This week, we’ll be going over news from the 2019 American Society for Radiation Oncology (ASTRO) Annual Meeting, including an analysis of the effect of long-term hormonal therapy on men with low prostate-specific antigen levels treated with early salvage radiotherapy after radical prostatectomy and an update on the landmark PACIFIC trial in non–small cell lung cancer. We also discuss the launch of Project Orbis, which led to a joint approval from the FDA, the Australian Therapeutic Goods Administration, and Health Canada for lenvatinib in combination with pembrolizumab in the treatment of some patients with advanced endometrial carcinoma.