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colorectal cancer
issues in oncology

Very Overweight Teens May Double Their Risk of Bowel Cancer in Middle Age

Being very overweight in your teens may double the risk of developing bowel cancer by the time you are middle-aged, suggested research published by Kantor et al in the journal Gut. A high level of an indicator of systemic inflammation—erythrocyte sedimentation rate—at this age is...

colorectal cancer

First-in-Class Antibody Mixture Shows Clinical Activity Against Treatment-Resistant, Advanced Colorectal Cancer

Patients with advanced colorectal tumors without mutations in the RAS genes derive substantial benefit from anti-EGFR (epidermal growth factor receptor) therapies; however, the disease eventually progresses, leaving these patients with few alternative therapeutic options. Over the past decade, some ...

colorectal cancer
solid tumors
issues in oncology
issues in oncology
issues in oncology

Study Finds Noninvasive Colon Cancer Screening May Be Promising for African Americans

In a first-of-its-kind clinical trial, physician-scientists at University Hospitals (UH) Case Medical Center, Seidman Cancer Center, and Case Western Reserve University School of Medicine found that a new, noninvasive technology for colon cancer screening is a promising alternative to colonoscopy...

colorectal cancer
issues in oncology
issues in oncology

Cobas KRAS Mutation Test Receives FDA Approval

Roche announced that the U.S. Food and Drug Administration (FDA) has approved the cobas KRAS Mutation Test for diagnostic use. The real-time polymerase chain reaction (PCR) test is designed to identify KRAS mutations in tumor samples from patients with metastatic colorectal cancer and aid...

issues in oncology
colorectal cancer
issues in oncology
issues in oncology

Progress Made in Discovering Link Between Aspirin Use and Colorectal Cancer Prevention

Taking aspirin reduces a person's risk of colorectal cancer, but the molecular mechanisms involved have remained unknown, until a recent discovery by researchers at The Hormel Institute, University of Minnesota. These findings were published by Li et al in EBioMedicine. EGFR and COX-2 Association ...

issues in oncology
colorectal cancer
issues in oncology

Two-Week International Diet Swap Shows Potential Effects of Food on Colon Cancer Risk

African Americans and Africans who swapped their typical diets for just 2 weeks similarly exchanged their respective risks of colon cancer, as reflected by alterations of their gut bacteria, according to an international study led by researchers at the University of Pittsburgh School of...

colorectal cancer

FDA Approves Ramucirumab for Metastatic Colorectal Cancer

The U.S. Food and Drug Administration today approved ramucirumab (Cyramza) for use in combination with FOLFIRI (leucovorin, fluorouracil, irinotecan) for the treatment of patients with metastatic colorectal cancer whose disease has progressed on a first-line bevacizumab (Avastin)-, oxaliplatin-,...

colorectal cancer
solid tumors
issues in oncology
gastroesophageal cancer

AACR 2015: Long-Term, Regular Aspirin Use Modestly Decreased Cancer Risk

Long-term, regular aspirin use was associated with a modestly reduced overall risk for cancer, driven primarily by a reduction in the risk for colorectal cancers, according to research presented at the AACR Annual Meeting 2015, held April 18 to 22 in Philadelphia (Abstract 876). “Previous...

colorectal cancer
prostate cancer
survivorship
issues in oncology

Physical Activity Helps Cancer Survivors Fend Off Side Effects

Three or more hours of walking per week can boost the vitality and health of prostate cancer survivors. Men and women who have survived colorectal cancer and are regular walkers also reported lower sensations of burning, numbness, tingling, or loss of reflexes that many often experience after...

breast cancer
colorectal cancer
lung cancer
prostate cancer
issues in oncology
issues in oncology

Asian Americans Have Better Cancer-Specific Mortality Than Non-Hispanic Whites

Numerous studies have documented racial differences in deaths from cancer among non-Hispanic whites and African Americans, but little has been known about survival outcomes for Asian Americans who have been diagnosed with cancer. In a new study published in the Journal of the National Cancer...

colorectal cancer
hepatobiliary cancer

Liver-Sparing Surgery Associated With Higher Survival Rates in Cancer Patients

According to researchers at Memorial Sloan Kettering Cancer Center (MSKCC), hepatic parenchymal preservation, in which a surgeon removes less than a lobe of the liver in a patient undergoing an operation for liver cancer, is associated with lower mortality and complication rates. Their study...

colorectal cancer
issues in oncology

Overweight Girls Face Increased Risk of Colorectal Cancer Later in Life

Girls who are overweight as young children and teens may face an increased risk for colorectal cancer decades later, regardless of what they weigh as adults, suggests a new study published by Zhang et al in Cancer Epidemiology, Biomarkers & Prevention. “Our study supports the growing...

colorectal cancer

ASCP, CAP, AMP, and ASCO Issue Draft Colorectal Cancer Molecular Marker Testing Guideline, Announce Opening of Public Comment Period

The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) today released a draft of a clinical practice guideline on the use of molecular marker testing for...

colorectal cancer

New Approach to Colorectal Surgical Care Results in Shorter Recovery Times, Lower Costs

A new, multidisciplinary approach to managing patients undergoing a colorectal operation results in shorter hospital stays, fewer complications, and lower medical costs, according a study published by Thiele et al in the Journal of the American College of Surgeons. Currently, patients undergoing...

colorectal cancer

Phase II and III Trials Support First-Line Panitumumab in Combination With FOLFOX in Wild‑Type RAS Metastatic Colorectal Cancer

New data from the phase II PEAK and phase III PRIME studies support the first-line use of panitumumab (Vectibix) in combination with FOLFOX (fluorouracil, leucovorin, oxaliplatin) in patients with wild-type RAS metastatic colorectal cancer. The study results were presented during a poster session...

colorectal cancer

Study Finds Decreasing Rates of Primary Tumor Resection and Better Survival Among Patients With Advanced Colorectal Cancer

The annual rate of primary tumor removal for stage IV colorectal cancer has decreased since 1988, and the trend toward nonsurgical management of the disease noted in 2001 coincides with the availability of newer chemotherapy and biologic treatments, according to study reported by Hu et al in JAMA...

colorectal cancer

Combining Newer, More Intensive First-Line Chemotherapy With Bevacizumab Improves Long-Term Outcome in Advanced Colorectal Cancer

Updated results from TRIBE, an Italian phase III study of patients with metastatic colorectal cancer, indicate that FOLFOXIRI (leucovorin, fluorouracil [5-FU], oxaliplatin, irinotecan) chemotherapy in combination with bevacizumab (Avastin) is superior to the standard FOLFIRI (leucovorin, 5-FU,...

colorectal cancer

Second-Line Ramucirumab Added to Standard Chemotherapy Improves Survival in Patients With Advanced Colorectal Cancer

New findings from an international phase III study of 1,072 patients with advanced colorectal cancer whose disease progressed on or after initial therapy indicate that a combination of the targeted drug ramucirumab (Cyramza) and FOLFIRI (irinotecan, fluorouracil, leucovorin) chemotherapy provides a ...

colorectal cancer

Chemoradiation Plus Nonsurgical Management of Rectal Cancer Appears Safe, May Offer Better Quality of Life Than Surgery

A retrospective review of clinical data on 145 patients with stage I to III rectal cancer indicates that patients who achieved complete response after treatment with chemoradiation and systemic chemotherapy had similar 4-year survival rates regardless of whether they had immediate surgery or...

colorectal cancer

Higher Vitamin D Levels Associated With Markedly Improved Survival in Patients With Advanced Colorectal Cancer

A prospective analysis of data from a phase III study of patients newly diagnosed with metastatic colorectal cancer indicates that patients with higher vitamin D levels have better outcomes after treatment with chemotherapy and targeted therapy. The median overall survival for patients with the...

colorectal cancer

Long-Term Follow-up Shows Favorable Overall Survival Rates With Concurrent Neoadjuvant Chemoradiotherapy Regimens in Rectal Cancer

Patients with locally advanced rectal cancer who receive neoadjuvant radiation therapy with either irinotecan plus capecitabine or oxaliplatin plus capecitabine have a 4-year overall survival rate of 85% and 75%, respectively, according to a study reported by Wong et al in the International Journal ...

colorectal cancer

Number of Young Patients With Newly Diagnosed Colorectal Cancer Anticipated to Double

In the next 15 years, more than 1 in 10 colon cancers and nearly 1 in 4 rectal cancers will be diagnosed in patients younger than the traditional screening age, according to researchers at The University of Texas MD Anderson Cancer Center. This growing public health problem is underscored by data...

colorectal cancer

Rewiring Cell Metabolism Slows Colorectal Cancer Growth

Cancer is an unwanted experiment in progress. As the disease advances, tumor cells accumulate mutations, eventually arriving at ones that give them the insidious power to grow uncontrollably and spread. Distinguishing drivers of cancer from benign mutations open opportunities for developing...

colorectal cancer

TAS-102 Receives FDA Fast Track Designation for Refractory Metastatic Colorectal Cancer

The U.S. Food and Drug Administration (FDA) has granted Fast Track designation for Taiho Oncology’s TAS-102, a novel agent currently under investigation for the treatment of refractory metastatic colorectal cancer. TAS-102 is an oral combination investigational anticancer drug consisting of...

colorectal cancer

Hormone Loss Could Be Involved in Colon Cancer

Some cancers, like breast and prostate cancer, are driven by hormones such as estrogen and testosterone, but to date, there are none that are understood to be driven by the lack of a hormone. New evidence reported by researchers at Thomas Jefferson University, Philadelphia, suggests that human...

colorectal cancer

Fiber-Based Laxatives Linked to Decreased Risk of Colorectal Cancer

A large, prospective study involving more than 75,000 adults in western Washington has found that frequent use of fiber-based laxatives is associated with a decreased risk of colorectal cancer. The study also found that use of nonfiber laxatives is linked to significantly increased risk of...

colorectal cancer
issues in oncology

Study Finds Increase in Colonoscopy Rates Has Lead to Overuse

A retrospective study led by researchers at Brigham and Women's Hospital has found an overuse of colonoscopies for colorectal cancer screening and surveillance. The study demonstrated that endoscopists commonly recommended shorter follow-up intervals than established guidelines support, and these...

colorectal cancer

Addition of Irinotecan to Standard Chemotherapy Improves Survival in a Subset of Stage III Colon Cancer Patients

A subset of patients with stage III colon cancer had improved survival rates when treated with irinotecan-based therapy, according to a new study in Gastroenterology. When added to the standard chemotherapy treatment—fluorouracil [5-FU] and leucovorin—adjuvant irinotecan therapy...

colorectal cancer

Study Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism

A team of researchers led by the University of Arizona Steele Children’s Research Center discovered that curcumin—the bioactive molecule derived from the spice turmeric—blocks the protein cortactin in colon cancer. Cortactin, a protein essential for cell movement, is frequently...

colorectal cancer
issues in oncology

FDA Approves First Noninvasive DNA Screening Test for Colorectal Cancer

The U.S. Food and Drug Administration (FDA) today approved Cologuard, the first stool-based colorectal screening test that detects the presence of red blood cells and DNA mutations that may indicate the presence of certain kinds of abnormal growths that may be cancers such as colon cancer or...

colorectal cancer

Phase III Trial Shows Improved Survival With TAS-102 in Metastatic Colorectal Cancer Refractory to Standard Therapies

The new combination agent TAS-102 can improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers reported at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona (Abstract O-0022). “Around 50%...

colorectal cancer

Synthetic Triterpenoids Show Promise in Preventing Colitis-Associated Colon Cancer in Preclinical Study

Researchers from Case Western Reserve and Dartmouth have shown that a class of small antioxidant molecules carries promise for suppressing colon cancer associated with colitis. These preclinical findings, published in the Journal of Clinical Investigation, offer hope that physicians ultimately will ...

colorectal cancer

ASCO 2014: Patients With Metastatic Colon Cancer Respond to New Combination Therapy, Phase IB Study Shows

In a new study presented at the 2014 ASCO Annual Meeting in Chicago (Abstract 3516), researchers from The University of Texas MD Anderson Cancer Center found patients with advanced colorectal cancer responded well to a combination therapy of the drugs vemurafenib (Zelboraf), cetuximab (Erbitux),...

colorectal cancer

FDA Approves Panitumumab Plus FOLFOX for Wild-Type KRAS Metastatic Colorectal Cancer

The U.S. Food and Drug Administration (FDA) has approved panitumumab (Vectibix) for use in combination with FOLFOX (fluorouracil, leucovorin, oxaliplatin) as first-line treatment in patients with wild-type KRAS (exon 2) metastatic colorectal cancer. This approval converts the accelerated...

colorectal cancer

Dual Method to Remove Precancerous Colon Polyps May Substantially Reduce Health-Care Costs

A surgical method combining two techniques for removing precancerous polyps during colonoscopies can substantially reduce the recovery time and the length of hospital stays, which may translate into significant cost savings, according to research presented this week at Digestive Disease Week in...

colorectal cancer

New Gene Variant Found That Increases the Risk of Colorectal Cancer From Eating Processed Meat

A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to a study published today in PLOS Genetics by Figueiredo et al. The study of over 18,000 people from the United States,...

colorectal cancer
issues in oncology

Obesity Primes the Colon for Cancer, According to NIH Study

Obesity, rather than diet, causes changes in the colon that may lead to colorectal cancer, according to a study in mice by the National Institutes of Health. The finding bolsters the recommendation that calorie control and frequent exercise are not only key to a healthy lifestyle, but a strategy to ...

colorectal cancer
issues in oncology

NCCN Advocates for Universal Lynch Syndrome Screening in Newly Diagnosed Colorectal Cancer

The National Comprehensive Cancer Network (NCCN) is recommending that newly diagnosed colorectal cancer patients be screened for Lynch syndrome, previously called hereditary nonpolyposis colorectal cancer. The NCCN’s proactive position should greatly help identify individuals and their...

colorectal cancer

Blacks, Hispanics, Older Americans Not Benefiting Equally From Improvements in Colon Cancer Treatment

While new and better treatments have improved the odds of survival for patients diagnosed with late-stage colorectal cancer, that progress has been largely confined to non-Hispanic whites and Asians and those under age 65, according to a new study published in Cancer Causes and Control. Sineshaw et ...

colorectal cancer

Irinotecan Drug-Eluting Beads Improve Outcomes in Colorectal Cancer Patients With Liver Metastases

Irinotecan drug-eluting beads given simultaneously with FOLFOX (leucovorin, fluorouracil, oxaliplatin) and bevacizumab (Avastin) in patients with unresectable liver metastasis from colorectal cancer improved response rates, increased resectability and prolonged hepatic progression-free survival in...

colorectal cancer
issues in oncology

RAS Status Predicts Response to Second-Line Treatment With Panitumumab for Metastatic Colorectal Cancer

New data from a phase III clinical trial shows that patients with metastatic colorectal cancer tumors that contain RAS mutations beyond KRAS exon 2 are unlikely to benefit from the addition of panitumumab (Vectibix) to second-line FOLFIRI (leucovorin, fluorouracil, irinotecan) chemotherapy....

colorectal cancer

Preoperative Oral Capecitabine Chemotherapy Is Equivalent to Infusional 5-FU for Rectal Cancer

New findings from a four-arm phase III clinical trial in patients with stage II or stage III rectal cancer indicate that combining preoperative radiation with either capecitabine or fluorouracil (5-FU) results in equivalent outcomes. This study provides strong clinical evidence that using either...

colorectal cancer
issues in oncology

Prolonged Sedentary Behavior Linked to Recurrence of Precancerous Colorectal Tumors in Men

Men who spend the most time engaged in sedentary behaviors are at greatest risk for recurrence of colorectal adenomas, benign tumors that are known precursors of colorectal cancers, according to results presented at the 12th Annual AACR International Conference on Frontiers in Cancer Prevention...

colorectal cancer
issues in oncology

Novel Gene-Diet Interaction May Explain Association Between Red and Processed Meat Consumption and Colorectal Cancer Risk

A newly discovered potential gene-diet interaction for colorectal cancer may shed light on the statistically significant increased risk of colorectal cancer that is associated with consumption of red and processed meat, according to a study reported yesterday at the American Society of Human...

breast cancer
colorectal cancer

FDA Approves First Generic Capecitabine to Treat Colorectal and Breast Cancers

The U.S. Food and Drug Administration (FDA) has approved the first generic version of capecitabine (Xeloda), an oral chemotherapy agent used in the treatment of metastatic colorectal cancer and breast cancers. Teva Pharmaceuticals USA has gained FDA approval to market generic capecitabine in 150...

colorectal cancer
issues in oncology

Noninvasive Test Optimizes Colon Cancer Screening Rates

Organized mailing campaigns could substantially increase colorectal cancer screening among uninsured patients, according to a study published online in JAMA Internal Medicine. The research also suggested that a noninvasive colorectal screening approach, such as a fecal immunochemical test, might be ...

issues in oncology
colorectal cancer

New Biomarker for Colorectal Cancer Could Help Predict Whether Disease Will Spread

Scientists have identified a protein that could play a crucial role in recognizing whether patients with colorectal cancer are candidates for chemotherapy due to a high risk of their cancer spreading, according to a new study published in the British Journal of Cancer. Scientists at the University...

colorectal cancer
survivorship

Colorectal Cancer Survivors Face Increased Risk of Developing Subsequent Cancers of Different Types

According to a new study, colorectal cancer survivors face an increased risk of developing subsequent primary cancers, particularly second colorectal cancers and small intestinal cancers. These findings, published online in Cancer, may help in the development of screening guidelines for patients...

colorectal cancer

BRAF Mutation Status May Have Effect on Benefit of Aspirin Use for Patients with Colorectal Cancer

In two large studies, the association between aspirin use and risk of colorectal cancer was affected by BRAF mutation status, with regular aspirin use associated with a lower risk of BRAF wild-type colorectal cancer but not with risk of BRAF-mutated cancer. The findings, published today in JAMA,...

colorectal cancer
issues in oncology

Screening Colonoscopy Associated with Increased Survival Duration and Rates for Patients with Colon Cancer

Patients with colon cancer identified on screening colonoscopy appear to have lower-stage disease on presentation and better outcomes independent of their staging, according to a report published online today in JAMA Surgery. Since their introduction in 2000, National Institutes of Health...

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