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Gastroesophageal Cancer
Lung Cancer

Pulsed Low-Dose–Rate Chemoradiation Reduces Severe Esophagitis in Esophageal Cancer and NSCLC

Chemoradiation with a pulsed low-dose–rate technique led to lower-than-usual rates of severe esophagitis without compromising efficacy in patients with esophageal and non–small cell lung cancer (NSCLC), according to findings from a single-arm phase I study presented as a poster during the American Society for Radiation Oncology (ASTRO) 67th Annual Meeting (Abstract 3437). 

 

Breast Cancer

Predicting Future Breast Cancer Outcomes: Efficacy of a Polygenic Risk Score

Studies show that if left untreated, between 20% and 40% of ductal carcinoma in situ (DCIS) lesions may evolve into invasive breast cancer over time. And, according to the American Cancer Society, women diagnosed with lobular carcinoma in situ (LCIS) have between a 7 and 12 times higher risk of developing invasive cancer in either breast over time.

 

Leukemia

Use of Obecabtagene Autoleucel CAR T-Cell Therapy for B-Cell Acute Lymphocytic Leukemia

Treatment with obecabtagene autoleucel was the focus of the phase Ib/II multicenter FELIX study of more than 100 adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL).1 The initial report in 2024 revealed a rate of complete remission or complete remission with incomplete hematologic recovery of 78%. This CD19-directed, genetically modified autologous T-cell immunotherapy was approved for this hematologic malignancy in late 2024.


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Thyroid Cancer

Genetic Modification of the AJCC Classification for Papillary Thyroid Cancer

In an international, multicenter retrospective cohort study reported in The Lancet Oncology, Xing et al found that incorporating the genetic status of BRAF and TERT genes into the American Joint Committee on Cancer (AJCC) staging system for papillary thyroid cancer resulted in a modification of AJCC risk stages and improved mortality risk classification.    

 

Lung Cancer

Immunotherapy Addition Yields QOL Benefits in Limited-Stage Small Cell Lung Cancer

Clinically meaningful improvements in longer-term quality of life were achieved with the addition of atezolizumab immunotherapy to chemoradiation in patients with limited-stage small cell lung cancer (LS-SCLC), according to patient-reported outcome findings from the NRG LU005 trial presented during the 2025 American Society for Radiation Oncology (ASTRO) Annual Meeting (Abstract LBA 08). 

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Study Identifies Rectal Bleeding as Key Predictor of Early-Onset Colorectal Cancer

In individuals younger than age 50 undergoing a colonoscopy, greater odds for having colorectal cancer were observed among those who presented with rectal bleeding, according to findings from a study presented at the American College of Surgeons (ACS) Clinical Congress 2025 and published in the...

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ASCO Remembers Past President Harvey M. Golomb, MD, FASCO

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Prostate Cancer

New NIH-Funded Study Identifies Urine-Based Assay for Prostate Cancer

Researchers have developed a novel method to test for prostate cancer using biomarkers present in urine. This approach may significantly reduce the need for invasive, often painful biopsies, the researchers said in a statement. The study, which was funded in part by the National Institutes of...

Financial Toxicity Tied to Increased Risk of Mortality Among Patients With Cancer

Patients with cancer who developed financial toxicity and falling credit scores faced higher mortality risks, according to findings from a study presented at the American College of Surgeons (ACS) Clinical Congress 2025 and published in the Journal of the American College of Surgeons. “Our work...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

ASCO Thanks Richard L. Schilsky, MD, FACP, FSCT, FASCO, for His Vision and Leadership of TAPUR

ASCO extends its thanks and appreciation to Richard L. Schilsky, MD, FACP, FSCT, FASCO, for his decade of leadership and dedication as the inaugural Principal Investigator of the groundbreaking Targeted Agent and Profiling Utilization Registry (TAPUR) Study. The ASCO-sponsored TAPUR study is a...

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Antidepressants May Improve Surgical Outcomes in Patients With GI Cancer and Depression

New research revealed that depression can impact surgical outcomes, making it more difficult for patients to recover from surgery, thus leading to higher postoperative costs as well. In patients with gastrointestinal cancers and depression who were undergoing surgery specifically, antidepressants...

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