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Gynecologic Cancers

Addition of Cadonilimab to Platinum-Based Chemotherapy With or Without Bevacizumab in Cervical Cancer

In interim analyses of a Chinese phase III trial (COMPASSION-16) reported in The Lancet, Wu et al found that the addition of cadonilimab, a bispecific antibody targeting PD-1 and CTLA-4, to platinum-based chemotherapy with or without bevacizumab significantly improved progression-free and overall...

Gynecologic Cancers

Addition of Induction Chemotherapy to Standard Chemoradiotherapy in Locally Advanced Cervical Cancer

As reported in The Lancet by McCormack et al, the phase III INTERLACE trial has shown improved progression-free and overall survival with the addition of induction chemotherapy to standard chemoradiotherapy in patients with locally advanced cervical cancer. Study Details In the open-label trial,...

Gynecologic Cancers

Sintilimab/Bevacizumab in Relapsed or Persistent Ovarian Clear Cell Carcinoma

In a Chinese phase II trial (INOVA) reported in The Lancet Oncology, Peng et al found that the combination of sintilimab and bevacizumab showed activity in patients with relapsed or persistent ovarian clear cell carcinoma. Study Details In the multicenter trial, 37 evaluable patients with exposure...

Gynecologic Cancers
Issues in Oncology

One-Dose HPV Vaccination Approach May Help to Eliminate Cervical Cancer

Canadian vaccination programs may switch to a one-dose, gender-neutral human papillomavirus (HPV) vaccination approach to eliminate cervical cancer, according to a recent study published by Drolet et al in the Canadian Medical Association Journal. Background HPV is known to cause cervical cancer...

Gynecologic Cancers

Sexual Health and Quality of Life With Simple vs Radical Hysterectomy in Low-Risk, Early-Stage Cervical Cancer

In an analysis from the phase III SHAPE trial reported in the Journal of Clinical Oncology, Ferguson et al found that simple hysterectomy was associated with a reduced risk of sexual dysfunction vs radical hysterectomy in patients with low-risk, early-stage cervical cancer. The trial showed...

Gynecologic Cancers

Atezolizumab Plus Platinum Doublet and Maintenance Niraparib for Late-Relapsing Recurrent Ovarian Cancer

As reported in the Journal of Clinical Oncology by González-Martín et al, a phase III trial (ENGOT-OV41/GEICO 69-O/ANITA) has shown no progression-free survival benefit with the addition of atezolizumab to a carboplatin doublet and maintenance niraparib in patients with recurrent ovarian cancer...

Gynecologic Cancers
Immunotherapy

Overall Survival Results With Pembrolizumab and Chemoradiotherapy in Newly Diagnosed, High-Risk, Locally Advanced Cervical Cancer

As reported in The Lancet by Lorusso et al, overall survival results from the phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 trial indicated a significant benefit of pembrolizumab vs placebo with concurrent chemoradiotherapy followed by pembrolizumab vs placebo in patients with newly diagnosed,...

Gynecologic Cancers

KEYNOTE-A18: Overall Survival in Cervical Cancer Improved by Pembrolizumab Plus Chemoradiotherapy

  In the phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 trial presented at the European Society for Medical Oncology (ESMO) Congress 2024, the PD-1 inhibitor pembrolizumab plus chemoradiotherapy, with pembrolizumab continued as monotherapy, improved overall survival in previously untreated, high-risk...

Gynecologic Cancers

Tisotumab Vedotin-tftv for Recurrent or Metastatic Cervical Cancer

On April 29, 2024, tisotumab vedotin-tftv (Tivdak) was granted regular approval for recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.1 Tisotumab vedotin is a tissue factor–directed antibody and microtubule inhibitor conjugate. The agent was granted...

Breast Cancer
Gynecologic Cancers
Genomics/Genetics

Breast and Ovarian Cancers May Be Linked to Thousands of RAD51C Gene Variants

Researchers have identified thousands of genetic changes in a gene that may increase the risk of developing breast and ovarian cancers, according to a recent study published by Olvera-León et al in Cell. The findings may pave the way for better risk assessment and more personalized care. ...

Gynecologic Cancers

Study Finds Nearly $70 Billion in Socioeconomic Losses Across 11 Countries Attributable to Ovarian Cancer

A study by Hutchinson et al quantifying the socioeconomic burden of ovarian cancer in 11 countries, including the United States, estimates that nearly $70 billion in socioeconomic losses may be attributable to ovarian cancer. Moreover, health expenditures to cover treatment in the first 2 years...

Solid Tumors
Gynecologic Cancers
Breast Cancer

Novel Antibody-Drug Conjugate Puxitatug Samrotecan May Demonstrate Manageable Safety Profile and Preliminary Efficacy in First-in-Human Trial

The novel antibody-drug conjugate puxitatug samrotecan may have a manageable safety profile consistent with similar antibody-drug conjugates and demonstrated initial efficacy in patients with heavily pretreated advanced or metastatic solid tumors, according to new findings presented by...

Gynecologic Cancers

Immunotherapy and Novel Targeted Drug Appear Beneficial in Women With Early-Stage Gynecologic Disease

Studies reported at the European Society for Medical Oncology (ESMO) Congress 2024 reveal new groups of women with early-stage cervical1 and endometrial cancers2 who gain clinically meaningful benefit from adding immunotherapy to current standard treatments, and a first-in-human study found...

Gynecologic Cancers

Menopausal Hormone Therapy and Risk of Ovarian and Endometrial Cancers

In a long-term follow-up of Women’s Health Initiative (WHI) randomized trials reported in the Journal of Clinical Oncology, Rowan T. Chlebowski, MD, PhD, and colleagues identified risks of ovarian and endometrial cancers associated with the use of menopausal hormone therapy. Study Details The...

Gynecologic Cancers
Issues in Oncology

HPV Vaccination Rate Among Young Female Patients With Psychiatric Diagnoses

The rate of human papillomavirus (HPV) vaccination may be lower among female individuals with mental health issues or neurodevelopmental conditions compared with their peers, according to a recent study published by Hu et al in The Lancet Public Health. Background The HPV vaccine is capable of...

Gynecologic Cancers
Genomics/Genetics

Targetable Variant Found in Chinese Patients With Ovarian Cancer

Researchers may have uncovered the germline mutational landscape of Chinese patients with ovarian cancer and identified an enriched RAD51D variant in these patients, according to a recent study published by Feng et al in JCO Global Oncology. The findings could serve as a critical reference for...

Gynecologic Cancers
Geriatric Oncology

Age Is Just a Number: Treatment Considerations for Endometrial Cancer in Older Women

Endometrial cancer is most frequently diagnosed among women aged 55 to 65, with a median age at diagnosis of 64 years.1 In epidemiologic studies, women diagnosed with endometrial cancer at an older age are more likely to have high-grade disease, aggressive histology, deep myometrial invasion, lower ...

Gynecologic Cancers
Global Cancer Care

Causal Attribution of HPV Genotypes to Invasive Cervical Cancer

In a systemic analysis of global literature reported in The Lancet, Wei et al estimated the proportion of invasive cervical cancer cases caused by specific human papillomavirus (HPV) genotypes. Study Details A literature search through February 2024 was performed to identify studies reporting HPV...

Gynecologic Cancers

Are Some Uterine Tumors More Aggressive in Black Patients?

Researchers have discovered that uterine serous carcinoma tumors in Black patients tend to express more aggressive and immunosuppressive features than tumors in White patients, according to a recent study published by Foley et al in Proceedings of the National Academy of Sciences. Uterine serous...

Gynecologic Cancers

Recurrent or Advanced Endometrial Cancer: Atezolizumab Plus Chemotherapy

As reported in The Lancet Oncology by Nicoletta Colombo, MD, and colleagues, the phase III AtTEnd trial showed improved progression-free survival with the addition of atezolizumab to chemotherapy in patients with recurrent or advanced endometrial cancer, particularly among those with mismatch...

Gynecologic Cancers

Efficacy of ‘Symptom-Triggered Testing’ for Detection of Ovarian Cancer

“Symptom-triggered testing”—prompted by symptoms such as pain, abdominal bloating/swelling, and feeling full soon after starting to eat—detected early-stage aggressive ovarian cancer in one of four individuals affected, according to an analysis from the ROCkeTS trial published by Kwong et al in the ...

Gynecologic Cancers
Issues in Oncology

Salpingectomy vs Tubal Occlusion

Women whose fallopian tubes are removed during sterilization via laparoscopy may have only marginally more surgical complications compared with those whose tubes are cut during tubal occlusion, according to a recent study published by Strandell et al in The Lancet Regional Health–Europe. The...

Cost of Care
Breast Cancer
Gynecologic Cancers
Colorectal Cancer
Lung Cancer
Prostate Cancer

Cancer Screening Estimated to Cost $43 Billion Annually in United States

Cancer screening may cost more than $40 billion annually in the United States, according to a recent study published by Halpern et al in the Annals of Internal Medicine. Study Methods and Results In the recent modeling study, investigators used national health-care survey and cost resources data to ...

Gynecologic Cancers
Leukemia
Survivorship

Births and Adverse Obstetric Outcomes Among Female Survivors of Adolescent and Young Adult Cancers

In a population-based retrospective cohort study (Teenage and Young Adult Cancer Survivor Study; TYACSS) reported in The Lancet Oncology, Sunguc et al identified risks of adverse obstetric outcomes among female survivors of adolescent and young adult cancers in England and Wales. Study Details The...

Gynecologic Cancers

Sacituzumab Govitecan in Advanced Endometrial Cancer

As reported in the Journal of Clinical Oncology by Alessandro D. Santin, MD, and colleagues, findings in the endometrial cancer cohort of the phase II multicohort TROPiCS-03 trial indicated activity of the Trop-2–directed antibody-drug conjugate sacituzumab govitecan-hziy in pretreated patients...

Colorectal Cancer
Prostate Cancer
Pancreatic Cancer
Breast Cancer
Gynecologic Cancers
Issues in Oncology
Supportive Care

Common Blood Tests May Improve Early Cancer Diagnosis

The results of routine blood tests could be used to speed up cancer diagnoses among patients with abdominal symptoms, according to a recent study published by Rafiq et al in PLOS Medicine. Background Most patients who report symptoms of abdominal pain or bloating to their physicians are referred...

Gynecologic Cancers

FDA Expands Endometrial Cancer Indication for Dostarlimab-gxly With Chemotherapy

On August 1, the U.S. Food and Drug Administration (FDA) approved dostarlimab-gxly (Jemperli) with carboplatin and paclitaxel, followed by single-agent dostarlimab, for adults with primary advanced or recurrent endometrial cancer. Dostarlimab was previously approved in July 2023 with carboplatin...

Gynecologic Cancers
Global Cancer Care

In Remembrance of My Friend, Lyn Denny, MD, PhD: I Will Never Forget Her

I first met Lyn Denny, MD, PhD, in Ghana, in 2004, when she became the Secretary Treasurer of AORTIC and brought the organization back to life. We’ve been friends ever since. I equate Lyn’s unwavering dedication to bringing health equity to women in Africa to Nelson Mandela’s fight for social...

Gynecologic Cancers
Global Cancer Care

Gynecologic Oncologist Lynette Ann Denny, MD, PhD, Dies at Age 66

The global oncology and public health communities are mourning the death of Lynette Ann Denny, MD, PhD, a world-renowned gynecologic oncologist and a leading researcher in the prevention of cervical cancer in low-resource settings. Dr. Denny died on June 9, 2024, in Cape Town, South Africa, of...

Breast Cancer
Gynecologic Cancers
Issues in Oncology

Risk of Breast Cancer May Be Lower Within First 10 Years Following Ovarian Cancer Diagnosis

Patients with BRCA1- or BRCA2-mutated ovarian cancer may have a lower risk of developing breast cancer following treatment, according to a recent study published by Evans et al in Genetics in Medicine. Background Previous research has estimated that the risk of developing breast cancer by the age...

Genomics/Genetics
Breast Cancer
Gynecologic Cancers
Colorectal Cancer
Solid Tumors

Uncovering the Genetic Risk of Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome

Some patients with a genetic predisposition for cancer may not qualify for genetic screenings under the current guidelines, according to a recent study published by Samadder et al in JCO Precision Oncology. Researchers are investigating how to advance personalized medicine and tailor prevention and ...

Gynecologic Cancers

How Does Endometriosis Typology Influence Ovarian Cancer Risk?

In a Utah population–based cohort study reported in JAMA Network Open, Barnard et al found that women with ovarian endometriomas and/or deep-infiltrating endometriosis had a markedly increased risk of developing ovarian cancer. Those with such severe subtypes may represent an important population...

Gynecologic Cancers

Recurrent Cervical Cancer: Tisotumab Vedotin in Second- or Third-Line Therapy

As reported in The New England Journal of Medicine by Ignace Vergote, MD, PhD, and colleagues, interim analysis of the phase III innovaTV 301 trial has shown improved overall survival and other efficacy outcomes with the antibody-drug conjugate tisotumab vedotin-tftv vs investigator’s choice of...

Gynecologic Cancers

Endometrial Thickness in Triage for Endometrial Cancer Among Black Women

In a study reported in JAMA Oncology, Kemi Doll, MD, MSCR, and colleagues found that ultrasonography-measured endometrial thickness was not reliable in triage for diagnosing endometrial cancer among Black women. Study Details The retrospective U.S. multicenter study focused on data from 1,494 women ...

Gynecologic Cancers
Issues in Oncology

Exploring Health-Care Provider Attitudes Toward HPV Self-Collection Testing

Investigators found that more than 50% of health-care providers surveyed might offer human papillomavirus (HPV) self-collection testing to their patients if the U.S. Food and Drug Administration (FDA) approved the procedure, according to a recent study published by Fontenot et al in Women’s Health...

Gynecologic Cancers
Leukemia
Survivorship

Risk of Adverse Obstetric Outcomes in Adolescent and Young Adult Cancer Survivors

In an English and Welsh study (The Teenage and Young Adult Cancer Survivor Study) reported in The Lancet Oncology, Sunguc et al found that cervical cancer and leukemia survivors have a heightened risk of experiencing several serious obstetric complications. “Therefore, any pregnancy [in these...

Gynecologic Cancers

Estrogen Alone Increased Ovarian Cancer Incidence and Mortality, Combination Hormone Therapy Did Not

In 2002, the federally funded Women’s Health Initiative (WHI),1 a randomized, placebo-controlled clinical trial investigating menopausal hormone therapy for healthy menopausal women, was abruptly halted when it was determined that taking estrogen and progestin hormones after menopause increased the ...

Gynecologic Cancers

Retroperitoneal Lymphadenectomy: Can It Be Safely Omitted for Some Patients With Advanced Ovarian Cancer?

Adding retroperitoneal lymphadenectomy to cytoreductive surgery during primary debulking surgery or interval cytoreductive surgery after neoadjuvant chemotherapy failed to improve progression-free or overall survival in patients with advanced ovarian cancer who have no suspicious nodes, according...

Gynecologic Cancers

Mirvetuximab Soravtansine-gynx for FRα-Positive, Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

On March 22, 2024, mirvetuximab soravtansine-gynx (Elahere) was granted regular approval for adult patients with folate receptor–alpha (FRα)-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment...

Colorectal Cancer
Breast Cancer
Gynecologic Cancers
Prostate Cancer
Issues in Oncology

Study Evaluates Cancer Screening Behaviors Among a Population of Muslim Individuals

Investigators uncovered crucial insights into the cancer screening behaviors of a population of Muslim individuals residing in the Washington, DC, metropolitan area that could help illuminate the influence of cultural and religious beliefs on health practices, according to a recent study published...

Gynecologic Cancers

FDA Approves Two Immunochemotherapy Combinations for Endometrial Cancer

On June 17, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda) in combination with carboplatin and paclitaxel followed by single-agent pembrolizumab for adult patients with primary advanced or recurrent endometrial carcinoma; on June 14, the agency approved durvalumab...

gynecologic cancers

Stage IIIC High-Grade Serous Ovarian Cancer After Progression on Platinum-Based Therapy and PARP Inhibitor

This is Part 3 of Overcoming Platinum Resistance in Ovarian Cancer: New Strategies and Novel Targets, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kathleen Moore, Katherine Fuh, and Bhavana Pothuri discuss the treatment of advanced ovarian cancer after progression on both platinum-based therapy and a PARP inhibitor. The patient is a 72-year-old woman with a history of stage IIIC high-grade serous ovarian cancer diagnosed in 2019. Molecular profiling revealed that she is BRCA wild-type and HRD-positive. She was treated with neoadjuvant paclitaxel and carboplatin plus bevacizumab, followed by bevacizumab maintenance for 1 year. Twenty-four months after her last platinum-based therapy, she experienced disease recurrence with liver metastases. At the time of her recurrence, she was treated with carboplatin and pegylated liposomal doxorubicin for six cycles and had a partial response. She was then treated with maintenance olaparib for 12 months, experienced disease progression, and returned to carboplatin monotherapy. Unfortunately, after four cycles of carboplatin, her disease progressed again.   In the conversation that follows, the faculty discuss whether prior progression on a PARP inhibitor and platinum-based therapy influence their choice of therapy in the platinum-resistant setting, the role of HER2-targeting antibody-drug conjugates, and the importance of next-generation sequencing and testing for immunohistochemistry to better match patients to clinical trials.

gynecologic cancers

Stage IIIC High-Grade Serous Ovarian Cancer With Disease Progression After Platinum-Based Therapy

This is Part 2 of Overcoming Platinum Resistance in Ovarian Cancer: New Strategies and Novel Targets, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kathleen Moore, Katherine Fuh, and Bhavana Pothuri discuss the treatment of advanced ovarian cancer when progression of disease has occurred after platinum-based therapy. The patient is a 66-year-old woman with a history of stage IIIC high-grade serous ovarian cancer diagnosed in 2019. She was treated with primary cytoreductive surgery with no gross residual disease, followed by paclitaxel and carboplatin plus bevacizumab, and then bevacizumab maintenance for 1 year. She is BRCA wild-type and HRD-negative. Eighteen months after her last platinum, she experienced disease recurrence with abdominal disease and subsequently received carboplatin and pegylated liposomal doxorubicin plus bevacizumab for six cycles, achieving a partial response. Unfortunately, 5 months after her last platinum, she experienced disease recurrence again, with liver metastases and moderate ascites.   In the conversation that follows, the faculty discuss key biomarkers to look for when determining a patient’s treatment course, whether platinum-based therapy is ever warranted in the setting of platinum resistance, the role of folate receptor inhibitors, and new therapies on the horizon.

gynecologic cancers

Stage IV High-Grade Endometrioid Ovarian Cancer After Progression on Platinum-Based Therapy

This is Part 1 of Overcoming Platinum Resistance in Ovarian Cancer: New Strategies and Novel Targets, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kathleen Moore, Katherine Fuh, and Bhavana Pothuri discuss the treatment of advanced ovarian cancer with disease progression on platinum-based therapy. The patient is a 75-year-old woman with a history of stage IV high-grade endometrioid ovarian cancer diagnosed in 2020. She is BRCA wild-type. She was treated with neoadjuvant paclitaxel and carboplatin for three cycles and underwent successful interval cytoreductive surgery. She then received three additional cycles of paclitaxel and carboplatin and 1 year of niraparib maintenance, at which point she was found to have progressive disease. Following recurrence, she received carboplatin and pegylated liposomal doxorubicin plus bevacizumab for three cycles until her disease progressed again. She is now considered to be platinum-resistant.   In the conversation that follows, the faculty discuss patient-specific considerations when choosing therapy for platinum-resistant ovarian cancer, the importance of obtaining tissue for thorough biomarker evaluation to assess eligibility for clinical trials, and current standard of care options.

Gynecologic Cancers
Immunotherapy

LEAP-001: Study Misses Endpoints but Still Shows Benefit for Lenvatinib/Pembrolizumab in Endometrial Cancer Subsets

The highly anticipated ENGOT-en9/LEAP-001 trial in endometrial cancer has missed both its primary endpoints. At the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer, the study investigators reported no significant benefit in progression-free survival or overall survival...

Breast Cancer
Gynecologic Cancers
Issues in Oncology

Study Finds Early Menopause May Be Linked to Greater Risk of Breast and Ovarian Cancers

The risk of breast cancer and ovarian cancer may be increased in some women who experience early menopause, according to new findings presented by Welt et al at the Endocrine Society’s Annual Meeting & Exposition 2024. Primary ovarian insufficiency is a condition that occurs when a woman’s...

gynecologic cancers

Yukio Suzuki, MD, PhD, on Endometrial Cancer: Long-Term Survival Outcomes With Hormonal Therapy in Reproductive-Age Patients

Yukio Suzuki, MD, PhD, of Columbia University College of Physicians and Surgeons, discusses data showing that reproductive-age patients with early-stage endometrial cancer who use fertility-preserving hormonal therapy seemed to have good overall survival after a 10-year follow-up (Abstract 5508).

gynecologic cancers

Alex Andrea Francoeur, MD, on Endometrial Cancer and Obesity Trends

Alex Andrea Francoeur, MD, of UC Irvine Health, discusses data showing an association between the increasing incidence of endometrial cancer and obesity, which disproportionately affects younger women and women of color. According to Dr. Francoeur, the findings warrant targeted health services and public health interventions to stabilize and ultimately reverse the rising rates (Abstract 5507).

gynecologic cancers

Mostafa Eyada, MD, on Oral Cyclophosphamide Plus Bevacizumab in Recurrent Ovarian Cancer

Mostafa Eyada, MD, of The University of Texas MD Anderson Cancer Center, discusses study results showing that bevacizumab in combination with oral cyclophosphamide had a response rate of 40% in patients with recurrent platinum-resistant high-grade ovarian cancer (Abstract 5517).

gynecologic cancers

Jean-Marc Classe, MD, PhD, on Ovarian Cancer: New Data on Lymphadenectomy From the CARACO Trial

Jean-Marc Classe, MD, PhD, of France’s Nantes Université, discusses phase III results showing that systematic lymphadenectomy should be omitted in patients with advanced epithelial ovarian cancer with clinically negative lymph nodes, as well as those undergoing neoadjuvant chemotherapy and interval complete surgery (LBA5505).

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