Treatment With PI3K Inhibitors May Cause Cancers to Become More Aggressive and Metastatic
The enzyme phosphatidylinositol-3 kinase (PI3K) appears to be exploited in almost every type of human cancer, making it the focus of considerable interest as a therapeutic target, with many PI3K-inhibiting drugs currently in various stages of clinical development. However, PI3K inhibitors have only shown modest clinical activity, with patients who receive these drugs experiencing little improvement in survival.
New research from scientists at the Wistar Institute shows that treatment with PI3K inhibitors alone may actually promote more aggressive tumor cell behavior and increase the cancer’s potential of metastasize. These findings were published by Caino et al in the journal Proceedings of the National Academy of Sciences.
PI3K’s Considered Role
Many cancer researchers consider PI3K to be a ‘master switch’ that enables cell proliferation, cell survival, and metastasis. Despite PI3K’s appeal as a target, patients who receive PI3K inhibitors soon become resistant to the drugs after treatment.
Considerable effort is being devoted to garner a better understanding of how tumors adapt to therapy, allowing them to maintain their continued growth and metastatic potential.
In this study, a team of researchers led by Dario C. Altieri, MD, President and CEO of the Wistar Institute, Director of Wistar’s Cancer Center, and the Robert and Penny Fox Distinguished Professor, focused on the role of the mitochondria in tumors. Specifically, they looked at how these mitochondria are reprogrammed when exposed to PI3K inhibition and how these energy sources might prevent targeted agents from being as effective as expected.
“Our prior studies have confirmed that tumor cells rely on energy produced by mitochondria more significantly than previously thought,” Dr. Altieri said. “What we have shown in this study is that, in somewhat of a paradox, treatment with a PI3K inhibitor causes a tumor cell’s mitochondria to produce energy in a localized manner, promoting a far more aggressive and invasive phenotype. The treatment appears to be doing the opposite of its intended effect.”
Study Findings
The study showed that treatment with a PI3K inhibitor causes the mitochondria to migrate to the peripheral cytoskeleton of the tumor cells. Although the mitochondria in untreated cells cluster around the cell’s nucleus, exposure of tumor cells to PI3K therapy causes the mitochondria to move to specialized regions of the cell’s membrane implicated in cell motility and invasion. In this "strategic" position, tumor mitochondria are ideally positioned to provide a concentrated source of energy to support an increase in cell migration and invasion.
PI3K-targeted therapies appear to paradoxically promote a more aggressive tumor behavior, but the dependence of this response on mitochondrial function may offer a new therapeutic angle. Dr. Altieri and his team have shown that targeting mitochondrial function for tumor therapy is feasible and may enhance the anticancer activity of PI3K inhibitors when used in combination.
“These findings continue to support the idea that the mitochondria of tumor cells are crucial to tumor survival and proliferation,” Dr. Altieri said. “It’s certainly counterintuitive that a drug designed to fight cancer may in actuality help it spread, but by identifying why this is happening, we can develop better strategies that allow these drugs to treat tumors the way they should.”
Dr. Altieri is the corresponding author of the Proceedings of the National Academy of Sciences article.
This work was supported by the National Institutes of Health, the Office of the Assistant Secretary of Defense for Health Affairs, and Instituto Nazionale Genetica Molecolare.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
