Eva M. Ciruelos, MD, PhD, on HER2-Positive and PAM50 Luminal Breast Cancer: Primary Results From the PATRICIA Trial
2024 ASCO Annual Meeting
Eva M. Ciruelos, MD, PhD, of Spain’s Hospital 12 de Octubre and the Instituto de Investigación Sanitaria Hospital 12 de Octubre, discusses phase II data showing that the combination of palbociclib, trastuzumab, and endocrine therapy improved progression-free survival in patients with previously treated PAM50 luminal A or B, HER2-positive advanced breast cancer, as compared with treatment of physicians’ choice (Abstract 1008).
Transcript
Disclaimer: This video transcript has not been proofread or edited and may contain errors.
We presented the first primary results of the PATRICIA cohort C trial. This is an open level, phase two randomized trial that recruited HER2-positive advanced breast cancer patients who received an experimental combination consisted on palbociclib, trastuzumab and endocrine therapy versus treatment of physician choice with T-DM1 or the combination of trastuzumab chemotherapy or endocrine treatment.
These patients were pre-treated patients, at least two prior lines of treatment, and all of them were selected based on the intrinsic subtyping. Just luminal A and luminal B tumors were included in this trial.
Primary result was achieved and progression for survival was significantly improved with combination of palbociclib trastuzumab endocrine treatment over treatment of physician's choice, with a reduction in the risk of progression of about 48%, which is statistically significant. These results are unique as we try to select patients based on a new biomarker, which is intrinsic subtype, and offering this non-chemotherapy combination for these patients that harbored about 50% within the HER-positive HER2-positive disease.
Regarding tolerability, no dose reductions were done differently from these two arms and no dose discontinuations were needed in the experimental arm. That is why our conclusions says that this is a new way to classify in patients within the HER2-positive disease. This is a non-chemo alternative for these patients that will translate, for sure, into quality of life. But still we should validate our results as our trial had some limitations due to a small sample size, so maybe new prospective randomized designs will be needed to confirm our [inaudible 00:02:21] results.
The ASCO Post Staff
Lisa A. Carey, MD, of University of North Carolina, Chapel Hill and UNC Lineberger Comprehensive Cancer Center, and Kevin Kalinsky, MD, of the Winship Cancer Institute of Emory University, discuss the first phase III findings showing a benefit of continued CDK4/6 inhibition with abemaciclib plus fulvestrant, following disease progression in patients with hormone receptor–positive, HER2-negative advanced breast cancer (LBA1001).
The ASCO Post Staff
Emily L. Podany, MD, of Washington University, St. Louis, discusses disparities in the use of PI3K inhibitors for Black patients with estrogen receptor–positive, HER2-negative metastatic breast cancer while other drugs that do not require genomic profiling were similarly used (Abstract 1017).
The ASCO Post Staff
Yukio Suzuki, MD, PhD, of Columbia University College of Physicians and Surgeons, discusses data showing that reproductive-age patients with early-stage endometrial cancer who use fertility-preserving hormonal therapy seemed to have good overall survival after a 10-year follow-up (Abstract 5508).
The ASCO Post Staff
Minesh P. Mehta, MD, of Miami Cancer Institute, part of Baptist Health South Florida, discusses results from the METIS (EF-25) trial evaluating the efficacy and safety of tumor treating fields therapy following stereotactic radiosurgery in patients with mutation-negative non–small cell lung cancer (NSCLC) and brain metastases. Tumor treating fields therapy prolongs time to intracranial disease progression and may postpone whole-brain radiation therapy without declines in quality of life and cognition (Abstract 2008).
The ASCO Post Staff
William G. Wierda, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses up to 5.5 years of follow-up data from the phase II CAPTIVATE study, showing that in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), fixed duration ibrutinib plus venetoclax continues to provide clinically meaningful progression-free disease in those with high-risk genomic features as well as in the overall population (Abstract 7009).