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issues in oncology
solid tumors

High Presurgical Levels of Angiogenic and Growth Factors Are Associated With Poorer Survival After Gastric Resection

In patients undergoing gastric resection for gastric/gastroesophageal junction cancers, high levels of angiogenic and growth factors are associated with poorer overall survival, according to the results of a retrospective study presented by Park et al in the Annals of Surgical Oncology. Thus, these ...

colorectal cancer
issues in oncology

Known Lung Cancer Oncogenes ALK and ROS1 May Also Drive Certain Colorectal Tumors

ALK and ROS1 gene rearrangements, which are known to drive subsets of lung cancer, appear to be present in some colorectal cancers as well, according to the results of a study published in Molecular Cancer Research. The findings by Aisner et al suggest that therapies used to target these two...

Oral Insulin Sensitizers Associated With Decreased Cancer Risk in Women With Type 2 Diabetes

According to the findings of a meta-analysis by Sun et al published in Diabetes, Obesity, and Metabolism, patients with type 2 diabetes mellitus who are on certain therapies, such as insulin secretagogues, may be at higher risk for cancer. This increased risk was seen more frequently in women, and...

prostate cancer

Second-Line Therapies May Benefit Patients With Castration-Resistant Prostate Cancer and Poor Performance Status

Patients with castration-resistant prostate cancer and a poor performance status who were previously treated with docetaxel may benefit from currently available second-line therapies, according to the findings of a meta-analysis by Iacovelli et al published in Prostate Cancer and Prostatic...

prostate cancer

Long-Term Symptoms Beyond 10 Years Experienced by Prostate Cancer Survivors

Years after receiving treatment, many patients who survive prostate cancer continue to experience treatment-related symptoms, according to the findings of a study by Darwish-Yassine et al published in the Journal of Cancer Survivorship. These findings highlight the need for improvements in survivor ...

lung cancer

Reduced Renal Function Observed in Patients Taking Crizotinib for Non‒Small Cell Lung Cancer

Patients receiving crizotinib (Xalkori) for the treatment of anaplastic lymphoma kinase (ALK)-positive non?small cell lung cancer (NSCLC) had reductions in their estimated glomerular filtration rate, according to the findings of a study by Brosnan et al published in the journal Cancer. In the...

colorectal cancer

Alternate VEGF Ligands Associated With Bevacizumab Resistance in Metastatic Colorectal Cancer

Results from a University of Colorado Cancer Center study indicated that bevacizumab (Avastin) resistance in patients with colorectal cancer may be due to increases in growth factors other than the targeted VEGF-A. The study, led by Christopher Lieu, MD, and published in the journal PLoS One,...

supportive care

Most Patients Experience Nocturnal Care Disturbances Following Hematopoietic Stem Cell Transplantation

In a study reported in the Clinical Journal of Oncology Nursing, Eileen Danaher Hacker, PhD, APN, AOCN, of the University of Illinois College of Nursing, and colleagues attempted to identify and quantify nocturnal care disruptions in patients undergoing hematopoietic stem cell transplantation. They ...

breast cancer

Surgical Management of Male Breast Cancer Differs Dramatically From That of Female Breast Cancer

In a study reported in the International Journal of Radiation Oncology Biology Physics, Emma C. Fields, MD, of the University of Colorado School of Medicine, and colleagues analyzed the stage-specific management of male breast cancer with surgery and radiation therapy and related them to outcomes...