Effects of Tumor-Infiltrating Clonal Hematopoiesis

A study investigated tumor-infiltrating clonal hematopoiesis (TI-CH) in patients with early-stage non–small cell lung cancer and solid tumors, uncovering an association with increased risk of death or recurrence. It revealed CHIP mutations in early-stage NSCLC and solid tumors, with the TET2 mutation being the strongest genetic predictor of TI-CH. The findings suggest a role for aging-related hematologic clonal proliferation in cancer evolution.

Source: The New England Journal of Medicine