Cancer Is Observed After Treatment With HPV-Targeted Tumor-Infiltrating T Cells
As reported in the Journal of Clinical Oncology, Stevanovíc et al observed complete regression of metastatic cervical tumors in two patients following a single infusion of human papillomavirus (HPV)-targeted tumor-infiltrating T cells. In the protocol, nine patients with metastatic cervical ...
Cancer Experts Find Too Many People Are Being Screened, Diagnosed, and Treated for Disease
A recent commentary published in Annals of Internal Medicine discusses the paradoxical finding that most patients are at below-average risk of disease and can expect to experience less-than-average benefits from a treatment. Yet, argue Vickers et al, too many people are being screened, diagnosed,...
Persistence of HER2-Specific CAR T Cells in HER2‑Positive Sarcoma
In a phase I/II study reported in Journal of Clinical Oncology, Ahmed et al found that infusion of T cells expressing HER2-specific chimeric antigen receptor (CAR) with a CD28.ζ signaling domain (HER2-CAR T cells) could produce persistent CAR T cell levels for ≥ 6 weeks in patients with...
Improved Quality Metrics for Robotic Pancreaticoduodenectomy With Increased Performance
In a retrospective single-institution study reported in JAMA Surgery, Boone et al found significant improvements in blood loss, incidence of conversion to open surgery, pancreatic fistula incidence, and operative time with increased number of patients treated with robotic pancreaticoduodenectomy....
Improved Progression-Free Survival With Brentuximab Vedotin Consolidation After Transplantation in Hodgkin Lymphoma
In the phase III AETHERA trial reported in The Lancet, Moskowitz et al found that brentuximab vedotin (Adcetris) consolidation therapy after autologous stem cell transplantation prolonged progression-free survival by 18 months vs placebo in patients with Hodgkin lymphoma at risk for relapse or...
New Study Reveals Effective Treatment Program for Breast Cancer Survivors With ‘Chemobrain’
In a new study, UCLA researchers have developed a cognitive rehabilitation program to address post-treatment cognitive changes, sometimes known as “chemobrain,” which can affect up to 35% of post-treatment breast cancer patients. Their findings were reported by Erocli et al in...
Overweight Girls Face Increased Risk of Colorectal Cancer Later in Life
Girls who are overweight as young children and teens may face an increased risk for colorectal cancer decades later, regardless of what they weigh as adults, suggests a new study published by Zhang et al in Cancer Epidemiology, Biomarkers & Prevention. “Our study supports the growing...
Experimental Immunotherapy Delays Recurrence for Stage III and IV Ovarian Cancers
According to a phase II study presented at the Society of Gynecologic Oncology Annual Meeting on Women’s Cancer, an experimental immunotherapy is in the works that can target an individual woman’s ovarian tumor and extend the time period between initial treatment and the cancer’s...
Sentinel Lymph Node Mapping Identifies Positive Lymph Nodes in Women With High-Risk Endometrial Cancer
In a study of women with high-grade endometrial cancer, researchers at The University of Texas MD Anderson Cancer Center found sentinel lymph node mapping accurately identified all women with node-positive, high-risk endometrial cancer, when prospectively compared to a complete pelvic and...
Addition of Bevacizumab to Chemotherapy Extends Survival in Women With Platinum-Sensitive Recurrent Ovarian Cancer
In a phase III study of women with ovarian cancer, researchers found that the addition of bevacizumab (Avastin) to standard chemotherapy extended median overall survival by 5 months compared to standard chemotherapy alone. The bevacizumab combination was also associated with a significant...
ASCP, CAP, AMP, and ASCO Issue Draft Colorectal Cancer Molecular Marker Testing Guideline, Announce Opening of Public Comment Period
The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) today released a draft of a clinical practice guideline on the use of molecular marker testing for...
Smokers Have Twice the Risk of Prostate Cancer Recurrence After Surgery as Never-Smokers
Current smokers, and those who have quit smoking less than 10 years previously, have twice the risk of a recurrence of prostate cancer after surgery, according to new research by Rieken et al presented at the European Association of Urology (EAU) 2015 Congress in Madrid (Abstract 508). In 2012,...
Study Compares Incidence and Severity of Treatment-Related Neuropathy in Patients With Colorectal Cancer vs Other Cancers
Patients with colorectal cancer experience significantly higher rates of numbness/tingling but comparable neuropathic pain relative to patients with other cancers, according to a study by Lewis et al in the Journal of Pain and Symptom Management. In addition, numbness/tingling was more likely to be ...
Effect of Smoking and Alcohol Consumption on Feeding Tube Duration in Head and Neck Cancer Patients
Current smoking and heavy alcohol consumption appear to be risk factors for prolonged use of a gastrostomy tube in patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy. The findings were published in a report by O’Shea et al in JAMA Otolaryngology-Head & Neck...
Genome-Wide CRISPR Screen Provides Better Understanding of Tumor Evolution and Metastasis
Scientists from the Broad Institute and the Koch Institute for Integrative Cancer Research at MIT used CRISPR-Cas9 gene-editing technology to “knock out,” or turn off, all genes across the genome systematically in a mouse model of non–small cell lung cancer cells and then tested...
Measuring Minimal Residual Disease Levels Proves to Be a Powerful Tool for Guiding Leukemia Treatment
According to a prospective study led by researchers at St. Jude Children's Research Hospital, measuring the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy may help boost survival of young leukemia patients by better matching patients with the right...
Preliminary Study Reveals Gene Regulatory Path as Target for Aggressive Pediatric Brain Cancer
Working with cells taken from children with a very rare but aggressive form of brain cancer, Johns Hopkins Kimmel Cancer Center scientists have identified a genetic pathway that acts as a master regulator of thousands of genes, and may spur cancer cell growth and resistance to anticancer treatment. ...
Comprehensive Genomic Profiling Shows Distribution of Targetable Alterations in Carcinomas of Unknown Primary Site
In a study reported in JAMA Oncology, Ross et al found potentially targetable genomic alterations in most carcinomas of unknown primary site using comprehensive genomic profiling. Adenocarcinomas of unknown primary site frequently harbored receptor tyrosine kinase/Ras/MAPK pathway alterations....
New Breast Cancer Test Links Immune ‘Hotspots’ to Better Survival
Scientists have developed a new test that predicts the survival chances of women with breast cancer by analyzing images of “hotspots” where there has been a fierce immune reaction to a tumor. Using statistical software previously used in criminology studies of crime hotspots,...
NIH-Funded Study Suggests Novel Strategy to Improve Vaccine Efficacy in the Treatment of Glioblastoma
Although dendritic cell–based immunotherapy has shown limited promise in the treatment of patients with advanced cancers, including glioblastoma, the factors dictating dendritic cell–based vaccine efficacy have been poorly understood. Now, a clinical trial funded by the National...
Breast Cancer Risk May Increase in Women Who Have First-Degree Relatives With a History of Prostate Cancer
Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer. Researchers from multiple institutions published their findings in a study by Beebe-Dimmer et al in Cancer. The study's results indicate that clinicians should take a...
Annual ASCO Report Shows Widespread Disturbance in Oncology Practice, Amid Growing Patient Demand and Administrative Burden
The U.S. cancer care system faces tremendous turbulence while dealing with growing numbers of cancer patients and survivors, mounting pressures to control rising health-care costs, and widespread oncology practice transformation, reports a new study by the American Society of Clinical Oncology...
NCCN Publishes New Guidelines for Smoking Cessation
Tobacco-related diseases are the most preventable cause of death worldwide; smoking cessation leads to improvement in cancer treatment outcomes, as well as decreased tumor recurrence. According to the American Cancer Society, in 2015, nearly 171,000 of the estimated 589,430 cancer deaths in the...
Study Finds Lycopene May Be Associated With Lower Risk for Kidney Cancer in Postmenopausal Women
A higher intake by postmenopausal women of lycopene, an antioxidant found in foods like tomatoes, watermelon, and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer. A study describing these findings was published by Ho et al in Cancer. In 2014, 63,920 estimated new cases...
Similar Local Recurrence Rates But Increased Distant Metastases With Adjuvant Localized vs Whole-Brain Radiotherapy in Patients With Brain Metastases
In patients who had undergone surgery for brain metastases, the rate of recurrence at the resected site was similar between patients who received adjuvant whole-brain radiotherapy vs those who underwent adjuvant localized radiotherapy, according to a retrospective study by Hsieh et al in the...
Thyroid Cancer Rare in Patients With Asymptomatic Benign Nodules
A prospective, multicenter, observational study involving 992 consecutive patients with one to four asymptomatic, sonographically or cytologically benign thyroid nodules found that “the majority of nodules exhibited no significant size change during 5 years of follow-up or they actually...
Age-Stratified Predictive Model May Provide Surgical Guidelines for Uterine Leiomyomas
A study by Brohl et al investigating the case incidence of unexpected uterine sarcoma following surgery for presumed benign leiomyoma (fibroids or myomas) has found that the risk of unexpected uterine sarcoma varies significantly across age groups, with a more than fivefold difference between the...
Simulation Study Based on ERSPC Data Shows Greatest Cost-Effectiveness With Two to Three PSA Screenings Between 55 and 59 Years of Age
The European Randomized Study of Screening for Prostate Cancer (ERSPC) trial showed a significant 29% prostate cancer mortality reduction with prostate-specific antigen (PSA) screening but a marked negative impact on quality-adjusted life-years gained due to the effect of overdiagnosis on quality...
Study Shows Targeting Cancer Cell ‘Cloak’ Could Benefit Drug Delivery
Cancer cells can cloak themselves within tumors by hiding behind a dense layer of cellular stroma. According to a new study by the Translational Genomics Research Institute (TGen), drugs that target and strip away the stroma would pave the way for other drugs to reach the cancerous cells within the ...
AACR Names Nancy E. Davidson, MD, President-Elect for 2015-2016
The American Association for Cancer Research (AACR) today announced the election of Nancy E. Davidson, MD, Director of the University of Pittsburgh Cancer Institute and UPMC CancerCenter in Pittsburgh, as its President-Elect for 2015–2016. Dr. Davidson will officially become President-Elect...
FDA Approves Dinutuximab Combination for Pediatric Patients With High-Risk Neuroblastoma
The U.S. Food and Drug Administration has approved dinutuximab (Unituxin) as part of first-line therapy for pediatric patients with high-risk neuroblastoma. Dinutuximab, a chimeric monoclonal antibody that binds to the surface of neuroblastoma cells, is being approved for use as part of a...
Neoadjuvant Chemotherapy for Breast Cancer Increases Chances of Lumpectomy, Decreases Chances of Mastectomy
Patients with larger malignant tumors of the breast who undergo chemotherapy before a breast cancer operation are more likely to undergo a lumpectomy than a mastectomy, according to a study published by Killelea et al in the Journal of the American College of Surgeons. Study investigators from...
Inherited Gene Variation Leaves Young Leukemia Patients at Risk for Peripheral Neuropathy
St. Jude Children’s Research Hospital scientists have identified the first genetic variation that is associated with an increased risk and severity of peripheral neuropathy following treatment with a widely used anticancer drug. Investigators also found evidence of how it may be possible to...
Colorectal Cancer Benefits With Flexible Sigmoidoscopy Screening in SCORE Trial Are Generalizable to Broader Population
The Italian SCORE trial is among several recent large European randomized trials showing the benefit of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality. In a study reported in the Journal of the National Cancer Institute, Senore et al found that characteristics of...
FDA Approves First Biosimilar Product Filgrastim‑Sndz
The U.S. Food and Drug Administration (FDA) today approved filgrastim-sndz (Zarxio), the first biosimilar product approved in the United States. A biosimilar product is a biologic product that is approved based on a showing that it is highly similar to an already-approved biologic. The biosimilar...
NRAS Mutations in Advanced Melanoma Correlate With Increased Benefit From Immunotherapies
Researchers investigating whether tumor genotype correlates with benefit from immune therapy in melanoma has found that patients whose tumors had NRAS mutations had better response to immunotherapy and better outcomes than patients whose tumors had other genetic subtypes. The results suggest that...
