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Showing 16651 - 16700Low Risk of Transformation to Melanoma for Biopsy-Diagnosed Mildly or Moderately Dysplastic Nevi, So Surgical Excision May Not Be Indicated
The risk of transformation to melanoma appears very low for biopsy-diagnosed mildly or moderately dysplastic nevi, and routine surgical excision of nevi with a positive biopsy margin may not be indicated. Patients with biopsy-diagnosed moderately-to-severely and severely atypical nevi, however,...
Enhanced Treatment, Surveillance Needed for Certain Melanoma Patients to Prevent Secondary Cancers, Researchers Say
Researchers at Moffitt Cancer Center in Tampa, Florida, suggest secondary cancers seen in melanoma patients who are being treated for a BRAF gene mutation may require new strategies, such as enhanced surveillance and combining BRAF-inhibitor therapy with other inhibitors, especially as they become...
Brain Cancer Survival Improved Following FDA Approval of Bevacizumab, Mayo Study Finds
A new population-based study has found that patients with glioblastoma who died in 2010, after the FDA approval of bevacizumab (Avastin), had lived significantly longer than patients who died of the disease in 2008, prior to the conditional approval of the drug for the treatment of brain...
Preclinical Tests May Lead to New Approach to Treat CNS Lymphoma
A drug recently approved for use in multiple myeloma is now being tested for its ability to fight central nervous system (CNS) lymphoma, a deadly cancer of the immune system that can affect the brain, spinal cord and fluid, and eyes. The clinical trial, now open at the three campuses of Mayo Clinic ...
Researchers Identify Key Protein in Treatment-Resistant Prostate Cancer
Prostate cancer is one of the most common forms of cancer in men and the leading cause of cancer deaths in white, African American, and Hispanic men, according to the Centers for Disease Control. However, it remains unclear why, despite treatment, some prostate cancers progress and may become...
New Research Suggests Restricting Calories May Improve Response to Cancer Treatment
New research suggests that restricting calories for a defined period of time may improve the success of cancer treatment, offering valuable new data on how caloric intake may play a role in programmed cancer cell death and efficacy of targeted cancer therapies. Study results were published online...
New MRI Technique Reveals Brain Tumor Response to Antiangiogenesis Therapy
A new way of analyzing data acquired in magnetic resonance imaging (MRI) appears to be able to identify whether or not tumors are responding to antiangiogenesis therapy, which may help physicians determine the most appropriate treatments for patients. In a report published online in Nature...
Gene That Helps Control Aging Is Linked to Multiple Myeloma
A telomerase RNA component gene called TERC, which is responsible for regulating the length of caps on the ends of DNA molecules and believed to be involved in the aging process, has been linked to the development of multiple myeloma, according to a study published in Nature Genetics. Researchers...
Neoadjuvant Carboplatin Before Radiotherapy May Reduce Risk of Relapse and Long-Term Side Effects in Men With Testicular Cancer
A new study published in the Annals of Oncology reports that giving men with testicular cancer a single dose of chemotherapy before radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side effects. As many as 96% of men with testicular cancer are predicted to ...
Tumor Measurements Predict Survival in Advanced Non–Small Cell Lung Cancer
For the two-thirds of lung cancer patients with locally advanced or metastatic disease, tumor size is not used currently to predict overall survival times. However, a new study led by researchers at UT Southwestern Medical Center has shown that even in advanced stages total tumor size can have ...
Finasteride Reduces Risk of Low-Grade Prostate Cancer With No Impact on Long-Term Survival
In the Prostate Cancer Prevention Trial (PCPT), initially reported in 2003, finasteride significantly reduced the risk of prostate cancer by 24.8% but was associated with a relative 26.9% increase in risk of high-grade disease compared with placebo. In a study reported in The New England Journal of ...
Best of ASCO 2013: Promises and Challenges of Applying Molecular Profiling to Clinical Practice
A “new kind of pathology,” in which anatomy and histology are supplemented by molecular etiology, has been emerging over the past decade and promises better response rates among cancer patients as genomic alterations in cancer continue to be identified and treated with targeted...
Study Finds 1 in 5 Women Don’t Believe Their Breast Cancer Risk
Despite taking a tailored risk assessment tool that factors in family history and personal habits, nearly 20% of women did not believe their breast cancer risk, according to a new study from the University of Michigan Comprehensive Cancer Center. The findings, published in Patient Education and...
Breastfeeding for More Than 6 Months May Protect Against Breast Cancer in Nonsmoking Women
A new analysis has found that breastfeeding for more than 6 months may safeguard nonsmoking mothers against breast cancer. However, the same does not seem to hold true for mothers who smoke. Published early online in the Journal of Clinical Nursing, the findings add to the list of benefits of...
‘Reprogrammed’ Treatment-Resistant Lymphomas Respond to Azacitidine
A phase I clinical trial showed diffuse large B-cell lymphomas resistant to chemotherapy can be reprogrammed to respond to treatment after being pretreated with drug azacitidine (Vidaza), according to a study published in Cancer Discovery. Patients whose lymphomas recur after initial chemotherapy...
Researchers Identify Key Mechanism Behind Castration-Resistant Prostate Cancer
A team of researchers from UC Davis, UC San Diego, and other institutions has identified a key mechanism behind aggressive prostate cancer. Published online today in Nature, the study shows that two long noncoding RNAs, PRNCR1 and PCGEM1, activate androgen receptors, circumventing...
Enhanced Treatment, Surveillance Needed for Patients With BRAF-Mutant Melanoma to Prevent Secondary Cancers
Researchers at Moffitt Cancer Center suggest secondary cancers seen in melanoma patients who are being treated for a BRAF gene mutation may require new strategies, such as enhanced surveillance and combining BRAF inhibitor therapy with other inhibitors, especially as they become more widely used....
New Study Supports Role of Epithelial-to-Mesenchymal Transition in Patients With Ovarian Cancer
In a study of ovarian cancer cells taken from patients, scientists from Georgia Institute of Technology have confirmed that metastasizing cancer cells have a different molecular structure from primary tumor cells and display genetic signatures consistent with epithelial-to-mesenchymal transition....
Study Suggests Neural Stem Cells May Regenerate After Radiation Therapy
Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new research in mice suggests that neural stem cells, the body's source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like...
FDA Approves Dolutegravir to Treat HIV-1 Infection
The U.S. Food and Drug Administration (FDA) today approved dolutegravir (Tivicay), a new drug to treat HIV-1 infection. Dolutegravir is an oral integrase strand transfer inhibitor that interferes with one of the enzymes necessary for HIV to multiply. The drug is taken in combination with other...
Study Identifies Interleukin-11 as a Potential New Anticancer Target
According to a study published online today in Cancer Cell, the molecule interleukin-11 may be a potential new target for anticancer therapies. Until now, interleukin-11’s role in cancer development has been underestimated, but researchers have recently identified this molecule as a "dark...
Carbon Ion Radiotherapy Safe and Effective for Treating Inoperable Spinal Tumors
A new analysis has found that a type of radiation therapy called carbon ion radiotherapy can control cancer growth and prolong survival in patients with spinal tumors. The study, published online in Cancer, indicates that the treatment is a promising alternative for patients whose spinal tumors...
Burkitt Lymphoma Survival Outcomes Improve for Younger Patients
According to a new study published in the journal Cancer, the survival outcome of patients with Burkitt lymphoma has improved substantially over the past decade, with notable exceptions. To help doctors and researchers better understand who responds well to treatment and who does not, the study...
No Benefit/Detriment of New Donor in Second Hematopoietic Stem Cell Transplantation for Leukemia Relapse
Minimal data are available on outcomes of second allogeneic hematopoietic stem cell transplantation from unrelated donors after first hematopoietic stem cell transplantation in patients with hematologic relapse of acute leukemia. In a study reported in Journal of Clinical Oncology, Maximilian...
Study Suggests Pattern in Lung Cancer Pathology May Predict Cancer Recurrence After Surgery
A new study by thoracic surgeons and pathologists at Memorial Sloan-Kettering Cancer Center shows that a specific pattern found in the tumor pathology of some lung cancer patients is a strong predictor of recurrence. Knowing that this feature exists in a tumor's pathology could be an important...
Biomarker May Predict Risk of Graft-vs-Host Disease After Stem Cell Transplant
Researchers from Indiana University, the University of Michigan, the Fred Hutchinson Cancer Research Center, and the Dana-Farber Cancer Institute have identified and validated a biomarker accessible in blood tests that could be used to predict which stem cell transplant patients are at highest risk ...
Loss of MicroRNA Decoy Might Contribute to Development of Soft-Tissue Sarcoma
Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have discovered a novel mechanism responsible for the loss of a critical tumor-suppressor gene in rhabdomyosarcoma and other...
Researchers Identify Origin of Inflammation-Driven Pancreatic Cancer
Researchers at Mayo Clinic in Florida have revealed the process by which pancreatitis—chronic inflammation of the pancreas—morphs into pancreatic cancer. They say their findings point to ways to identify pancreatitis patients at risk of pancreatic cancer and to potential drug therapies...
Study Reveals Genes That Drive Glioblastoma
A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published online...
Sanford-Burnham Researchers Map a New Metabolic Pathway Involved in Cell Growth
Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In a study published in...
Mechanism Offers Promising New Approach for Harnessing the Immune System to Fight Cancer
Scientists at St. Jude Children’s Research Hospital have discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. Researchers also found evidence that the same mechanism may operate in humans. The study was published online today...
Omega-3 Fatty Acids May Aid in Treatment and Prevention of Skin and Oral Cancers
Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early- and late-stage oral and skin squamous cell carcinomas, according to new research from scientists at Queen Mary, University of London. The findings were published online...
FDA Warns of Rare but Serious Skin Reactions with Acetaminophen
The U.S. Food and Drug Administration (FDA) is informing the public that acetaminophen has been associated with a risk of rare but serious skin reactions. These skin reactions, known as Stevens-Johnson Syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis, can...
PET/CT Superior to Bone Marrow Biopsy for Diagnosis and Prognosis of Lymphoma Patients
A more precise method for determining bone marrow involvement in patients with diffuse large B-cell lymphoma—a key factor in tailoring patient management plans—has been identified by researchers in a study published in the August issue of The Journal of Nuclear Medicine. Imaging with...
Lenalidomide plus Dexamethasone Delays Progression and Improves Survival in High-risk Smoldering Multiple Myeloma
In a study reported in The New England Journal of Medicine, María-Victoria Mateos, MD, PhD, of the Universidad de Salamanca, and colleagues compared induction lenalidomide (Revlimid) plus dexamethasone followed by maintenance lenalidomide with observation in patients with high-risk...
Targeted Therapy Identified for Protein that Protects and Nourishes Cancer
Scientists at The University of Texas MD Anderson Cancer Center who identified a protein’s dual role in cancer promotion have discovered a way to shut it down, opening a potential new avenue for cancer treatment. Reporting their findings in the journal Cell, the researchers describe the first ...
Blocking Sugar Intake May Reduce Cancer Risk or Progression in Certain Malignant Tumors
Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine at Mount Sinai in New York. The study, conducted in fruit flies and published in the August issue of Cell, provides insight as to why...
Researchers Uncover How a Potent Compound Kills Prostate Cancer Cells
A new study led by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress. The study, recently published in Oncotarget, uncovered...
Acute Myeloid Leukemia Induces Bone Marrow Failure by Inhibiting Production of Hematopoietic Stem Cells
Scientists studying acute myeloid leukemia (AML) have discovered that rather than displacing hematopoietic stem cells in the bone marrow as previously believed, the cancer is in fact inhibiting production of downstream hematopoietic cells, effectively putting them to sleep. The findings were...
Digital Breast Tomosynthesis Reduces Breast Cancer Screening Recall Rate Compared to Mammography Alone
The addition of tomosynthesis to standard digital mammography resulted in a 30% reduction in overall recall rates among women being screened for breast cancer, according to a new study published online in Radiology. The results demonstrate that digital tomosynthesis is an effective tool in reducing ...
Some Women with Abnormal Breast Lesions May Avoid Surgery
Surgery is not always necessary for women with a type of breast tissue abnormality associated with a higher risk of cancer, according to a new study published online in Radiology. Researchers said that periodic imaging and clinical exam are effective in these patients when radiology and pathology...
James L. Mulshine, MD, Comments on U.S. Preventive Services Task Force Recommendations for CT Screening for Lung Cancer in High-risk Individuals
The recommendation by the U.S. Preventive Services Task Force (USPSTF) for the use of low-dose, computed tomography (CT) to detect early lung cancer in high-risk individuals is a major milestone in the war on cancer. Lung cancer is the leading cause of cancer death across the world. Despite...
Low-dose CT Screening for Lung Cancer: Details of First Round of Screening in National Lung Screening Trial
The National Lung Screening Trial found that 3 years of annual screening with low-dose helical computed tomography (CT) reduced lung cancer mortality compared with chest radiography in older persons who were heavy smokers. The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial also...
Higher Incidence of Non-Hodgkin Lymphoma Found in Regions with Close Proximity to Benzene Release Sites
The incidence of a non-Hodgkin lymphoma (NHL) is significantly higher in regions near facilities that release the chemical benzene into the environment, according to a new study published early online in Cancer. This and other studies like it will be critical to identifying and enacting public...
Gene Test Highly Accurate in Predicting Metastasis in Patients with Thymoma
Patients diagnosed with thymoma, a rare cancer of the thymus gland, may be able to avoid certain cancer treatments associated with severe adverse events if the results of a new test reveal they are at low risk of metastasis, according to a study published in PLOS ONE. The study, by researchers at...
Richard I. Fisher, MD, Named President and CEO of Fox Chase Cancer Center
Richard I. Fisher, MD, a leading cancer center administrator and nationally recognized hematology/oncology expert, has been appointed President and CEO of Fox Chase Cancer Center. Dr. Fisher will also hold the title of Cancer Center Director of Fox Chase, serving as the principal investigator on...
FDA Limits Usage of Oral Ketoconazole Due to Potentially Fatal Liver Damage
The U.S. Food and Drug Administration (FDA) announced today that oral ketoconazole should not be used as first-line treatment for any fungal infection and should only be used for the treatment of endemic mycoses when alternative antifungal therapies are not available or tolerated. The use of...
CDC Report Shows Stagnated HPV Vaccination Rate for Girls
For the first time since the human papillomavirus (HPV) vaccine became available for adolescent girls in 2006, the vaccination rate for the teenagers has stalled, according to data published in the Centers for Disease Control and Prevention’s (CDC’s) Morbidity and Mortality Weekly...
New Biomarker for Colorectal Cancer Could Help Predict Whether Disease Will Spread
Scientists have identified a protein that could play a crucial role in recognizing whether patients with colorectal cancer are candidates for chemotherapy due to a high risk of their cancer spreading, according to a new study published in the British Journal of Cancer. Scientists at the University...
FDA Invites Public Input on Menthol in Cigarettes
The U.S. Food and Drug Administration (FDA) has issued an Advance Notice of Proposed Rulemaking (ANPRM) seeking additional information to help the agency make informed decisions about menthol in cigarettes. Despite decades of work to reduce tobacco use in the United States, it continues to be the...
