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Your search for The ASCO Post matches 132 pages

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cns cancers
lung cancer
gynecologic cancers

Aldoxorubicin Receives FDA Orphan Drug Designations for Glioblastoma, Small Cell Lung Cancer, and Ovarian Cancer

The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designations to aldoxorubicin in three indications: glioblastoma multiforme, small cell lung cancer, and ovarian cancer. Aldoxorubicin combines doxorubicin with a novel single-molecule linker that binds directly and...

cns cancers

FDA Grants Orphan Drug Designation to Bivalent Vaccine for Neuroblastoma

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to MabVax Therapeutics’ vaccine for the treatment of relapsed or recurrent high-risk neuroblastoma in remission or with limited residual disease after best available treatment. The bivalent vaccine is intended to...

cns cancers

FDA Grants Priority Review to Lanreotide Injection for Gastroenteropancreatic Neuroendocrine Tumors

The U.S. Food and Drug Administration (FDA) has accepted and granted priority review to Ipsen’s supplemental New Drug Application (sNDA) for the somatostatin analog lanreotide (Somatuline Depot) 120 mg injection in the treatment of gastroenteropancreatic neuroendocrine tumors. The FDA...

cns cancers

Early Study Identifies Tumor-Suppressor Gene, Potential Therapy for Medulloblastoma

An international, multi-institutional research group led by scientists at the Cancer and Blood Diseases Institute (CBDI) at Cincinnati Children’s Hospital Medical Center has identified a novel molecular pathway that causes an aggressive form of medulloblastoma, The study, reported by He et al ...

cns cancers

Investigational Compound ABT-414 Receives Orphan Drug Designation for Glioblastoma Multiforme

The U.S. Food and Drug Administration has granted orphan drug designation to AbbVie’s investigational compound ABT-414, which is being evaluated for safety and efficacy in patients with glioblastoma multiforme. ABT-414 is an investigational anti-EGFR (epidermal growth factor receptor)...

cns cancers

Lanreotide Significantly Prolongs Progression-Free Survival in Metastatic Gastroenteropancreatic Neuroendocrine Tumors

Although somatostatin analogs are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors, data on their antitumor effects are limited. In the phase III CLARINET trial reported in The New England Journal of Medicine, Caplin et al found that somatostatin...

cns cancers

Brain Tumor Invasion Along Blood Vessels May Lead to New Cancer Treatments, Preclinical Study Suggests

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain’s protective barrier, preclinical study published in Nature Communications indicated. The finding by Watkins et al could ultimately lead to new ways to bring about the ...

cns cancers

Brain Tumor Risk Greater in Women Who Begin Menstruation at Older Age, Study Reports

Women who begin menstruation at an older age have a significantly increased risk of developing a brain tumor, a Moffitt Cancer Center study shows. The results are part of a large multicenter study to determine potential risk factors associated with the development of glioma and meningioma. The...

cns cancers

ASCO 2014: Addition of Chemotherapy to Radiotherapy Improves Survival in Low-Grade Glioma

In a long-term follow-up analysis of RTOG 9802, the addition of PCV (procarbazine [Matulane], lomustine [CeeNu], and vincristine) to radiotherapy prolonged both progression-free survival and overall survival in adult patients with low-grade glioma. The findings were reported at the 2014 ASCO Annual ...

cns cancers
issues in oncology

Gene Sequencing Project Discovers Mutations Tied to High-Grade Gliomas in Young Children

The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric high-grade gliomas. The findings by Wu et al were published in Nature Genetics and may lead to improved outcomes for children with these brain...

cns cancers
issues in oncology

Researchers Identify Transcription Factors Distinguishing Glioblastoma Stem Cells

The activity of four transcription factors appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by Suvà et al, published online in Cell, support the importance of epigenetics in...

cns cancers
issues in oncology

Deep, Integrated Genomic Analysis Reclassifies Lower-Grade Brain Tumors

Using comprehensive genomic analysis, researchers have sorted low-grade brain tumors into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme, the most lethal of brain tumors. The findings were reported at the American Association for Cancer...

cns cancers

Pemetrexed and Gemcitabine Show Promise Against Aggressive Childhood Brain Tumor

The quest to improve survival of children with a high-risk brain tumor has led investigators at St. Jude Children's Research Hospital to two drugs already used to treat adults with breast, pancreatic, lung, and other cancers. The study by Morfouace at al was published today in Cancer Cell....

cns cancers

Study Identifies Possible New Target for Future Glioblastoma Drugs

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by Yan et al published in Cancer Research. The findings show that high levels of the enzyme PRMT5...

cns cancers

Study Identifies Common Driver of a Childhood Brain Tumor

The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The findings were published online in...

cns cancers

Optimized Radiation Treatment Schedule for Glioblastoma May Extend Survival

An altered radiation treatment schedule for glioblastoma, the most common and lethal form of brain cancer, extended the survival period of mice with the disease, according to a new study published in Cell. Because the research involved mice, the study does not recommend a specific new schedule for...

cns cancers
pancreatic cancer

Combination Capecitabine/Temozolomide Appears Highly Effective in Patients With Treatment-Resistant Neuroendocrine Tumors

Interim results from an ongoing phase II clinical trial in patients with various types of advanced neuroendocrine tumors show that a new chemotherapy combination of capecitabine and temozolomide either stalled disease progression or shrank tumors in 95% of patients whose disease worsened after...

cns cancers

Imaging Studies May Predict Tumor Response to Antiangiogenic Drugs

Advanced imaging techniques may be able to distinguish which patients' tumors will respond to treatment with antiangiogenic drugs and which will not. In a report published online in PNAS, researchers studied patients with newly diagnosed glioblastoma who were treated with the antiangiogenic agent...

cns cancers

Researchers Identify Potential New Drug for Inherited Cancer

Scientists from The Scripps Research Institute have identified a new drug candidate for an inherited form of cancer with no known cure. The new study showed the drug candidate—known as FRAX97—slowed the proliferation and progression of tumor cells in animal models of neurofibromatosis...

cns cancers

ASTRO: Younger Adults With a Limited Number of Brain Metastases Have Improved Overall Survival After Stereotactic Radiosurgery Alone

When treated with stereotactic radiosurgery that is not combined with whole-brain radiotherapy, adult brain cancer patients who were 50 years old and younger were found to have improved survival, according to research presented on Sunday, September 22, at the American Society for Radiation...

cns cancers

ASTRO: Proton Therapy Yields Encouraging Outcomes for Pediatric Brain Tumor Patients

When used to treat pediatric patients with intracranial malignant tumors, proton therapy may limit the toxicity of radiation therapy while preserving tumor control, according to research presented on Sunday, September 22, at the American Society for Radiation Oncology’s 55th Annual Meeting...

cns cancers

New Laser-Based Tool Could Dramatically Improve the Accuracy of Brain Tumor Surgery

A new laser-based technology may make brain tumor surgery much more accurate, allowing surgeons to tell cancer tissue from normal brain at the microscopic level while they are operating, and avoid leaving behind cells that could spawn a new tumor. In a new paper published in Science Translational...

cns cancers

Brain Cancer Survival Improved Following FDA Approval of Bevacizumab, Mayo Study Finds

A new population-based study has found that patients with glioblastoma who died in 2010, after the FDA approval of bevacizumab (Avastin), had lived significantly longer than patients who died of the disease in 2008, prior to the conditional approval of the drug for the treatment of  brain...

cns cancers

New MRI Technique Reveals Brain Tumor Response to Antiangiogenesis Therapy

A new way of analyzing data acquired in magnetic resonance imaging (MRI) appears to be able to identify whether or not tumors are responding to antiangiogenesis therapy, which may help physicians determine the most appropriate treatments for patients. In a report published online in Nature...

cns cancers

Study Suggests Neural Stem Cells May Regenerate After Radiation Therapy

Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new research in mice suggests that neural stem cells, the body's source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like...

cns cancers
issues in oncology

Study Reveals Genes That Drive Glioblastoma

A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published online...

issues in oncology
cns cancers

Digital PCR Technology Detects Brain Tumor–associated Mutation in Cerebrospinal Fluid

Researchers at Massachusetts General Hospital have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid of patients with brain tumors.  In a report published in Molecular Therapy – Nucleic Acids, the...

cns cancers

Virus Combination Effective Against Temozolomide-resistant Glioblastoma Multiforme

A combination of the myxoma virus and the immune suppressant rapamycin can kill glioblastoma multiforme, the most common and deadliest malignant brain tumor, according to new research published in Neuro-Oncology. Study lead author Peter A. Forsyth, MD, Chair of the Neuro-oncology Program at Moffitt ...

cns cancers

Metabolic Molecule Drives Growth of High-grade Glioma

A study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has identified an abnormal metabolic pathway that drives cancer cell growth in a particular glioblastoma...

cns cancers

Cytomegalovirus Might Speed Brain Cancer Growth

A study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) and Dana-Farber Cancer Institute suggests that cytomegalovirus, a virus that infects most adults in the United...

cns cancers

ASCO 2013: Adding Bevacizumab to Standard First-line Chemoradiation for Glioblastoma Does Not Improve Overall Survival

A randomized phase III study found no improvement in overall survival after the addition of bevacizumab (Avastin) to standard first-line chemoradiation for glioblastoma. Patients who received bevacizumab also experienced more side effects compared to those treated with chemoradiation alone. The...

cns cancers

New Minimally Invasive, MRI-guided Laser Treatment for Glioblastoma Found to Be Promising in Study

The NeuroBlate Thermal Therapy System provides a new, safe, and minimally invasive procedure for treating recurrent glioblastoma, according to the first-in-human study of the system. The study, published online today in the Journal of Neurosurgery, was written by lead author Andrew Sloan, MD,...

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