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Pancreatic Cancer

Performance of First-Line Chemotherapy Regimens in Unresectable Advanced or Metastatic Pancreatic Cancer

In a meta-analysis reported in The Lancet Oncology, Mastrantoni et al identified first-line chemotherapy regimens associated with better outcomes in patients with unresectable advanced or metastatic pancreatic cancer.


Pancreatic Cancer

Increase in Young-Onset Pancreatic Cancer May Be Due to Overdiagnosis of Early-Stage Endocrine Cancer

A recent analysis of pancreatic cancer data in young adults (aged 15–39) has found that although there is an increase in incidence, the mortality rate remains stable. According to Patel et al, who published their findings in the Annals of Internal Medicine, the rise in incidence is primarily due to an increase in the detection of smaller, early-stage endocrine cancer, and not an increase in pancreatic adenocarcinoma. The investigators explained that their findings reflect the detection of previously undetected disease, rather than a true increase in cancer occurrence.

 

Immunotherapy

New Technique May Allow for Visualization of CAR T Cells Postinjection

The University of Cincinnati Cancer Center announced the launch of a new study funded by a $2.3 million National Cancer Institute (NCI) grant to develop a novel technique to visualize where genetically modified immune cells go after being administered in patients with cancer.


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Issues in Oncology

AI Tool May Detect Cancer Gene Signatures in Biopsy Images

Researchers have developed an artificial intelligence (AI)-powered computational program that may be capable of predicting the activity of thousands of genes within tumor cells based on standard microscopy images of a biopsy, according to a recent study published by Pizurica et al in Nature Communications. The findings demonstrated that the novel tool may use routinely collected biopsy images to predict genetic variations in breast cancers as well as patient outcomes.

 

Issues in Oncology

Cancer-Specific Mortality Trends Among U.S. Asian and Pacific Islander Populations

In a study reported in JAMA Network Open, Zhu et al found that cancer-specific mortality rates have decreased overall among U.S. Asian and Pacific Islander populations during recent years, although increases in cancer-specific mortality have been reported for some cancers.

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Hematologic Malignancies

Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease

Hematologic Malignancies

ASH to Present 2024 Honorific Awards at Annual Meeting

The American Society of Hematology (ASH) will recognize exemplary hematologists who have made significant contributions to the field with several honorific awards at the 2024 ASH Annual Meeting and Exposition, being held December 7–10 in San Diego. Mohandas Narla, DSc “ASH is honored to...

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Is There a Role for Neoadjuvant Chemotherapy in HR-Positive, HER2-Negative Early Breast Cancer?

Kazuki Nozawa, MD Question: Based on NATALEE and monarchE data, is there still a need for neoadjuvant chemotherapy in hormone receptor (HR)-positive, HER2-negative early breast cancer? Answer: In monarchE trial, the CDK4/6 inhibitor abemaciclib combined with endocrine therapy demonstrated...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Supportive Care
Issues in Oncology

Exploring Issues in Oncofertility

  Ann H. Partridge, MD, MPH, FASCO Lisa Campo-Engelstein, PhD Kara N. Goldman, MD “Cancer in young adults is more complicated in part [because of the risk of] infertility and premature menopause,” commented Ann H. Partridge, MD, MPH, FASCO, Interim Chair, Department of Medical...

Lymphoma

Determining the Optimal First-Line Management of Advanced Classical Hodgkin Lymphoma

While clinical trials emphasize improvement in cure rates for patients with advanced classical Hodgkin lymphoma, an important goal is reducing the potential long-term effects of treatment. — Iris Isufi, MD Tweet this quote “While clinical trials emphasize improvement...

Suicide-Related Mortality in Male AYA Cancer Survivors

Investigators have found that among all cancer survivors, male adolescents and young adults (AYAs) may have the highest rate of suicide-related mortality, according to a recent study published by Matsuo et al in JAMA Network Open. Cancer is becoming more common among young patients, and cancer...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Solid Tumors
Bladder Cancer
Kidney Cancer
Gastroesophageal Cancer

In Case You Missed It: Roundup From ESMO Congress 2024

In addition to our in-depth analysis of important clinical trials presented at the European Society for Medical Oncology (ESMO) Congress 2024, there is always room for more coverage from The ASCO Post, including these brief summaries of other presentations of interest. They focus on a potential...

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International Cancer Organizations Present Collaborative Work During Oncology Event in China

The National Comprehensive Cancer Network (NCCN) took part in the 2024 International Congress of the Asian Oncology Society and the 2024 Chinese Congress on Holistic Integrative Oncology, which highlighted international collaborations to improve cancer therapy and outcomes across China and Asia....

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