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Showing 201 - 250Fam-Trastuzumab Deruxtecan-nxki in Unresectable or Metastatic HER2-Positive Solid Tumors
On April 5, 2024, fam-trastuzumab deruxtecan-nxki (T-DXd) was granted accelerated approval for adults with unresectable or metastatic HER2-positive (immunohistochemistry 3+) solid tumors who received prior systemic treatment and have no satisfactory alternative treatment options.1 Supporting...
New Study Illuminates Variations in Performance Characteristics Between FIT Tests
Researchers have found substantial variations in the performance characteristics of five commonly used fecal immunochemical tests (FIT), according to a recent study published by Levy et al in the Annals of Internal Medicine. Background Stool-based tests like FIT are currently recommended for...
Early-Onset Colorectal Cancer: Rurality and Poverty May Be Linked to Lower Survival
Patients with early-onset colorectal cancer living in rural vs urban areas were found to have a lower likelihood of 5-year survival, with persistent poverty compounding this association in some age groups, according to an analysis published in a research letter by Tsai et al in JAMA Network Open....
Preclinical Study Examines Novel Pancreatic Cancer Treatment
Early-stage research demonstrated the synergistic effects of a novel nanoparticle drug–delivery system to activate an immune pathway in combination with tumor-targeting agents in mice with pancreatic ductal adenocarcinoma, according to a preclinical study published by Chibaya et al in Science...
Can a Blood Test Predict Obesity-Related Cancer Risk in Patients With Type 2 Diabetes?
Researchers have found that a blood test may effectively identify patients with type 2 diabetes who may be at a higher risk of developing certain cancers, according to new findings to be presented by Bennetsen et al at the upcoming European Association for the Study of Diabetes Annual Meeting 2024...
Can Mindful Breathing Reduce the Intensity of Cancer-Related Pain?
Twenty minutes of mindful breathing, which focuses a person’s attention on their breath, seems to rapidly reduce the intensity and unpleasantness of cancer pain and relieve the associated anxiety, suggest findings from a small comparative study published by Tan et al in BMJ Supportive &...
New Modeling Data Show Effective Detection and Health-Care Savings Associated With the Multitarget Stool DNA Test
New modeling data have been released that describe the projected impact of the first and only multitarget stool DNA test (marketed as Cologuard) on patients, health-care professionals, and the U.S. health-care system since its U.S. Food and Drug Administration (FDA) approval 10 years ago. About the ...
Cancer Mortality Among Adults With Learning Disabilities
Investigators have found that adults with learning disabilities may be more likely to die from cancer compared with those in the general population, according to a recent study published by Ward et al in BMJ Open. Background Many cancers are considered either preventable or treatable. However,...
Dietary Risk Factors for Early-Onset Colorectal Cancer
Researchers have found that diet-derived molecules known as metabolites may be the main drivers of early-onset colorectal cancer risk, especially those associated with red and processed meat, according to a recent study published by Jayakrishnan et al in npj Precision Oncology. Background Despite...
Corticosteroids for Immune-Related Adverse Events and Clinical Outcomes With ICIs for Solid Tumors
In an analysis reported in the Journal of Clinical Oncology, Verheijden et al found that higher peak corticosteroid doses for patients with immune-related adverse events were associated with poorer outcomes in patients receiving immune checkpoint inhibitors (ICIs) for solid tumors. Study Details...
New Study May Unveil Prognostic Genetic Insights Into Colorectal Cancer
Researchers have reported novel genetic alterations and molecular classifiers of tumor variants in patients with colorectal cancer, according to a recent study published by Nunes et al in Nature. Background “Since 2018, Uppsala University and BGI [Genomics] have carried out in-depth cooperation on...
T-DXd in HER2-Positive Advanced Colorectal Cancer
As reported in The Lancet Oncology by Kanwal Raghav, MD, and colleagues, the phase II DESTINY-CRC02 trial has identified the preferred dosage of single-agent fam-trastuzumab deruxtecan-nxki (T-DXd) in patients with HER2-positive advanced colorectal cancer. Study Details In the international study, ...
Association of Regular Aspirin Use With Colorectal Cancer Risk According to Lifestyle Factors
In a study reported in JAMA Oncology, Sikavi et al found that regular aspirin use was associated with a reduced risk of colorectal cancer overall and among individuals with less healthy vs more healthy lifestyles. Study Details The prospective cohort study focused on data from 107,655 participants...
Primary Ovarian Insufficiency, Early Menopause May Be Linked to Increased Risk of Breast Cancer
The risk of developing breast cancer may be increased among some women who undergo menopause prior to age 46, according to a recent study published by Allen-Brady et al in The Journal of Clinical Endocrinology & Metabolism. Background Early menopause occurs in women aged 40 to 45 years. Primary ...
Cancer Screening Estimated to Cost $43 Billion Annually in United States
Cancer screening may cost more than $40 billion annually in the United States, according to a recent study published by Halpern et al in the Annals of Internal Medicine. Study Methods and Results In the recent modeling study, investigators used national health-care survey and cost resources data to ...
Common Blood Tests May Improve Early Cancer Diagnosis
The results of routine blood tests could be used to speed up cancer diagnoses among patients with abdominal symptoms, according to a recent study published by Rafiq et al in PLOS Medicine. Background Most patients who report symptoms of abdominal pain or bloating to their physicians are referred...
Estrogen Plus Progestin and Risk of Colorectal Cancer
As reported in the Journal of Clinical Oncology by Rowan T. Chlebowski, MD, PhD, and colleagues, long-term follow-up of the Women’s Health Initiative trial showed no benefit of treatment with estrogen plus progestin in reducing the risk of colorectal cancer in postmenopausal women. Study Details...
Liver Transplantation vs Standard Therapies in Patients With Colorectal Cancer Liver Metastasis
Certain patients with colorectal cancer that has metastasized to the liver may experience improved progression-free survival with liver transplantation compared with standard therapies, according to a recent study published by Byrne et al in JAMA Surgery. Background Colorectal cancer often...
Generation X and Millennials Have Higher Risk for Many Cancers Compared to Older Generations
Even though cancer rates continue to fall in older populations, the disease is becoming ever more common among younger age groups. A recent analysis of data from 13 cancer registries in the United States published by Rosenberg et al in JAMA Network Open found that those born between 1965 and 1980...
Guardant Health’s Shield Blood Test Approved by the FDA as a Primary Screening Option for Colorectal Cancer
On July 29, the U.S. Food and Drug Administration (FDA) approved Guardant Health’s Shield blood test for colorectal cancer screening in adults aged 45 years and older who are at average risk for the disease. It is the first blood test to be approved by the FDA as a primary screening option for...
Update on Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial in Patients With Breast Cancer
Guest Editor’s Note: Chemotherapy and its side effects can lead to decreased physical activity and poor diet quality, resulting in unfavorable changes in physical functioning and quality of life. However, adopting healthy behaviors during cancer treatments can be challenging because of physical,...
Cancer and Fatherhood: A Story of Personal Power in the Face of a Mortal Disease
Iron Dad: A Cancer Survivor’s Story of Discovering Strength, Life, and Love Through Fatherhood by Paul Weigel is an inspiring and deeply moving memoir that transcends the traditional boundaries of parenthood and personal transformation. This story begins with a sense of discontent and a desire for...
Neoadjuvant Camrelizumab Plus Apatinib in Locally Advanced Colorectal Cancer
In a Chinese phase II study (NEOCAP) reported in The Lancet Oncology, Yu et al found that neoadjuvant camrelizumab plus apatinib produced promising complete response rates in patients with locally advanced microsatellite instability–high or mismatch repair–deficient colorectal cancer. Study ...
Eliminating Racial Disparities in Colorectal Cancer Screening
Eliminating racial disparities in colorectal cancer testing may reduce the rate of colorectal cancer incidence and mortality among Black patients in the United States, according to a recent study published by Alagoz et al in the Journal of the National Cancer Institute. Background Although both the ...
Panel Issues First Guidelines to Prevent Anal Cancer in Patients With HIV
Researchers have introduced the first screening and treatment recommendations to prevent anal cancer in patients with the human immunodeficiency virus (HIV), according to new guidelines based on the results of a 2022 study published by Palefsky et al in The New England Journal of Medicine....
pMMR/MSS Locally Advanced Rectal Cancer: Immunotherapy-Based Total Neoadjuvant Therapy
In a Chinese phase II trial (TORCH) reported in the Journal of Clinical Oncology, Xia et al found that integration of the PD-1 inhibitor toripalimab into total neoadjuvant therapy was associated with good outcomes in patients with mismatch repair–proficient or microsatellite-stable (pMMR/MSS)...
Uncovering the Genetic Risk of Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
Some patients with a genetic predisposition for cancer may not qualify for genetic screenings under the current guidelines, according to a recent study published by Samadder et al in JCO Precision Oncology. Researchers are investigating how to advance personalized medicine and tailor prevention and ...
Overcoming the Disparity in Cancer Incidence and Mortality Rates Among Alaska Native Individuals
Research has consistently shown that Native American and Alaska Native individuals are among the most underserved minority populations in the United States and are disproportionately affected by cancer. The results from a 50-year report by the Alaska Native Tribal Health Consortium’s Alaska Native...
Long-Term Survival Possible After Liver Transplant for Colorectal Liver Metastases
In selected patients with unresectable colorectal liver metastases, liver transplantation plus chemotherapy significantly boosted overall survival as compared with chemotherapy alone in the multicenter, European TRANSMET trial, presented at the 2024 ASCO Annual Meeting.1 The combined approach led...
Out-of-Pocket Costs From Diagnostic Testing After Prostate Cancer Screening
Prostate-specific antigen (PSA) screening aims to identify patients who may harbor potentially lethal prostate cancer, and those with high PSA results often require more extensive—and expensive—diagnostic testing to establish a diagnosis. New research reveals that the out-of-pocket costs for such...
Novel Immunotherapy Approach in Metastatic Solid Tumors
A novel personalized cellular immunotherapy approach may be effective at treating certain patients with metastatic solid tumors, according to early findings from a recent study published by Parkhurst et al in Nature Medicine. Background Chimeric antigen receptor (CAR) T-cell therapy has already...
40% of Cancer Cases and Almost Half of All Cancer Deaths in the United States Linked to Modifiable Risk Factors
A recent study led by researchers at the American Cancer Society has found that 4 in 10 cancer cases and about half of all cancer deaths in adults aged 30 and older in the United States (or 713,340 cancer cases and 262,120 cancer deaths in 2019) may be attributed to modifiable risk factors,...
RNAs May Help to Identify Patients With Stage II Colorectal Cancer Who May Benefit From Adjuvant Chemotherapy
Investigators have assessed whether RNAs can be used as a biomarker to predict which patients with stage II colorectal cancer may benefit from postsurgical chemotherapy, according to a recent study published by Korsgaard et al in The American Journal of Pathology. Background Colorectal cancer is...
Can GLP-1 Receptor Agonists Prevent Obesity-Associated Cancers in Patients With Type 2 Diabetes?
Based on the results of a retrospective U.S. population–based cohort study, which were reported in JAMA Network Open by Wang et al, treatment with glucagon-like peptide 1 (GLP-1) receptor agonists vs insulins seemed to be associated with a decreased risk of developing specific obesity-associated...
Strategies for Reducing the Risk of Cancers in Patients With Alcohol Dependence
Investigators have uncovered the potential benefit of undergoing alcohol rehabilitation and maintaining abstinence in patients with alcohol dependence at risk of developing alcohol-associated cancers, according to a recent study published by Schwarzinger et al in The Lancet Public Health. The...
Neoadjuvant Combination of PD-1 and Angiogenesis Inhibitors in Genomically Unstable Colorectal Cancer: NEOCAP
As reported in The Lancet Oncology by Yu et al, based on results from the ongoing phase II NEOCAP trial, neoadjuvant therapy with the PD-1 inhibitor camrelizumab plus the angiogenesis inhibitor apatinib appears to demonstrate “promising” antitumor activity and a manageable toxicity profile in...
Adding COX-2 Inhibition to Chemotherapy in PIK3CA-Activated Stage III Colon Cancer
In an analysis from the CALGB/SWOG 80702 (Alliance) trial published by Nowak et al in the Journal of Clinical Oncology, researchers found that the addition of the cyclooxygenase 2 (COX-2) inhibitor celecoxib to standard adjuvant chemotherapy was associated with improved disease-free survival and...
Modified Perioperative Chemotherapy Regimen May Benefit Patients With Pancreatic Ductal Adenocarcinoma
Administering chemotherapy prior to and following surgery may extend survival in patients with pancreatic ductal adenocarcinoma compared with postoperative administration alone, according to a recent study published by Cecchini et al in JAMA Oncology. The findings may be encouraging for the 15% to...
FDA Grants Accelerated Approval to Adagrasib With Cetuximab for KRAS G12C–Mutated Colorectal Cancer
On June 21, the U.S. Food and Drug Administration (FDA) granted accelerated approval to the KRAS G12C inhibitor adagrasib (Krazati) plus cetuximab for adults with KRAS G12C–mutated locally advanced or metastatic colorectal cancer, as determined by an FDA-approved test, who have received prior...
Metastatic Colorectal Cancer: Addition of Atezolizumab to First-Line FOLFOXIRI/Bevacizumab
As reported in the Journal of Clinical Oncology by Antoniotti et al, 4-year follow-up of the Italian phase II ATEZOTRIBE trial showed a numeric benefit in overall survival with the addition of atezolizumab to first-line FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and...
Celecoxib May Benefit a Subset of Patients With PIK3CA Mutations
Researchers have found that administering the anti-inflammatory drug celecoxib after surgery may improve disease-free survival in a subset of patients with PIK3CA-mutated stage III colorectal cancer, according to a study published by Nowak et al in the Journal of Clinical Oncology. The findings...
Study Evaluates Cancer Screening Behaviors Among a Population of Muslim Individuals
Investigators uncovered crucial insights into the cancer screening behaviors of a population of Muslim individuals residing in the Washington, DC, metropolitan area that could help illuminate the influence of cultural and religious beliefs on health practices, according to a recent study published...
Pretargeted Dual-Isotope Radionuclide Therapy in Colorectal Cancer
A combination of alpha- and beta-radionuclide therapy may be feasible, tolerable, and effective in colorectal cancer, according to preclinical findings presented by Rinne et al at the 2024 Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting (Abstract 241498). The new approach...
Previously Treated Metastatic Colorectal Cancer: Lenvatinib/Pembrolizumab vs Standard of Care
As reported in the Journal of Clinical Oncology by Akihito Kawazoe, MD, and colleagues, the final analysis of the phase III LEAP-017 trial showed no significant overall survival benefit with lenvatinib plus pembrolizumab vs the standard of care in previously treated patients with mismatch...
How Often Do Patients With Cancer Face Barriers When Attempting to Access Care?
Many patients with cancer encounter significant barriers to the receipt of care, according to a recent study published by Chen et al in JAMA Network Open. Background When attempting to access cancer care, patients often must go through several different levels of communication both before their...
I Am Living With Recurring Stage IV Colorectal Cancer
Despite urgings from my primary care physician to get a colonoscopy screening after I turned 50, I resisted. As a health-care provider, and someone who is tuned into changes in my body, I thought I would instinctively know if I had a serious illness. I was wrong. Even after finally relenting to at...
Can Pembrolizumab Improve Outcomes in Soft-Tissue Sarcoma?
The PD-1 inhibitor pembrolizumab may offer benefit in patients with soft-tissue sarcoma, according to recent findings presented by Mowery et al at the 2024 ASCO Annual Meeting (Abstract 11504). Background Soft-tissue sarcoma is a rare type of cancer affecting muscles, fat, and other connective...
Andrea Cercek, MD, on Rectal Cancer: Durable Complete Responses to PD-1 Blockade Alone
Andrea Cercek, MD, of Memorial Sloan Kettering Cancer Center, discusses expanded data on the durability of complete response to dostarlimab-gxly, a PD-1 single-agent therapy administered to patients with locally advanced mismatch repair–deficient rectal cancer. The drug yielded recurrence-free...
Study Finds Early Menopause May Be Linked to Greater Risk of Breast and Ovarian Cancers
The risk of breast cancer and ovarian cancer may be increased in some women who experience early menopause, according to new findings presented by Welt et al at the Endocrine Society’s Annual Meeting & Exposition 2024. Primary ovarian insufficiency is a condition that occurs when a woman’s...
Neoadjuvant Pembrolizumab May Improve Outcomes in Some Patients With Colorectal Cancer Surgery
Researchers examined whether the PD-1 inhibitor pembrolizumab given neoadjuvantly may improve outcomes in certain patients with stage II or III mismatch repair–deficient/microsatellite instability–high colorectal cancer. Interim findings from the phase II NEOPRISM-CRC clinical trial were presented...
