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gynecologic cancers

Study Reports No Overall Benefit of Adding Farletuzumab to Chemotherapy in Relapsed Ovarian Cancer, but Potential Subgroup Benefit Identified

Addition of the antifolate receptor-α antibody farletuzumab to carboplatin/taxane did not improve progression-free survival in patients with ovarian cancer in first platinum-sensitive relapse, reported Vergote et al in the Journal of Clinical Oncology. However, benefit was observed in...

gynecologic cancers

SGO 2016: Advanced Ovarian Cancer Caused by Genetic Mutations Linked to Better PFS and OS Following Treatment Including Bevacizumab

Women with advanced ovarian cancer caused by genetic mutations—including in BRCA1 and BRCA2—lived significantly longer than those who did not have a mutation following treatment with a chemotherapy regimen that included bevacizumab (Avastin). According to a study, those with BRCA1 and a ...

gynecologic cancers

Adding Cediranib to Platinum Therapy Increases Progression-Free Survival in Relapsed Platinum-Sensitive Ovarian Cancer

The phase III ICON6 trial showed that adding cediranib to platinum-based therapy increased progression-free survival and toxicity in women with first relapse of platinum-sensitive ovarian cancer, reported Ledermann et al in The Lancet. Study Details In the double-blind trial, 456 women with...

gynecologic cancers
supportive care
symptom management

Fosaprepitant Combination Reduces Risk of Emesis During Chemoradiotherapy for Cervical Cancer

The addition of fosaprepitant (Emend) to palonosetron and dexamethasone reduced the risk of emesis during 5 weeks of chemoradiotherapy for cervical cancer, according to the phase III GAND-emesis trial reported in The Lancet Oncology by Ruhlmann et al. Study Details In the double-blind trial, 234...

gynecologic cancers

Frequent Copy Number Gain of Genes for PD-1 Ligands in Squamous Cell Carcinoma of the Cervix or Vulva

In a study reported in JAMA Oncology, Howitt et al identified copy number gain of genes encoding programmed cell death protein 1 (PD-1) ligands in a sizable proportion of patients with squamous cell carcinoma of the cervix or vulva. Study Details The study involved fluorescence in situ...

gynecologic cancers

Study Finds No Progression-Free Survival Benefit for Weekly Dose-Dense vs Every-3-Week Paclitaxel Plus Carboplatin in Ovarian Cancer

Weekly dose-dense paclitaxel did not provide a progression-free survival benefit over every-3-week paclitaxel in combination with carboplatin and with or without elective bevacizumab (Avastin) in patients with previously untreated ovarian cancer, according to the results of the phase III GOG-0262...

gynecologic cancers

Study Finds No Adverse Impact of Minimally Invasive Hysterectomy on Long-Term Survival in Endometrial Cancer

Use of minimally invasive hysterectomy did not seem to have an adverse impact on long-term survival in women with endometrial cancer, according to an analysis reported in the Journal of Clinical Oncology by Wright et al. Study Details The study involved Surveillance, Epidemiology, and End Result...

gynecologic cancers
issues in oncology

Sparing Ovaries and Removing Fallopian Tubes May Cut Cancer Risk, but Few Have Procedure

During hysterectomies for noncancerous conditions, removing both fallopian tubes while keeping the ovaries may help protect against ovarian cancer and preserve hormonal levels, but few women receive this surgical option, according to a new study by Yale School of Medicine researchers. Published by ...

gynecologic cancers
colorectal cancer
head and neck cancer
issues in oncology
issues in oncology

100% of NCI-Designated Cancer Centers Endorse the Promotion of the HPV Vaccination for Cancer Prevention

All National Cancer Institute (NCI)-designated cancer centers have united to support human papillomavirus (HPV) vaccination. A team of HPV experts drafted a consensus statement that advises widespread use of HPV vaccines to prevent cancer. HPV causes cancer of the cervix, anus, and throat. The HPV ...

gynecologic cancers

New NCCN Guidelines for Vulvar Cancer Available

The National Comprehensive Cancer Network (NCCN) has published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for vulvar cancer; these NCCN Guidelines® are currently available as Version 1.2016. The NCCN Drugs & Biologics Compendium (NCCN Compendium®) has been...

gynecologic cancers
issues in oncology

New Method to Improve Preoperative Diagnosis of Ovarian Cancer Based on Ultrasound

In a landmark study, investigators from Europe proposed a new and simple method to assess the risk of malignancy of women with an adnexal mass. The method identified between 89% and 99% of patients with ovarian cancer using the results of ultrasound examination, which can be obtained in referral...

gynecologic cancers
issues in oncology

UK Study Suggests Potential Mortality Benefit of Ovarian Cancer Screening in Postmenopausal Women

As reported in The Lancet by Jacobs et al, the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) suggests there may be a mortality benefit of ovarian cancer screening in postmenopausal women. Study Details In the trial, 202,546 postmenopausal women aged 50 to 74 years from 13 centers...

gynecologic cancers
issues in oncology

HPV Vaccine Uptake Is Highest Among Girls in High-Poverty and Majority Hispanic Communities

Adolescent girls living in high-poverty communities and majority Hispanic communities were more likely to have received at least one dose of a human papillomavirus (HPV) vaccine than those living in low-poverty communities and in communities of other racial and ethnic compositions. These findings...

gynecologic cancers
gynecologic cancers
issues in oncology

Study Shows ACA Coverage Expansion Resulted in Increased Cervical Cancer Diagnosis at Early Stage in Young Women

In a study reported in a research letter in JAMA, Robbins et al found evidence that the Affordable Care Act Dependent Coverage Expansion (ACA-DCE) has resulted in increased diagnosis of cervical cancer at an early stage and increased use of fertility-sparing treatments in women aged 21 to 25 years. ...

breast cancer
colorectal cancer
gynecologic cancers
issues in oncology

Follow-up Times for Colorectal Cancer Screening Abnormalities Lag Behind Others

Follow-up times of abnormal screening exams were shorter for breast cancer than they were for colorectal and cervical cancers, according to a recent study involving more than 1 million individuals who underwent these screenings. Recently published by Tosteson et al in the Journal of General...

gynecologic cancers

Access to Minimally Invasive Hysterectomies in Early Uterine Cancer Remains Persistently Limited

A new study led by Johns Hopkins researchers shows wide racial and economic disparities in access to minimally invasive hysterectomies for early uterine cancer in the United States. This is despite years of accumulating evidence that the procedures to remove the uterus are linked to fewer...

gynecologic cancers

Moore Scoring System Helps Identify Women With Advanced Cervical Cancer Who May Not Benefit From Bevacizumab

Previously published reports from the randomized phase III Gynecologic Oncology Group (GOG) protocol 240 clinical trial showed that adding bevacizumab (Avastin) to a chemotherapy regimen of paclitaxel plus cisplatin or topotecan significantly increased overall survival and progression-free survival ...

gynecologic cancers
gynecologic cancers

European Trial Shows Front-Line Addition of Nintedanib to Standard Chemotherapy Improves Progression-Free Survival in Advanced Ovarian Cancer

In a European phase III trial (AGO-OVAR 12) reported in The Lancet Oncology, du Bois et al found that adding the antiangiogenic multikinase inhibitor nintedanib (Ofev) to carboplatin/paclitaxel improved progression-free survival in patients with newly diagnosed ovarian cancer. Gastrointestinal...

gynecologic cancers
issues in oncology
issues in oncology

Study Identifies Ovarian Cancer Cell Hierarchy

Can any cancer cell form another tumor, or is it only select cancer stem cells that give rise to new cancer cells? The answer, a new study finds, is both. Researchers at the University of Michigan Comprehensive Cancer Center looked at human ovarian cancer cells, and found that, for the most part,...

gynecologic cancers

Risk of Undetected Cancer in Gynecologic Surgery Higher Than Previously Thought

Minimally invasive gynecologic surgeries have advantages for patients, including shorter hospital stays, quicker recoveries, and less pain. However, power morcellation, a technique that cuts the uterus or fibroid into small pieces in order to extract them from the abdomen through a small incision,...

gynecologic cancers
supportive care

Researchers Find Experimental Drug Reduces Ascites With Minimal Side Effects in Preclinical Studies

Women who have ovarian cancer often develop a condition called ascites, which is a buildup of fluids in the abdomen. The most common treatment for ascites is puncturing the abdomen and manually draining the fluid, which is painful, risky, and must be repeated every few weeks. University of...

gynecologic cancers
issues in oncology

Healthy Diet May Reduce Risk of Ovarian Cancer in African American Women

A healthy diet may reduce the risk of ovarian cancer in African American women, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held November...

gynecologic cancers

Previous Oral Contraceptive Use May Be Associated With Better Outcomes in Patients With Ovarian Cancer

Patients who develop ovarian cancer appear to have better outcomes if they have a history of oral contraceptive use, according to a study by Mayo Clinic researchers published by Jatoi et al in BMC Cancer. “Multiple studies from a variety of sources have indicated that oral contraceptives are ...

issues in oncology
gynecologic cancers
gynecologic cancers

Protein CK5 a Marker for Cisplatin-Resistant Ovarian Cancer

A University of Colorado Cancer Center study recently published by Corr et al in the International Journal of Gynecological Cancer shows that protein cytokeratin 5 (CK5), known to be a marker of poor prognosis in breast cancer, also marks ovarian cancers likely to be resistant to the common...

gynecologic cancers

Addition of Cediranib to Carboplatin/Paclitaxel Improves Progression-Free Survival in Metastatic/Recurrent Cervical Cancer in UK Phase II Trial

In a UK phase II trial reported in The Lancet Oncology, Symonds et al found that the addition of the investigational VEGFR1, -2, and -3 inhibitor cediranib to carboplatin/paclitaxel improved progression-free survival in patients with metastatic or relapsed cervical cancer. The addition of cediranib ...

gynecologic cancers
supportive care
issues in oncology

ASTRO 2015: Image-Guided Intensity-Modulated Radiation Therapy Reduces Bowel Side Effects in Cervical Cancer Patients

For cervical cancer patients undergoing postsurgical radiation therapy, image-guided intensity-modulated radiation therapy (IMRT) resulted in a 14% reduction in moderate-to-severe bowel side effects when compared to conventional three-dimensional conformal radiation therapy (3D CRT), according to...

gynecologic cancers
issues in oncology

How Physicians Communicate With Parents May Discourage HPV Vaccination of Adolescents

A nationwide online survey of 776 pediatricians and family physicians assessing the quality of their human papillomavirus (HPV) vaccine recommendations to parents has found that a sizable minority of physicians—27%—said they do not strongly endorse HPV vaccination, and 26% and 39%...

gynecologic cancers
gynecologic cancers

Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian Cancer

Results of the phase III AHT trial reported in the Journal of Clinical Oncology by Eeles et al suggest that adjuvant hormonal therapy may improve survival in women with epithelial ovarian cancer. The trial, started in 1990, was stopped early due to low recruitment. Study Details In the open-label ...

gynecologic cancers
gynecologic cancers

Therapeutic HPV-16/18 Vaccine Produces Regression of Cervical Intraepithelial Neoplasia Grade 2/3 in Phase II Trial

In a phase IIb trial reported in The Lancet, Trimble et al found that a therapeutic synthetic vaccine (VGX-3100) targeting human papillomavirus (HPV) 16 and 18 E6 and E7 proteins increased the frequency of regression of HPV-16/18–related cervical intraepithelial neoplasia grade 2/3 vs...

gynecologic cancers
issues in oncology

Bariatric Surgery May Resolve Precancerous Uterine Lining Changes in Obese Women

A study evaluating the effects of bariatric surgery on obese women most at risk for cancer has found that the weight-loss surgery slashed participants' weight by one-third and eliminated precancerous uterine growths in those who had them. Other effects included improving patients' physical quality...

gynecologic cancers

Co-infection With High-Risk and Low-Risk HPV Reduces Risk of Squamous Cervical Cancer vs High-Risk HPV Alone

In a study reported in the Journal of the National Cancer Institute, Sundström et al found that women co-infected with high-risk and low-risk human papillomavirus (HPV) had reduced risk of squamous cervical cancer (SCC), but not cancer in situ (CIS) compared with women with high-risk HPV...

gynecologic cancers
gynecologic cancers
issues in oncology

Study Finds Improving Cervical Cancer Screening Practice May Generate Health Gains With Nominal Increases in Cost

Cytology-based screening has led to substantial declines in cervical cancer incidence and mortality since it was introduced in the 1940s. A population-based, cost-effective analysis investigating the benefits, costs, and cost-effectiveness of current cervical cancer screening practice, however, has ...

breast cancer
gynecologic cancers
issues in oncology
issues in oncology
cost of care

Study Questions Cost-Effectiveness of Universal BRCA Screening

Women who are carriers of mutated BRCA genes are known to have a significantly higher risk for developing breast and ovarian cancers than those who do not have the mutations. A viewpoint published recently in JAMA Oncology by researchers at the University of California Los Angeles questioned...

issues in oncology
gynecologic cancers
issues in oncology

Study Explores Link Between MAPK Pathway Alteration and Long-Term Response to MEK Inhibitor in Serous Ovarian Cancer

In a study reported in the Journal of Clinical Oncology, Grisham et al identified a novel alteration in the MAP2K1 gene encoding for MEK1 that appeared to explain a complete response ongoing for more than 5 years in a patient treated with the MEK inhibitor selumetinib for metastatic low-grade...

gynecologic cancers

Japanese Phase II Trial Shows Activity of Nivolumab in Platinum-Resistant Ovarian Cancer

In a Japanese phase II trial reported in the Journal of Clinical Oncology, Hamanishi et al found that the anti–PD-1 (programmed cell death protein 1) antibody nivolumab (Opdivo) was active in patients with relapsed or advanced platinum-resistant ovarian cancer. Study Details In the study,...

gynecologic cancers

Beta-Blockers May Prolong Survival in Women With Ovarian Cancer

In a first-of-its-kind study, researchers demonstrated a benefit in overall survival among patients with epithelial ovarian cancer receiving generic beta-blocker heart medications. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to...

gynecologic cancers
issues in oncology

Imaging Probe May Be More Accurate Than the Best External Detector for Early Cervical Cancer Diagnosis

An endovaginal magnetic resonance imaging technique is more accurate at detecting early-stage cervical cancer than the best available external detection technique, a new study reported. Researchers at The Institute of Cancer Research and The Royal Marsden Hospital found that using an...

gynecologic cancers
issues in oncology

Black Women Less Likely Than Women of Other Races and Ethnicities to Survive Endometrial Cancer

Non-Hispanic black women with endometrial cancer had worse outcomes than women of other racial/ethnic groups diagnosed with the same subtype of endometrial cancer and at the same stage of disease, according to a study published by Cote et al in Cancer Epidemiology, Biomarkers & Prevention....

breast cancer
gynecologic cancers
issues in oncology
issues in oncology

Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment

Multigene testing of women who tested negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations—most commonly, moderate-risk breast and ovarian cancer genes, as well as Lynch syndrome genes (which increase the risk of ovarian cancer)—according to an...

gynecologic cancers
issues in oncology

Analysis Indicates That Tubal Ligation Is Associated With Lower Endometrial Cancer Stage at Diagnosis and Improved Survival

In an analysis from the NRG Oncology/Gynecologic Oncology Group 210 trial reported in the Journal of the National Cancer Institute, Felix et al found that tubal ligation, which should impede transtubal passage of cells, was associated with lower stage of endometrial cancer at presentation and...

gynecologic cancers

POLE-Mutant and Microsatellite-Unstable Endometrial Tumors May Be Candidates for Anti–PD-1 Treatment

In a study reported in JAMA Oncology, Howitt et al found that polymerase e (POLE)-mutant and microsatellite-unstable endometrial tumors may be candidates for anti–PD-1 (programmed cell death protein 1) immunotherapy. Study Details In the study, neoantigen load was predicted on the basis of...

gynecologic cancers
issues in oncology

Oral Contraceptives May Offer Long-Term Protection From Endometrial Cancer

In an individual-patient meta-analysis reported in The Lancet Oncology, the Collaborative Group on Epidemiological Studies on Endometrial Cancer found that oral contraceptive use was associated with long-term protection from endometrial cancer. Reduction in risk was greater for carcinomas than...

gynecologic cancers
gynecologic cancers
survivorship

Long-Term Survival in Ovarian Cancer May Be Better Than Expected in Some Patients

Combing data collected on thousands of California patients with ovarian cancer, University of California Davis researchers have determined that almost one-third of patients survived at least 10 years after diagnosis. The findings upend the notion that women diagnosed with cancer of the ovaries...

issues in oncology
gynecologic cancers

Birinapant in Combination With Carboplatin May Be Effective Against Serous Ovarian Cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but it frequently recurs after the first line of treatment. A team of University of California, Los Angeles, researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, ...

issues in oncology
gynecologic cancers
issues in oncology

Protein Imbalance in Akt Pathway May Trigger Cancer

Cancer can be caused solely by protein imbalance within cells, a study of ovarian cancer has found. Until now, genetic aberrations have been seen as the main cause of almost all cancer. The research, published by Timsah et al in Oncogene, demonstrates that protein imbalance is a powerful prognostic ...

gynecologic cancers

Intraperitoneal Plus Intravenous Chemotherapy—an Underused Strategy—May Improve Survival in Advanced Ovarian Cancer

An observational study investigating the use and effectiveness of a combination regimen of intraperitoneal and intravenous chemotherapy in the treatment of advanced-stage ovarian cancer has found that although the dual approach substantially improved survival—81% of those treated with the...

gynecologic cancers
issues in oncology
issues in oncology

Modified Mullerian-Inhibiting Substance Suppresses Growth of Some Recurrent Ovarian Tumors in Mouse Model

Use of gene therapy to deliver a protein that suppresses the development of female reproductive organs may improve the survival of patients with ovarian cancer that has recurred after chemotherapy. In a study published by Pepin et al in PNAS Early Edition, a Massachusetts General Hospital (MGH)...

issues in oncology
gynecologic cancers

New Research Uncovers Key Molecule in Ovarian Cancer

Scientists at Lawson Health Research Institute have uncovered an important new target for ovarian cancer therapy. Contrary to current research, this new study found that LKB1, a molecule that regulates the metabolism of many adult cells, is important in the cancer's promotion and survival. These...

cns cancers
gynecologic cancers
colorectal cancer
leukemia
lymphoma
skin cancer
gynecologic cancers
issues in oncology
issues in oncology
issues in oncology

Noninvasive Prenatal Testing May Also Detect Some Maternal Cancers

A study published by Bianchi et al in the Journal of the American Medical Association (JAMA) showed that genetic test results revealed by noninvasive prenatal testing for fetal chromosomal abnormalities may detect underlying conditions in the mother, including cancer. The study reports on a case...

breast cancer
multiple myeloma
gynecologic cancers
issues in oncology

Study Links Leisure Time Sitting to Higher Risk of Specific Cancers and Total Cancer Risk in Women

Spending more leisure time sitting was associated with a higher risk of total cancer risk in women, specifically heightened multiple myeloma, breast, and ovarian cancer risk, according to a new study by the American Cancer Society. The higher risk was present even after taking into account body...

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