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Prostate Cancer
Symptom Management

Botulinum Toxin and Scopolamine for Radiation-Induced Salivary Gland Toxicity in Metastatic Prostate Cancer

Injection with botulinum toxin (BTX) type A (IncoA) plus transdermal scopolamine led to the reduction in radiation-induced salivary gland toxicity without compromising PSMA (prostate-specific membrane antigen) tumor uptake in patients with metastatic prostate cancer who were receiving...

Hematologic Malignancies
Symptom Management

Experimental Approach to GVHD Prophylaxis Offers Alternative to Standard Regimen

Prevention of graft-vs-host disease (GVHD) was superior with a cyclophosphamide/cyclosporin-based regimen compared with standard prophylaxis in patients receiving a matched-sibling donor stem cell transplant in a large Australian randomized trial, investigators reported at the European Hematology...

Solid Tumors
Supportive Care
Symptom Management

Psilocybin May Benefit Patients With Cancer, Major Depressive Disorder

A single dose of psilocybin may provide sustained reductions in depression and anxiety among patients with cancer and major depressive disorder, according to a recent study published by Agrawal et al in Cancer. Patients with cancer often experience depression. Psilocybin is a naturally occurring...

Issues in Oncology
Symptom Management

Novel Prediction Model for Hearing Loss From Chemotherapy in Pediatric Patients With Cancer

In a study reported in the Journal of Clinical Oncology, Millstein et al attempted to develop a predictive model—Pediatric Holistic Evaluation of Auditory Risk (PedsHEAR)—for hearing loss associated with cisplatin chemotherapy in children and adolescents with cancer. Study Details PedsHEAR was...

Colorectal Cancer
Lung Cancer
Solid Tumors
Symptom Management

In Case You Missed It: Additional Abstracts of Interest From AACR

Thousands of forward-looking research studies defined the 2025 American Association for Cancer Research (AACR) Annual Meeting. Here, aside from our fuller coverage of key presentations in The ASCO Post, we offer a snapshot of a few additional abstracts that may be of interest to cancer researchers...

Symptom Management
Pain Management

Symptoms Preceding Unplanned Acute Care in Patients With Cancer

In a single-institution cohort study reported in JAMA Network Open, Chang et al identified patterns of symptoms preceding unplanned acute care encounters for patients with cancer. Study Details The study involved data from all unplanned acute care encounters (emergency department visits and...

Multiple Myeloma
Symptom Management

Use of Ruxolitinib to Resolve Ciltacabtagene Autoleucel–Induced Parkinsonism in Patients With Multiple Myeloma

Ruxolitinib may prove to be an effective treatment of parkinsonism arising from ciltacabtagene autoleucel treatment for patients with multiple myeloma, according to the results of a case report published in the Journal of Hematology. The report featured two cases of patients with multiple myeloma...

Supportive Care
Symptom Management

AACR 2025: Topical BRAF Inhibitor Under Study for Managing Acneiform Rash

Compared with a placebo gel, an investigational topical BRAF inhibitor (LUT014) was found to improve the symptoms of acneiform rash in patients with colorectal cancer. These phase II clinical trial results were presented by Anisha B. Patel, MD, Associate Professor of Dermatology, Deputy Chair of...

Symptom Management
Colorectal Cancer
Pancreatic Cancer
Gynecologic Cancers

AACR 2025: AI-Driven Model For Identifying Cancer Cachexia

Use of a multimodal deep learning–based model led to more accurate and earlier identifications of cancer cachexia than standard clinical and radiological observations, according to findings presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting (Abstract 1143)....

Solid Tumors
Head and Neck Cancer
Supportive Care
Symptom Management

Novel Limonene-Lipid Formulation May Help Alleviate Xerostomia in Patients With Cancer

When combined with a novel lipid formulation, a natural citrus essential oil from oranges, lemons, and limes—known as limonene—may prove to be effective in relieving xerostomia without significant adverse effects among patients with cancer, according to a recent study published by Wright et al in...

Solid Tumors
Breast Cancer
Issues in Oncology
Cardio-oncology
Supportive Care
Symptom Management

SGLT2 Inhibitors Could Help Protect Against Heart Failure in Patients With Cancer

A common type of diabetes drug known as sodium-glucose cotransporter-2 (SGLT2) inhibitors could help patients with cancer achieve greater long-term recovery, according to a novel study published by Bhalraam et al in the European Journal of Preventive Cardiology. Background Many patients with cancer ...

Supportive Care
Immunotherapy
Symptom Management
Issues in Oncology

Text Message Platform May to Help Address ‘Time Toxicity’ in Patients With Cancer

Digital technology may help to safely reduce the amount of time some patients with cancer spend receiving care—also referred to as “time toxicity”—according to a recent study published by Bange et al in NEJM Catalyst. Background Patients with cancer often spend a large amount of time on activities...

Breast Cancer
Survivorship
Supportive Care
Symptom Management
Issues in Oncology

Telephone-Based Therapy May Reduce Fatigue Interference With Functioning in Metastatic Breast Cancer Survivors

Telephone-delivered acceptance and commitment therapy may be effective in reducing the interference of fatigue with functioning and improving the quality of life among survivors of metastatic breast cancer, according to a recent study published by Mosher et al in the Journal of Clinical Oncology....

Supportive Care
Symptom Management
Solid Tumors
Issues in Oncology

Psilocybin-Based Therapy May Address Mental Health Issues in Patients With Cancer, Addiction

Treatment with psilocybin may improve mental health issues among patients with cancer when accompanied by psychotherapy and could result in lasting, positive personality changes in patients with alcohol use disorder, according to two recent studies published by Petridis et al in Nature Mental...

Supportive Care
Symptom Management

Novel Formulation Used in Preventing Cisplatin-Based Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting

In a Chinese phase III trial (PROFIT) reported in Journal of Clinical Oncology, Zhou et al found that mixed-formulation fosrolapitant/palonosetron (HR20013) plus dexamethasone was noninferior to individually dosed fosrolapitant plus palonosetron plus dexamethasone in preventing chemotherapy-induced ...

Symptom Management
Supportive Care

Rilzabrutinib Found Safe and Effective for Refractory Immune Thrombocytopenia

The experimental drug rilzabrutinib was well tolerated and generated an increase in platelet counts among some adults with immune thrombocytopenia (ITP) who had not experienced lasting improvements with other available ITP treatments, according to the results of a phase III trial. These findings...

Integrative Oncology
Symptom Management

Participation in Virtual Prehabilitation and Outcomes Following Thoracic Cancer Surgery

Guest Editor’s Note: Oncology guidelines recommend prehabilitation exercises to minimize postoperative complications. However, the COVID-19 pandemic imposed severe restrictions on patient access to in-person exercise programs offered by hospitals and clinics. In this article, Dr. Krupali Desai...

Solid Tumors
Symptom Management
Supportive Care
Issues in Oncology

Olanzapine May Reduce Chemotherapy-Induced Nausea and Improve Quality of Life Among Patients With Cancer

Researchers have found that olanzapine may be more effective in controlling severe nausea and improving the quality of life in patients with cancer who are undergoing treatment with chemotherapy, according to new findings presented by Peppone et al at the 2024 ASCO Quality Care Symposium (Abstract...

Supportive Care
Symptom Management

Role of Patient-Reported Outcome Measures in Assessing Chemotherapy-Induced Peripheral Neuropathy

A cohort study reported in JAMA Network Open by Li et al demonstrated the superiority of patient-reported outcome measures vs other methods in assessing nerve damage in patients with cancer who underwent neurotoxic chemotherapy. “Accordingly, the adoption of chemotherapy-induced peripheral...

Breast Cancer
Supportive Care
Pain Management
Symptom Management

Exercise Program May Improve Symptoms, Quality of Life in Patients With Metastatic Breast Cancer

Researchers have shown that participating in an exercise program may improve pain, fatigue, and the quality of life in patients with metastatic breast cancer, according to a recent study published by Hiensch et al in Nature Medicine. Background “Although there’s substantial evidence for the...

Breast Cancer
Supportive Care
Symptom Management
Genomics/Genetics

Germline Risk of Taxane-Induced Peripheral Neuropathy in Black Women With Early-Stage Breast Cancer

Results from the ECOG-ACRIN EAZ171 trial—reported in the Journal of Clinical Oncology by Schneider et al—showed that germline predictors of taxane-induced peripheral neuropathy were not associated with an increased risk of taxane-induced peripheral neuropathy in Black women with early-stage breast...

Breast Cancer
Supportive Care
Symptom Management
Integrative Oncology

Tai Chi vs Cognitive Behavioral Therapy: Measuring Inflammatory Biomarkers in Breast Cancer Survivors With Insomnia

Both tai chi and cognitive behavioral therapy may reduce insomnia and inflammation and bolster antiviral defenses in breast cancer survivors, according to a recent study published by Irwin et al in Brain, Behavior, and Immunity.   Background Chronic insomnia—one of the most prominent symptoms...

Breast Cancer
Supportive Care
Symptom Management

Can Acupuncture Improve Hormonal Side Effects in Women Undergoing Breast Cancer Therapy?

Acupuncture may be effective at reducing the hormonal side effects of endocrine therapy in women with breast cancer, according to a recent study published by Lu et al in Cancer.   Background Although endocrine therapy—which is capable of blocking the hormone signaling that drive some types of...

Supportive Care
Symptom Management

Can Methylphenidate Be Used to Treat Fatigue in Patients With Advanced Cancer?

In a UK trial reported in the Journal of Clinical Oncology, Stone et al found that the stimulant methylphenidate did not significantly improve fatigue vs placebo in patients with advanced cancers receiving palliative care. Study Details In the double-blind multicenter study, 159 patients with...

Solid Tumors
Issues in Oncology
Symptom Management

ASTRO Releases Updated Clinical Guidelines on Radiation Therapy for Patients With Bone Metastases

The American Society for Radiation Oncology (ASTRO) outlined recommendations on best practices for treating patients with symptomatic bone metastases and strategies to improve their quality of life, according to updated clinical guidelines published by Alcorn et al in Practical Radiation Oncology....

Head and Neck Cancer
Supportive Care
Symptom Management

Head and Neck Cancer: Osteoradionecrosis of the Jaw Classification System

In a single-institution study reported in the Journal of Clinical Oncology, Watson et al identified risk factors for osteoradionecrosis of the jaw and developed a classification system for the condition in patients receiving radiation therapy for head and neck cancer. Study Details The study...

Prostate Cancer
Symptom Management

GU and GI Symptoms With Postprostatectomy Radiotherapy for Prostate Cancer

As reported in JAMA Oncology by Mark K. Buyyounouski, MD, MS, and colleagues, the phase III NRG-GU003 trial showed noninferiority of hypofractionated postprostatectomy radiotherapy (HYPORT) vs conventionally fractionated postprostatectomy radiotherapy (COPORT) for genitourinary (GU) and...

Breast Cancer
Supportive Care
Symptom Management
Pain Management

Effect of Exercise on Symptom Burden and Quality of Life in Patients With Metastatic Breast Cancer

Taking part in an exercise program may improve pain, fatigue, and quality of life in patients with metastatic breast cancer, according to recent findings presented by Hiensch et al at the 2024 European Breast Cancer Conference (EBCC; Abstract 1). Background “Although there’s been quite a lot of...

Immunotherapy
Symptom Management

CAR T-Cell Therapy Complications: Comparison of Three Testing Modalities

Magnetic resonance imaging (MRI) and lumbar puncture may not always be necessary for diagnosing and managing a serious neurologic complication associated with chimeric antigen receptor (CAR) T-cell therapy, according to a new study published by Mauget et al in Blood Advances. Findings further...

Breast Cancer
Pain Management
Symptom Management

Hyperbaric Oxygen Therapy for Late Local Toxic Effects in Patients Receiving Adjuvant Radiotherapy for Breast Cancer

In a Dutch study (HONEY) reported in JAMA Oncology, van der Molen et al found that patients with breast cancer and late local toxic effects after adjuvant radiotherapy who completed hyperbaric oxygen therapy (HBOT) had reductions in pain and fibrosis. However, only a minority of patients offered...

Prostate Cancer
Symptom Management
Supportive Care

Plant-Based Diet May Be Linked to Improved Sexual Health in Men Treated for Prostate Cancer

Plant-based diets may be linked to a lower risk of erectile dysfunction, urinary incontinence, and other common side effects experienced by patients receiving treatment for prostate cancer, according to a new study published by Loeb et al in Cancer. The findings indicated that nutrition may lead to ...

Supportive Care
Symptom Management
Solid Tumors

Psilocybin-Assisted Therapy May Reduce Depressive Symptoms in Patients With Cancer

Researchers have uncovered that psilocybin-assisted therapy may be safe and effective in patients with cancer and comorbid major depressive disorder, according to two novel studies published by Agrawal et al and Beaussant et al in Cancer. Background Psilocybin is a hallucinogenic chemical found in...

Hematologic Malignancies
Issues in Oncology
Symptom Management

Ruxolitinib Plus Navitoclax May Reduce Spleen Volume in Patients With Myelofibrosis

The Janus kinase (JAK) inhibitor ruxolitinib plus the B-cell lymphoma 2 protein inhibitor navitoclax may be twice as effective at spleen volume reduction compared with standard-of-care ruxolitinib monotherapy in adult patients with intermediate- or high-risk myelofibrosis, according to new findings ...

Supportive Care
Symptom Management
Solid Tumors

Mind-Body Fitness Classes May Reduce Unplanned Hospitalizations, Urgent Care Visits During Cancer Care

Participation in virtual mind-body fitness classes may be effective at reducing hospitalizations, urgent care visits, and the length of hospital stays among patients with cancer by about 50%, according to new findings presented by Mao et al at the 2023 ASCO Quality Care Symposium (Abstract 473)....

Leukemia
Issues in Oncology
Symptom Management

Do Low- and Moderate-Grade Adverse Events Affect Rates of Treatment Discontinuation in CLL?

In an analysis from the phase III ECOG/ACRIN E1912 trial in chronic lymphocytic leukemia (CLL) published in the Journal of Clinical Oncology, O’Connell et al found that grade 1 and 2 adverse events were significant contributors to patient-reported side-effects bother, with grade 2 events being...

Supportive Care
Pain Management
Palliative Care
Symptom Management

Using Recent Diagnostic Scans May Cut Time to Treatment for Patients Needing Urgent Palliative Radiotherapy

Using previously taken diagnostic computed tomography (CT) scans in place of CT simulation scans to plan simple palliative radiation treatments may substantially reduce the time spent waiting for urgent treatment, improving the patient experience, a new study suggests. Patients who may benefit from ...

Gynecologic Cancers
Supportive Care
Symptom Management

Psilocybin and Other Psychedelics May Help Patients With Late-Stage Gynecologic Cancer Tackle Mental Health Symptoms

Investigators revealed that psilocybin-assisted psychotherapy and other psychedelics may effectively ease symptoms of anxiety and depression in patients with late-stage gynecologic cancers, according to a new commentary published by Yaniv et al in the International Journal of Gynecological Cancer.  ...

CNS Cancers
Issues in Oncology
Symptom Management

Preoperative Stereotactic Radiosurgery May Help Patients With Metastatic Brain Tumors Reduce the Risk of Disease Progression and Adverse Effects

Researchers have found that preoperative stereotactic radiosurgery is associated with low rates of tumor recurrence, adverse radiation effects, and meningeal disease in patients with metastatic brain tumors, according to a novel study published by Prabhu et al in JAMA Oncology. Background As...

Supportive Care
Symptom Management

Chemotherapy-Induced Peripheral Neuropathy May Be More Severe With Paclitaxel Than With Docetaxel

Researchers have found that patients who have breast cancer who undergo treatment with taxanes show a pattern of clinically meaningful, persistent sensory and motor symptoms associated with chemotherapy-induced peripheral neuropathy, according to new findings presented by Trivedi et al at the 2023...

Supportive Care
Symptom Management

Patients Who Practice Qigong May Be Able to Improve Their Cancer-Related Fatigue

Researchers have found that patients with cancer-related fatigue who practiced qigong may have demonstrated clinically significant improvements in their fatigue burden after 10 weeks, according to a new study published by Zimmerman et al in Integrative Cancer Therapies. The findings revealed that...

supportive care
symptom management
breast cancer
colorectal cancer

Lindsay L. Peterson, MD, on Exercise and Cancer Outcomes

Lindsay L. Peterson, MD, of the Washington University, St. Louis, discusses the value of physical activity in improving cancer prognosis, especially for patients with breast or colon cancer. Aerobic exercises and resistance training are recommended during and after treatment. Exercise may help inhibit tumor growth, improve quality of life by decreasing fatigue and anxiety, build muscle mass, increase physical function, and reduce surgical complications and treatment delays.

Symptom Management

Olanzapine to Prevent Chemotherapy-Related Anorexia in Newly Diagnosed Patients With Advanced Cancers

In an Indian single-center study reported in the Journal of Clinical Oncology, Sandhya et al found that olanzapine was associated with weight gain and improved appetite vs placebo in patients receiving chemotherapy for newly diagnosed locally advanced or metastatic gastric,...

Symptom Management
Hematologic Malignancies
Immunotherapy

CAR T-Cell Therapy May Improve Quality of Life of Patients With Hematologic Malignancies

Patients with hematologic malignancies may experience a significant improvement in their reported quality of life 6 months after receiving chimeric antigen receptor (CAR) T-cell therapy, according to a new study published by Johnson et al in Blood Advances. Background Although CAR T-cell therapy...

Symptom Management

Study Assesses Prevalence, Severity, and Co-occurrence of Common Symptoms That May Be Undertreated in Patients With Cancer

Investigators have revealed the findings from an examination of the prevalence, severity, and co-occurrence of sleep disturbance, pain, physical function impairment, anxiety, depression, and low energy/fatigue (SPPADE) symptoms, as well as their association with different cancer types and patient...

Symptom Management

New Study Demonstrates Inferior Vena Cava Filters May Be Safe and Effective Way to Prevent Venous Thromboembolism

Researchers have discovered that few adverse events may be associated with the use of inferior vena cava filters to help prevent deep vein thrombosis from developing into pulmonary embolisms, according to a new study jointly published by Johnson et al in the Journal of Vascular and Interventional...

Integrative Oncology
Symptom Management

Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: Health-Related Quality-of-Life Outcomes From a Randomized Clinical Trial

Guest Editor’s Note: Chemotherapy-induced peripheral neuropathy is a common and potentially debilitating side effect of neurotoxic chemotherapy. It worsens the quality of life for many cancer survivors, with limited treatment options. In this installment of The ASCO Post’s Integrative Oncology...

Issues in Oncology
Symptom Management

Common Immune-Related Adverse Events: Spotlight on Gastrointestinal and Hepatic Toxicities

At the inaugural MD Anderson Clinical Education Symposium on Immunotherapy Organ Toxicity Management (IOTOX), a panel of experts discussed common immune-related adverse events associated with immune checkpoint inhibitor therapy, including gastrointestinal (GI), hepatic, dermatologic, pulmonary, and ...

Hematologic Malignancies
Symptom Management

Axatilimab for Refractory Chronic Graft-vs-Host Disease

In a phase I/II study reported in the Journal of Clinical Oncology, Carrie L. Kitko, MD, and colleagues found that axatilimab, an anti–colony-stimulating factor 1 receptor (CSF-1R) antibody, produced high response rates in patients who had undergone allogeneic hematopoietic cell transplantation and ...

Integrative Oncology
Symptom Management

Massage Therapy May Improve Symptom Burden for Pediatric Patients With Hematologic and/or Oncologic Conditions

A new study from University Hospitals (UH) Connor Whole Health found children, adolescents, and young adults with cancer or sickle cell disease treated at a pediatric academic medical center reported clinically significant reductions in pain, stress, and anxiety in response to massage therapy....

Symptom Management
Cost of Care

Study Compares the Cost and Efficacy of Anticoagulant Therapies

Research conducted by UC Davis Comprehensive Cancer Center and the University of Cincinnati showed that direct oral anticoagulants (DOACs) are more effective—and more cost-effective—than low–molecular-weight heparin for treating cancer-associated thrombosis. A study published by Gulati et al in...

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