Stephanie Walker on Increasing the Participation of Black Women With Metastatic Breast Cancer in Clinical Trials
2022 ASCO Annual Meeting
Stephanie Walker, a former nurse and current activist with the Metastatic Breast Cancer Alliance, discusses findings from the BECOME project (Black Experience of Clinical Trials and Opportunities for Meaningful Engagement). They show that, even though Black patients comprise between 4% and 6% of all clinical trial participants, Black women with metastatic breast cancer are willing to consider taking part if steps were taken to increase their awareness, build trust through clear communication with health-care providers, involve people of shared racial/ethnic identity and health experience, and help patients find and access trials (Abstract 1014).
Transcript
Disclaimer: This video transcript has not been proofread or edited and may contain errors.
My project for ASCO this year was to include or increase participation of black men and women with metastatic breast cancer in clinical trials. First of all, I think we need to inform. We not only need to inform the patients about clinical trials, but we also need to inform you as a healthcare provider to ask us. Because the majority of the patients that were asked on this survey, if they knew about clinical trials, they didn't know. I think it is part of the job of the healthcare provider to ask us. Don't assume that we don't know about it, or we know about it and choose not to. Don't assume that we can't afford it. Don't assume that we're not educated enough to do this. Everybody needs to be informed. Next, we need to inspire. You need to inspire us as the patient. You need to help build that bond regarding trust and the healthcare provider, which is you. We need to inspire trust, even though we know the trials and tribulations in the past, we need to go forward. You need to ensure that we know where we can get in touch with people regarding the clinical trials. We also need to ensure that we know how to utilize the resources, to look for clinical trials or where to find those. Also, you need to address the barriers. Financial is the biggest barrier that we have. You need to help us by providing a meal because a clinical trial is all day. Or parking. We have childcare that we need to attend to. Help address some of those little barriers. They may seem little to you, but they are huge barriers for us. If you take care of the barriers, ensure that we know where to contact or where to enroll in clinical trials, inspire, develop the trust, and we need to inform the patient and yourself about including and talking to us about clinical trials. With that being said, we are going to do a follow-up study to reach those that we were unable to reach, which were those people in rural communities that are not connected to internet or not connected to a university-based institution, because 80% of all the cancer patients are treated in community-based cancer centers. I encourage you to look at other methods of including us in clinical trials. Instead of having me fly from the east coast to the west coast, to do a clinical trial or fly from the east coast to the west coast, to get CT scans when I can get them five minutes down the road. I need you to address some of those logistics, some of the barriers regarding finances. I also need you to know us. Get to know your patients in that 15 minutes, I know is a short period of time that you have to spend with us in the office, but you also need to inform us. Do not assume. Inform us of clinical trials.
The ASCO Post Staff
Sriram Yennu, MD, of The University of Texas MD Anderson Cancer Center, discusses the placebo response in patients with advanced cancer and cancer-related fatigue. His latest findings show that open-labeled placebo was efficacious in reducing cancer-related fatigue and improving quality of life in fatigued patients with advanced cancer at the end of 1 week. The improvement in fatigue was maintained for 4 weeks (Abstract 12006).
The ASCO Post Staff
Georgina V. Long, MD, PhD, of the Melanoma Institute Australia, The University of Sydney, discusses phase III findings from the KEYNOTE-716 study. The trial showed that compared with placebo, adjuvant pembrolizumab significantly improved distant metastasis–free survival in patients with resected stage IIB and IIC melanoma. The findings also suggest a continued reduction in the risk of recurrence and a favorable benefit-risk profile (Abstract LBA9500).
The ASCO Post Staff
Gilberto de Lima Lopes, Jr, MD, MBA, of the Sylvester Comprehensive Cancer Center at the University of Miami, and Karen L. Reckamp, MD, of Cedars-Sinai Medical Center, discuss phase II findings from substudy S1800A of the Lung-MAP protocol. The data showed that ramucirumab and pembrolizumab improved overall survival compared with the standard of care for patients with advanced non–small cell lung cancer who were previously treated with immunotherapy and platinum-based chemotherapy (Abstract 9004).
Paul G. Richardson, MD, of Dana-Farber Cancer Institute, discusses phase III findings from the DETERMINATION trial, which showed that, for patients with newly diagnosed multiple myeloma, lenalidomide, bortezomib, and dexamethasone (RVd) with or without autologous stem cell transplant (ASCT) and lenalidomide maintenance to disease progression resulted in the longest median progression-free survival reported for each approach, and a highly significant difference in progression-free survival in favor of early transplant. While overall response rates were similar, rates of MRD favored early transplant also, but toxicity was greater and quality of life was transiently but significantly diminished. No overall survival advantage has been observed to date (Abstract LBA4).
The ASCO Post Staff
Ursula A. Matulonis, MD, of Dana-Farber Cancer Institute, and Domenica Lorusso, MD, PhD, of Italy’s Gemelli University Hospital, discuss phase III data from the MITO23 trial on single-agent trabectedin vs clinician’s choice of chemotherapy in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancers of BRCA-mutated or BRCAness phenotype. Although trabectedin has demonstrated antitumor activity in relapsed platinum-sensitive disease, it does not appear to improve survival outcomes when compared with standard chemotherapy in the BRCA-mutated population (Abstract LBA5504).