Advertisement


Toni K. Choueiri, MD, on Renal Cell Carcinoma: Potential Predictive Biomarkers of Treatment Efficacy

2023 ASCO Genitourinary Cancers Symposium

Advertisement

Toni K. Choueiri, MD, of Dana-Farber Cancer Institute, discusses a biomarker analysis from the phase III CheckMate 9ER trial of nivolumab plus cabozantinib vs sunitinib for the treatment of patients with advanced renal cell carcinoma. The ongoing study aims to identify a predictive biomarker that may potentially guide therapeutic choices. (Abstract 608).



Transcript

Disclaimer: This video transcript has not been proofread or edited and may contain errors.
What we presented was the biomarker analysis. So, we had data on RNA-Seq, on immunohistochemistry. We asked a lot of questions during this study. The first question we asked is if there are any gene signatures that were previously described in RCC with VEGF inhibitor, but PD-L1 inhibitor with nivolumab that's a PD-L1 inhibitor. So are they different? And actually we couldn't validate any of the signature that were described with PD-L1 inhibitors plus VEGF inhibitors such as the bevacizumab atezolizumab from emotion 151 or from JAVELIN Renal 101 with axitinib and avelumab. But of course this is a PD-L1 inhibitor, so we weren't able to validate that. But we actually found some hallmark gene sets and some individual genes associated with progression-free survival. And that started us to characterize the tumor microenvironment of the responders to PD-L1 plus VEGF inhibitor better. We also looked at immunohistochemistry, specifically at CDAT cell, at PD-L1 and at c-MET looking at different cutoff and definitions. And also we couldn't find anything that is predictive for the combination versus single agent sunitinib. The only thing that came up, and this was not surprising, is that some prognostic markers, so for example, in sunitinib treated patient PD-L1 positivity is associated with worse outcome. We knew that. This is not new at all and nivolumab, cabozantinib resulted in better PFS regardless. Same thing with MET, the membrane CT, c-Met expression was not associated with much, but the cytoplasmic c-Met was associated with worse prognosis. So this was not predictive. Overall in term of next step and what that means that we continue to try to identify predictive biomarkers, probably the next step using a composite model for nivolumab, cabozantinib efficacy. But it seems all these biomarker we identify, they may be specific to a drug or a combination rather than class of agents such as VEGF and PD-1, PD-L1 inhibitor.

Related Videos

Bladder Cancer
Kidney Cancer
Prostate Cancer

Updates From City of Hope on Renal Cell, Prostate, and Urothelial Cancers

Sumanta K. Pal, MD, introduces his City of Hope colleagues, Hedyeh Ebrahimi, MD, MPH, who discusses the prevalence of dietary modification and supplement use in patients with metastatic renal cell carcinoma, and Daniela Castro, MSc, who discusses expanding eligibility criteria in kidney, prostate, and urothelial cancer trials to more accurately reflect the real-world population and reducing exclusion criteria. (Abstract 662, 612, 34, 453)

Bladder Cancer

Aristotelis Bamias, MD, on Urothelial Carcinoma: Final Overall Survival Analysis of Atezolizumab Monotherapy vs Chemotherapy

Aristotelis Bamias, MD, of the National and Kapodistrian University of Athens, discusses results from the phase III IMvigor130 study, which suggest that atezolizumab monotherapy continues to show better tolerability vs chemotherapy for patients with untreated locally advanced or metastatic urothelial carcinoma. (Abstract LBA441).

Bladder Cancer

Matt D. Galsky, MD, on Bladder or Upper Urinary Tract Cancer: Extended Follow-up Results From CheckMate 274

Matt D. Galsky, MD, of the Icahn School of Medicine at Mount Sinai and Tisch Cancer Institute, discusses results from CheckMate 274, which investigated nivolumab compared with placebo in patients with bladder or upper urinary tract cancer, following radical surgery to remove invasive disease. (Abstract LBA443).

Kidney Cancer

Laurence Albiges, MD, PhD, on Renal Cell Carcinoma: New Phase II Data on Cabozantinib and Checkpoint Inhibitor Therapy

Laurence Albiges, MD, PhD, of France’s Gustave Roussy Cancer Centre, discusses interim results from the CaboPoint study, which evaluated cabozantinib as second-line treatment in patients with unresectable, locally advanced or metastatic renal cell carcinoma with a clear cell component. Disease in the study participants had progressed after prior treatment with ipilimumab and nivolumab in combination or combined with VEGF-targeted therapy. (Abstract 606).

Prostate Cancer

Alan H. Bryce, MD, on Prostate Cancer: Phase III Results on Rucaparib, Docetaxel, and Androgen Pathway Inhibitor Therapy

Alan H. Bryce, MD, of the Mayo Clinic, discusses the final results of the primary endpoint of rPFS and interim results on overall survival among patients with chemotherapy-naive metastatic castration-resistant prostate cancer. The data showed that rucaparib improved radiographic progression-free survival compared with either docetaxel or abiraterone and enzalutamide in disease with BRCA1/2 alterations. (Abstract 18).

Advertisement

Advertisement




Advertisement