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Your search for The ASCO Post matches 260 pages

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colorectal cancer

Michael J. Overman, MD, and John Marshall, MD, on Metastatic Colorectal Cancer: Interim Results of the CheckMate 142 Trial

Michael J. Overman, MD, of the University of Texas MD Anderson Cancer Center, and John Marshall, MD, of Georgetown University Lombardi Comprehensive Cancer Center, discuss interim findings on nivolumab with or without ipilimumab in the treatment of patients with metastatic colorectal cancer with...

colorectal cancer

Alan P. Venook, MD, and John Marshall, MD, on Metastatic Colorectal Cancer: Analysis of CALGB-SWOG 80405

Alan Venook, MD, of the University of California, San Francisco, and John Marshall, MD, of the Lombardi Cancer Center at Georgetown University, discuss the impact of primary tumor location on overall survival and progression-free survival in patients with advanced disease (Abstract 3504).

colorectal cancer

DDW 2016: Rates of Colorectal Cancer Continue to Increase in Those Under 50

A new study shows the rate of colorectal cancer continues to increase in individuals under 50 years old, despite the fact that the overall rate of the disease has been declining in recent years. Following examination of more than 1 million colorectal cancer patient records over 10 years,...

colorectal cancer

DDW 2016: Low-Residue Diet Prior to Colonoscopy Shows Improved Tolerance and Bowel Preparation vs Clear Liquid Diet

A new study finds that patients who ate certain solid foods, considered “low residue,” were better prepared for their colonoscopies than individuals who followed the conventional liquid diet. Additionally, researchers saw that these patients who ate foods such as eggs, white bread,...

colorectal cancer

DDW 2016: Endoscopist’s Knowledge of Positive Cologuard Test Improves Colonoscopy Performance

An endoscopist's knowledge of a positive Cologuard test improves colonoscopy performance, according to a poster presentation by Johnson et al at Digestive Disease Week (DDW) 2016 (Abstract Su1044). Cologuard is an at-home, stool-DNA colorectal cancer screening test that has been approved by the...

colorectal cancer

Body Mass Index and Mortality in Patients With Colorectal Cancer

Overweight colorectal cancer patients were 55% less likely to die from their cancer than normal-weight patients who have the disease, according to a new Kaiser Permanente study published by Kroenke et al in JAMA Oncology. Of cancers affecting both men and women, colorectal cancer is the...

colorectal cancer

Specific Version of the FCGR2A Gene Identifies Colorectal Cancer Patients Likely to Benefit Most From Cetuximab

Among patients with metastatic colorectal cancer harboring normal forms of the KRAS gene, only those who had two copies of a specific version of the FCGR2A gene (FCGR2A H/H) had a statistically significant increase in median overall survival when cetuximab (Erbitux) treatment was added to best...

colorectal cancer

ASCO 2016: Left- vs Right-Sided Primary Tumor Location Predicts Survival in Metastatic Colorectal Cancer

For a longer-form examination of these data, click here. A retrospective analysis from a large, federally funded clinical trial finds that the location of the primary tumor within the colon predicts survival and may help inform optimal treatment selection for patients with metastatic colorectal...

colorectal cancer

New Study Suggests Cholesterol Levels, Not Statins, Influence Colorectal Cancer Risk

Long-term use of the cholesterol-lowering drugs statins does not appear to decrease a patient’s risk of colorectal cancer, suggests a new, large case-control study from Penn Medicine published by Mamtani et al in PLOS Medicine. The observational analysis of over 100,000 patients’...

colorectal cancer

AACR 2016: Cologuard Detected Colorectal Cancer in Previously Unscreened Patients

A noninvasive colorectal cancer-screening test detected the disease in patients who had previously avoided more invasive screening measures, according to research presented by Prince et al at the 2016 AACR Annual Meeting (Abstract LB-296). The study of nearly 400 patients revealed four patients...

colorectal cancer

New Study Links Coffee Consumption to Decreased Risk of Colorectal Cancer

Researchers at the University of Southern California (USC) Norris Comprehensive Cancer Center of Keck Medicine of USC and Clalit National Israel Cancer Control Center have found that coffee consumption may be inversely associated with the risk of colorectal cancer. The findings by Schmit et...

colorectal cancer

Christopher Willett, MD, on Localized Rectal Cancer: Emerging Treatment Paradigms

Christopher Willett, MD, of Duke Cancer Center, discusses short and long courses of treatment, neoadjuvant chemotherapy with or without radiation, and organ preservation without surgery.

colorectal cancer

Alan Venook, MD, on Metastatic Colorectal Cancer: Choosing Optimal Treatment Strategies

Alan Venook, MD, of the UCSF Helen Diller Family Comprehensive Cancer Center, discusses new observations on biomarkers, the best combinations of therapies, and how to sequence them.

colorectal cancer

Endoscopic Mucosal Resection Is an Alternative to Surgery in Most Patients With Complex Colon Polyps

Using the latest advances in endoscopic resection techniques, more than 75% of patients with complex colon polyps could avoid surgery for their polyp removal, according to new research from The University of Texas MD Anderson Cancer Center. The findings, published by Raju et al in Gastrointestinal ...

colorectal cancer

Increased Travel Burden Decreases Likelihood of Receiving Radiation Therapy for Rectal Cancer Treatment

Increased travel distance to a cancer treatment facility negatively impacts the likelihood that patients with stage II/III rectal cancer will receive radiation therapy to treat their disease, according to a study analyzing 26,845 patient records from the National Cancer Data Base (NCDB) published...

colorectal cancer

Laboratory Study Explores How High-Fat Diet Influences the Development of Intestinal Tumors

A study published by Beyaz et al in Nature reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous. It joins a growing body of research that finds obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer....

colorectal cancer
issues in oncology

Half of Elderly Patients With Colorectal Cancer Receive Expensive Therapy With Little Survival Benefit

A study published by Bradley et al in Medical Care showed that over a recent 10-year period, the rate of metastatic colorectal cancer patients older than age 75 receiving three or more treatments increased from 2% to 53%. During this period, 1-year treatment costs increased 32% to reach an...

colorectal cancer

Adding Immunotherapy to Radiofrequency Ablation in Colorectal Cancer With Liver Metastasis Shows Promise in Preclinical Models

In a retrospective case-controlled study conducted in patients with colorectal cancer who had received primary tumor resection with or without preoperative radiofrequency ablation for liver metastases, the electrical procedure was found to induce antitumor immune responses in the...

colorectal cancer
issues in oncology
issues in oncology

Updated Guidelines Recommend That Patients With Colorectal Cancer Undergo Colonoscopy After Cancer Resection

According to new recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer published by Kahi et al in Gastroenterology, postoperative colonoscopy is associated with improved overall survival for colorectal cancer patients. Therefore, it is critically important that colorectal...

gynecologic cancers
colorectal cancer
head and neck cancer
issues in oncology
issues in oncology

100% of NCI-Designated Cancer Centers Endorse the Promotion of the HPV Vaccination for Cancer Prevention

All National Cancer Institute (NCI)-designated cancer centers have united to support human papillomavirus (HPV) vaccination. A team of HPV experts drafted a consensus statement that advises widespread use of HPV vaccines to prevent cancer. HPV causes cancer of the cervix, anus, and throat. The HPV ...

palliative care
colorectal cancer

One in Seven Colorectal Cancer Patients Diagnosed Before Recommended Screening Age

Nearly 15% of patients diagnosed with colorectal cancer were younger than 50, the age at which screening recommendations begin. The study by researchers at the University of Michigan Comprehensive Cancer Center also found that younger patients were more likely to have advanced disease. The authors ...

colorectal cancer

Link Between Obesity and Increased Risk of Colorectal Cancer Revealed in Preclinical Models

Obesity has long been associated with increased risk of colorectal cancer, but the link has never been understood. Now, a research team led by investigators at Thomas Jefferson University has revealed the biologic connection, and in the process, has identified an approved drug that might prevent...

colorectal cancer
issues in oncology

National Colorectal Cancer Awareness Month

March is Colorectal Cancer Awareness Month, and the U.S. Department of Health and Human Services is committed to boosting public awareness about the importance of screening and treatment for colorectal cancer. Colorectal cancer poses the greatest risk to adults over age 50, and the U.S. Preventive...

colorectal cancer
lung cancer
gastroesophageal cancer

Researchers at Roswell Park Receive Grants to Study New Anticancer Agent in Lung, Colorectal, and Gastrointestinal Cancers

Researchers at Roswell Park Cancer Institute have been awarded three of four grants by the National Comprehensive Cancer Network (NCCN) Oncology Research Program to evaluate and define the clinical effectiveness of the investigational compound nintedanib. Nintedanib is an investigational...

colorectal cancer
issues in oncology

Gene Thought to Suppress Cancer May Actually Promote Spread of Colorectal Cancer

A gene that is known to suppress the growth and spread of many types of cancer has the opposite effect in some forms of colorectal cancer, University of Missouri (MU) School of Medicine researchers have found. It is a finding that may lay the foundation for new colorectal cancer treatments. Results ...

breast cancer
colorectal cancer
gynecologic cancers
issues in oncology

Follow-up Times for Colorectal Cancer Screening Abnormalities Lag Behind Others

Follow-up times of abnormal screening exams were shorter for breast cancer than they were for colorectal and cervical cancers, according to a recent study involving more than 1 million individuals who underwent these screenings. Recently published by Tosteson et al in the Journal of General...

colorectal cancer

Colorectal Cancer Risk Varies Based on Latino Subgroup Affiliation

In the first study of its kind, University of Southern California (USC) researchers have found that colorectal cancer risk in Californian Latinos varies widely depending on the country of origin. Their study was published by Stern et al in Cancer Causes & Control. “Hispanics are a very...

colorectal cancer
issues in oncology

Citywide Effort Boosts New York City's Colorectal Cancer Screening Rates

A coalition formed by the New York City Department of Health and Mental Hygiene (DOHMH) to increase colorectal cancer screening rates in New York resulted in a 40% increase in screening rates over 4 years. The program may serve as a foundation for other communities to boost cancer screening rates,...

colorectal cancer
issues in oncology

Disparities in Colorectal Cancer Death Rates Take a Large Economic Toll

Disparities in colorectal cancer death rates take a large toll on the national economy, with poorer, less-educated communities bearing the greatest burden, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health...

colorectal cancer
issues in oncology

Stool DNA Test Accurate in Screening for Colorectal Cancer in Alaska Native People

Cologuard stool DNA testing for colorectal cancer was found to be an accurate noninvasive screening option for Alaska Native people, a population with one of the world's highest rates of colorectal cancer, concluded researchers from the Alaska Native Tribal Health Consortium and Mayo Clinic. The...

breast cancer
colorectal cancer
lung cancer

A Tolerant Immune System May Increase Cancer Risk

For a malignant tumor to form, cancer cells must evade the immune system's attack. Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment. “But we didn't...

colorectal cancer
issues in oncology

Many Patients Do Not Accurately Recall Important Colonoscopy Details as Time Lapses

As time lapses, many patients who have undergone a colonoscopy become less and less likely to recall when and where they last had the procedure performed, who the doctor was who performed it, whether polyps were found, and, if so, the number and size of those polyps, according to new study results...

colorectal cancer

All Relatives of Patients With Colorectal Cancer May Be at Increased Risk Regardless of Age at Diagnosis of Index Patient

All relatives of individuals with colorectal cancer are at increased risk for this cancer, regardless of the age of diagnosis of the index patient in the family, according to a study published by Samadder et al in Clinical Gastroenterology and Hepatology. These findings may impact future guidelines ...

colorectal cancer
issues in oncology

ECC 2015: Discovery of Differences Between Tumors of Younger and Older Patients With Colorectal Cancer May Lead to Better Treatments

Colorectal cancer is on the rise among younger patients. Although some of the younger-onset cases can be explained by hereditary factors, the majority arise spontaneously. Researchers have now found that tumors in younger patients with colorectal cancer may be molecularly distinct from those of...

colorectal cancer

FDA Approves New Oral Medication for the Treatment of Refractory Metastatic Colorectal Cancer

The U.S. Food and Drug Administration today approved trifluridine/tipiracil (Lonsurf) for patients with metastatic colorectal cancer who have been previously treated with chemotherapy and biologic therapy and are no longer responding to treatment. The new agent is an oral combination of...

colorectal cancer
solid tumors

Synchronous vs Sequential Tumor Resection in Patients With Advanced Colorectal Cancer

About 20% of patients with colorectal cancer have cancers that have metastasized beyond the colon at the time of their diagnosis, with the liver being the most common site for these metastases. The approach to treating primary tumors within the colon and metastatic tumors in the liver continues to...

colorectal cancer
issues in oncology

Longer Colonoscopies Linked to Lower Rate of Colorectal Cancer

Research by a Veterans Affairs team has confirmed that longer-lasting colonoscopies are associated with lower cancer rates. Their findings were published by Shaukat et al in Gastroenterology, and were based on nearly 77,000 screening colonoscopies. Experts already know about the link between...

colorectal cancer
issues in oncology

Genetic Test Predicts Colon Tumor Sensitivity to Radiation Therapy

Recent advances in the understanding of cancer have led to the development of more personalized therapies. Moffitt Cancer Center researchers have contributed to these advances by developing the first test that analyzes the sensitivity of tumors to radiation therapy. Their findings were published by ...

cns cancers
gynecologic cancers
colorectal cancer
leukemia
lymphoma
skin cancer
gynecologic cancers
issues in oncology
issues in oncology
issues in oncology

Noninvasive Prenatal Testing May Also Detect Some Maternal Cancers

A study published by Bianchi et al in the Journal of the American Medical Association (JAMA) showed that genetic test results revealed by noninvasive prenatal testing for fetal chromosomal abnormalities may detect underlying conditions in the mother, including cancer. The study reports on a case...

palliative care
issues in oncology
colorectal cancer

ESMO World GI 2015: Studies Confirm Regorafenib Benefit in Pretreated Metastatic Colorectal Cancer

The phase IIIb CONSIGN trial has confirmed the benefit of regorafenib (Stivarga) in patients with previously treated metastatic colorectal cancer, researchers announced July 3 at the European Society for Medical Oncology World Congress on Gastrointestinal Cancer in Barcelona, Spain (Abstract...

colorectal cancer
solid tumors
pancreatic cancer
supportive care

ESMO World GI 2015: SENRI Trial Evaluates NK1 Antagonists for Emesis Prevention in Oxaliplatin-Based Chemotherapy

The SENRI trial has opened the window to evaluate neurokinin 1 (NK1) antagonists for emesis prevention in patients taking oxaliplatin chemotherapy, said European Society for Medical Oncology World Congress on Gastrointestinal Cancer (ESMO) spokesperson and antiemetics expert Fausto Roila, MD....

palliative care
colorectal cancer

ESMO World GI 2015: Low Body Mass Index Associated With Poorer Survival in Metastatic Colorectal Cancer

Although being overweight with a high body mass index (BMI) has long been associated with a higher risk for colorectal cancer, thinner patients might not fare as well as previously expected after treatment for advanced cancer, according to a new study from Duke Medicine. The study, which was...

palliative care
colorectal cancer
head and neck cancer

Development of New Blood Vessels Not Essential to Growth of Lymph Node Metastases

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed. Now a study from the Massachusetts General Hospital (MGH) Cancer Center may have...

issues in oncology
colorectal cancer
issues in oncology

New Biomarkers Might Help Personalize Metastatic Colorectal Cancer Treatment

Metastatic colorectal cancer patients have improved survival rates when they respond to the first line of chemotherapy their doctors recommend. To better predict how patients will respond to chemotherapeutic agents before they begin treatment, researchers at University of California (UC) San Diego...

breast cancer
colorectal cancer
health-care policy
issues in oncology
issues in oncology
issues in oncology
cost of care

Colorectal Cancer Screening Increase May Reflect Affordable Care Act Provision

Screening for colorectal cancer increased in individuals with a lower socioeconomic status after 2008, perhaps reflecting the Affordable Care Act’s removal of financial barriers to screening, according to a new analysis. The study, by American Cancer Society investigators, was published by...

colorectal cancer

ASCO 2015: New Targeted Treatment IMMU-130 Shows Activity in Patients With Metastatic Colon Cancer

Although various drugs have improved outcomes for metastatic colon cancer patients, researchers continually strive to find new agents to improve treatment. Antibody-drug conjugates are a promising option, due to the fact that they can deliver chemotherapy directly into a targeted cell, destroy...

colorectal cancer
solid tumors
lung cancer

ASCO 2015: Entolimod May Be a Promising Treatment Option for Many Solid Tumors

A collaborative team of researchers led by Alex A. Adjei, MD, PhD, FACP, of Roswell Park Cancer Institute, shared results from the first clinical study of the anticancer effects of the novel agent entolimod on May 30 at the 2015 ASCO Annual Meeting in Chicago (Abstract 3063). Their findings confirm ...

colorectal cancer
issues in oncology

ASCO 2015: Colorectal Cancer Genetically Different in Older and Younger Patients

Although the overall rate of colorectal cancer is declining, colorectal cancer specifically among young patients is increasing. Previous studies have shown that colorectal cancer in patients younger than 50 years old tends to be more aggressive than in older patients. A University of Colorado (CU)...

colorectal cancer
solid tumors
gynecologic cancers

ASCO 2015: Mismatch Repair Deficiency Predicts Response to Pembrolizumab Among Patients With Colorectal and Other Cancers

A phase II study identified the first genomic marker—mismatch repair deficiency—to predict clinical benefit of immune checkpoint blockade with the anti–PD-1 antibody pembrolizumab (Keytruda). Among 50 patients with colorectal cancer, 62% of the 25 patients with mismatch...

colorectal cancer
issues in oncology

Very Overweight Teens May Double Their Risk of Bowel Cancer in Middle Age

Being very overweight in your teens may double the risk of developing bowel cancer by the time you are middle-aged, suggested research published by Kantor et al in the journal Gut. A high level of an indicator of systemic inflammation—erythrocyte sedimentation rate—at this age is...

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