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Your search for Susan Reckling,Susan Reckling matches 71 pages
Showing 51 - 71Improved Overall Survival With Primary Over Consolidation Intraperitoneal Chemotherapy After Optimal Cytoreduction for Advanced Ovarian Cancer
Compared with intravenous (IV) followed by consolidation intraperitoneal (IP) chemotherapy, primary IV/IP chemotherapy was associated with a statistically significant improvement in overall survival—but not progression-free survival—in patients with advanced epithelial ovarian cancer...
First Surveillance Imaging at 6 Months May Be Adequate for Most Patients After Treatment for Early-Stage Non‒Small Cell Lung Cancer
Early surveillance imaging (< 6 months) after stereotactic body radiation therapy for early-stage non–small cell lung cancer (NSCLC) seems to be of limited benefit, resulting in definitive intervention in only 3% of patients, according to the findings of a study in Practical Radiation...
Noninvasive Image Texture Analysis May Provide Tumor Heterogeneity Information With Prognostic Potential in NSCLC
Noninvasive quantitative computed tomography–based texture analysis can accurately differentiate the presence of a KRAS mutation from pan–wild-type non–small cell lung cancer (NSCLC), based on the results of a study in PLOS ONE. Weiss et al reported that this tumor heterogeneity...
Preclinical Study Reveals Heparan Sulfate Suppresses Growth of Neuroblastoma
A heparin derivative differentiated cancer cells and caused neuroblastomas to regress without causing severe bleeding, according to the findings of a preclinical study presented in The Journal of Clinical Investigation. Knelson et al identified novel roles for heparan sulfate proteoglycans in...
Similar Survival Rates, Less Toxicity Reported With Reduced-Intensity vs Myeloablative Total-Body Irradiation Before Transplant in Acute Leukemia
Used as a conditioning regimen for allogeneic transplantation in patients with acute leukemia, reduced-intensity total-body irradiation yielded similar overall and relapse-free survival rates to those seen with myeloablative total-body irradiation but with shorter hospital stays and fewer intensive ...
Study Reveals Long-Term Benefits With Prone Hypofractionated Radiation Therapy and a Concurrent Boost in Early-Stage Breast Cancer
Prone accelerated intensity-modulated radiation therapy with a concomitant boost produced excellent local tumor control and cosmesis while sparing normal tissues in women with early-stage breast cancer, according to the 5-year study results reported by Osa et al in the International Journal of...
Palliative Resection of Primary Tumor May Improve Survival in Patients With Metastatic Colorectal Cancer
Palliative resection of the primary tumor was associated with a statistically significant and clinically meaningful improvement in overall survival in patients with metastatic colorectal cancer, according to the results of a study reported in the Annals of Surgical Oncology. Gresham et al noted...
Initial Treatment of Ductal Carcinoma in Situ May Affect Subsequent Treatment of Tumor Recurrences After Surgery
The use of radiotherapy for the index ductal carcinoma in situ (DCIS) may affect subsequent treatment of tumor recurrences and complications after breast-conserving surgery, reported Greenberg et al in the Annals of Surgical Oncology. Based on the results of this retrospective cohort study, the...
Proactive Patient-Centered Program May Reduce the Risk of Lymphedema in Survivors of Breast Cancer
A patient-centered educational and behavioral program focusing on self-care strategies appears to be an effective way to reduce the risk of lymphedema in survivors of breast cancer, according to the results of a prospective study by Fu et al at New York University. These findings, reported in the...
More Toxicity Associated With Addition of Sorafenib to Yttrium-90 Radioembolization Prior to Liver Transplantation
The addition of sorafenib (Nexavar) to yttrium-90 radioembolization was associated with higher rates of biliary complications and potentially more acute rejections prior to transplantation in patients with hepatocellular carcinoma, according to the results of a prospective randomized pilot study....
Newly Created Risk Stratification Database Aids in Predicting Outcomes in Prostate Cancer
The pan-Canadian Prostate Cancer Risk Stratification database was created to report on the patient, tumor, and treatment factors that were predictive of biochemical and clinical outcomes in patients who underwent radiotherapy for prostate cancer. Risk stratification in the management of those with...
Unfavorable Prognosis in Advanced Serous Ovarian Cancer May Be Linked to Estrogen Receptor Beta Isoform
Anomalies in the cytoplasmic expression of estrogen receptor beta 2 appear to be associated with poorer outcomes in patients with advanced serous ovarian cancer, according to the results of a study reported by Ciucci et al in Gynecologic Oncology. This isoform may represent an independent...
Sentinel Lymph Node Biopsy Associated With Survival Advantage in Merkel Cell Carcinoma
In patients with Merkel cell carcinoma, sentinel lymph node biopsy was shown to be associated with improved survival, according to the results of a retrospective study reported by Kachare et al in the Annals of Surgical Oncology. Thus, sentinel lymph node biopsy offers prognostic information that...
Wider Surgical Margins Do Not Appear To Reduce Local Recurrence Rates in Triple-Negative Breast Cancer
Wider surgical margins did not reduce the rate of local recurrence in women with triple-negative breast cancer treated with breast-conserving therapy, according to the results of a study published in the Annals of Surgical Oncology. Pilewskie et al reported that their data support the definition of ...
Nonsignificant Reduction in Breast Cancer Risk Seen With Low-Dose Tamoxifen in Postmenopausal Hormone Replacement Therapy Users
In postmenopausal women receiving hormone replacement therapy, low-dose tamoxifen did not significantly reduce the risk of breast cancer but did increase climacteric symptoms, according to the phase III study results presented by DeCensi et al in the Annals of Oncology. However, beneficial trends...
Grade 3 Endometrioid Carcinoma With PIK3CA Mutation Linked to Unfavorable Outcome
The presence of PIK3CA missense mutation appears to be associated with shorter disease-specific survival in grade 3 endometrioid but not serous endometrial carcinoma, according to a study in Gynecologic Oncology. Although McIntyre et al found this type of mutation across all histologic types of...
Hypercholesterolemia May Drive the Growth of Breast Cancer
High levels of the cholesterol metabolite 27-hydroxycholesterol seem to function like estrogen and may independently drive the growth of breast cancer, according to the findings of a preclinical study by Nelson et al published in Science. They also found a possible connection between...
Estrogen Levels Affect the Efficacy of PARP Inhibitors in PTEN-Deficient Endometrial Tumors
PARP inhibition appears to be an effective way to shrink PTEN-deficient endometrial tumors with low levels of estrogen but is ineffective in those with high levels of estrogen, according to preclinical study results reported by Janzen et al in Molecular Cancer Therapeutics. The findings suggest...
Internet-Based Intervention Improves Cancer-Related Sexual Dysfunction in Women
An Internet-based intervention may significantly improve both sexual function and satisfaction in women with sexual dysfunction years after treatment for breast or gynecologic cancer, according to a randomized trial reported in the November issue of the Journal of the National Comprehensive Cancer...
Timing and Choice of Treatment May Affect the Quality of Life of Young Breast Cancer Survivors
The choice and timing of therapeutic interventions may significantly affect the quality of life of young breast cancer survivors in the short term, although other quality-of-life domains such as family relationships may not be negatively impacted after treatment. These findings were reported by...
Assay-Sensitive Treatment Improves Outcomes in Recurrent Ovarian Cancer
The use of assay-sensitive treatment significantly improved both progression-free survival and overall survival compared with nonsensitive treatment in women with recurrent ovarian cancer, according to the results of a prospective clinical trial reported in Gynecologic Oncology. Thomas Rutherford,...
