Sherene Loi, MD, PhD, on Early-Stage Breast Cancer: Weighing the Prognostic Value of ctDNA Detection
2024 ASCO Annual Meeting
Sherene Loi, MD, PhD, of Peter MacCallum Cancer Centre, discusses a circulating tumor DNA (ctDNA) analysis from a cohort of patients with early-stage breast cancer who were enrolled in the monarchE trial. This large cohort was studied to look at the usefulness of a personalized tumor-informed assay for ctDNA detection in early stage high-risk patients (LBA507).
Transcript
Disclaimer: This video transcript has not been proofread or edited and may contain errors.
The monarchE study was a trial which was looking specifically a high-risk node-positive estrogen receptor positive early-stage breast cancer patients. We know that these patients have an extremely high risk of recurrence, particularly those that have four or more nodes or larger tumors with one to three positive nodes or high grade. The monarchE study showed the benefit of two years of adjuvant abemaciclib when added to endocrine therapy. In this particular study, we looked at 910 patients from the monarchE study. These patients were cross-treatment arms, and this group was enriched for invasive disease events. This is because we wanted to look at the sensitivity of the assay. The assay's tumor-informed, which means whole exome sequencing was performed on the primary tumor, and then each assay was designed specifically for the individual patient using that information. Patients had blood samples taken at baseline, so prior to treatment, or at three, six, or at the end of 24 months of treatment.
What we found in these 910 patients was that the detection of ctDNA positivity at baseline occurred in about 8% of patients. This is a very low frequency of patients had positive ctDNA by this assay compared to the 27% of patients who had events that was enriched in this study. This was despite a high-risk population. What we did find, however, that serial sampling was very informative. Some patients that were undetectable at baseline became detectable. This was a further 10% of patients, so around 17% of patients of the 27% of patients who had an event were picked up by this assay.
Of most interest was the patients that were negative or undetectable at baseline that became positive. We know that they did poorly actually. Most of these patients recurred, 100% of patients recurred. There were patients that were positive at baseline that remained positive. Those patients also did poorly, 100% rates. Of most interest to me were the patients who were positive at baseline, but then became undetectable using serial sampling. These patients had a better outcome than those patients who remained positive by the ctDNA. This suggests that the treatment was having an effect on the disease, perhaps curing some patients. This suggests that clearance of ctDNA may be a useful surrogate endpoint for evaluation of future therapies in the future or in future clinical trials. Our data also suggests that patients who are positive for ctDNA at baseline and remain positive have very aggressive disease and are resistant to treatment and in the future will need some sort of rethink or different types of therapy quite early on.
The ASCO Post Staff
Omid Hamid, MD, of The Angeles Clinic and Research Institute, a Cedars-Sinai affiliate, discusses updated data on IMC-F106C, a novel bispecific protein that, in a phase I safety and efficacy study, exhibited clinical activity in patients with unresectable or metastatic cutaneous melanoma who were pretreated with immune checkpoint inhibitors. A phase III trial of IMC-F106C with nivolumab in the first-line setting of metastatic disease has been initiated (NCT06112314; Abstract 9507).
The ASCO Post Staff
Tony S.K. Mok, MD, of The Chinese University of Hong Kong, discusses phase III findings from the KRYSTAL-12 study, which showed that adagrasib improved progression-free survival and overall response rate over docetaxel in patients with locally advanced or metastatic non–small cell lung cancer harboring a KRAS G12C mutation who had previously received a platinum-based chemotherapy with anti–PD-(L)1 treatment.
The ASCO Post Staff
Heather Wakelee, MD, of Stanford University Medical Center, discusses phase III findings showing that the disease-free survival benefit with adjuvant atezolizumab continues to translate into a positive overall survival trend vs best supportive care in patients with stage II–IIIA non–small cell lung cancer (NSCLC). These results further support the use of adjuvant atezolizumab in PD-L1–selected populations, according to Dr. Wakelee (LBA8035).
The ASCO Post Staff
Pierfranco Conte, MD, of the University of Padua, discusses phase III findings from the A-BRAVE trial, which was designed to evaluate the efficacy of avelumab, an anti–PD-L1 antibody, as adjuvant treatment for patients with early-stage triple-negative breast cancer who are at high risk (LBA500).
The ASCO Post Staff
Jonathan E. Rosenberg, MD, of Memorial Sloan Kettering Cancer Center, and Thomas Powles, MD, PhD, of Barts Cancer Institute and the University of London, discuss phase III findings from two studies: the first, investigating enfortumab vedotin-ejfv and pembrolizumab vs platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic urothelial cancer; and the second, looking at nivolumab plus gemcitabine and cisplatin vs gemcitabine and cisplatin alone in patients with lymph node–only metastatic disease enrolled in the CheckMate 901 trial (Abstracts 4581 and 4565).