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Bladder Cancer

Addition of Durvalumab to BCG After TURBT for BCG-Naive, High-Risk NMIBC

In the final analysis of the phase III POTOMAC trial reported in The Lancet, De Santis et al found that the addition of durvalumab to bacillus Calmette-Guérin (BCG) induction and maintenance improved disease-free survival in patients with high-risk non–muscle-invasive bladder cancer (NMIBC) who underwent transurethral resection of bladder tumor (TURBT).

 

Issues in Oncology
Legislation

Limited or No State Regulation of STLD Health Plans Linked to Decreases in Timely Cancer Treatment Initiation

In 2018, the federal government expanded the coverage duration of short-term limited-duration (STLD) health plans from 3 months to less than 12 months, with the option to renew for a total duration of up to 36 months. Some states imposed more stringent regulations than those federally imposed or banned the sale of these STLD plans, while other states did not have any additional regulations.

 

AI in Oncology

Regulatory Agencies Establish Principles of Good AI Use in Drug Development

The U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) have collaborated with the European Medicines Agency (EMA) to develop a set of 10 guiding principles for good uses of artificial intelligence (AI) in drug development. The principles are aimed at industry members and product developers who are using AI to facilitate and accelerate drug/biological product development. 

 


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Head and Neck Cancer

Intensity-Modulated Proton vs Photon Radiotherapy in Oropharyngeal Cancer

In a prespecified interim analysis of a phase III trial (University of Texas MD Anderson Cancer Center Clinical Trial Consortium trial) reported in The Lancet, Frank et al found that intensity-modulated proton therapy (IMPT) was noninferior to standard intensity-modulated photon radiation therapy (IMRT) in progression-free survival among patients with stage III or IV oropharyngeal cancer.

 

Global Cancer Care
AI in Oncology

Global Cancer Survival Gaps Assessed Using a Country-Level Machine-Learning Framework

A machine-learning model has calculated country-specific cancer mortality-to-incidence ratios and evaluated the factors that contribute the most to each country's survival gaps. Additionally, the artificial intelligence (AI) tool mapped out actions each country could take to improve cancer outcomes. A report explaining the establishment of the machine learning framework and its country-specific findings was published in Annals of Oncology

 

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Hematologic Malignancies

Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease

Leukemia

A Battle With My Blood

Editor’s note: On November 22, 2025—the 62nd anniversary of her grandfather President John F. Kennedy’s assassination—Tatiana Celia Kennedy Schlossberg published an essay in The New Yorker detailing her diagnosis of acute myeloid leukemia with chromosome 3 inversion, a rare and aggressive subtype...

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Pembrolizumab Plus Lenvatinib in Recurrent Gynecologic Clear Cell Carcinoma

In a phase II trial (LARA) reported in The Lancet Oncology, Ngoi et al found that the combination of pembrolizumab and lenvatinib was active in patients with recurrent gynecologic clear cell carcinoma. Study Details In the trial, 25 efficacy-eligible patients (27 in safety population) with at least ...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Issues in Oncology

New ASCO Guideline Addresses Management of Cancer During Pregnancy, From Diagnosis Through Survivorship

A new ASCO guideline provides recommendations on managing cancer during pregnancy, addressing a range of topics from the selection and timing of diagnostic testing and therapeutic interventions to delivery planning and ethical and legal considerations.1 The guideline aims to inform evidence-based...

Gastroesophageal Cancer

Novel HER2-Targeted Bispecific Improves Outcomes in Patients With Gastroesophageal Cancer

In patients with advanced HER2-positive gastroesophageal adenocarcinoma, treatment with the bispecific antibody zanidatamab-hrii and chemotherapy, with or without the PD-1 inhibitor tislelizumab-jsgr, reduced the risk of disease progression or death by 35% over trastuzumab plus chemotherapy in the...

Leader in Global Cancer Care, Paul E. Goss, MD, PhD, Dies at 70

The oncology community is mourning the loss of Paul E. Goss, MD, PhD, who died on December 19, 2025, at his home in Hopkinton, Massachusetts, from multiple system atrophy—a rare, progressive neurologic disorder with symptoms resembling those of Parkinson’s disease. He was 70 years old. Born in...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Deb Schrag, MD, MPH, FASCO, Elected 2027–2028 ASCO President

Deb Schrag, MD, MPH, FASCO On December 19, 2025, ASCO announced its members had elected Deb Schrag, MD, MPH, FASCO,as President for the 2027–2028 term. Dr. Schrag will begin her term as President-Elect upon the conclusion of the 2026 ASCO Annual Meeting. Dr. Schrag, a gastrointestinal...

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Nutrition, Muscle Loss Compromises Survival in Patients With Cervical Cancer Undergoing Chemoradiotherapy

A scoping review of cachexia, sarcopenia, and malnutrition in patients with locally advanced cervical cancer undergoing chemoradiotherapy revealed that women who lost at least 10% muscle mass during treatment had a six times higher mortality rate, regardless of their weight at the start of...

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