The Evolving Role of Biomarkers in Oncology

Vamsi Velcheti, MD, and Hossein Borghaei, DO, MS, discuss challenges in using programmed death-ligand 1 (PD-L1) and tumor mutation burden (TMB) as biomarkers to determine which patients will or won’t respond to immunotherapy with a checkpoint inhibitor as well as whether biomarkers exist to identify which patients will experience adverse events from immunotherapies.

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