New data from an ongoing phase II trial evaluating first-line intratumoral administration of sotigalimab, a CD40 agonist antibody, in combination with systemic pembrolizumab, an anti–PD-1 antibody, in metastatic melanoma was presented by Bentebibel et al at the Society for Immunotherapy of Cancer (SITC) 2022 Annual Meeting (Abstract 782). Results showed that the combination therapy was well tolerated in the trial, and an improved best overall response rate was observed relative to the standard of care, pembrolizumab monotherapy. Broad innate and adaptive immune activation was observed in both local and distant (noninjected) lesions.
Adi Diab, MD
“While checkpoint inhibitors are the current standard of care for metastatic melanoma, many patients are unresponsive or develop resistance after initial tumor regression,” said Adi Diab, MD, Associate Professor of Melanoma Medical Oncology at The University of Texas MD Anderson Cancer Center and principal investigator of the study. “Results from the ongoing phase II trial of intratumoral sotigalimab and the PD-1 inhibitor pembrolizumab showed a promising overall response rate, including responses achieved in PD-L1–negative tumors. Moreover, this encouraging antitumor activity correlated with treatment-induced immunologic changes, such as activated myeloid dendritic cells and macrophages, which support the mechanism of action and differentiated activity of sotigalimab—ultimately leading to inflammatory immune responses in the local injected tumor as well as distant noninjected lesions."
Key data and conclusions featured in the SITC presentation include:
Disclosure: For full disclosures of the study authors, visit jitc.bmj.com.The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.