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Showing 12401 - 12450ASCO 2013: New Drug Targeting PI3K-delta Shows Strong Activity in Early Trial for High-risk Chronic Lymphocytic Leukemia
Results from a phase I study of a new oral targeted drug, idelalisib (GS-1101), show the agent has potential as a therapy for relapsed or treatment-resistant chronic lymphocytic leukemia (CLL). The drug produced rapid and long-lasting tumor shrinkage in half of the patients treated with...
ASCO 2013: PARP Inhibitor Shows Activity in Pancreatic, Prostate Cancers among Patients Carrying BRCA Mutations
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers. Results of the study, led by researchers ...
ASCO 2013: Men’s Fitness in Middle Age Protects against Developing and Dying from Cancer Later in Life
Findings from a large, prospective 20-year study indicate that a high level of cardiovascular fitness in middle age reduces men’s risk of developing and dying from lung and colorectal cancer, two of the most common cancers affecting men. Better fitness also reduces the risk of dying from,...
ASCO 2013: Phase I Trial Suggests Ipilimumab and PD-1 Drug Nivolumab May Be Better Together than Alone for Advanced Melanoma
Results from a phase I study show that combination therapy with ipilimumab (Yervoy) and the investigational antibody drug nivolumab led to lasting tumor shrinkage in approximately half of patients with aggressive, advanced melanoma. The results will be presented at the 2013 ASCO Annual Meeting in...
FDA Approves Radium-223 Dichloride for Patients with Castration-resistent Prostate Cancer
On May 15, 2013, the U.S. Food and Drug Administration approved radium Ra 223 dichloride (Xofigo) for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic disease. Radium-223 dichloride is an...
FDA Approves Expanded Use for Erlotinib, Companion Diagnostic to Detect Genetic Mutations in NSCLC
The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test, a companion diagnostic for erlotinib (Tarceva). This is the first FDA-approved companion diagnostic that detects epidermal growth factor receptor (EGFR) gene mutations, which are present in approximately 10% of...
Study Establishes Basis for Genomic Classification of Endometrial Cancers
A comprehensive genomic analysis of nearly 400 endometrial tumors suggests that certain molecular characteristics, such as the frequency of mutations, could complement current pathology methods and help distinguish between principal types of endometrial tumors, as well as provide insights into...
Blocking a Single Gene Renders Tumors Less Aggressive, Johns Hopkins Researchers Find
Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that this so-called “master regulator” gene may be the key to...
Emil ‘Tom’ Frei III, MD, Trailblazer in the Development of Combination Chemotherapy, Dies at 89
The pages of medical history are dog-eared with breakthroughs that have transformed medicine and saved lives. One of those dog-eared pages belongs to Emil Frei III, MD, known to his colleagues and friends as Tom. In the dawn of oncology, Dr. Frei, along with his associate, Emil Freireich, MD, did...
Experimental Drug Beneficial in NIH Trial to Treat a Rare Sarcoma
Patients with advanced alveolar soft part sarcoma achieved some control of their disease using the experimental anticancer drug cediranib. The results from this largest clinical trial on alveolar soft part sarcoma to date were published online ahead of print on April 29, 2013, in the Journal of...
Radiation Therapy May Be Unnecessary for Postmenopausal Patients with Early-stage Breast Cancer after Conservative Surgery
Postmenopausal women aged 55 to 75 with early-stage breast cancer can be safely treated with breast-conserving surgery without postoperative radiation therapy, according to a double-arm, prospective, randomized study presented this week at the American Society of Breast Surgeons Annual Meeting. The ...
Researchers Identify New Pathway, Enhancing Tamoxifen to Tame Aggressive Breast Cancer
Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center (URMC) team has shown how to exploit tamoxifen’s secondary activities so that it might work on more aggressive breast...
Researchers Observe an Increased Risk of Cancer in People with History of Nonmelanoma Skin Cancer
A prospective study by researchers at Brigham and Women's Hospital observed an association between risk of second primary cancer and history of nonmelanoma skin cancer in white men and women. The researchers found that people with a history of nonmelanoma skin cancer had a modestly increased risk...
Majority of Children Readmitted to Hospital Following Stem Cell Transplant
Nearly two-thirds of children receiving stem cell transplants returned to the hospital within 6 months for treatment of unexplained fevers, infections, or other problems, according to a study performed at Dana-Farber/Children’s Hospital Cancer Center in Boston. Children who received donor...
Chernobyl Follow-up Study Finds High Survival Rate among Young Thyroid Cancer Patients
More than a quarter of a century after the Chernobyl nuclear disaster, many children and teenagers who developed thyroid cancer due to radiation are in complete or near remission, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology ...
Bipartisan Group of 124 Lawmakers Express Concern That Medicare Cuts to Life-sustaining Cancer Drugs Threaten Patient Care
The American Society of Clinical Oncology, Community Oncology Alliance, ION Solutions, and The US Oncology Network today commended a bipartisan group of 124 lawmakers in the U.S. House of Representatives who sent a letter to the Centers for Medicare and Medicaid Services (CMS) expressing concern...
Study to Treat Deadly Form of Thyroid Cancer Shows Promise, Mayo Clinic Says
A combination of therapies may prove to be a promising advance for the treatment of anaplastic thyroid cancer based on results of a phase I clinical trial, said researchers at Mayo Clinic in Florida. Anaplastic thyroid cancer is one of the deadliest of all cancers. Nearly all patients diagnosed...
The U.S. Supreme Court Hears Arguments Challenging Patents on Breast and Ovarian Cancer Genes
The U.S. Supreme Court heard arguments Monday in a case seeking to invalidate patents on two genes associated with hereditary breast and ovarian cancer. The American College of Medical Genetics and Genomics (ACMG) was one of the first plaintiffs to sign onto this historic legal case. ACMG was also ...
Asbestos Exposure, Asbestosis, and Smoking Combined Greatly Increase Lung Cancer Risk
The chances of developing lung cancer associated with asbestos exposure, asbestosis, and smoking are dramatically increased when these three risk factors are combined, and quitting smoking significantly reduces the risk of developing lung cancer after long-term asbestos exposure, according to a new ...
NIH Trial Shows Promising Results in Treating Primary Mediastinal B-cell Lymphoma
Patients with primary mediastinal B-cell lymphoma who received infusions of chemotherapy, but who did not have radiation therapy to the mediastinum, had excellent outcomes, according to clinical trial results. Until now, most standard treatment approaches for patients with this type of...
Joint Statement on the President's Budget from ASCO, Community Oncology Alliance, ION Solutions, and the US Oncology Network
The President has released his proposed budget for fiscal year 2014, which proposes new reductions for cancer care services. Taken in combination with existing strains imposed by sequestration, this proposal threatens access to care for some of America's most vulnerable: elderly patients with ...
Novel Drug Combination Showed Antitumor Activity in Patients with Incurable BRCA-deficient Cancers
When given sequentially, two orally available experimental drugs—sapacitabine and seliciclib—worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, DC, April...
Adding Cetuximab to Chemotherapy Enables Select Patients with Advanced Colorectal Cancer and Liver Metastasis to Undergo Surgery
New results from a clinical trial conducted in Shanghai, China, indicate that adding cetuximab (Erbitux) to standard chemotherapy enables some patients with otherwise inoperable liver metastases due to colorectal cancer have their metastases surgically removed. Such surgery can be curative, and is...
Black Women Had Worse Breast Cancer Mortality Regardless of Cancer Subtype
Black women with breast cancer had significantly worse survival compared with other racial and ethnic groups across cancer subtypes, which suggests that the survival differences are not solely attributable to the fact that black women are more frequently diagnosed with less treatable breast cancer...
Immunotherapy Showed Promising Antileukemia Activity in Pediatric Patients
Researchers using patients’ own immune cells in an immunotherapy approach called anti-CD19 chimeric antigen receptor (CAR) T-cell therapy achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant, according to preliminary results...
Novel Two-step Immunotherapy Showed Promise for Patients with Recurrent Ovarian Cancer
A novel two-step immunotherapy approach yielded clinically beneficial responses in patients with advanced ovarian cancer, including one patient who achieved complete remission, according to data from two phase I clinical trials presented at the AACR Annual Meeting 2013, held in Washington, DC,...
Statement by ASCO President Sandra M. Swain, MD, FACP, in Support of the Rally for Medical Research, April 8, 2013
A strong, stable federal investment in cancer research, prevention, and treatment is critical to continue the progress we are making for the more than 1.66 million Americans newly diagnosed with cancer every year. ASCO calls on Congress to renew its commitment to this life-sustaining research. As...
New Type of Experimental Drug Active in Platinum-resistant Ovarian Cancers
The antibody-drug conjugate DMUC5754A, a novel member of a relatively new class of drugs, showed activity in women with ovarian cancer, even those with hard-to-treat, platinum-resistant disease, in a phase I trial presented at the AACR Annual Meeting 2013, held in Washington, DC, April 6 to 10....
Leading Health-care Organizations Issue Guideline Recommendations for Molecular Testing and Targeted Therapies
The emergence of molecular diagnostic testing in lung cancer offers new hope for patients battling the number 1 cancer killer in the United States and abroad. Now, for the first time after a decade of biomarker testing in lung cancer, a uniform approach for testing for the EGFR mutation and ALK...
For the First Time, Researchers Isolate Adult Stem Cells from Human Intestinal Tissue
For the first time, researchers at the University of North Carolina at Chapel Hill have isolated adult stem cells from human intestinal tissue. The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology. It also enables them to ...
On-and-off Approach to Prostate Cancer Treatment May Compromise Survival
Taking a break from hormone-blocking prostate cancer treatments once the cancer seems to be stabilized is not equivalent to continuing therapy, a new large-scale international study finds. Previous smaller studies had indicated that intermittent androgen deprivation therapy might be just as good...
Cisplatin-resistant Cancer Cells Sensitive to PARP Inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research, a journal of the American Association for...
Roswell Park Scientists Advance Findings about Novel, Low-toxicity Anticancer Agent
Researchers at Roswell Park Cancer Institute (RPCI) have found that a new formulation of a promising anticancer agent, the small chemical molecule FL118, is even more effective in controlling two types of cancer than a version reported in PLOS ONE 6 months earlier proved to be. Additional evidence...
Mayo Clinic: New DNA Sequences Hone in on Breast, Ovarian Cancer Risk
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences associated with breast cancer and ovarian cancer. The findings, which appear in three studies in the journals PLoS Genetics and Nature Genetics, will help reveal the underlying causes of these diseases and help researchers...
Moffitt Cancer Center Researchers Analyze HPV Vaccination Disparities among Girls from Low-income Families
Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health-care providers to determine the factors associated with disparities in human papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination...
Number of Cancer Survivors Expected to Increase to 18 Million by 2022
The American Association for Cancer Research released its second Annual Report on Cancer Survivorship in the United States in advance of the AACR Annual Meeting 2013, which will be held in Washington, DC, April 6-10. The report, published in the AACR’s journal Cancer Epidemiology, Biomarkers ...
Pathologists Identify Patterns of Mutations to Help Inform Design of Future Trials
Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non–small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the...
New Imaging Agent Enables Better Cancer Detection, More Accurate Staging
Researchers at the University of California, San Diego School of Medicine have shown that a new imaging dye, designed and developed at UC San Diego Moores Cancer Center, is an effective agent in detecting and mapping cancers that have reached the lymph nodes. The radioactive dye technetium Tc-99m...
Gene Profile May Help Identify Risk for Hormone-sensitive, Hormone-insensitive Breast Cancer
The overexpression or underexpression of a newly identified set of genes related to lipid metabolism may help physicians identify whether or not a woman is at risk for hormone receptor–positive or hormone receptor–negative breast cancer and to subsequently tailor prevention strategies...
Amgen Announces Results of Phase III Talimogene Laherparepvec Trial in Late-stage Melanoma
Amgen has announced results from a phase III trial evaluating the efficacy and safety of talimogene laherparepvec for the treatment of unresected stage IIIB, IIIC, or IV melanoma compared to treatment with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Talimogene...
Inherited Genetic Variations Have a Major Impact on Childhood Leukemia Risk
Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children’s Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute...
NCCN Adds Two New Member Institutions
The National Comprehensive Cancer Network (NCCN) announced today the addition of two new NCCN Member Institutions: UC San Diego Moores Cancer Center in La Jolla, California, and the University of Colorado Cancer Center in Aurora, Colorado. "We are extremely pleased that UC San Diego Moores Cancer...
NCCN Issues New Guidelines for Survivorship
The National Comprehensive Cancer Network (NCCN) has issued its first ever NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Survivorship. The new NCCN Guidelines were presented at the NCCN 18th Annual Conference: Advancing the Standard of Cancer Care by Panel Chair, Crystal S....
More Than 60% of Ovarian Cancer Patients Do Not Receive Recommended Treatment, Study Shows
Women are 30% less likely to die of ovarian cancer if they have guideline-recommended treatment, yet nearly two-thirds of those with the disease do not receive it, often because they are cared for at hospitals that treat a small number of ovarian cancer patients. These are the findings of a study...
Intraperitoneal Chemotherapy Gives Ovarian Cancer Patients Better Chance of Survival
Patients with advanced ovarian cancer who undergo intensive treatment with chemotherapy that bathes the abdomen are significantly more likely to live longer than those who receive standard intravenous (IV) chemotherapy, according to a study that analyzed long-term follow-up from two landmark...
FDA Approves New Radioactive Diagnostic Imaging Agent to Help Locate Lymph Nodes in Patients with Certain Cancers
The FDA has approved technetium Tc 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent that helps doctors locate lymph nodes in patients with breast cancer or melanoma who are undergoing surgery to remove tumor-draining lymph nodes. Technetium Tc 99m tilmanocept is an...
Indiana University Researchers Earn $3.2 Million Grant to Develop, Improve Therapies for Pancreatic Cancer
Two Indiana University researchers have been awarded a multiyear, $3.2 million grant to develop and improve therapies for pancreatic cancer, the fourth leading cause of cancer death in the United States. Mark R. Kelley, PhD, Betty and Earl Herr Professor of Pediatric Oncology Research, and Melissa ...
Study Shows Confidence Builds Better Exercise Habits for Cancer Survivors
Endometrial cancer survivors are more likely to complete physical activity, and for longer durations, when their daily self-efficacy is higher, according to a study published online in the journal Health Psychology, a publication of the American Psychology Association. “Sedentary behavior is ...
Tackling Tobacco Consumption and Improving Vaccination Access Are Two of the Best Ways to Reduce Global Cancer Burden
Combatting the tobacco industry’s tactics in the world’s poorest countries as well as ensuring the best cancer vaccines are available to those most in need are key in order to reduce the number of cancer deaths worldwide, according to a new report published in the journal Science...
Focal Therapy Offers Middle Ground for Some Prostate Cancer Patients
Men with low-risk prostate cancer who previously had to choose between aggressive treatment, with the potential for significant side effects, and active surveillance, with the risk of disease progression, may have a new option. Focal laser ablation uses precisely targeted heat, delivered through a...
