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Masumi Ueda Oshima, MD, on, a Posttransplant GVHD Prophylaxis Strategy
Masumi Ueda Oshima, MD, of Fred Hutchinson Cancer Center, discusses findings from a phase II trial exploring the use of cyclosporine and sirolimus combined with mycophenolate mofetil or posttransplant cyclophosphamide as graft-vs-host disease (GVHD) prophylaxis.
John Magenau, MD, on Alpha-1-Antitrypsin for High-Risk Acute GVHD
John Magenau, MD, of the University of Michigan, presents results from the phase III BMT CTN 1705 trial, which explored the efficacy of alpha-1-antitrypsin (AAT) plus corticosteroids vs corticosteroids alone for the treatment of high-risk acute graft-vs-host disease (GVHD) following allogeneic hematopoietic stem cell transplant.
Kristina Maas-Bauer, MD, on ROCK1/2 Inhibition and GVHD
Kristina Maas-Bauer, MD, of the University of Freiburg, discusses preclinical research on the role of ROCK1/2 in graft-vs-host disease (GVHD), which found an effect on myeloid cells, both in phenotype profile and migration capabilities. Additionally, she discusses the potential of combining ROCK1/2 inhibitors with ruxolitinib for refractory GVHD.
Betty Hamilton, MD: Research Highlights in GVHD
Betty Hamilton, MD, of Cleveland Clinic, outlines key data from a clinical session she co-chaired on graft-vs-host disease (GVHD), including the role of JAK inhibitors in the prevention of the condition and novel therapies for the management of acute GVHD.
Case 3: Steroid-Refractory Chronic GVHD With Sclerosis
This is Part 3 of Treatment Sequencing Considerations for Chronic Graft-vs-Host Disease, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Corey Cutler, Betty K. Hamilton, and Hannah K. Choe discuss the management of steroid-refractory chronic graft-vs-host disease (GVHD) with sclerosis. Following 10 weeks of second-line therapy, the patient has now developed signs of sclerosis with fibrotic bands on the upper inner arms, muscle cramps, and shiny, hairless lower legs with an ulcer. In the conversation that follows, the faculty discuss sclerotic and fibrotic manifestations of chronic GVHD, new agents targeting the fibrosis pathways, and the management of bronchiolitis obliterans.
Case 2: Moderate Chronic GVHD
This is Part 2 of Treatment Sequencing Considerations for Chronic Graft-vs-Host Disease, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Corey Cutler, Betty K. Hamilton, and Hannah K. Choe discuss the management of moderate chronic graft-vs-host disease (GVHD). The case follows a patient previously treated with corticosteroids who received ruxolitinib for his steroid-refractory GVHD. Seven months after transplant, after being tapered off corticosteroids while on a small dose of ruxolitinib, he presents with new generalized achiness with full range of motion, dry mouth with oral sensitivity, and dry eyes. He is diagnosed with moderate chronic GVHD and begins treatment with prednisone at 0.5 mg/kg/d. At 8 weeks, his eye and mouth symptoms are better but not resolved, his muscle aches are unchanged, and he notes that he is developing some forearm and wrist tightening without functional limitation. In the conversation that follows, the faculty discuss second- and third-line treatment options for steroid-refractory chronic GVHD, the clinical data supporting the use of ruxolitinib or ibrutinib, and whether combination regimens are an option.
Case 1: Acute GVHD in a Patient With Lymphoma
This is Part 1 of Treatment Sequencing Considerations for Chronic Graft-vs-Host Disease, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Corey Cutler, Betty K. Hamilton, and Hannah K. Choe discuss the first-line treatment of acute graft-vs-host disease (GVHD). The patient is a 56-year-old man with a prior history of atrial fibrillation who presents with recurrent mantle cell lymphoma following autologous stem cell transplantation. While in remission following second-line intensive chemotherapy, he undergoes a peripheral blood stem cell transplant, receiving reduced-intensity conditioning and a posttransplant cyclophosphamide regimen with tacrolimus and mycophenolate mofetil for GVHD prevention. The transplant goes well, but on day 48 the patient presents with classic symptoms of grade 2 GVHD, with a maculopapular rash and a bilirubin of 3.1 mg/dL. In the conversation that follows, the faculty discuss front-line treatment options for acute GVHD, appropriate preventative regimens, and the clinical implications of the REACH2 trial.
Patient With Transfusion-Dependent Myelofibrosis and Severe Thrombocytopenia
This is Part 3 of Personalizing Therapy for Myelofibrosis, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Andrew Kuykendall, Anthony Hunter, and Stephen Oh discuss the management of a transfusion-dependent patient with myelofibrosis and severe thrombocytopenia. The patient is an 82-year-old man who presents with progressive decline. He has a hemoglobin of 6.8 g/dL, a platelet count of 48,000 cells/µL, WBC count of 4,000 cells/µL, and 2% circulating blasts. He is symptomatic and has mild splenomegaly. A bone marrow biopsy confirms primary myelofibrosis. Next-generation sequencing reveals JAK2, SRSF2, ASXL1, TET2, and RUNX1 mutations, and cytogenetics show deletion 7q. In the conversation that follows, the faculty discuss the symptoms in this case that drive their decision making, goals of therapy in patients with high-risk features, and current treatment options for cytopenic myelofibrosis.
Patient With Ruxolitinib-Treated Myelofibrosis Who Develops Anemia
This is Part 2 of Personalizing Therapy for Myelofibrosis, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Andrew Kuykendall, Anthony Hunter, and Stephen Oh discuss the management of a patient with myelofibrosis who develops anemia while on ruxolitinib. The patient is a 75-year-old woman who presents with night sweats, itching, and abdominal pain. Her hemoglobin is 10.1 g/dL, platelet count is 185,000 cells/µL, and WBC count is 9,000 cells/µL. Next-generation sequencing reveals CALR and TET2 mutations, and she has splenomegaly. She is diagnosed with primary myelofibrosis and, after initiating treatment with ruxolitinib, experiences a reduction in spleen length by palpation and significant symptom improvement. Two years later, although her symptoms remain well controlled on ruxolitinib, she develops progressive fatigue, anemia, and a reduced platelet count. In the conversation that follows, the faculty discuss how to differentiate disease-related anemia from treatment-related anemia, how they would approach the management of anemia in a patient like this, and the impact of switching JAK inhibitors on spleen and symptoms.
Patient With Newly Diagnosed Myelofibrosis and Moderate Anemia
This is Part 1 of Personalizing Therapy for Myelofibrosis, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Andrew Kuykendall, Anthony Hunter, and Stephen Oh discuss the first-line treatment of a newly diagnosed patient with myelofibrosis and moderate anemia. The patient is 62-year-old man who presents to his primary care physician with progressive abdominal pain, fatigue, and night sweats. He is found to have anemia, leukocytosis, and mild thrombocytopenia, and an abdominal ultrasound reveals splenomegaly. Bone marrow biopsy confirms primary myelofibrosis, and molecular testing reveals JAK2 and U2AF1 mutations. He has normal cytogenetics, and his EPO level is 42 mU/mL. In the conversation that follows, the faculty discuss the factors impacting this patient’s prognosis, how to develop a treatment plan, and the role of momelotinib in treating patients with myelofibrosis and anemia.
Justin Arnall, PharmD, BCOP, FCCP, on Complicating “Factors”: When Malignancy and Non-Malignant Hematology Collide
Justin Arnall, PharmD, BCOP, FCCP, of Atrium Health Specialty Pharmacy Service in Charlotte, North Carolina, discusses his JADPRO Live presentation on critical considerations when planning for cancer-related procedures in patients with hereditary/congenital as well as acquired bleeding disorders.
Erik Thiele Orberg, MD, PhD, on Recovery of the Intestinal Microbiome in Patients at Day +100 after Allogeneic Stem Cell Transplantation Is Defined by Microbial Metabolite Profiles and Linked to Long-Term Outcomes
Erik Thiele Orberg, MD, PhD, of University Hospital Regensburg, shares findings of a longitudinal, prospective study investigating microbial and metabolite recovery in the post-transplant period. He discusses how these findings could have significant implications for future microbiome-modulating therapies, leading to improved long-term outcomes (Abstract 780).
Hannah Choe, MD, on Dynamics of Overall and Organ-Specific Responses to Axatilimab in Chronic Graft-Versus-Host Disease: Analysis from the AGAVE-201 Study
Hannah Choe, MD, of The Ohio State University Comprehensive Cancer Center – James Cancer Hospital, reviews results from a secondary analysis of the phase 2 AGAVE-201 study, which assessed axatilimab, an anti-colony stimulating factor 1 receptor monoclonal antibody, in the setting of chronic graft-versus-host disease (cGVHD). Dr. Choe reports on findings from the secondary analysis, which assessed the timing/dynamics of clinical and symptom responses in patients with cGVHD with axatilimab in AGAVE-201 (Abstract 98).
Jenny Paredes, PhD, on How Increased Fiber Intake Results in Better Overall Survival and Lower GI-aGVHD in Allo-HCT Recipients and Pre-Clinical GVHD Models
Jenny Paredes, PhD, of City of Hope National Medical Center, discusses a study investigating the effects of dietary fiber on acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). The researchers evaluated a preclinical mouse model of GVHD with defined diet fiber concentrations and analyzed the dietary patterns of 173 allo-HCT patients (Abstract 259).
John O. Mascarenhas, MD, on Myelofibrosis: Novel Combination of Imetelstat Plus Ruxolitinib
John O. Mascarenhas, MD, of Icahn School of Medicine at Mount Sinai, discusses early results from the ongoing phase I/IB IMproveMF trial, which is evaluating the safety and activity of the novel combination of imetelstat and ruxolitinib in patients with intermediate- or high-risk myelofibrosis (Abstract 998).
John O. Mascarenhas, MD, on Relapsed/Refractory Myelofibrosis: Navtemadlin vs Best Available Therapy After JAK Inhibitor Treatment
John O. Mascarenhas, MD, of Icahn School of Medicine at Mount Sinai, discusses the results of the phase III BOREAS study evaluating the efficacy and safety of single-agent navtemadlin vs best available therapy in patients with relapsed/refractory myelofibrosis who had previously received JAK inhibitor therapy. Navtemadlin is a potent, selective, orally available MDM2 inhibitor that restores p53 function (Abstract 1000).
Nikolaos Katsivelos, MD, and John Levine, MD, MS, on How Serial Clinical and Biomarker Monitoring During Treatment Can Stratify Patients With Low-Risk GVHD
Nikolaos Katsivelos, MD, and John Levine, MD, MS, of Icahn School of Medicine at Mount Sinai report on an investigation into the potential for serial monitoring of graft-versus-host disease (GVHD) symptom severity and MAGIC algorithm probabilities in patients with clinical and biomarker-defined low-risk GVHD to further risk-stratify patients into clinically meaningful groups (Abstract 380).
Wendy Vogel, MSN, FNP, AOCNP, FAPO, on the Evolving Role of Advanced Practice Providers in Oncology Care
Wendy Vogel, MSN, FNP, AOCNP, FAPO, of the Advanced Practitioner Society for Hematology and Oncology, summarizes a panel discussion in which she took part, on forming interprofessional oncology care teams that include advanced practitioners. Such collaboration may improve patient outcomes and help practices work more efficiently.
Managing Treatment-Emergent Anemia in a Patient With Myelofibrosis
This is Part 1 of Addressing Unmet Needs in Myelofibrosis, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. John Mascarenhas, Gabriela Hobbs, and Abdulraheem Yacoub discuss the management of treatment-emergent anemia in a patient with myelofibrosis who is receiving ruxolitinib. The patient is a 77-year-old man with a history of polycythemia vera diagnosed 10 years ago and treated with hydroxyurea. He has now developed anemia, progressive splenomegaly, and drenching night sweats. On exam, he has temporal wasting and a spleen that is easily palpated 10 cm below the left costal margin. After undergoing bloodwork, bone marrow biopsy, and next-generation sequencing, he is diagnosed with intermediate-2 or high-risk myelofibrosis. He begins treatment with ruxolitinib at 20 mg twice daily, experiencing immediate resolution of symptoms; after 6 months of therapy, the spleen is no longer palpable, but his anemia has progressively worsened. In the conversation that follows, the faculty discuss treatment options to address anemia in patients with myelofibrosis who receive ruxolitinib, what data points might assist in decision making, understanding risk scores, and new therapies available in the second-line setting.
Andrew Srisuwananukorn, MD, on Myelofibrosis vs Essential Thrombocythemia: A Potential New Clinical Decision Tool
Andrew Srisuwananukorn, MD, of The Ohio State University Comprehensive Cancer Center, discusses a novel artificial intelligence model that can distinguish between prefibrotic primary myelofibrosis and essential thrombocythemia. This proposed model may assist clinicians in identifying patients who may benefit from disease-specific therapies or enrollment in clinical trials (Abstract 901).
Sara Khan, DO, on the Gender Gap in Receiving NIH Grants for Hematology Research
Sara Khan, DO, of the University of South Florida Morsani College of Medicine and HCA Healthcare, discusses her findings showing that women received only 33% of grants from the National Institutes of Health from 2012 to 2022 in nonmalignant hematologic research. Although some agencies have made strides in this area, others continue to have a significant gap. Identifying these areas of gender disparity will enable targeted efforts to bridge this gap and advance gender equality (Abstract 5113).
Potential Clinical Uses of Identifying New Hematologic Malignancy Predisposition Gene
Hamish S. Scott, PhD, and Chris Hahn, PhD, both of Australia’s SA Pathology and Centre for Cancer, discuss ERG, a new predisposition gene for bone marrow failure and hematologic malignancy. Identifying causal germline ERG variants has direct clinical implications for diagnosis, counseling, surveillance, and treatment strategies, according to Drs. Scott and Hahn (Abstract LBA5).
Mikkael A. Sekeres, MD, on Therapies for Hematologic Cancers: Is More or Less Better?
Mikkael A. Sekeres, MD, of the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, reviews key abstracts from ASH 2023 on treatment of myelofibrosis, chronic lymphocytic leukemia, large B-cell lymphoma, and acute myeloid leukemia (Abstracts 620, 631, 781, 425).
Nicholas J. Short, MD, on Acute Lymphoblastic Leukemia: New Analysis of Ponatinib and Blinatumomab
Nicholas J. Short, MD, of The University of Texas MD Anderson Cancer Center, discusses findings from a phase II study subgroup analysis that explored the question of whether ponatinib and blinatumomab, both active in Philadelphia chromosome–positive acute lymphoblastic leukemia, could offer an effective chemotherapy-free treatment for patients with newly diagnosed disease as well as reduce the need for allogeneic stem cell transplantation (Abstract S118).
Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease
Rami S. Komrokji, MD, of Moffitt Cancer Center, discusses an assessment of new classifications for myeloid neoplasms and the ongoing efforts to harmonize these classifications, so researchers can better understand risk, outcomes, and survival among patients with genetically distinct types of the disease.
Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin
Nigel Russell, MD, of Guy’s and St. Thomas’ NHS Foundation Trust, discusses the latest results from the AML19 trial, which showed the chemotherapy regimen FLAG-Ida (fludarabine, high-dose cytarabine, idarubicin, and granulocyte-colony stimulating factor), when combined with gemtuzumab ozogamicin, reduced levels of measurable residual disease and improved overall survival in patients with NPM1-mutated acute myeloid leukemia after induction therapy.
Matthew J. Frank, MD, PhD, on Large B-Cell Lymphoma: New Data on CD22 CAR T-Cell Therapy
Matthew J. Frank, MD, PhD, of Stanford University School of Medicine, discusses new findings showing that CD22 chimeric antigen receptor (CAR) T-cell therapy is an effective and safe salvage therapy for patients with CAR19-refractory large B-cell lymphoma. A multicenter phase II clinical trial is planned for 2023 (Abstract S230).
Jennifer R. Brown, MD, PhD, on CLL: Resistance to Pirtobrutinib in Pretreated Disease
Jennifer R. Brown, MD, PhD, of Dana-Farber Cancer Institute, discusses phase I/II findings from the Bruin study of resistance to pirtobrutinib in patients with covalent BTK inhibitor–pretreated chronic lymphocytic leukemia (CLL). The aim of the study was to explore the genomic evolution of resistance to this agent.
Goals of Care in Primary Myelofibrosis
This is Part 3 of Updates in Myeloproliferative Neoplasms, a three-part video roundtable series. In this video, Dr. Naveen Pemmaraju and Dr. Gabriela Hobbs discuss goals of care in primary myelofibrosis. The patient is a 27-year-old woman who presents to the clinic after 6 months of unintentional weight loss, night sweats, and fatigue. On physical exam, she has splenomegaly that is palpable at 7 cm below the left costal margin. Lab tests show anemia, leukocytosis, 1% circulating blasts in her peripheral blood, and high LDH. Bone marrow biopsy reveals marked reticulum fibrosis corresponding with MF-3 on the WHO histological grading, JAK V617F mutation, and diploid cytogenetics, and she is diagnosed with primary myelofibrosis. In the conversation that ensues, the faculty discuss initial treatment options for primary myelofibrosis, the role of JAK inhibitors, and how treatment goals are beginning to move beyond spleen and symptoms and to instead focus on disease modification. They review the current approved JAK inhibitors, as well as novel therapies and combinations that are on the horizon.
Deborah M. Stephens, DO, on CLL/SLL: NCCN Clinical Practice Guidelines in Oncology® Update
Deborah M. Stephens, DO, of the Huntsman Cancer Institute at the University of Utah, discusses NCCN’s updates to treatment recommendations for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Dr. Stephens details the key factors in selecting front-line and subsequent therapies, including IGHV status, del(17p)/TP53 mutation status, age, comorbidities, and resistance mutations.
Early Detection of Chronic Graft-vs-Host Disease
This is Part 1 of Clinical Considerations in Chronic Graft-vs-Host Disease, a two-part video roundtable series. In this video, Dr. Yi-Bin Chen and Dr. Mitchell E. Horwitz discuss the case of a 55-year-old man with FLT3-ITD–mutated acute myeloid leukemia in first complete remission who received a myeloablative peripheral blood stem cell transplantation from an unrelated donor. He receives myeloablative conditioning with busulfan plus fludarabine and graft-vs-host disease (GVHD) prophylaxis with tacrolimus plus methotrexate, and maintenance gilteritinib is started on day 30. On day 40, he presents with a stage 3 skin acute GVHD, which resolves after treatment with prednisone at 1 mg/kg/d. Prednisone and tacrolimus are both tapered and discontinued. However, on day 300, he presents to the transplant clinic with dry and irritated eyes; dry, sensitive mouth; and a sharkskin-like rash with painful sores, consistent with chronic GVHD. In the conversation that ensues, the faculty discuss the identification of chronic graft-vs-host disease, the importance of early detection, and the tools that can be used to facilitate the diagnosis of chronic graft-vs-host disease.
Myelofibrosis-Related Anemia
This is Part 2 of Updates in Myeloproliferative Neoplasms, a three-part video roundtable series. In this video, Dr. Srden Verstovsek and Dr. Abdulraheem Yacoub discuss the management of patients with anemia as a presenting symptom of myelofibrosis. The patient is a 68-year-old woman who presents to the clinic complaining of shortness of breath, fatigue, night sweats, and weight loss. During the physical exam, she is found to have an enlarged spleen. Presenting blood counts include a hemoglobin of 8.7 g/dL, hematocrit of 26.1%, white blood cell count of 22 x 109/L, and platelets of 122 x 109/L. She has 2% blasts in the peripheral blood, LDH of 1,780 U/L, and elevated erythropoietin of 35 mU/mL. Bone marrow biopsy reveals clusters of dysplastic megakaryocites with marked reticulin fibrosis, and she is positive for JAK2 V617F mutation, leading to a diagnosis of myelofibrosis. However, the patient is not interested in transplant at this time. In the conversation that ensues, the faculty discuss the current treatment options for myelofibrosis and how they might impact a patient’s quality of life, highlighting the role of JAK inhibitors in the management of myelofibrosis-related anemia.
Smita Bhatia, MD, MPH: Some Clonal Mutations May Predict Therapy-Related Myeloid Neoplasms
Smita Bhatia, MD, MPH, of the Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, discusses study findings that showed key somatic mutations in the peripheral blood stem cell product increases the risk of developing therapy-related myeloid neoplasms (Abstract 119).
Joseph Schroers-Martin, MD, on Posttransplant Lymphoproliferative Disorders: Tumor Microenvironment Determinants of Immunotherapy Response
Joseph Schroers-Martin, MD, of Stanford University, discusses immunogenomic features reflecting divergent biology in posttransplant lymphoproliferative disorders (PTLD). These include evidence of mismatch repair defects in Epstein-Barr virus–positive PTLD, tumor microenvironment depletion, and MYC pathway enrichment in certain patients (Abstract 72).
Managing the Risk of Thrombosis in Polycythemia Vera
This is Part 1 of Updates in Myeloproliferative Neoplasms, a three-part video roundtable series. Stay tuned for future installments in the coming months. In this video, Dr. Prithviraj Bose and Dr. Ruben Mesa discuss how best to manage the risk of thrombosis in patients with polycythemia vera. The patient is a 57-year-old man who presents to the clinic with frequent headaches and dizziness. A bone marrow biopsy is done and shows trilineage proliferation and pleomorphic megakaryocytes. Next-generation sequencing on the bone marrow reveals the JAK2 V617F mutation with allele burden of 65%. Presenting blood counts include a white blood cell count of 21,000/µL, hemoglobin of 22 g/dL, hematocrit of 66%, platelets of 650,000/µL, and a mean corpuscular volume of 72 fL. He is diagnosed with polycythemia vera and is prescribed aspirin at 81 mg/d with once-monthly phlebotomy for a goal hematocrit of < 45%. As they follow the case over 6 months, the faculty highlight the critical importance of maintaining strict hematocrit and white blood cell control to minimize the risk of thrombosis, and also discuss indications for cytoreductive therapy in patients both at high and low risk for thrombosis.
Leslie S. Kean, MD, PhD, on Bone Marrow Transplantation: Using Abatacept to Prevent Graft-vs-Host Disease
Leslie S. Kean, MD, PhD, of Dana-Farber/Boston Children's Cancer and Blood Disorders Center, discusses findings from her analysis of the International Blood and Marrow Transplant Research Database, which led to the recent FDA approval of abatacept for the prevention of acute graft-vs-host disease (GVHD) in adult and pediatric patients. The data suggest improved overall survival with the immunosuppressant abatacept in combination with a calcineurin inhibitor and methotrexate following 7/8 HLA–matched unrelated allogeneic hematopoietic stem cell transplantation (Abstract 3912).
Ronald S. Go, MD, on Managing Histiocytic Neoplasms: New NCCN Guidelines
Ronald S. Go, MD, of Mayo Clinic Cancer Center, discusses the new NCCN Clinical Practice Guidelines in Oncology for the most common types of histiocytic neoplasms in adults—Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease, all considered rare among hematologic cancers.
Alexey V. Danilov, MD, PhD, on Lymphoid Malignancies: Novel Agents Targeting BTK Inhibitor–Resistant Disease
Alexey V. Danilov, MD, PhD, of City of Hope, discusses the uses and side effects of cellular and immune therapies, including venetoclax and obinutuzumab, which may prove to be effective in treating highly resistant lymphoid malignancies such as chronic lymphocytic leukemia.
Jared E. Matya, PharmD, BCOP, on Supportive Therapies for Side Effects Related to Novel Oral Treatments
Jared E. Matya, PharmD, BCOP, of Nebraska Medicine, discusses oral agents and their toxicity profiles, as well as newer-generation agents that are often more selective and better tolerated. He describes how toxicity monitoring and management help to ensure patients with cancer remain on treatment.
Peihua (Peggy) Lu, MD, on CAR T-Cell Therapy: Research in China
Peihua Lu, MD, of Lu Daopei Hospital, discusses the state of research in China on CAR T-cell therapy, placing it in the context of the global development pipeline and the progress being made.
Ruben A. Mesa, MD, on Myelofibrosis, Transfusion Independence, and Momelotinib
Ruben A. Mesa, MD, of UT Health San Antonio Cancer Center, discusses new findings on momelotinib, a potent JAK1, JAK2, and ACVR1 inhibitor with clinical activity against hallmark features of myelofibrosis such as anemia and splenomegaly. Results showed that transfusion independence was associated with improved overall survival in patients who had received momelotinib (Abstract S202).
Claire Harrison, MD, DM, on Myelofibrosis: Fedratinib as First-Line Therapy After Prior Ruxolitinib
Claire Harrison, MD, of Guy’s and St. Thomas’ Hospital, discusses survival results from the JAKARTA and JAKARTA2 trials, which showed that fedratinib, an oral JAK2 inhibitor, significantly improved progression-free survival vs placebo as a first-line treatment for patients with myelofibrosis (Abstract S203).
Efstathios Kastritis, MD, on Amyloidosis: Standard of Care Plus Daratumumab
Efstathios Kastritis, MD, of the University of Athens, discusses updated phase III results from the ANDROMEDA study of patients with newly diagnosed light chain amyloidosis. The trial further supports the use of daratumumab plus VCd (bortezomib, cyclophosphamide, and dexamethasone), which was shown to be clinically superior to VCd alone (Abstract S189).
Lena E. Winestone, MD, MSHP, on Health-Care Disparities in Hematologic Cancers: Real-World Data
Lena E. Winestone, MD, MSHP, of the University of California, San Francisco and Benioff Children’s Hospital, reviews different aspects of bias in treatment delivery, including patient selection for clinical trials; racial and ethnic disparities in survival for indolent non-Hodgkin diffuse large B-cell lymphomas; and end-of-life hospitalization of patients with multiple myeloma, as well as outcome disparities (Abstracts 207-212).
Jyoti Nangalia, MBBChir, on MPN: A New Paradigm for the Development of Blood Cancer?
Jyoti Nangalia, MBBChir, of Wellcome Sanger Institute and the University of Cambridge, discusses how her team used large-scale whole-genome sequencing to precisely time the origins of a blood cancer and measure how it grew. The information could provide opportunities for early diagnosis and intervention (Abstract LBA-1).
Radhika Gangaraju, MD, and Smita Bhatia, MD, MPH, on Coronary Heart Disease Risk in Blood or Marrow Transplant Survivors
Smita Bhatia, MD, MPH, and Radhika Gangaraju, MD, both of the Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, discuss findings that showed survivors of bone marrow transplants are at a 7- to 12-fold higher risk of coronary heart disease than a sibling comparison group. They recommend aggressive management of cardiovascular risk factors to prevent morbidity from heart disease in this patient population (Abstract 73).
Miguel-Angel Perales, MD, and Syed A. Abutalib, MD, on Bone Marrow Transplants During the COVID-19 Pandemic
Syed A. Abutalib, MD, of Cancer Treatment Centers of America, talks with Miguel-Angel Perales, MD, of Memorial Sloan Kettering Cancer Center, about the challenges and concerns related to transplants for patients with hematologic malignancies who are particularly vulnerable to infection with the coronavirus. Recorded July 13, 2020.
Mehdi Hamadani, MD: In My Experience Question 4
How have the activities of the Center for International Blood and Marrow Transplant Research been affected by the COVID-19 pandemic? Recorded April 21, 2020.
William A. Wood, MD, MPH, on the New ASH Research Collaborative Data Hub COVID-19 Registry for Hematologic Malignancy
William A. Wood, MD, MPH, of the University of North Carolina at Chapel Hill, and Oversight Group Chair for the new COVID-19 registry, talks about why it was formed, how it can help patients and providers, and how it operates and could evolve in the future. Filmed April 3, 2020.
