Carlos L. Arteaga, MD

CARLOS L. ARTEAGA, MD, Director of the Harold C. Simmons Comprehensive Cancer Center and Associate Dean of Oncology Programs at The University of Texas Southwestern Medical Center, Dallas, expressed some caution about the overall applicability of the findings of the PADDY trial. Primarily, he noted, as with many large trials, the study was initiated many years ago, at a time when the portfolio of validated prognostic biomarkers and treatment was different.

“For example, one has to wonder if results would have been the same if patients with luminal B tumors had been treated with more current adjuvant therapy,” said Dr. Arteaga. “And it is common practice to treat most women with early operable breast cancer anyway, that is those with and without detectable disseminated tumor cells.” ■

DISCLOSURE: Dr. Arteaga reported no conflicts of interest.