Effects of Tumor-Infiltrating Clonal Hematopoiesis

1. TI-CH may be associated with increased risk of death or recurrence in patients with early-stage NSCLC and solid tumors.

2. CHIP mutations were observed in 34% of NSCLC patients.

3. TET2 mutation was identified as the strongest genetic predictor of TI-CH.

4. TI-CH was linked to remodeling of the tumor immune microenvironment.

Source: The New England Journal of Medicine