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Breast Cancer
Issues in Oncology

Poor Agreement Reported Among Diagnostic Tests for Breast Cancer–Related Lymphedema

Various tests, ranging from a tape measure to sophisticated imaging technology, show low to moderate agreement in diagnosing breast cancer–related lymphedema, according to a recent study published by Brunelle et al in Rehabilitation Oncology.

 

Breast Cancer

Renowned Breast Cancer Physician-Scientist Hope S. Rugo, MD, FASCO, to Lead Women’s Cancers Program at City of Hope

City of Hope has announced that Hope S. Rugo, MD, FASCO, has joined the organization to serve as Director of its Women’s Cancers Program; new Division Chief, Breast Medical Oncology; and Professor in the Department of Medical Oncology & Therapeutics Research.

Skin Cancer

Can ctDNA Monitoring Help to Predict Melanoma Recurrence?

A new study showed that approximately 80% of patients with stage III melanoma who had detectable levels of circulating tumor DNA (ctDNA) before they started treatment to suppress their tumors went on to experience recurrence. Researchers also found that the disease returned more than four times faster in this group than in those with no detectable levels of the biomarker—and the higher their ctDNA levels, the faster their cancer returned. These findings were published by Syeda et al in The Lancet Oncology.


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Lung Cancer

Dual Use of Cigarettes and E-Cigarettes on Par With Sole Cigarette Use in Terms of Toxic Exposure

Individuals who reported exclusive use of combustible cigarettes as well as those who reported dual use of both cigarettes and e-cigarettes showed similarly high toxicant exposure, according to the results of a study published in Nicotine & Tobacco ResearchBoth groups of smokers showed higher rates of exposure than those who exclusively used e-cigarettes.  

Gastroesophageal Cancer

Advanced Esophageal Cancer: NOTCH1 Mutation and Efficacy of Tislelizumab

In an analysis from the phase III RATIONALE-302 trial reported in the Journal of Clinical Oncology, Lu et al found that the presence of NOTCH1 mutation was associated with improved overall survival in patients receiving second-line tislelizumab vs investigator’s choice of chemotherapy for advanced or metastatic esophageal squamous cell carcinoma.

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Hematologic Malignancies

Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease

Colorectal Cancer

FDA Approves Nivolumab With Ipilimumab for Unresectable or Metastatic MSI-H/dMMR Colorectal Cancer

On April 8, the U.S. Food and Drug Administration (FDA) approved the PD-1 inhibitor nivolumab (Opdivo) with the CTLA-4 inhibitor ipilimumab (Yervoy) for adult and pediatric patients aged 12 years and older with unresectable or metastatic microsatellite instability–high (MSI-H) or mismatch...

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Is This the End of Cancer Research as We Know It?

Jennifer W. Pegher, MA, MBA Emily E. Stimmel, MA Ongoing efforts to rein in government spending have been described as a “chainsaw for bureaucracy.” It’s an apt metaphor for the haphazard budget cuts that many federal agencies are still experiencing. On February 7, 2025, the chainsaw made ...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Gynecologic Cancers

Combination Therapy for Newly Diagnosed, BRCA-Nonmutated, Advanced Epithelial Ovarian Cancer

The outcomes from the phase III ENGOT-OV43/GOG-3036/KEYLYNK-001 trial in advanced BRCA-nonmutated ovarian cancer indicate a statistically significant and clinically meaningful benefit for the PD-1 inhibitor pembrolizumab and chemotherapy, followed by pembrolizumab plus maintenance with the PARP...

Issues in Oncology

Proton Therapy and Intensity-Modulated Radiation Therapy for Localized Prostate Cancer

Proton beam therapy and intensity-modulated radiation therapy (IMRT) were found to offer equivalent quality-of-life outcomes for patients with localized prostate cancer, according to data from the PARTIQoL trial. This phase III trial showed no measurable differences between the two approaches in...

Polygenic Risk Score for Prostate Cancer Screening

In a U.K. study (BARCODE1) reported in The New England Journal of Medicine, McHugh et al found that screening for prostate cancer with a polygenic risk score was more accurate in diagnosis than screening with prostate-specific antigen (PSA) and magnetic resonance imaging (MRI). Study Details In...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Lung Cancer
Issues in Oncology

AI Integration in Global Programs of CT Screening for Lung Cancer and Other Tobacco-Related Illnesses

A new consortium, the Alliance for Global Implementation of Lung and Cardiac Early Disease Detection and Treatment (AGILE), has proposed a public health program of longitudinal chest computed tomography (CT) screenings among a global high-risk population of tobacco-exposed individuals utilizing...

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Benefits of Walnut Consumption: Curbing Inflammation, Colorectal Cancer Risk

Researchers have uncovered that eating walnuts may improve systemic inflammation and reduce the risk for colorectal cancer, according to a recent study published by Moussa et al in Cancer Prevention Research. Background Ellagitannins—plant-derived polyphenol compounds found in walnuts—have been...

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