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Showing 501 - 517Repeating Abnormal PSA Tests Reduces Number of Unnecessary Biopsies
For more than 20 years, the prostate-specific antigen (PSA) test has been used to help screen for prostate cancer. However, in recent years, some task forces have called for this blood test to be abandoned because it leads to many unnecessary biopsies. Now, a new study from The Ottawa Hospital and...
Ibrutinib Produces Responses in Patients With Refractory Classic Hodgkin Lymphoma
In a letter to The New England Journal of Medicine, Hamadani et al describe near-complete and complete responses with the Bruton’s tyrosine kinase inhibitor ibrutinib (Imbruvica) in two heavily pretreated patients with classic Hodgkin lymphoma. Patient 1 The first patient was a 28-year-old...
Internationally Acclaimed Cancer Researcher, Gianni Bonadonna, MD, Dies at 81
Gianni Bonadonna, MD, was considered the “Father of Italian Oncology,” but his scientific contributions to the field and his generous collegial spirit extended far beyond the shores of his native land. Dr. Bonadonna was at the forefront in the battle to convince the surgical...
Fluorescent Imaging of Lung Lesions During Surgery May Localize Tumors and Improve Precision
More than 80,000 people undergo resection of a pulmonary tumor each year, and currently the only method to determine whether the tumor is malignant is histologic analysis. A new study reported that a targeted molecular contrast agent can be used successfully to render lung adenocarcinomas...
Study Supports Early Intervention for Prostate Cancer Patients Who Experience Significant Emotional Distress
A study led by the University at Buffalo (UB) and Roswell Park Cancer Institute (RPCI) has identified beliefs and personality traits associated with higher levels of distress in patients with newly diagnosed prostate cancer. The findings support the value of emotional and informational support for...
AUA 2015: New Studies Call for Smarter Approach to Prostate Cancer Screening
Prostate cancer is one of the most common cancers in American men, yet controversy over the utilization and frequency of prostate-specific antigen (PSA) screening methods remains, due to the overdiagnosis and overtreatment of men with low-grade, less-aggressive forms of the disease. At the 110th...
Regional-Level Correlation of Inappropriate Prostate Imaging and Inappropriate Breast Imaging
In a study reported in JAMA Oncology, Makarov et al found that hospital referral regions marked by higher rates of inappropriate imaging in patients with low-risk breast cancer also had high rates of inappropriate prostate imaging in patients with low-risk prostate cancer. Inappropriate imaging...
Testosterone Therapy May Help Some Men With Castration-Resistant Prostate Cancer
According to researchers at the Johns Hopkins Kimmel Cancer Center, testosterone, which is generally thought to be a feeder of prostate cancer, has been found to suppress some advanced prostate cancers. The hormone may also reverse resistance to testosterone-blocking drugs used to treat prostate...
High Rate of Hepatitis B Reactivation in Chinese Patients Receiving Rituximab for Lymphoma
In a prospective Chinese study reported in the Journal of Clinical Oncology, Seto et al found a 2-year rate of hepatitis B virus (HBV) reactivation of 41.5% in hepatitis B surface antigen (HBsAg)-negative and anti–hepatitis B core antigen antibody (anti-HBc)–positive patients receiving...
Loss of Y Chromosome Associated With Higher Mortality and Risk of Cancer in Men
Age-related loss of the Y chromosome from blood cells, a frequent occurrence among elderly men, is associated with elevated risk of various cancers and earlier death, according to research presented at the American Society of Human Genetics 2014 Annual Meeting in San Diego (Abstract 295). This...
Prostate Cancer Prevention Trial Identifies Men Most Likely to Undergo Challenging Study Procedures
Healthy men participating in the Prostate Cancer Prevention Trial who actively participate in all steps of the clinical trial are most likely to undergo a biopsy, according to a study by Gritz et al published in Cancer Epidemiology, Biomarkers & Prevention. The Prostate Cancer Prevention Trial, ...
Successful Vemurafenib Treatment of Progressive BRAF V600E–Mutated Anaplastic Pleomorphic Xanthoastrocytoma
The BRAF inhibitor vemurafenib (Zelboraf) is approved for treatment of BRAF-mutated metastatic melanoma. There are reports indicating that vemurafenib may be active in the treatment of intracranial neoplasms with BRAF mutations. As reported in the Journal of Clinical Oncology, Lee et al from...
MEK Inhibitor Use Associated With Bilateral Subfoveal Neurosensory Retinal Detachment
As reported in JAMA Ophthalmology, McCannel and colleagues identified three cases of subfoveal neurosensory retinal detachment among patients receiving MEK inhibitor therapy for metastatic cancer in clinical trials requiring ophthalmologic examination at their institution. In all cases, the toxic...
New Test Developed to Detect Men at High Risk of Prostate Cancer Recurrence
A new genetic signature to identify prostate cancer patients who are at high risk of their cancer recurring after surgery or radiotherapy has been developed by researchers in Canada, according to a study presented at the 33rd Conference of the European Society for Radiotherapy and Oncology in...
Selenium and Vitamin E Supplements May Increase Risk of Prostate Cancer in Some Men
A multicenter study led by Fred Hutchinson Cancer Research Center has found that high-dose supplementation with both the trace element selenium and vitamin E may increase the risk of high-grade prostate cancer. This risk is dependent upon a man’s selenium status prior to taking the...
Shortened Telomeres in Blood Leukocytes May Be Associated With Increased Risk of Aggressive Prostate Cancer
Men with short-ended chromosomes in the immune cells in their blood were at increased risk for aggressive prostate cancer compared with men with long-ended chromosomes in blood immune cells, according to results presented at the 12th Annual AACR International Conference on Frontiers in Cancer...
Telomere Length May Be a Prognostic Marker for Prostate Cancer
Cancer cells are known to have short telomeres, but just how short they are from cancer cell to cancer cell may be a determining factor in a prostate cancer patient's prognosis, according to a study led by scientists at Johns Hopkins. "Doctors are looking for new ways to accurately predict...
