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Showing 2001 - 2050ASCO Guides Members Through MACRA Implementation With a Robust Set of New Resources
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA), passed earlier this year, repealed the fundamentally flawed Sustainable Growth Rate formula and introduced significant changes in how Medicare will pay oncologists for the care they provide in the coming years. The new law will be...
Minimally Invasive Surgery for Rectal Cancer: An Evolving Issue
Over 10 years ago, we welcomed a new approach to cancer surgery when the 2004 COST trial demonstrated the benefits of laparoscopic compared with open surgery for colon cancer. This randomized trial of 872 patients showed improved perioperative recovery with laparoscopic colectomy without...
ASTRO Launches Template to Help Radiation Oncologists Guide Cancer Survivors Through Ongoing Care
A new template published by the American Society for Radiation Oncology (ASTRO) standardizes and streamlines the creation of patient-focused plans for long-term cancer survivor care following radiation therapy. As the number of cancer patients and survivors in the United States continues to...
Friends of Cancer Research Releases White Paper on Patient-Reported Outcomes
On November 17, Friends of Cancer Research (FOCR) released a white paper report, Enhancing Use of Patient-Centered Data in Regulatory Decision Making.1 The contents of that paper are summarized below. Improving Patient Input Many stakeholders agree that to ensure truly transformational therapies,...
Partnering Therapies for Estrogen Receptor–Positive Breast Cancer Requires Close Monitoring and Patient Communication
Partnering endocrine therapy with new targeted agents for women with estrogen receptor–positive breast cancer “changes the nature of endocrine therapy from something easily tolerated, with not a lot that you have to do as physicians to monitor it,” William J. Gradishar, MD, of the Robert H. Lurie...
ASCO and AAHPM Define Primary Palliative Care in Oncology
A new guidance statement from ASCO and the American Academy of Hospice and Palliative Medicine (AAHPM) could potentially lead to more standardized primary palliative care delivery across oncology settings, according to Kathleen E. Bickel, MD, MPhil, who presented the study findings at the 2015...
A Shot to End Cancer: HPV Vaccination
As health-care providers, we have an obligation and a responsibility not only to care for our patients, but also to educate them—and the general public—about their cancer risk and ways to reduce or prevent it. We are living in the golden era of cancer prevention and treatment, made possible by...
Kieron Dunleavy, MD, on Burkitt Lymphoma: Preliminary Report of the DA-EPOCH-R Trial
Kieron Dunleavy, MD, of the National Cancer Institute, discusses a multi-center trial that set out to validate the effectiveness of DA-EPOCH-R-based therapy and whether a risk-adapted approach using the regimen is beneficial for patients with Burkitt lymphoma (Abstract 342).
Preoperative Use of Blood-Thinning Drugs Is Safe for Patients With Cancer
Among patients undergoing major cancer operations, the preoperative use of blood-thinning drugs such as heparin does not increase rates of major bleeding or transfusions, and is associated with a decreased risk of blood clots, according to new study results published by Selby et al in the Journal...
Depressed Head and Neck Cancer Patients 3.5 Times Less Likely to Survive, Have Higher Recurrence Risk
Depression is a significant predictor of 5-year survival and recurrence in head and neck cancer patients, according to a new study from The University of Texas MD Anderson Cancer Center. These findings, published by Shinn et al in Psychosomatic Medicine, represent one of the largest reported...
Study Advances Potential Test to Distinguish Precancerous Pancreatic Cysts From Harmless Ones
In a retrospective analysis of data from 130 patients with pancreatic cysts, scientists at Johns Hopkins have used gene-based tests and a fixed set of clinical criteria to more accurately distinguish precancerous cysts from those less likely to do harm. The findings may eventually help some...
ASCO Calls for Comprehensive Payment Reform to Address Issue of Site Neutrality
ASCO has called for comprehensive physician payment reform to support the full scope of services required by patients with cancer, rather than jeopardizing patient outcomes by reducing the available resources in a particular cancer care setting in an effort to achieve "site neutrality" in...
Low-Dose CT Lung Cancer Screenings in 20 to 29 Pack-Year Smokers
The potential risks and harms of low-dose computed tomography lung cancer screening in current 20 to 29 pack-year smokers needs to be assessed before recommending such screening to this group, according to a study published by Pinsky and Kramer in the Journal of the National Cancer Institute....
Five-Gene Signature May Help Predict Survival Outcomes for Some Children With Rhabdomyosarcoma
Among children with intermediate-risk rhabdomyosarcoma that is negative for a fusion gene, those who had a high score for expression of a specific gene signature called MG5 had poorer survival outcomes compared with those who had a low MG5 score, according to a study published by Hingorani et al in ...
Targeted Chemotherapy Shows Early Signs of Slowing Neuroblastoma Tumor Growth With Less Toxicity in Preclinical Models
Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself, mainly because of the toxic effects of chemotherapy. But a team of surgeons is in the nascent stages of developing a more targeted, less toxic method of treating neuroblastoma patients with chemotherapy....
Palliative Care 2015: Collaboration Between Radiation Oncologists and Palliative Care Specialists Improves Care for Patients With Advanced Cancer
An innovative service model that partners radiation oncology with palliative care leads to better results for patients, according to a new analysis. The model of care, established at Mount Sinai Medical Center, is one of only a handful in the country. The study (Abstract 110) will be presented at...
Postprostatectomy Radiation Therapy Yields Low Toxicity and Favorable Patient-Reported Quality of Life
A prospective study of guideline-based, postoperative, image-guided intensity-modulated radiation therapy in patients with prostate cancer found low toxicity profiles and favorable patient-reported quality of life following treatment, with researchers concluding that toxicity and health-related...
Immune System–Boosting Agent May Reduce Early-Stage Melanoma Recurrences
Among patients with clinically stage I or stage II melanoma, those treated with the immune system–boosting agent CpG-B were less likely to experience recurrence of their disease than those who received placebo, according to results from two randomized, placebo-controlled phase II clinical...
MicroRNA Panel Shows Early Potential as Biomarker of Pancreatic Precancers
Assessing blood plasma levels of certain microRNAs (miRNAs) distinguished individuals with noninvasive pancreatic precancers from healthy individuals and discriminated between patients with high-risk and low-risk neoplasms, according to a preliminary, proof-of-principle study published by...
Internationally Acclaimed Cancer Researcher, Gianni Bonadonna, MD, Dies at 81
Gianni Bonadonna, MD, was considered the “Father of Italian Oncology,” but his scientific contributions to the field and his generous collegial spirit extended far beyond the shores of his native land. Dr. Bonadonna was at the forefront in the battle to convince the surgical...
WCLC: Adding Bevacizumab to Chemotherapy Does Not Improve Overall Survival in Early-Stage NSCLC
Adding the monoclonal antibody bevacizumab (Avastin) to chemotherapy for patients with surgically removed non–small cell lung cancer (NSCLC) did not improve overall survival, according to research (Abstract PLEN04.03) presented at the 16th World Conference on Lung Cancer (WCLC) in Denver,...
ASCO Releases Updated Policy Statement on Genetic and Genomic Testing for Cancer Susceptibility
The American Society of Clinical Oncology (ASCO) issued an updated policy statement on genetic and genomic testing for cancer susceptibility. Published in the Journal of Clinical Oncology, the statement reviews the ways in which new technologies are transforming the assessment and identification of ...
Long-Term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs May Be Associated With Reduced Colorectal Cancer Risk
A large population-based control study of the use of low-dose aspirin or other nonsteroidal anti-inflammatory drugs and colorectal cancer risk has found that taking 75 mg to 150 mg of aspirin for 5 years or longer was associated with a 27% reduced risk of colorectal cancer. In addition, 5 or more...
Study Identifies Genes Associated With Improved Survival for Patients With Pancreatic Cancer
A multi-institutional study has found a new set of genes that may indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the...
Black Women Less Likely Than Women of Other Races and Ethnicities to Survive Endometrial Cancer
Non-Hispanic black women with endometrial cancer had worse outcomes than women of other racial/ethnic groups diagnosed with the same subtype of endometrial cancer and at the same stage of disease, according to a study published by Cote et al in Cancer Epidemiology, Biomarkers & Prevention....
Organ Transplant Recipients May Be More Likely to Develop Aggressive Melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant and three times more likely to die of the skin cancer, suggested new research by a multi-institutional team. The findings, reported by Robbins et al in the Journal of Investigative...
Study Identifies Gene Mutations Associated With Aggressive Multiple Myeloma
Using whole-exome sequencing on newly diagnosed patients with multiple myeloma, British researchers identified 15 genes that were significantly mutated in a subset of patients and mapped how these mutations related to long-term survival. They found 90% of patients with very aggressive disease who...
Clinical Scoring System May Help Identify Appropriate Colorectal Cancer Screening Methods
Researchers investigating a risk index for colorectal cancer and advanced precancerous polyps among average-risk people have found that patients classified as low risk had fewer advanced adenomas than patients classified as high risk. Their findings suggest that those at low risk for colorectal...
Study Identifies Genetic Mutations That Predict Response to Chemotherapy in Bladder Cancer
Although cisplatin-based neoadjuvant chemotherapy before cystectomy is the standard of care for muscle-invasive bladder cancer, only between 25% and 50% of patients achieve a pathologic response. A study investigating biomarkers that can predict response to chemotherapy in patients with...
Sequencing Studies Show High Frequency of Actionable MET Mutations in Pulmonary Sarcomatoid Carcinoma
In a study reported in the Journal of Clinical Oncology by Liu et al, next-generation sequencing revealed a high frequency of actionable MET mutations in patients with pulmonary sarcomatoid carcinoma. Study Details In the study, whole-exome sequencing was used in a discovery set of 10 patients...
Emergency Department Febrile Neutropenia Pathway for Patients With Cancer Reduces Time to Antibiotic Administration
In a study reported in the Journal of Oncology Practice, Keng et al at Cleveland Clinic found that institution of an emergency department febrile neutropenia pathway for patients with cancer reduced the time to antibiotic administration compared with historical and direct admission cohorts....
30-Year Study Shows Moderate Hormone Suppression May Be Sufficient in Thyroid Cancer
A study of long-term thyroid cancer outcomes shows, among other findings, that moderate suppression of thyroid-stimulating hormone, which drives the disease, may be as beneficial as more extreme hormone suppression. Extreme thyroid-stimulating hormone suppression is associated with increased side...
DNA Shed From Head and Neck Tumors Detected in Blood and Saliva
On the hunt for better cancer screening tests, Johns Hopkins scientists led a proof-of-principle study that successfully identified tumor DNA shed in the blood and saliva of 93 patients with head and neck cancer. A report on the findings was published by Wang et al in Science Translational...
Daratumumab Expanded Access Program Open to Eligible U.S. Patients With Heavily Pretreated Multiple Myeloma
Janssen Biotech, Inc, announced the opening of a daratumumab expanded access program for eligible U.S. patients. Daratumumab is an investigational human anti-CD38 monoclonal antibody being evaluated in clinical trials as a treatment for patients with multiple myeloma. The multicenter, open-label...
ETV6 Mutation May Trigger Lymphoblastic Leukemia
The results of a nearly 10-year investigation that identified a key gene mutation that can trigger acute lymphoblastic leukemia (ALL) and several other types of cancer were recently published by Noetzli et al in Nature Genetics. The findings have, for the first time, pinpointed a mutation that...
Study Supports Early Intervention for Prostate Cancer Patients Who Experience Significant Emotional Distress
A study led by the University at Buffalo (UB) and Roswell Park Cancer Institute (RPCI) has identified beliefs and personality traits associated with higher levels of distress in patients with newly diagnosed prostate cancer. The findings support the value of emotional and informational support for...
Study Examines Nerve Involvement in Cancer Pain
More than half of all cancer patients experience pain, most often associated with the malignancy type, body location, and disease progression. Pain researchers participating in a symposium at the American Pain Society Annual Scientific Meeting last month reported that the relationship between...
ASCO Releases Proposal for Payment Reform to Support Higher-Quality, More Affordable Cancer Care
Expanding on the Consolidated Payments for Oncology Care (CPOC) payment model circulated last year to improve the quality and affordability of care for patients with cancer, ASCO’s new Patient-Centered Oncology Payment: Payment Reform to Support Higher Quality, More Affordable Cancer Care...
AACR 2015: Study Identifies a Frequent Genomic Alteration in Pleomorphic Invasive Lobular Carcinoma
Research from Rutgers Cancer Institute of New Jersey shows genomic profiling identifies mutations in a gene associated with a rare subset of breast cancer—mutations that cannot otherwise be identified with standard clinical analysis of cells and tissue. The findings, presented at the AACR...
AACR 2015: Pembrolizumab Shows Promise in Non–Small Cell Lung Cancer
The immunotherapy pembrolizumab (Keytruda) was found to be safe and yielded durable responses in patients with advanced, non–small cell lung cancer (NSCLC). Those with high levels of the protein PD-L1 in their tumors had better clinical outcomes, according to phase I KEYNOTE-001 clinical...
Increasing Number of Boys Vaccinated Against HPV Could Protect More People at the Same Price
Public health programs that devote a portion of their funding to encourage more boys to be vaccinated against human papillomavirus (HPV)—rather than merely attempting to raise coverage among girls—may ultimately protect more people for the same price, a study from Duke University...
Overweight Girls Face Increased Risk of Colorectal Cancer Later in Life
Girls who are overweight as young children and teens may face an increased risk for colorectal cancer decades later, regardless of what they weigh as adults, suggests a new study published by Zhang et al in Cancer Epidemiology, Biomarkers & Prevention. “Our study supports the growing...
ASCP, CAP, AMP, and ASCO Issue Draft Colorectal Cancer Molecular Marker Testing Guideline, Announce Opening of Public Comment Period
The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) today released a draft of a clinical practice guideline on the use of molecular marker testing for...
Elevated C-Reactive Protein Associated With Poorer Outcome in Melanoma
In a study reported in the Journal of Clinical Oncology, Fang et al found that an elevated C-reactive protein level was associated with poorer overall and melanoma-specific survival in patients with melanoma and that sequential increases in C-reactive protein were associated with an increased risk...
Experts Explore the Reasons Behind the High Cost of Cancer Drugs in America
Increasingly high prices for cancer drugs are affecting patient care, as well as the health-care system overall, in the United States. These findings were published in a special article by Rajkumar and Kantarjian in the journal Mayo Clinic Proceedings. “Americans with cancer pay 50% to 100%...
Left-Sided Primary Tumor Location More Common and Associated With Better Survival in Metastatic Colorectal Cancer
In a study reported in the Journal of the National Cancer Institute, Loupakis et al found that most treatment-naive patients with metastatic colorectal cancer had left-sided primary tumor location and that left-sided tumor location was associated with improved overall survival. Study Details The...
EGFR L858R Mutation in Circulating Free DNA From Blood Samples of Patients With Non–Small Cell Lung Cancer Shown to Be Negative Prognostic Marker
Using a novel polymerase chain reaction assay “to efficiently assess” epidermal growth factor receptor (EGFR) mutations in circulating free DNA (cfDNA) from blood samples of patients with advanced non–small cell lung cancer (NSCLC), the Spanish Lung Cancer Group has “shown...
Study Shows Lack of RNA Editing Leads to Melanoma Growth and Metastasis
In a new study reported by Shoshan et al in Nature Cell Biology, researchers at The University of Texas MD Anderson Cancer Center established a link between melanoma and lack of RNA editing, which leads to tumor growth and progression through manipulation of proteins. Study Findings Study lead...
Early Study Suggests Olaparib May Be Effective in Ovarian Cancers Expressing High Levels of POLQ
Last December, the U.S. Food and Drug Administration (FDA) approved olaparib (Lynparza) in the treatment of advanced ovarian cancer in women with BRCA1 or BRCA2 gene mutations. Now, a laboratory study by Ceccaldi et al has found that the drug may also be effective in breast and ovarian tumors that...
Study Uncovers Range of Molecular Alterations in Head and Neck Squamous Cell Carcinomas, New Potential Drug Targets
Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences—with potentially important clinical implications—in human papillomavirus (HPV)-associated head and neck cancers. These findings were reported in Nature. The researchers also uncovered ...
