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Bladder Cancer

Addition of Durvalumab to BCG After TURBT for BCG-Naive, High-Risk NMIBC

In the final analysis of the phase III POTOMAC trial reported in The Lancet, De Santis et al found that the addition of durvalumab to bacillus Calmette-Guérin (BCG) induction and maintenance improved disease-free survival in patients with high-risk non–muscle-invasive bladder cancer (NMIBC) who underwent transurethral resection of bladder tumor (TURBT).

 

Issues in Oncology
Legislation

Limited or No State Regulation of STLD Health Plans Linked to Decreases in Timely Cancer Treatment Initiation

In 2018, the federal government expanded the coverage duration of short-term limited-duration (STLD) health plans from 3 months to less than 12 months, with the option to renew for a total duration of up to 36 months. Some states imposed more stringent regulations than those federally imposed or banned the sale of these STLD plans, while other states did not have any additional regulations.

 

AI in Oncology

Regulatory Agencies Establish Principles of Good AI Use in Drug Development

The U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) have collaborated with the European Medicines Agency (EMA) to develop a set of 10 guiding principles for good uses of artificial intelligence (AI) in drug development. The principles are aimed at industry members and product developers who are using AI to facilitate and accelerate drug/biological product development. 

 


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Head and Neck Cancer

Intensity-Modulated Proton vs Photon Radiotherapy in Oropharyngeal Cancer

In a prespecified interim analysis of a phase III trial (University of Texas MD Anderson Cancer Center Clinical Trial Consortium trial) reported in The Lancet, Frank et al found that intensity-modulated proton therapy (IMPT) was noninferior to standard intensity-modulated photon radiation therapy (IMRT) in progression-free survival among patients with stage III or IV oropharyngeal cancer.

 

Global Cancer Care
AI in Oncology

Global Cancer Survival Gaps Assessed Using a Country-Level Machine-Learning Framework

A machine-learning model has calculated country-specific cancer mortality-to-incidence ratios and evaluated the factors that contribute the most to each country's survival gaps. Additionally, the artificial intelligence (AI) tool mapped out actions each country could take to improve cancer outcomes. A report explaining the establishment of the machine learning framework and its country-specific findings was published in Annals of Oncology

 

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Hematologic Malignancies

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Breast Cancer
AI in Oncology

AI Tops Density in Predicting Breast Cancer Risk

An image-only artificial intelligence (AI) model for predicting the 5-year risk of breast cancer provided stronger and more precise risk stratification than breast density assessment, according to a news statement issued about a study presented at the annual meeting of the Radiological Society of...

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Limited or No State Regulation of STLD Health Plans Linked to Decreases in Timely Cancer Treatment Initiation

In 2018, the federal government expanded the coverage duration of short-term limited-duration (STLD) health plans from 3 months to less than 12 months, with the option to renew for a total duration of up to 36 months. Some states imposed more stringent regulations than those federally imposed or...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Gastroesophageal Cancer

Neoadjuvant Dual ICI Blockade vs Perioperative FLOT in dMMR/MSI-H Gastroesophageal Adenocarcinoma

In an individual-patient pooled analysis reported in the Journal of Clinical Oncology, Raimondi et al found that neoadjuvant treatment with dual CTLA-4/PD-(L)1 immune checkpoint inhibitors (ICIs) was associated with higher pathologic response rates vs perioperative FLOT (fluorouracil, leucovorin,...

Lung Cancer

Ironically, Smoking May Have Saved My Life

I was diagnosed with stage IV non-small cell lung (NSCLC) adenocarcinoma on August 1, 2013—World Lung Cancer Day. If it hadn’t been for an article that caught my eye the year before about the recommendation from the United States Preventive Services Task Force that all men aged 65 to 75 who have...

FDA Releases Draft Guidance for Use of MRD and CR as Primary Endpoints in Multiple Myeloma Trials

On January 20, 2026, the U.S. Food and Drug Administration (FDA) released a draft guidance for industry regarding the use of minimal residual disease and complete response as primary endpoints in clinical trials evaluating drugs and biologics for the treatment of patients with multiple myeloma that ...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Geriatric Oncology

Hear, Hear to ‘Advancing Geriatric Oncology: Where We Have Been and Where We Are Going’

We read with interest the commentary by Stuart Lichtman, MD, FASCO,on “Advancing Geriatric Oncology: Where We Have Been and Where We Are Going,“ in the October 25, 2025 issue of The ASCO Post.1 Dr. Lichtman outlines the challenges in delivering cancer care to the elderly population. Among these...

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Meningiomas: Phase II Trial Shows Activity of Targeted Therapy

A national clinical trial led by the Alliance for Clinical Trials in Oncology has found that the CDK 4/6 inhibitor abemaciclib may slow tumor growth in patients with aggressive meningiomas that have specific genetic mutations. The primary analysis of Alliance A071401 was published by Priscilla...

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