Advertisement

Advertisement
Bladder Cancer

Addition of Durvalumab to BCG After TURBT for BCG-Naive, High-Risk NMIBC

In the final analysis of the phase III POTOMAC trial reported in The Lancet, De Santis et al found that the addition of durvalumab to bacillus Calmette-Guérin (BCG) induction and maintenance improved disease-free survival in patients with high-risk non–muscle-invasive bladder cancer (NMIBC) who underwent transurethral resection of bladder tumor (TURBT).

 

Issues in Oncology
Legislation

Limited or No State Regulation of STLD Health Plans Linked to Decreases in Timely Cancer Treatment Initiation

In 2018, the federal government expanded the coverage duration of short-term limited-duration (STLD) health plans from 3 months to less than 12 months, with the option to renew for a total duration of up to 36 months. Some states imposed more stringent regulations than those federally imposed or banned the sale of these STLD plans, while other states did not have any additional regulations.

 

AI in Oncology

Regulatory Agencies Establish Principles of Good AI Use in Drug Development

The U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) have collaborated with the European Medicines Agency (EMA) to develop a set of 10 guiding principles for good uses of artificial intelligence (AI) in drug development. The principles are aimed at industry members and product developers who are using AI to facilitate and accelerate drug/biological product development. 

 


Advertisement
Head and Neck Cancer

Intensity-Modulated Proton vs Photon Radiotherapy in Oropharyngeal Cancer

In a prespecified interim analysis of a phase III trial (University of Texas MD Anderson Cancer Center Clinical Trial Consortium trial) reported in The Lancet, Frank et al found that intensity-modulated proton therapy (IMPT) was noninferior to standard intensity-modulated photon radiation therapy (IMRT) in progression-free survival among patients with stage III or IV oropharyngeal cancer.

 

Global Cancer Care
AI in Oncology

Global Cancer Survival Gaps Assessed Using a Country-Level Machine-Learning Framework

A machine-learning model has calculated country-specific cancer mortality-to-incidence ratios and evaluated the factors that contribute the most to each country's survival gaps. Additionally, the artificial intelligence (AI) tool mapped out actions each country could take to improve cancer outcomes. A report explaining the establishment of the machine learning framework and its country-specific findings was published in Annals of Oncology

 

Advertisement
Advertisement




More Top Stories


Hematologic Malignancies

Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease

Leukemia

A Battle With My Blood

Editor’s note: On November 22, 2025—the 62nd anniversary of her grandfather President John F. Kennedy’s assassination—Tatiana Celia Kennedy Schlossberg published an essay in The New Yorker detailing her diagnosis of acute myeloid leukemia with chromosome 3 inversion, a rare and aggressive subtype...

Advertisement

AACR Announces Fellows of the AACR Academy Class of 2026

The American Association for Cancer Research (AACR) has announced its newly elected 2026 class of Fellows of the AACR Academy. The Fellows of the AACR Academy was established to honor scientists, clinicians, and physician-scientists whose visionary work has reshaped the landscape of cancer...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Issues in Oncology

New ASCO Guideline Addresses Management of Cancer During Pregnancy, From Diagnosis Through Survivorship

A new ASCO guideline provides recommendations on managing cancer during pregnancy, addressing a range of topics from the selection and timing of diagnostic testing and therapeutic interventions to delivery planning and ethical and legal considerations.1 The guideline aims to inform evidence-based...

Gastroesophageal Cancer

Novel HER2-Targeted Bispecific Improves Outcomes in Patients With Gastroesophageal Cancer

In patients with advanced HER2-positive gastroesophageal adenocarcinoma, treatment with the bispecific antibody zanidatamab-hrii and chemotherapy, with or without the PD-1 inhibitor tislelizumab-jsgr, reduced the risk of disease progression or death by 35% over trastuzumab plus chemotherapy in the...

Ultrasound-Guided DOT May Reduce Unnecessary Breast Biopsies by Nearly 25%

A team of researchers and physicians found that utilizing ultrasound-guided diffuse optical tomography (DOT) technology may reduce unnecessary breast biopsy rates by nearly 25%. Using this new method first—rather than starting with a biopsy—may help to determine if additional diagnoses are needed...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Deb Schrag, MD, MPH, FASCO, Elected 2027–2028 ASCO President

Deb Schrag, MD, MPH, FASCO On December 19, 2025, ASCO announced its members had elected Deb Schrag, MD, MPH, FASCO,as President for the 2027–2028 term. Dr. Schrag will begin her term as President-Elect upon the conclusion of the 2026 ASCO Annual Meeting. Dr. Schrag, a gastrointestinal...

Advertisement

Adjuvant Durvalumab in Resected Early-Stage NSCLC

In a phase III trial (Canadian Cancer Trials Group BR.31) reported in the Journal of Clinical Oncology, Goss et al found that adjuvant durvalumab did not improve disease-free survival vs placebo in patients with completely resected early-stage non–small cell lung cancer (NSCLC). Study Details In...

ASCO Post X Feed
Social Media Hub by Everwall