Advertisement


Nicholas C. Turner, MD, PhD, on INAVO120: Final Overall Survival Analysis

2025 ASCO Annual Meeting

Advertisement

Nicholas C. Turner, MD, PhD, of the Royal Marsden Hospital, presents final overall survival data from the INAVO120 trial of inavolisib/placebo plus palbociclib and fulvestrant in patients with PIK3CA-mutated, HR-positive, HER2-negative, endocrine-resistant advanced breast cancer (Abstract 1003).



Transcript

Disclaimer: This video transcript has not been proofread or edited and may contain errors.
Here at ASCO, we're presenting the overall survival results of the ANAVO-120 trial. This is a trial for patients with metastatic hormone receptor-positive, HER2-negative breast cancer that has got PIK3CA mutations and specifically for patients that are relapsing on endocrine therapy. We know that this is an aggressive type of breast cancer and we're very much in need of new therapies. And so the ANAVO-120 trial randomized these patients in the first-line setting to the standard of care, which was fulvestrant and palbociclib, or the addition of the PI3 kinase inhibitor inavolisib in the triplet. Inavolisib is a novel PI3 kinase inhibitor. It inhibits PIK3CA alpha, but also it degrades the alpha mutant protein and that probably improves the therapeutic window with inavolisib compared to other PI3 kinase inhibitors. And very importantly, inavolisib is combinable with fulvestrant and palbociclib at the maximum single agent doses. And so what we're doing in that triple combination is we're targeting the estrogen receptor, CDK4/6, and the PI3 kinase inhibitor. And by targeting all of these three key aspects of this type of breast cancer, we're really starting to get really significant efficacy. So in the primary readout of ANAVO-120, we demonstrated that adding in inavolisib substantially improved progression-free survival. And now with longer follow-up, we're also demonstrating that adding in inavolisib improved overall survival with a hazard ratio of 0.67, passing the statistical significance barrier. So that's improving overall survival by 33% on average. A median improvement is 7 months. But we also can look at some other really important endpoints in the study, in particular time to first use of chemotherapy. I mean, this is an endpoint that is very important for people, and the addition of inavolisib delayed the time to chemotherapy on average by almost two years. Now why are we seeing such a big improvement in the study? Partly it's that first-line efficacy substantially improving PFS by over half, as well as a substantial improvement in the response rate. And that of course carries through to delaying time to chemotherapy, but also because we're seeing such a reduction in tumor burden with the triplet that also enabled people in the second line to avoid chemotherapy more often. And it's all translated through to that almost doubling in time to chemotherapy. So this is potentially a really important new treatment option for these patients who've relapsed on endocrine therapy with PIK3CA mutant breast cancer.

Related Videos

Lung Cancer

Bjorn Henning Gronberg, MD, PhD, on SCLC: Adjuvant Immunotherapy After CRT

Bjorn Henning Gronberg, MD, PhD, of Norwegian University of Science and Technology (NTNU) and St. Olavs Hospital, presents phase II findings on the efficacy of atezolizumab after chemoradiotherapy (CRT) in limited-stage small cell lung cancer (SCLC) (LBA8005).  

Gynecologic Cancers

Alicia Latham, MD, MS, on Using ctDNA to Detect Endometrial Cancer

Alicia Latham, MD, MS, of Memorial Sloan Kettering Cancer Center, discusses the feasibility of using Pap-derived ctDNA for the detection of sporadic and Lynch syndrome–associated endometrial cancer (Abstract 10503). 

Issues in Oncology

Suneel Deepak Kamath, MD, on Disparities in NIH and Federal Funding Across Different Cancer Types

Suneel Deepak Kamath, MD, of the Cleveland Clinic, reports findings from a study that evaluated funding from the NIH and Congressionally Directed Medical Research Programs supporting lung, breast, colorectal, pancreatic, hepatobiliary, ovarian, cervical, endometrial, and prostate cancers, as well as leukemia, lymphoma, and melanoma, from 2013 to 2022 (Abstract 11025). 

Lung Cancer

Rami Manochakian, MD, FASCO, on Tarlatamab vs Chemotherapy for Second-Line Treatment of SCLC: Expert Point of View

Rami Manochakian, MD, FASCO, of Mayo Clinic Florida, offers his thoughts on findings from the primary analysis of the phase III DeLLphi-304 trial, which compared tarlatamab-dlle, a bispecific T-cell engager immunotherapy targeting delta-like ligand 3 and CD3, with chemotherapy as a second-line treatment of patients with small cell lung cancer (SCLC) (LBA8008). 

Breast Cancer

Mafalda Oliveira, MD, PhD, on How Does Hyperglycemia Affect Treatment of Advanced Breast Cancer?

Mafalda Oliveira, MD, PhD, of Vall d’Hebron University Hospital and Vall d’Hebron Institute of Oncology, discusses findings on the incidence and management of hyperglycemia in a subset of patients with prediabetes and/or obesity included in the phase I trial of inavolisib alone and in combination with endocrine therapy with or without palbociclib for PIK3CA-mutated, hormone receptor–positive, HER2-negative locally advanced/metastatic breast cancer (Abstract 1004). 

 

Advertisement

Advertisement




Advertisement