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solid tumors
prostate cancer

Decreased Mortality for Men With Unfavorable-Risk Prostate Cancer and Moderate or Severe Comorbidities Treated With Radiotherapy Alone

Men with unfavorable-risk prostate cancer and moderate or severe comorbidities had significantly decreased overall and cardiac mortality when treated with radiotherapy alone vs radiotherapy and androgen-deprivation therapy, according to a study described in a research letter in JAMA. In the letter, ...

prostate cancer

Addition of Docetaxel to Androgen-Deprivation Therapy Improves Survival in Metastatic Prostate Cancer

In the phase III E3805 trial reported in The New England Journal of Medicine, Sweeney et al found that chemohormonal therapy with docetaxel plus androgen-deprivation therapy produced a significant 13.6-month increase in median overall survival vs androgen-deprivation therapy alone in men with...

breast cancer
prostate cancer

Packaging Paclitaxel in Nanoparticles May Increase Drug Efficacy in Preclinical Models

Duke University researchers found that packaging the widely used cancer drug paclitaxel into nanoparticles more than doubled the drug’s effectiveness in destroying tumors in preclinical models. Their findings were published by Bhattacharyya et al in Nature Communications. Paclitaxel has been ...

issues in oncology
prostate cancer

Biomarker Signature May Predict Aggressive Disease in African American Men With Prostate Cancer

In a study reported in Journal of Clinical Oncology, Yamoah et al identified a biomarker signature that may predict aggressive disease in African American men with prostate cancer. Study Details In the study, distribution of mRNA expression levels of 20 biomarkers associated with prostate cancer...

lung cancer
prostate cancer
issues in oncology

Long Telomere Length Associated With Increased Lung Cancer Risk

A large-scale genetic study of the links between telomere length and risk for five common cancers found that long telomeres are associated with an increased risk of lung adenocarcinoma. No significant associations between telomere length and other cancer types or subtypes were observed. The study,...

solid tumors
pancreatic cancer
prostate cancer
bladder cancer

Analysis Suggests Use of Pioglitazone for Diabetes May Increase Risk of Prostate and Pancreatic Cancers But Not Bladder Cancer

Available data suggest an increased risk of bladder cancer with pioglitazone treatment for diabetes. In an analysis of Kaiser Permanente Northern California data reported in JAMA, Lewis et al found no significantly increased risk of bladder cancer in patients with diabetes ever using pioglitazone....

prostate cancer

Dose-Escalated EBRT Yields Survival Benefit in Intermediate- and High-Risk but Not Low-Risk Nonmetastatic Prostate Cancer

In a retrospective study reported in JAMA Oncology, Kalbasi et al found that dose-escalated external-beam radiation therapy was associated with improved overall survival among men with intermediate- and high-risk, but not low-risk, nonmetastatic prostate cancer. Study Details The study involved...

prostate cancer
issues in oncology
issues in oncology

Risk-Appropriate Therapies Now Commonplace in Prostate Cancer Treatment

After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at the University of California, San...

pancreatic cancer
prostate cancer

Study Identifies Mechanism Fueling Growth of Pancreatic and Prostate Cancer Cells

UCLA Jonsson Cancer Center scientists have identified a new mechanism that delivers a key substance that fuels the growth of pancreatic and prostate cancer cells, a finding that offers new hope in the fight against two of the deadliest forms of the disease. Their findings were published by...

prostate cancer
issues in oncology

DNA Repair Kinase Identified as Key Driver of Metastasis in Prostate Cancer

Researchers at Thomas Jefferson University reported finding a single molecule that appears to be the central regulator driving metastasis in prostate cancer. The study, published by Goodwin et al in Cancer Cell, offers a target for the development of a drug that could prevent metastasis in prostate ...

prostate cancer
issues in oncology
issues in oncology

Study Finds Significant Drop in New Prostate Cancer Diagnoses

A new study led by Vanderbilt University Medical Center investigators found new diagnoses of prostate cancer in the United States declined 28% in the year following the draft recommendation from the U.S. Preventive Services Task Force (USPSTF) against routine prostate-specific antigen (PSA)...

prostate cancer

Statin Use at Start of Androgen-Deprivation Therapy Increases Time to Progression During Androgen-Deprivation Therapy in Prostate Cancer

Statin use has been associated with improved outcome in prostate cancer. In a study reported in JAMA Oncology, Harshman et al found that statin use at the time of initiation of androgen-deprivation therapy was associated with prolonged time to progression during androgen-deprivation therapy in men...

prostate cancer
issues in oncology

Transient Adverse Quality-of-Life Impact of Radiotherapy Added to Androgen-Deprivation Therapy in Locally Advanced Prostate Cancer

In a study reported in the Journal of Clinical Oncology, Brundage et al found that the addition of radiotherapy to androgen-deprivation therapy in patients with locally advanced prostate cancer in the NCIC CTG PR3/MRC PR07 trial had a transient negative impact on health-related quality of life over ...

palliative care
issues in oncology
prostate cancer
issues in oncology
cost of care

Chemotherapy May Be Preferred Option for Some With Advanced Prostate Cancer

In a small clinical trial, scientists at Johns Hopkins Kimmel Cancer Center and James Buchanan Brady Urological Institute found that men with advanced prostate cancer and detection of androgen receptor splice variant-7 (AR-V7) respond to chemotherapy just as well as men who lack the variant. The...

prostate cancer

National Cancer Data Base Analysis Indicates Survival Benefit of Adding Radiotherapy to ADT in Clinically Node-Positive Prostate Cancer

In an analysis reported in the Journal of the National Cancer Institute, Lin et al found that the addition of radiotherapy to androgen-deprivation therapy was associated with a significant improvement in overall survival in patients with clinically node-positive prostate cancer. Study Details The ...

issues in oncology
prostate cancer
issues in oncology
issues in oncology

Whole-Exome Sequencing Identifies Biologically Informative Alterations in the Majority of Metastatic Cancers

In a study reported in JAMA Oncology, Beltran et al found that whole-exome sequencing of metastatic and treatment-resistant cancers revealed biologically informative alterations in the majority of cases. Although treatment recommendations could be made in the majority of cases, treatment was guided ...

prostate cancer
supportive care
issues in oncology
issues in oncology

Study Supports Early Intervention for Prostate Cancer Patients Who Experience Significant Emotional Distress

A study led by the University at Buffalo (UB) and Roswell Park Cancer Institute (RPCI) has identified beliefs and personality traits associated with higher levels of distress in patients with newly diagnosed prostate cancer. The findings support the value of emotional and informational support for...

prostate cancer

French Trial Shows Addition of Docetaxel and Estramustine to ADT Improves Relapse-Free Survival in High-Risk Localized Prostate Cancer

In a French phase III trial (GETUG 12) reported in The Lancet Oncology, Fizazi et al found that the addition of docetaxel and estramustine (Emcyt) to androgen-deprivation therapy (ADT) improved relapse-free survival among patients with high-risk localized prostate cancer. Study Details In the...

prostate cancer

Men With Asthma Less Likely to Develop Lethal Prostate Cancer

A recent analysis of a large observational study has revealed that men with a history of asthma are less likely than those without it to develop lethal prostate cancer, researchers at Johns Hopkins reported. These findings were published by Platz et al in the International Journal of Cancer....

prostate cancer

ASCO 2015: First Effective Adjuvant Chemotherapy for High-Risk, Localized Prostate Cancer

“For the first time, improvement in overall survival was observed with tolerable adjuvant chemotherapy for localized, high-risk prostate cancer,” Howard Sandler, MD, Professor of Radiation Oncology at Cedars-Sinai Medical Center in Los Angeles, announced at a press briefing at the...

issues in oncology
prostate cancer

Study Finds Prostate Cancer Survivors Who Maintained a Western Diet Had an Increased Risk of Death

A large study evaluating the relationship of dietary patterns with prostate cancer–specific and all-cause mortality among men diagnosed with nonmetastatic prostate cancer has found that the men who ate a Western-style diet of foods rich in processed meats, red meats, and high-fat dairy...

prostate cancer

Multimodal Therapy Benefits Men With Prostate Cancer Experiencing Biochemical Recurrence After Local Therapy

In men who experience biochemical disease recurrence after local therapy for prostate cancer, docetaxel, bevacizumab (Avastin), and androgen-deprivation therapy may be beneficial, according to a study by McKay et al in Cancer. Further evaluation of this combination treatment is warranted to...

prostate cancer

Obesity Poses Greater Prostate Cancer Risk for African American vs White Men

In an analysis of participants in the SELECT prevention trial reported in JAMA Oncology, Barrington et al found that obesity in African American men was associated with a greater risk of prostate cancer than in white men. African American men have the highest prostate cancer incidence and mortality ...

prostate cancer
issues in oncology

AUA 2015: Studies Evaluate Effectiveness of Active Surveillance in Prostate Cancer Patients

Active surveillance has become a viable option for many men with low-risk prostate cancer who choose not to undergo active treatment such as surgery or radiotherapy. Four studies evaluating effectiveness, trends, and other considerations for active surveillance in managing prostate cancer were...

prostate cancer
issues in oncology

AUA 2015: New Studies Call for Smarter Approach to Prostate Cancer Screening

Prostate cancer is one of the most common cancers in American men, yet controversy over the utilization and frequency of prostate-specific antigen (PSA) screening methods remains, due to the overdiagnosis and overtreatment of men with low-grade, less-aggressive forms of the disease. At the 110th...

issues in oncology
prostate cancer
issues in oncology

Urine-Based Test Improves on PSA for Detecting Prostate Cancer

A new urine-based test improved prostate cancer detection—including detecting more aggressive forms of prostate cancer—compared to traditional models based on prostate-specific antigen (PSA) levels. The results were published by Tomlins et al in European Urology. The test, developed at ...

breast cancer
gynecologic cancers
colorectal cancer
gynecologic cancers
prostate cancer
issues in oncology

American College of Physicians Offers Advice on High-Value Screening in Five Cancers

To provide guidance on high-value cancer care screening strategies, the American College of Physicians (ACP) recently reviewed clinical guidelines issued by various medical organizations for screening strategies in five common cancers for asymptomatic, average-risk adults. The five cancers focused...

prostate cancer
issues in oncology
issues in oncology
issues in oncology

Androgen-Deprivation Therapy May Lead to Cognitive Impairment in Prostate Cancer Patients

Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. This side effect, when occurring with chemotherapy, is commonly referred to as “chemobrain.” Signs of cognitive impairment...

palliative care
prostate cancer

ASCO 2015: Adding Chemotherapy to Initial Therapy Improves Survival in Patients With Advanced, Hormone-Naive Prostate Cancer

The UK-led STAMPEDE trial found that adding docetaxel chemotherapy to standard hormone therapy markedly improved survival for men with newly diagnosed advanced prostate cancer not previously treated with hormone therapy (hormone-naive). Men who received docetaxel plus standard therapy lived on...

prostate cancer
issues in oncology

Enzalutamide Improves Patient-Reported Outcomes and Time to Skeletal-Related Event vs Placebo in PREVAIL Trial

The PREVAIL trial showed that enzalutamide (Xtandi) improved overall survival and progression-free survival vs placebo in asymptomatic/minimally symptomatic chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In analyses reported in The Lancet Oncology, Loriot et al...

prostate cancer

Use of Radiotherapy After Prostate Cancer Surgery Declining, Despite Evidence of Benefit

Despite strong evidence and guidelines supporting its use, postsurgical radiation therapy for prostate cancer patients at risk of tumor recurrence is declining in the United States. The study, published by Sineshaw et al in European Urology, finds fewer than 10% of patients at risk of tumor...

hepatobiliary cancer
lymphoma
prostate cancer
kidney cancer

Cancer Rates Significantly Increased Among Patients With Hepatitis C

Results presented on April 24 at The International Liver Congress 2015 (Abstract O058) in Vienna, Austria, show that cancer rates in patients with the hepatitis C virus (HCV) were significantly increased compared to the non-HCV cohort. The researchers suggest an extrahepatic manifestation of HCV...

prostate cancer

No Improvement in Undetectable PSA Rate With Cixutumumab Plus Androgen-Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer

In a randomized phase II trial (SWOG S0925) reported in the Journal of Clinical Oncology, Yu et al found that the addition of cixutumumab to androgen-deprivation therapy did not significantly increase the rate of undetectable prostate-specific antigen (PSA) in patients with newly diagnosed...

breast cancer
gynecologic cancers
prostate cancer
issues in oncology
solid tumors

AACR 2015: New PARP Inhibitor Combination Shows Early Promise for a Wide Range of Cancer Patients

A combination of two molecularly targeted drugs, olaparib (Lynparza) and the investigational agent AZD5363, was safe and yielded responses in patients with a variety of cancer types, including breast, ovarian, and prostate cancers, regardless of BRCA1/2-mutation status, according to data from the...

prostate cancer
issues in oncology

AACR 2015: Subgroup of Men With Metastatic Prostate Cancer Respond to Olaparib Treatment

Men with metastatic, castration-resistant prostate cancer who had mutations in genes linked to repair of damaged DNA were significantly more likely to respond to treatment with olaparib (Lynparza) compared with patients who had the disease without these mutations. These findings from the first...

prostate cancer
issues in oncology
issues in oncology
issues in oncology
cost of care

Study Examines Impact of Hospital Volume on Complication Rates in Patients Undergoing Robotic Prostate Surgery

A disincentive for hospitals that have invested in expensive technology for robotic surgery may be jeopardizing prostate cancer patients who seek out the procedure, concluded a study published by Sammon et al in BJU International. The study compared complication rates in hospitals with low...

issues in oncology
prostate cancer
issues in oncology

Obesity Significantly Increases Prostate Cancer Risk in African American Men

Obesity in black men substantially increased the risk of low- and high-grade prostate cancer, whereas obesity in white men moderately reduced the risk of low-grade cancer and only slightly increased the risk of high-grade cancer, according to the first large, prospective study to examine how race...

colorectal cancer
prostate cancer
survivorship
issues in oncology

Physical Activity Helps Cancer Survivors Fend Off Side Effects

Three or more hours of walking per week can boost the vitality and health of prostate cancer survivors. Men and women who have survived colorectal cancer and are regular walkers also reported lower sensations of burning, numbness, tingling, or loss of reflexes that many often experience after...

prostate cancer

Circulating Tumor Cell Count and LDH Level as Patient-Level Surrogate for Survival in Metastatic Castration-Resistant Prostate Cancer

In an analysis reported in the Journal of Clinical Oncology, Scher et al found that circulating tumor cell count and LDH level served as an individual-level surrogate for survival among patients with metastatic castration-resistant prostate cancer receiving abiraterone acetate (Zytiga) plus...

breast cancer
prostate cancer

Regional-Level Correlation of Inappropriate Prostate Imaging and Inappropriate Breast Imaging

In a study reported in JAMA Oncology, Makarov et al found that hospital referral regions marked by higher rates of inappropriate imaging in patients with low-risk breast cancer also had high rates of inappropriate prostate imaging in patients with low-risk prostate cancer. Inappropriate imaging...

breast cancer
colorectal cancer
lung cancer
prostate cancer
issues in oncology
issues in oncology

Asian Americans Have Better Cancer-Specific Mortality Than Non-Hispanic Whites

Numerous studies have documented racial differences in deaths from cancer among non-Hispanic whites and African Americans, but little has been known about survival outcomes for Asian Americans who have been diagnosed with cancer. In a new study published in the Journal of the National Cancer...

prostate cancer

Gonadotropin-Releasing Hormone Agonist Treatment and Orchiectomy Linked to Increased Risk of Cardiovascular Disease in Men With Prostate Cancer

In a study of Swedish men with prostate cancer reported in the Journal of Clinical Oncology, O’Farrell et al found that use of gonadotropin-releasing hormone (GnRH) agonists and orchiectomy were associated with a significantly increased risk of incident cardiovascular disease. In patients...

prostate cancer

Younger Men Who Survive 10 Years After Radical Prostatectomy Are More Likely to Die of Non–Cancer-Related Causes

A new study suggests that after radical prostatectomy for high-risk prostate cancer, both the age of the patient and the time survived since the operation have a significant impact on the cause of death. This means that, for young men with high-risk prostate cancer, doctors may have to reevaluate...

prostate cancer

Low Nadir Testosterone in First Year of Hormone Therapy Linked to Improved Cause-Specific Survival and Delay of Hormone Resistance in Prostate Cancer

In an analysis from the PR-7 trial reported in the Journal of Clinical Oncology, Klotz et al found that in men with prostate cancer with biochemical failure after radiotherapy with or without surgery, a nadir serum testosterone level ≤ 0.7 nmol/L during the first year of continuous...

prostate cancer
issues in oncology

Smokers Have Twice the Risk of Prostate Cancer Recurrence After Surgery as Never-Smokers

Current smokers, and those who have quit smoking less than 10 years previously, have twice the risk of a recurrence of prostate cancer after surgery, according to new research by Rieken et al presented at the European Association of Urology (EAU) 2015 Congress in Madrid (Abstract 508). In 2012,...

prostate cancer

Addition of Lenalidomide to Docetaxel-Prednisone Worsens Survival in Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer

In the phase III MAINSAIL trial reported in The Lancet Oncology, Petrylak et al found that the addition of lenalidomide (Revlimid) to docetaxel-prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer was associated with significantly worse overall survival. The...

breast cancer
prostate cancer
issues in oncology
issues in oncology

Breast Cancer Risk May Increase in Women Who Have First-Degree Relatives With a History of Prostate Cancer

Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer. Researchers from multiple institutions published their findings in a study by Beebe-Dimmer et al in Cancer. The study's results indicate that clinicians should take a...

prostate cancer

Addition of Orteronel to Prednisone in Metastatic Castration-Resistant Prostate Cancer Does Not Meet Overall Survival Endpoint in Phase III Trial

In a phase III trial (ELM-PC 5) reported in the Journal of Clinical Oncology, Fizazi et al found that the addition of the 17,20-lyase inhibitor orteronel to prednisone in patients with metastatic castration-resistant prostate cancer progressing after docetaxel therapy resulted in an overall...

prostate cancer
issues in oncology

Simulation Study Based on ERSPC Data Shows Greatest Cost-Effectiveness With Two to Three PSA Screenings Between 55 and 59 Years of Age

The European Randomized Study of Screening for Prostate Cancer (ERSPC) trial showed a significant 29% prostate cancer mortality reduction with prostate-specific antigen (PSA) screening but a marked negative impact on quality-adjusted life-years gained due to the effect of overdiagnosis on quality...

prostate cancer
issues in oncology

Early Study Shows Cabazitaxel May Be More Effective Than Docetaxel in Some Patients With Advanced Prostate Cancer

In a new study reported by de Leeuw et al in Clinical Cancer Research, researchers found that the novel taxane cabazitaxel (Jevtana) has properties that could make it more effective than docetaxel in some patients with advanced prostate cancer. This hypothesis is currently being tested in a phase...

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