Less than half of community oncologists surveyed indicated that they use biomarker testing to guide patient discussions compared with 73% of academic clinicians, according to a report by Boehmer et al presented at the International Association for the Study of Lung Cancer (IASLC) 2021 World Conference on Lung Cancer (Abstract OA10.01).
Recent advances in cancer genomics and targeted therapies have substantially changed the management of lung cancer, but like many new medical technologies, there is a concern these new methods, which include biomarker testing, will not be used equally throughout the health-care system and may worsen existing disparities.
Survey Creation
To determine this, the Association of Community Cancer Centers (ACCC), led by Chief Medical Officer Leigh Boehmer, PharmD, developed a survey instrument for U.S. oncology clinicians. ACCC partnered with LUNGevity for the patient-facing components of this project.
This study used a mixed-methods approach to understand practice patterns, attitudes, and current educational needs related to biomarker testing to determine ongoing goals for related education and implementation needs. Objectives of the survey included assessment of current practice patterns, attitudes, barriers, and resource needs related to the ordering of biomarker testing.
To be included, clinicians had to care for patients with non–small cell lung cancer who were uninsured or covered by Medicaid (including dual-eligible beneficiaries).
The researchers developed a survey instrument that was based on data analysis, open-ended response coding, and subanalyses between demographic cohorts (with an emphasis on community vs academic clinicians) to capture differences in decision-making and attitudes. To provide context to these data, two virtual focus groups were also conducted.
Results
To help guide clinicians in the use of biomarker testing, the College of American Pathologists, the IASLC, and the Association for Molecular Pathology published the 2018 CAP/IASLC/AMP Molecular Testing Guidelines for Lung Cancer. Dr. Boehmer reported that of the 99 responses collected, only 40% indicated they were “very” or “extremely familiar” with the 2018 guidelines.
Clinicians were most confident in selecting appropriate tests to use, interpreting test results, and prognosticating based on test results, but less confident in determining when to order testing and coordinating care across the multidisciplinary team. This lack of communication was echoed in the focus groups, Dr. Boehmer reported.
He stated that clinicians are most likely to order biomarker testing to make more accurate treatment decisions and inform patient discussions, but only 48% of community clinicians indicated that they use biomarker testing to guide patient discussions compared to 73% of academic clinicians (P = .021).
When asked about their preferences when making a final testing decision, 41% of clinicians reported preferring that they share responsibility with the patient, while 52% have a more prescriptive approach, preferring to make the final decision themselves. Only 6% reported a preference that the patient make the final decision about testing. Focus groups suggest clinicians perceive that patients rarely understand what testing entails and what it means for their treatment options.
To make more informed decisions about biomarker testing, clinicians indicated that they need more information on financial resources, as well as education around both published guidelines and practical implications of clinical data. Sixty-seven percent of clinicians provide printed educational materials to their patients. When asked what resources their patients need most, 27% said their patients need handouts or educational resources, followed by psychosocial support (23%), and financial assistance (22%).
“This study identifies key areas of ongoing clinician need related to biomarker testing, including increased guideline familiarity, practical applications of guideline-concordant testing, and how to optimally help coordinate multidisciplinary care,” Dr. Boehmer said. “Professional organizations and advocacy groups should focus on developing impactful education materials and tools for improving patient-clinician discussions about biomarker testing.”
